{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T06:13:02Z","timestamp":1770531182059,"version":"3.49.0"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Intecmar (Xunta de Galicia)"},{"name":"FEDER INNTERCONECTA","award":["ITC-20133020"],"award-info":[{"award-number":["ITC-20133020"]}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["AGL2012-40185-C02-02"],"award-info":[{"award-number":["AGL2012-40185-C02-02"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicon"],"published-print":{"date-parts":[[2016,3]]},"DOI":"10.1016\/j.toxicon.2016.01.061","type":"journal-article","created":{"date-parts":[[2016,1,21]],"date-time":"2016-01-21T16:58:10Z","timestamp":1453395490000},"page":"1-7","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Effect of the industrial canning on the toxicity of mussels contaminated with diarrhetic shellfish poisoning (DSP) toxins"],"prefix":"10.1016","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2123-7747","authenticated-orcid":false,"given":"Juan","family":"Blanco","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabiola","family":"Ar\u00e9valo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Correa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Corina","family":"Porro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana G.","family":"Cabado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan M.","family":"Vieites","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angeles","family":"Moro\u00f1o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxicon.2016.01.061_bib1","series-title":"Harmful Marine Algal Blooms. Lavoisier","first-page":"777","article-title":"Dinophysis spp. toxicity to DSP outbreaks: a preliminary model of toxin accumulation in mussels","author":"Blanco","year":"1995"},{"key":"10.1016\/j.toxicon.2016.01.061_bib2","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.foodchem.2015.01.012","article-title":"Effect of the industrial steaming on the toxicity, estimated by LC-MS\/MS, of mussels exposed for a long time to diarrhetic shellfish poisoning (DSP) toxins","volume":"177","author":"Blanco","year":"2015","journal-title":"Food Chem."},{"key":"10.1016\/j.toxicon.2016.01.061_bib3","doi-asserted-by":"crossref","first-page":"3718","DOI":"10.3390\/md11103718","article-title":"Screening tests for the rapid detection of diarrhetic shellfish toxins in Washington state","volume":"11","author":"Eberhart","year":"2013","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.toxicon.2016.01.061_bib4","first-page":"1","article-title":"Scientific opinion of the panel on contaminants in the food chain on a request from the European commission on Marine biotoxins in shellfish \u2013 summary on regulated marine biotoxins","volume":"1306","author":"EFSA Panel on Contaminants in the Food Chain","year":"2009","journal-title":"EFSA J."},{"key":"10.1016\/j.toxicon.2016.01.061_bib5","first-page":"2","article-title":"Statement of the panel on contaminants in the food chain on a request from the European Commission on the influence of processing on the levels of lipophilic marine biotoxins in bivalve molluscs","volume":"1016","author":"EFSA Panel on Contaminants in the Food Chain","year":"2009","journal-title":"EFSA J."},{"key":"10.1016\/j.toxicon.2016.01.061_bib6","series-title":"EU-harmonised Standard Operating Procedure for Determination of Lipophilic Marine Biotoxins in Molluscs by LC-MS\/MS. Version 4","author":"EURLMB","year":"2011"},{"key":"10.1016\/j.toxicon.2016.01.061_bib7","series-title":"EU Harmonised Standard Operating Procedure for Detection of Liphophilic Toxins by Mouse Bioassay. Version 6","author":"EURLMB","year":"2013"},{"key":"10.1016\/j.toxicon.2016.01.061_bib8","series-title":"EU-harmonised Standard Operating Procedure for Determination of Lipophilic Marine Biotoxins in Molluscs by LC-MS\/MS. Version 5","author":"EURLMB","year":"2015"},{"key":"10.1016\/j.toxicon.2016.01.061_bib9","article-title":"Commission regulation (EU) No 15\/2011 of 10 January 2011 amending regulation (EC) No 2074\/2005 as regards recognised testing methods for detecting marine biotoxins in live bivalve molluscs","author":"European Commision","year":"2011","journal-title":"Official J. Eur. Union L 6\/3, 11.1.2011"},{"key":"10.1016\/j.toxicon.2016.01.061_bib10","series-title":"Manual on Harmful Marine Microalgae","article-title":"Mammalian bioassays","author":"Fern\u00e1ndez","year":"1995"},{"key":"10.1016\/j.toxicon.2016.01.061_bib11","series-title":"Harmful Algae","first-page":"449","article-title":"Detoxification of low polarity toxins (DTX3) from mussels Mytilus galloprovincialis in Spain","author":"Fern\u00e1ndez","year":"1998"},{"key":"10.1016\/j.toxicon.2016.01.061_bib12","first-page":"77","article-title":"Bioensayos con mam\u00edferos y ensayos bioqu\u00edmicos y celulares para la detecci\u00f3n de ficotoxinas","author":"Fern\u00e1ndez","year":"2002","journal-title":"Floraciones algales nocivas el Cono Am."},{"key":"10.1016\/j.toxicon.2016.01.061_bib13","series-title":"Manual on Harmful Marine Microalgae","first-page":"347","article-title":"In\u00a0vivo assays for phycotoxins","author":"Fern\u00e1ndez","year":"2003"},{"key":"10.1016\/j.toxicon.2016.01.061_bib14","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.hal.2012.06.001","article-title":"Protein phosphatase inhibition assays for okadaic acid detection in shellfish: matrix effects, applicability and comparison with LC-MS\/MS analysis","volume":"19","author":"Garibo","year":"2012","journal-title":"Harmful Algae"},{"key":"10.1016\/j.toxicon.2016.01.061_bib15","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1016\/j.chroma.2008.12.099","article-title":"Liquid chromatography\u2013tandem mass spectrometry method for the detection of marine lipophilic toxins under alkaline conditions","volume":"1216","author":"Gerssen","year":"2009","journal-title":"J.\u00a0Chromatogr. A"},{"key":"10.1016\/j.toxicon.2016.01.061_bib16","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.toxicon.2005.03.010","article-title":"Tissue distribution, effects of cooking and parameters affecting the extraction of azaspiracids from mussels, Mytilus Edulis, prior to analysis by liquid chromatography coupled to mass spectrometry","volume":"46","author":"Hess","year":"2005","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2016.01.061_bib17","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.toxlet.2015.06.004","article-title":"Diarrhetic effect of okadaic acid could be related with its neuronal action: changes in neuropeptide Y","volume":"237","author":"Louzao","year":"2015","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.toxicon.2016.01.061_bib18","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/j.toxicon.2008.01.009","article-title":"Effects of cooking and heat treatment on concentration and tissue distribution of okadaic acid and dinophysistoxin-2 in mussels (Mytilus edulis)","volume":"51","author":"McCarron","year":"2008","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2016.01.061_bib19","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1021\/jf8025138","article-title":"Formation of azaspiracids-3,-4,-6, and-9 via decarboxylation of carboxyazaspiracid metabolites from shellfish","volume":"57","author":"McCarron","year":"2009","journal-title":"J.\u00a0Agric. Food Chem."},{"key":"10.1016\/j.toxicon.2016.01.061_bib20","doi-asserted-by":"crossref","first-page":"549","DOI":"10.2331\/suisan.48.549","article-title":"Isolation and structural elucidation of the causative toxin of the diarrhetic shellfish poisoning","volume":"48","author":"Murata","year":"1982","journal-title":"Nippon. Suisan Gakkaishi"},{"key":"10.1016\/j.toxicon.2016.01.061_bib21","series-title":"Anuario de acuicultura 2014","author":"Pesca de Galicia","year":"2015"},{"key":"10.1016\/j.toxicon.2016.01.061_bib22","doi-asserted-by":"crossref","first-page":"50","DOI":"10.5923\/j.fph.20120202.09","article-title":"Domoic acid, okadaic acid and spirolides: Inter-species variability in contamination and cooking effects","volume":"2","author":"Picot","year":"2012","journal-title":"Food Public Health"},{"key":"10.1016\/j.toxicon.2016.01.061_bib23","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/j.toxicon.2008.09.001","article-title":"First detection of Pectenotoxin-11 and confirmation of OA-D8 diol-ester in dinophysis acuta from European waters by LC-MS\/MS","volume":"52","author":"Pizarro","year":"2008","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2016.01.061_bib24","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1016\/j.hal.2009.05.004","article-title":"Seasonal variability of lipophilic toxins during a Dinophysis acuta bloom in Western Iberia: differences between picked cells and plankton concentrates","volume":"8","author":"Pizarro","year":"2009","journal-title":"Harmful Algae"},{"key":"10.1016\/j.toxicon.2016.01.061_bib25","series-title":"Manual on Harmful Marine Microalgae","first-page":"211","article-title":"Chemical method for lipophilic shellfish toxins","author":"Quilliam","year":"2003"},{"key":"10.1016\/j.toxicon.2016.01.061_bib26","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.foodchem.2011.04.054","article-title":"Automated on-line solid-phase extraction coupled to liquid chromatography tandem mass spectrometry for determination of lipophilic marine toxins in shellfish","volume":"129","author":"Regueiro","year":"2011","journal-title":"Food Chem."},{"key":"10.1016\/j.toxicon.2016.01.061_bib27","doi-asserted-by":"crossref","first-page":"394","DOI":"10.3390\/md12010394","article-title":"Dinophysis toxins: causative organisms, distribution and fate in shellfish","volume":"12","author":"Reguera","year":"2014","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.toxicon.2016.01.061_bib28","first-page":"77","article-title":"Quantitative determination of the okadaic acid toxins group by a colorimetric phosphatase inhibition Assay: Interlaboratory study","volume":"96","author":"Smienk","year":"2013","journal-title":"J.\u00a0Aoac Int."},{"key":"10.1016\/j.toxicon.2016.01.061_bib29","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.toxicon.2004.04.002","article-title":"Differential dynamics of dinophysistoxins and pectenotoxins between blue mussel and common cockle: a phenomenon originating from the complex toxin profile of Dinophysis acuta","volume":"44","author":"Vale","year":"2004","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2016.01.061_bib30","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.2331\/suisan.44.1249","article-title":"Occurrence of a new type of shellfish poisoning in the Tohoku district","volume":"44","author":"Yasumoto","year":"1978","journal-title":"Bull. Jap. Soc. Sci. Fish."}],"container-title":["Toxicon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010116300125?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010116300125?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,15]],"date-time":"2018-09-15T22:23:26Z","timestamp":1537050206000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041010116300125"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3]]},"references-count":30,"alternative-id":["S0041010116300125"],"URL":"https:\/\/doi.org\/10.1016\/j.toxicon.2016.01.061","relation":{},"ISSN":["0041-0101"],"issn-type":[{"value":"0041-0101","type":"print"}],"subject":[],"published":{"date-parts":[[2016,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of the industrial canning on the toxicity of mussels contaminated with diarrhetic shellfish poisoning (DSP) toxins","name":"articletitle","label":"Article Title"},{"value":"Toxicon","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxicon.2016.01.061","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}