{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T17:57:42Z","timestamp":1791568662013,"version":"4.3.4"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001837","name":"Estonian Science Foundation","doi-asserted-by":"publisher","award":["9458"],"award-info":[{"award-number":["9458"]}],"id":[{"id":"10.13039\/501100001837","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicon"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1016\/j.toxicon.2016.05.004","type":"journal-article","created":{"date-parts":[[2016,5,11]],"date-time":"2016-05-11T17:36:56Z","timestamp":1462988216000},"page":"39-45","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Vipera lebetina venom nucleases"],"prefix":"10.1016","volume":"119","author":[{"given":"Katrin","family":"Trummal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K\u00fclli","family":"T\u00f5nism\u00e4gi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anu","family":"Aasp\u00f5llu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcri","family":"Siigur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ene","family":"Siigur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxicon.2016.05.004_bib1","first-page":"268","article-title":"Nuclease activity of the venoms of mid-Asia snakes","volume":"29","author":"Babkina","year":"1964","journal-title":"Biokhimiya"},{"key":"10.1016\/j.toxicon.2016.05.004_bib2","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1111\/j.1742-4658.2009.06908.x","article-title":"Ribonuclease H: the enzymes in eukaryotes (minireview)","volume":"276","author":"Cerritelli","year":"2009","journal-title":"FEBS J."},{"key":"10.1016\/j.toxicon.2016.05.004_bib3","doi-asserted-by":"crossref","first-page":"47","DOI":"10.2174\/092986606776819475","article-title":"Structure and function of bovine pancreatic deoxyribonuclease I","volume":"13","author":"Chen","year":"2006","journal-title":"Protein Pept. Lett."},{"key":"10.1016\/j.toxicon.2016.05.004_bib4","first-page":"469","article-title":"Hydrolysis of DNA by 17 venoms","volume":"135","author":"deRoodt","year":"2003","journal-title":"Comp. Biochem. Physiol. C"},{"key":"10.1016\/j.toxicon.2016.05.004_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1134\/S0006297910010013","article-title":"An overview on nucleases (DNase, RNase, and phosphodiesterase) in snake venoms","volume":"75","author":"Dhananjaya","year":"2010","journal-title":"Biochem. Mosc."},{"key":"10.1016\/j.toxicon.2016.05.004_bib6","series-title":"Venoms and Toxins of Reptiles","first-page":"155","article-title":"Snake venom nucleases, nucleotidases, and phosphomonoesterases","author":"Dhananjaya","year":"2010"},{"key":"10.1016\/j.toxicon.2016.05.004_bib7","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/0003-2697(69)90372-8","article-title":"A\u00a0new sensitive determination of phosphate","volume":"30","author":"Eibl","year":"1969","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.toxicon.2016.05.004_bib8","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1021\/bi00908a016","article-title":"Purification of an endonuclease from the venom of","author":"Georgatsos","year":"1962","journal-title":"Bothrops Atrox. Biochem."},{"key":"10.1016\/j.toxicon.2016.05.004_bib9","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","article-title":"Cleavage of structural proteins during the assembly of the head of bacteriophage T4","volume":"227","author":"Laemmli","year":"1970","journal-title":"Nature"},{"key":"10.1016\/j.toxicon.2016.05.004_bib10","doi-asserted-by":"crossref","first-page":"5125","DOI":"10.1093\/nar\/9.19.5125","article-title":"Mapping tRNA structure in solution using double-strand-specific ribonuclease V1 from cobra venom","volume":"9","author":"Lockard","year":"1981","journal-title":"Nucl. Acid. Res."},{"key":"10.1016\/j.toxicon.2016.05.004_bib11","doi-asserted-by":"crossref","first-page":"5396","DOI":"10.1016\/S0021-9258(19)57229-5","article-title":"On the recognition of helical RNA by cobra venom V1 nuclease","volume":"261","author":"Lowman","year":"1986","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.toxicon.2016.05.004_bib12","series-title":"Enzymes from Snake Venoms","first-page":"361","article-title":"Phosphodiesterases, ribonucleases and deoxyribonucleases","author":"Mackessy","year":"1998"},{"key":"10.1016\/j.toxicon.2016.05.004_bib13","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1139\/o68-014","article-title":"The chain termini of polynucleotides formed by limited enzymic fragmentation of wheat embryo ribosomal RNA. Part 2. Studies of a snake venom ribonuclease and pancreas ribonuclease","volume":"46","author":"McLennan","year":"1968","journal-title":"Can. J. Biochem."},{"key":"10.1016\/j.toxicon.2016.05.004_bib14","first-page":"360","article-title":"A\u00a0deoxyribonuclease II from Bothrops alternatus snake venom","volume":"13","author":"Nascimento","year":"2007","journal-title":"J.\u00a0Venom. Anim. Toxins Incl. Trop. Dis."},{"key":"10.1016\/j.toxicon.2016.05.004_bib15","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1016\/j.febslet.2013.03.020","article-title":"Crystal structure of metagenome-derived LC9-RNase H1 with atypical DEDN active site motif","volume":"587","author":"Nguyen","year":"2013","journal-title":"FEBS Lett."},{"key":"10.1016\/j.toxicon.2016.05.004_bib16","first-page":"85","article-title":"Nucleotidase and DNase activities in Brazilian snake venoms","volume":"147","author":"Sales","year":"2008","journal-title":"Comp. Biochem. Physiol. C"},{"key":"10.1016\/j.toxicon.2016.05.004_bib17","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0049-3848(98)00009-7","article-title":"Biochemical characterization of lebetase, a direct-acting fibrinolytic enzyme from Vipera lebetina snake venom","volume":"90","author":"Siigur","year":"1998","journal-title":"Thromb. Res."},{"key":"10.1016\/j.toxicon.2016.05.004_bib18","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0378-1119(00)00571-0","article-title":"Sequence diversity of Vipera lebetina snake venom gland serine proteinase homologs \u2013 result of alternative splicing or genome alteration","volume":"263","author":"Siigur","year":"2001","journal-title":"Gene"},{"key":"10.1016\/j.toxicon.2016.05.004_bib19","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.bbapap.2004.07.007","article-title":"Factor X activator from Vipera lebetina venom is synthesized from different genes","volume":"1702","author":"Siigur","year":"2004","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.toxicon.2016.05.004_bib20","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/0041-0101(91)90194-V","article-title":"DNase activity in Costa Rican crotaline snake venoms: quantification of activity and identification of electrophoretic variants","volume":"29","author":"Sittenfeld","year":"1991","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2016.05.004_bib21","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.biochi.2014.07.020","article-title":"Phosphodiesterase from Vipera lebetina venom \u2013 structure and characterization","volume":"106","author":"Trummal","year":"2014","journal-title":"Biochimie"},{"key":"10.1016\/j.toxicon.2016.05.004_bib22","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.toxicon.2014.11.234","article-title":"5\u2032-Nucleotidase from Vipera lebetina venom","volume":"93","author":"Trummal","year":"2015","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2016.05.004_bib23","first-page":"705","article-title":"Isolation and properties of ribonuclease isolated from cobra venom","volume":"30","author":"Vassilenko","year":"1965","journal-title":"Biokhimiya"},{"key":"10.1016\/j.toxicon.2016.05.004_bib24","first-page":"578","article-title":"Isolation of highly purified ribonuclease from cobra (Naja oxiana) venom","volume":"40","author":"Vassilenko","year":"1975","journal-title":"Biokhimiya"}],"container-title":["Toxicon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010116301337?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010116301337?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T20:31:42Z","timestamp":1655843502000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041010116301337"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":24,"alternative-id":["S0041010116301337"],"URL":"https:\/\/doi.org\/10.1016\/j.toxicon.2016.05.004","relation":{},"ISSN":["0041-0101"],"issn-type":[{"value":"0041-0101","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Vipera lebetina venom nucleases","name":"articletitle","label":"Article Title"},{"value":"Toxicon","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxicon.2016.05.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}