{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T17:18:10Z","timestamp":1764350290861},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicon"],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.1016\/j.toxicon.2015.11.010","type":"journal-article","created":{"date-parts":[[2015,11,22]],"date-time":"2015-11-22T09:45:19Z","timestamp":1448185519000},"page":"12-18","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Retrospective survey to evaluate the safety and efficacy of Japanese botulinum antitoxin therapy in Japan"],"prefix":"10.1016","volume":"110","author":[{"given":"Keita","family":"Mottate","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Yokote","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigemi","family":"Mori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Horita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinobu","family":"Miyatsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasushi","family":"Torii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunji","family":"Kozaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaaki","family":"Iwaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motohide","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiro","family":"Ginnaga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.toxicon.2015.11.010_bib1","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/0002-9343(80)90469-6","article-title":"Hypersensitivity reactions associated with botulinal antitoxin","volume":"69","author":"Black","year":"1980","journal-title":"Am. J. Med."},{"issue":"12","key":"10.1016\/j.toxicon.2015.11.010_bib2","doi-asserted-by":"crossref","first-page":"5111","DOI":"10.1073\/pnas.72.12.5111","article-title":"Activation of antibody Fc function by antigen induced conformational changes","volume":"72","author":"Brown","year":"1975","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.toxicon.2015.11.010_bib3","article-title":"Botulism in the United States, 1899\u20131996","author":"Center for Disease Control and Prevention","year":"1998"},{"key":"10.1016\/j.toxicon.2015.11.010_bib4","first-page":"191","article-title":"Human botulism in Canada (1919\u20131973)","volume":"19","author":"Dolman","year":"1974","journal-title":"Can. Med. Assoc. J."},{"issue":"4","key":"10.1016\/j.toxicon.2015.11.010_bib5","doi-asserted-by":"crossref","first-page":"442","DOI":"10.7326\/0003-4819-95-4-442","article-title":"Clinical features of types A and B food-borne botulism","volume":"95","author":"Hughes","year":"1981","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.toxicon.2015.11.010_bib6","series-title":"Proceedings of the First U.S.-Japan Conference on Toxic Micro-organisms","first-page":"357","article-title":"Epidemiological and clinical observations of botulism outbreaks in Japan","author":"Iida","year":"1970"},{"issue":"6","key":"10.1016\/j.toxicon.2015.11.010_bib7","doi-asserted-by":"crossref","first-page":"961","DOI":"10.3201\/eid1906.120873","article-title":"Foodborne botulism in Canada, 1985\u20132005","volume":"19","author":"Leclair","year":"2013","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.toxicon.2015.11.010_bib8","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.toxicon.2013.09.010","article-title":"Pathogenic mechanisms underlying adverse reactions induced by intravenous administration of snake antivenoms","volume":"76","author":"Leon","year":"2013","journal-title":"Toxicon"},{"issue":"4","key":"10.1016\/j.toxicon.2015.11.010_bib9","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1580\/1080-6032(2003)14[220:SSFAOA]2.0.CO;2","article-title":"Serum sickness following administration of antivenin (Crotalidae) polyvalent in 181 cases of presumed rattlesnake envenomation","volume":"14","author":"LoVecchio","year":"2003","journal-title":"Wilderness Environ. Med."},{"issue":"4","key":"10.1016\/j.toxicon.2015.11.010_bib10","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1093\/pubmed\/fdl053","article-title":"Food-borne botulism in the United Kingdom","volume":"24","author":"McLauchlin","year":"2006","journal-title":"J.\u00a0Public Health"},{"issue":"5","key":"10.1016\/j.toxicon.2015.11.010_bib11","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/0002-9343(84)90988-4","article-title":"Equine antitoxin use and other factors that predict outcome in type A foodborne botulism","volume":"76","author":"Tacket","year":"1984","journal-title":"Am. J. Med."},{"key":"10.1016\/j.toxicon.2015.11.010_bib12","first-page":"71","article-title":"Outbreaks of botulism in Hokkaido (1988)","volume":"40","author":"Aikawa","year":"1990","journal-title":"Rep. Hokkaido Inst. Public Health"},{"key":"10.1016\/j.toxicon.2015.11.010_bib13","first-page":"74","article-title":"Outbreaks of botulism in Hokkaido (1989)","volume":"40","author":"Aikawa","year":"1990","journal-title":"Rep. Hokkaido Inst. Public Health"},{"issue":"3","key":"10.1016\/j.toxicon.2015.11.010_bib14","first-page":"237","article-title":"Clostridium botulinum, a case and its background of widespread outbreaks of botulism","volume":"12","author":"Dohke","year":"1985","journal-title":"Clin. Microbiol."},{"key":"10.1016\/j.toxicon.2015.11.010_bib15","series-title":"A\u00a0Dead Case of Food Poisoning Caused by \u201cKarashi Renkon\u201d in Saga Prefecture","author":"Fujimoto","year":"1985"},{"key":"10.1016\/j.toxicon.2015.11.010_bib16","series-title":"An Outbreak of Type a Botulism Suspected as Food-borne","author":"Fukaya","year":"2009"},{"key":"10.1016\/j.toxicon.2015.11.010_bib17","series-title":"A\u00a0Case of Unexplained Botulism in Kumamoto Prefecture. Infectious Agents Surveillance Report 34","first-page":"112","author":"Furukawa","year":"2013"},{"key":"10.1016\/j.toxicon.2015.11.010_bib18","series-title":"A\u00a0Summary and a Response to Food-borne Botulism in Oita","author":"Hoashi","year":"1984"},{"key":"10.1016\/j.toxicon.2015.11.010_bib19","first-page":"6","article-title":"Outbreaks of botulism in Hokkaido in 1962","volume":"14","author":"Iida","year":"1964","journal-title":"Rep. Hokkaido Inst. Public Health"},{"key":"10.1016\/j.toxicon.2015.11.010_bib20","series-title":"National Institute of Infectious Diseases, Guide to Botulism","first-page":"137","article-title":"Type A botulism caused by vacuum-packed \u201cKarashi Renkon\u201d","author":"Ito","year":"2001"},{"key":"10.1016\/j.toxicon.2015.11.010_bib21","series-title":"An Outbreak of Food-borne Botulism in Iwate Prefecture","author":"Iwafuchi","year":"2008"},{"key":"10.1016\/j.toxicon.2015.11.010_bib22","series-title":"National Institute of Infectious Diseases, Guide to Botulism","first-page":"92","article-title":"The first incidence of type A food-borne botulism in Japan","author":"Kai","year":"2001"},{"key":"10.1016\/j.toxicon.2015.11.010_bib23","first-page":"82","article-title":"Outbreaks of botulism in Shiga (1989)","volume":"25","author":"Kakei","year":"1990","journal-title":"Rep. Shiga Prefect. Inst. Public Health Environ. Sci."},{"key":"10.1016\/j.toxicon.2015.11.010_bib24","first-page":"83","article-title":"Outbreaks of botulism in Hokkaido (1984)","volume":"35","author":"Kameyama","year":"1985","journal-title":"Rep. Hokkaido Inst. Public Health"},{"key":"10.1016\/j.toxicon.2015.11.010_bib25","series-title":"A\u00a0Case of Botulism Presenting Acute Flaccid Limb Palsy in Kashiwa City, Chiba in August 1999","author":"Kobayashi","year":"1999"},{"key":"10.1016\/j.toxicon.2015.11.010_bib26","series-title":"Two Outbreaks of Botulism Occurring Contemporarily in Hiroshima City. Infectious Agents Surveillance Report 33","first-page":"136","author":"Kyozuka","year":"2012"},{"key":"10.1016\/j.toxicon.2015.11.010_bib27","first-page":"104","article-title":"A\u00a0cace of type E food-borne botulism in Hokkaido in 1967","volume":"18","author":"Mitamura","year":"1968","journal-title":"Rep. Hokkaido Inst. Public Health"},{"key":"10.1016\/j.toxicon.2015.11.010_bib28","first-page":"65","article-title":"Outbreaks of botulism in Hokkaido (1968) part 1","volume":"22","author":"Mitamura","year":"1972","journal-title":"Rep. Hokkaido Inst. Public Health"},{"key":"10.1016\/j.toxicon.2015.11.010_bib29","first-page":"70","article-title":"Outbreaks of botulism in Hokkaido (1969-1971) part 2","volume":"22","author":"Mitamura","year":"1972","journal-title":"Rep. Hokkaido Inst. Public Health"},{"key":"10.1016\/j.toxicon.2015.11.010_bib30","first-page":"93","article-title":"Outbreaks of botulism in Hokkaido (1973)","volume":"24","author":"Mitamura","year":"1974","journal-title":"Rep. Hokkaido Inst. Public Health"},{"key":"10.1016\/j.toxicon.2015.11.010_bib31","series-title":"National Institute of Infectious Diseases, Guide to Botulism","first-page":"103","article-title":"An outbreak of botulism caused by pickled olive made in Italy","author":"Matsumura","year":"2001"},{"key":"10.1016\/j.toxicon.2015.11.010_bib32","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.ijid.2014.01.014","article-title":"Food-borne botulism in Japan in march 2012","volume":"24","author":"Momose","year":"2014","journal-title":"Int. J. Infect. Dis."},{"key":"10.1016\/j.toxicon.2015.11.010_bib33","series-title":"National Institute of Infectious Diseases, Guide to Botulism","first-page":"87","article-title":"A\u00a0case of food-borne botulism occurring in Chiba prefecture","author":"Nakamura","year":"2001"},{"key":"10.1016\/j.toxicon.2015.11.010_bib34","series-title":"A\u00a0Dead Case of Food-borne Botulism, a Case in Chiba Prefecture","author":"Nanayama","year":"1984"},{"key":"10.1016\/j.toxicon.2015.11.010_bib35","first-page":"16","article-title":"An outbreak of botulism in Rokkasho village, Kamikita","volume":"17","author":"Ohtomo","year":"1980","journal-title":"Rep. Aomori Prefect. Inst. Public Health"},{"key":"10.1016\/j.toxicon.2015.11.010_bib36","first-page":"21","article-title":"An outbreak of botulism in Aomori city in 1982","volume":"19","author":"Ohtomo","year":"1982","journal-title":"Rep. Aomori Prefect. Inst. Public Health"},{"key":"10.1016\/j.toxicon.2015.11.010_bib37","first-page":"79","article-title":"Two outbreaks of food poisoning incriminated with Clostridium type E in Aomori prefecture in 1991","volume":"3","author":"Ohtomo","year":"1992","journal-title":"Res. Pap. Aomori Prefect. Inst. Environ. Health"},{"key":"10.1016\/j.toxicon.2015.11.010_bib38","first-page":"32","article-title":"An outbreak of food-borne botulism in Shiga","author":"Shiga Prefectural Institute of Public Health","year":"1975","journal-title":"Inf. Public Health"},{"issue":"8","key":"10.1016\/j.toxicon.2015.11.010_bib39","first-page":"17","article-title":"Food borne botulism caused by \u201cIzushi\u201d in Suttsu town, Hokkaido","volume":"10","author":"Sugawara","year":"1996","journal-title":"Mon. Community Med."},{"key":"10.1016\/j.toxicon.2015.11.010_bib40","doi-asserted-by":"crossref","first-page":"29","DOI":"10.7883\/yoken1952.39.29","article-title":"A\u00a0case report on human type B botulism","volume":"39","author":"Takahashi","year":"1986","journal-title":"Jpn. J. Med. Sci. Biol."},{"key":"10.1016\/j.toxicon.2015.11.010_bib41","first-page":"126","article-title":"An outbreak of botulism in Hokkaido (1982)","volume":"33","author":"Takeshi","year":"1983","journal-title":"Rep. Hokkaido Inst. Public Health"},{"key":"10.1016\/j.toxicon.2015.11.010_bib42","first-page":"67","article-title":"Outbreaks of botulism in Hokkaido (1983)","volume":"34","author":"Takeshi","year":"1984","journal-title":"Rep. Hokkaido Inst. Public Health"},{"key":"10.1016\/j.toxicon.2015.11.010_bib43","first-page":"74","article-title":"Outbreaks of botulism in Hokkaido (1985)","volume":"36","author":"Takeshi","year":"1986","journal-title":"Rep. Hokkaido Inst. Public Health"},{"key":"10.1016\/j.toxicon.2015.11.010_bib44","series-title":"Botulism due to Clostridium butylicum occurring in Miyazaki prefecture. Infectious Agents Surveillance Report 35","first-page":"159","author":"Tashiro","year":"2014"},{"key":"10.1016\/j.toxicon.2015.11.010_bib45","first-page":"13","article-title":"An outbreak of botulism in Aomori city caused by \u201cIwana Izushi\u201d in 1976","volume":"14","author":"Yamamoto","year":"1976","journal-title":"Rep. Aomori Prefect. Inst. Public Health"},{"key":"10.1016\/j.toxicon.2015.11.010_bib46","first-page":"20","article-title":"An outbreak of botulism in Noheji town in 1977","volume":"15","author":"Yamamoto","year":"1979","journal-title":"Rep. Aomori Prefect. Inst. Public Health"},{"key":"10.1016\/j.toxicon.2015.11.010_bib47","first-page":"15","article-title":"Multiple outbreaks of botulism in Aomori prefecture in 1978","volume":"16","author":"Yamamoto","year":"1979","journal-title":"Rep. Aomori Prefect. Inst. Public Health"},{"key":"10.1016\/j.toxicon.2015.11.010_bib48","series-title":"Japanese Antitoxin Supply Support for Botulism Occurring in Thailand and Korea. Infectious Agents Surveillance Report 29","first-page":"45","author":"Yamamoto","year":"2008"},{"key":"10.1016\/j.toxicon.2015.11.010_bib49","series-title":"A\u00a0Summary and a Laboratory Examination of the First Outbreak of Type a Botulism in Akita Prefecture","author":"Yatsuyanagi","year":"1993"}],"container-title":["Toxicon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010115301367?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010115301367?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,17]],"date-time":"2018-09-17T10:21:07Z","timestamp":1537179667000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041010115301367"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2]]},"references-count":49,"alternative-id":["S0041010115301367"],"URL":"https:\/\/doi.org\/10.1016\/j.toxicon.2015.11.010","relation":{},"ISSN":["0041-0101"],"issn-type":[{"value":"0041-0101","type":"print"}],"subject":[],"published":{"date-parts":[[2016,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Retrospective survey to evaluate the safety and efficacy of Japanese botulinum antitoxin therapy in Japan","name":"articletitle","label":"Article Title"},{"value":"Toxicon","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxicon.2015.11.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}