{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:31:10Z","timestamp":1791307870390,"version":"4.3.1"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"FRABA-Universidad de Colima","award":["683\/10"],"award-info":[{"award-number":["683\/10"]}]},{"DOI":"10.13039\/501100003141","name":"CONACYT","doi-asserted-by":"publisher","award":["226165"],"award-info":[{"award-number":["226165"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Direccion General de Asuntos del Personal Acad\u00e9mico, UNAM","award":["IN203416"],"award-info":[{"award-number":["IN203416"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicon"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1016\/j.toxicon.2016.04.046","type":"journal-article","created":{"date-parts":[[2016,4,29]],"date-time":"2016-04-29T20:19:00Z","timestamp":1461961140000},"page":"95-103","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"special_numbering":"C","title":["Comprehensive analysis of venom from the scorpion Centruroides tecomanus reveals compounds with antimicrobial, cytotoxic, and insecticidal activities"],"prefix":"10.1016","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8474-1495","authenticated-orcid":false,"given":"L.L.","family":"Valdez-Velazqu\u00e9z","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.T.","family":"Romero-Gutierrez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Delgado-Enciso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1526-6517","authenticated-orcid":false,"given":"O.","family":"Dobrovinskaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Melnikov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Quintero-Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.G.","family":"Ceballos-Maga\u00f1a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6186-6121","authenticated-orcid":false,"given":"M.A.","family":"Gaitan-Hinojosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.I.","family":"Coronas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.M.","family":"Puebla-Perez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Zamudio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"De la Cruz-Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.F.","family":"V\u00e1zquez-Vuelvas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.D.","family":"Soriano-Hernandez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.D.","family":"Possani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxicon.2016.04.046_bib1","series-title":"Centro Nacional de Vigilancia Epidemiol\u00f3gica y Control de Enfermedades. 2014. Anuarios de Morbilidad. Informaci\u00f3n Epidemiol\u00f3gica","first-page":"1984","author":"CENAVECE","year":"2014"},{"issue":"4","key":"10.1016\/j.toxicon.2016.04.046_bib2","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/S0896-6273(00)80606-6","article-title":"Voltage sensor\u2013trapping","volume":"21","author":"Cest\u00e8le","year":"1998","journal-title":"Neuron"},{"issue":"9","key":"10.1016\/j.toxicon.2016.04.046_bib3","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/S0300-9084(00)01174-3","article-title":"Molecular mechanisms of neurotoxin action on voltage-gated sodium channels","volume":"82","author":"Cest\u00e8le","year":"2000","journal-title":"Biochimie"},{"issue":"2","key":"10.1016\/j.toxicon.2016.04.046_bib4","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1084\/jem.160.2.369","article-title":"Voltage-gated potassium channels are required for human T lymphocyte activation","volume":"160","author":"Chandy","year":"1984","journal-title":"J.\u00a0Exp. Med."},{"issue":"5","key":"10.1016\/j.toxicon.2016.04.046_bib5","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.tips.2004.03.010","article-title":"K+ channels as targets for specific immunomodulation","volume":"25","author":"Chandy","year":"2004","journal-title":"Trends Pharmacol. Sci."},{"issue":"7","key":"10.1016\/j.toxicon.2016.04.046_bib6","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.toxicon.2006.02.004","article-title":"Epidemiological and clinical characteristics of scorpionism in Colima, Mexico (2000\u20132001)","volume":"47","author":"Chowell","year":"2006","journal-title":"Toxicon"},{"issue":"2","key":"10.1016\/j.toxicon.2016.04.046_bib7","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0014-5793(00)01384-3","article-title":"Scorpine, an anti-malaria and anti-bacterial agent purified from scorpion venom","volume":"471","author":"Conde","year":"2000","journal-title":"FEBS Lett."},{"issue":"1","key":"10.1016\/j.toxicon.2016.04.046_bib8","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0014-5793(02)03652-9","article-title":"A\u00a0large number of novel Ergtoxin-like genes and ERG K\u00a0+-channels blocking peptides from scorpions of the genus Centruroides","volume":"532","author":"Corona","year":"2002","journal-title":"FEBS Lett."},{"issue":"1","key":"10.1016\/j.toxicon.2016.04.046_bib9","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0041-0101(82)90138-6","article-title":"Two types of scorpion toxin receptor sites, one related to the activation, the other to the inactivation of the action potential sodium channel","volume":"20","author":"Couraud","year":"1982","journal-title":"Toxicon"},{"issue":"4","key":"10.1016\/j.toxicon.2016.04.046_bib10","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.3390\/toxins7041079","article-title":"Chlorotoxin: a helpful natural scorpion peptide to diagnose glioma and fight tumor invasion","volume":"7","author":"Dardevet","year":"2015","journal-title":"Toxins"},{"issue":"9","key":"10.1016\/j.toxicon.2016.04.046_bib11","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/0041-0101(94)90383-2","article-title":"Scorpionism and serotherapy in Mexico","volume":"32","author":"Dehesa-D\u00e1vila","year":"1994","journal-title":"Toxicon"},{"issue":"6","key":"10.1016\/j.toxicon.2016.04.046_bib12","doi-asserted-by":"crossref","first-page":"4135","DOI":"10.1074\/jbc.M205662200","article-title":"Chlorotoxin inhibits glioma cell invasion via matrix metalloproteinase-2","volume":"278","author":"Deshane","year":"2003","journal-title":"J.\u00a0Biol. Chem."},{"issue":"2","key":"10.1016\/j.toxicon.2016.04.046_bib13","doi-asserted-by":"crossref","first-page":"164","DOI":"10.2174\/092986652202150128143048","article-title":"Cm38: a new antimicrobial peptide active against Klebsiella pneumoniae is homologous to Cn11","volume":"22","author":"Due\u00f1as-Cuellar","year":"2015","journal-title":"Protein Pept. Lett."},{"issue":"1","key":"10.1016\/j.toxicon.2016.04.046_bib14","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/ja.2012.87","article-title":"Antimicrobial peptides from arachnid venoms and their microbicidal activity in the presence of commercial antibiotics","volume":"66","author":"Garcia","year":"2013","journal-title":"J.\u00a0Antibiot."},{"issue":"2","key":"10.1016\/j.toxicon.2016.04.046_bib15","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s00424-011-1045-z","article-title":"Inhibition of HERG1 K+ channel protein expression decreases cell proliferation of human small cell lung cancer cells","volume":"463","author":"Glassmeier","year":"2012","journal-title":"Pfl\u00fcg. Arch."},{"issue":"2","key":"10.1016\/j.toxicon.2016.04.046_bib16","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.cbi.2009.11.006","article-title":"Apoptosis induction in human leukemic cells by a novel protein Bengalin, isolated from Indian black scorpion venom: through mitochondrial pathway and inhibition of heat shock proteins","volume":"183","author":"Gupta","year":"2010","journal-title":"Chem Biol. Interact."},{"issue":"3","key":"10.1016\/j.toxicon.2016.04.046_bib17","first-page":"527","article-title":"Structural and functional features of noxiustoxin: a K+ channel blocker","volume":"37","author":"Gurrola","year":"1995","journal-title":"Biochem. Mol. Biol. Int."},{"issue":"8","key":"10.1016\/j.toxicon.2016.04.046_bib18","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1096\/fasebj.13.8.953","article-title":"A\u00a0toxin to nervous, cardiac, and endocrine ERG K+ channels isolated from Centruroides noxius scorpion venom","volume":"13","author":"Gurrola","year":"1999","journal-title":"FASEB J."},{"key":"10.1016\/j.toxicon.2016.04.046_bib19","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.toxicon.2014.06.006","article-title":"Antimicrobial peptides from scorpion venoms","volume":"88","author":"Harrison","year":"2014","journal-title":"Toxicon Off. J. Int. Soc. Toxinol."},{"issue":"3","key":"10.1016\/j.toxicon.2016.04.046_bib20","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1042\/bj3450653","article-title":"Androctonin, a hydrophilic disulphide-bridged non-haemolytic anti-microbial peptide: a plausible mode of action","volume":"345","author":"Hetru","year":"2000","journal-title":"Biochem. J."},{"issue":"9","key":"10.1016\/j.toxicon.2016.04.046_bib21","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/0041-0101(88)90319-4","article-title":"Amino acid sequence and physiological characterization of toxins from the venom of the scorpion Centruroides limpidus tecomanus Hoffmann","volume":"26","author":"Martin","year":"1988","journal-title":"Toxicon"},{"issue":"7","key":"10.1016\/j.toxicon.2016.04.046_bib22","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/S0041-0101(02)00100-9","article-title":"A\u00a0short-chain peptide toxin isolated from Centruroides sculpturatus scorpion venom inhibits ether-\u00e0-go-go-related gene K\u00a0+ channels","volume":"40","author":"Nastainczyk","year":"2002","journal-title":"Toxicon"},{"issue":"4","key":"10.1016\/j.toxicon.2016.04.046_bib23","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.toxicon.2007.04.020","article-title":"Identification of insect-selective and mammal-selective toxins from Parabuthus leiosoma venom","volume":"50","author":"Ochola","year":"2007","journal-title":"Toxicon"},{"issue":"2","key":"10.1016\/j.toxicon.2016.04.046_bib24","first-page":"255","article-title":"Cytotoxic and apoptotic effects of scorpion Leiurus quinquestriatus venom on 293T and C2C12 eukaryotic cell lines","volume":"9","author":"Omran","year":"2003","journal-title":"J.\u00a0Venom. Anim. Toxins Incl. Trop. Dis."},{"key":"10.1016\/j.toxicon.2016.04.046_bib25","series-title":"El alacr\u00e1n y su piquete","author":"Possani","year":"2005"},{"key":"10.1016\/j.toxicon.2016.04.046_bib26","article-title":"Structure of scorpion toxins","volume":"2","author":"Possani","year":"1984"},{"issue":"2","key":"10.1016\/j.toxicon.2016.04.046_bib27","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1046\/j.1432-1327.1999.00625.x","article-title":"Scorpion toxins specific for Na+-channels","volume":"264","author":"Possani","year":"1999","journal-title":"Eur. J. Biochem."},{"issue":"2","key":"10.1016\/j.toxicon.2016.04.046_bib28","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/0041-0101(80)90071-9","article-title":"Purification and characterization of a mammalian toxin from venom of the Mexican scorpion, Centruroides limpidus tecomanus Hoffmann","volume":"18","author":"Possani","year":"1980","journal-title":"Toxicon"},{"issue":"9","key":"10.1016\/j.toxicon.2016.04.046_bib29","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/S0300-9084(00)01167-6","article-title":"Peptides and genes coding for scorpion toxins that affect ion-channels","volume":"82","author":"Possani","year":"2000","journal-title":"Biochimie"},{"issue":"9","key":"10.1016\/j.toxicon.2016.04.046_bib30","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/0041-0101(88)90318-2","article-title":"Isolation of several toxins from the venom of the scorpion Centruroides limpidus tecomanus Hoffmann","volume":"26","author":"Ram\u00edrez","year":"1988","journal-title":"Toxicon"},{"issue":"8","key":"10.1016\/j.toxicon.2016.04.046_bib31","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.toxicon.2005.09.006","article-title":"Overview of scorpion toxins specific for Na\u00a0+ channels and related peptides: biodiversity, structure\u2013function relationships and evolution","volume":"46","author":"Rodr\u00edguez de la Vega","year":"2005","journal-title":"Toxicon"},{"issue":"1","key":"10.1016\/j.toxicon.2016.04.046_bib32","doi-asserted-by":"crossref","first-page":"2","DOI":"10.3390\/toxins8010002","article-title":"Scorpions from Mexico: from species diversity to venom complexity","volume":"8","author":"Santib\u00e1\u00f1ez-L\u00f3pez","year":"2015","journal-title":"Toxins"},{"issue":"16","key":"10.1016\/j.toxicon.2016.04.046_bib33","doi-asserted-by":"crossref","first-page":"5023","DOI":"10.1046\/j.1432-1327.2000.01556.x","article-title":"Hadrurin, A new antimicrobial peptide from the venom of the scorpion Hadrurus aztecus","volume":"267","author":"Torres-Larios","year":"2000","journal-title":"Eur. J. Biochem."},{"issue":"1","key":"10.1016\/j.toxicon.2016.04.046_bib34","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1472-6750-6-18","article-title":"A\u00a0fusion protein containing a lepidopteran-specific toxin from the South Indian red scorpion (Mesobuthus tamulus) and snowdrop lectin shows oral toxicity to target insects","volume":"6","author":"Trung","year":"2006","journal-title":"BMC Biotechnol."},{"issue":"8","key":"10.1016\/j.toxicon.2016.04.046_bib35","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1111\/j.1432-1033.2004.04047.x","article-title":"Phaiodactylipin, a glycosylated heterodimeric phospholipase A from the venom of the scorpion Anuroctonus phaiodactylus","volume":"271","author":"Valdez-Cruz","year":"2004","journal-title":"Eur. J. Biochem."},{"issue":"6","key":"10.1016\/j.toxicon.2016.04.046_bib36","doi-asserted-by":"crossref","first-page":"e66486","DOI":"10.1371\/journal.pone.0066486","article-title":"Mass fingerprinting of the venom and transcriptome of venom gland of scorpion centruroides tecomanus","volume":"8","author":"Valdez-Vel\u00e1zquez","year":"2013","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.toxicon.2016.04.046_bib37","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.intimp.2005.11.011","article-title":"Dysregulation of the Th1\/Th2 cytokine profile is associated with immunosuppression induced by hypothalamic-pituitary-adrenal axis activation in mice","volume":"6","author":"Viveros-Paredes","year":"2006","journal-title":"Int. Immunopharmacol."},{"issue":"1","key":"10.1016\/j.toxicon.2016.04.046_bib38","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.yexmp.2011.04.008","article-title":"Scorpion (Androctonus crassicauda) venom limits growth of transformed cells (SH-SY5Y and MCF-7) by cytotoxicity and cell cycle arrest","volume":"91","author":"Zargan","year":"2011","journal-title":"Exp. Mol. Pathol."},{"issue":"5","key":"10.1016\/j.toxicon.2016.04.046_bib39","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1038\/bjp.2008.156","article-title":"Anticonvulsant effect of BmK IT2, a sodium channel-specific neurotoxin, in rat models of epilepsy","volume":"154","author":"Zhao","year":"2008","journal-title":"Br. J. Pharmacol."},{"issue":"8","key":"10.1016\/j.toxicon.2016.04.046_bib40","doi-asserted-by":"crossref","first-page":"3472","DOI":"10.1128\/AAC.01436-08","article-title":"Imcroporin, a new cationic antimicrobial peptide from the venom of the scorpion isometrus maculates","volume":"53","author":"Zhao","year":"2009","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.toxicon.2016.04.046_bib41","series-title":"Handbook of Experimental Pharmacology. Arthropod Venoms","first-page":"317","article-title":"Chemistry and pharmacology of buthidae scorpion venoms","author":"Zlotkin","year":"1978"}],"container-title":["Toxicon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010116301258?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010116301258?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T23:38:23Z","timestamp":1565393903000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041010116301258"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8]]},"references-count":41,"alternative-id":["S0041010116301258"],"URL":"https:\/\/doi.org\/10.1016\/j.toxicon.2016.04.046","relation":{},"ISSN":["0041-0101"],"issn-type":[{"value":"0041-0101","type":"print"}],"subject":[],"published":{"date-parts":[[2016,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comprehensive analysis of venom from the scorpion Centruroides tecomanus reveals compounds with antimicrobial, cytotoxic, and insecticidal activities","name":"articletitle","label":"Article Title"},{"value":"Toxicon","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxicon.2016.04.046","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}