{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T20:12:52Z","timestamp":1786997572327,"version":"build-2736575974"},"reference-count":73,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,5,27]],"date-time":"2017-05-27T00:00:00Z","timestamp":1495843200000},"content-version":"vor","delay-in-days":268,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003105","name":"Federal University of Uberlandia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003105","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["307973\/2012-3"],"award-info":[{"award-number":["307973\/2012-3"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["1594\/2011"],"award-info":[{"award-number":["1594\/2011"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["APQ-00403"],"award-info":[{"award-number":["APQ-00403"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicon"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1016\/j.toxicon.2016.05.010","type":"journal-article","created":{"date-parts":[[2016,5,21]],"date-time":"2016-05-21T04:48:42Z","timestamp":1463806122000},"page":"84-91","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"special_numbering":"C","title":["Anti-parasitic effect on Toxoplasma gondii induced by BnSP-7, a Lys49-phospholipase A2 homologue from Bothrops pauloensis venom"],"prefix":"10.1016","volume":"119","author":[{"given":"Isabela Pacheco","family":"Borges","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Let\u00edcia Eulalio","family":"Castanheira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bellisa Freitas","family":"Barbosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dayane Lorena Naves","family":"de Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafaela Jos\u00e9","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Roberto","family":"Mineo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly Aparecida Yoneyama","family":"Tudini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata Santos","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elo\u00edsa Am\u00e1lia Vieira","family":"Ferro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veridiana","family":"de Melo Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxicon.2016.05.010_bib1","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1017\/S0031182010000958","article-title":"Effect of Crotalus viridis viridis snake venom on the ultrastructure and intracellular survival of Trypanosoma cruzi","volume":"138","author":"Adade","year":"2010","journal-title":"Parasitology"},{"key":"10.1016\/j.toxicon.2016.05.010_bib2","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/0041-0101(96)00036-0","article-title":"Phospholipase A2\u2014a structural review","volume":"34","author":"Arni","year":"1996","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2016.05.010_bib3","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.toxicon.2005.04.024","article-title":"Renal and antibacterial effects induced by myotoxin I and II isolated from Bothrops jararacussu venom","volume":"46","author":"Barbosa","year":"2005","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2016.05.010_bib4","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1111\/j.1365-2249.2007.03583.x","article-title":"BeWo trophoblast cell susceptibility to Toxoplasma gondii is increased by interferongamma, interleukin-10 and transforming growth factor-beta1","volume":"151","author":"Barbosa","year":"2008","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.toxicon.2016.05.010_bib5","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.vetpar.2011.12.039","article-title":"Enrofloxacin is able to control Toxoplasma gondii infection in both in\u00a0vitro and in\u00a0vivo experimental models","volume":"187","author":"Barbosa","year":"2012","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.toxicon.2016.05.010_bib6","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.placenta.2013.12.013","article-title":"Susceptibility to Toxoplasma gondii proliferation in BeWo human trophoblast cells is dose-dependent of macrophage migration inhibitory factor (MIF), via ERK1\/2 phosphorylation and prostaglandin E2 production","volume":"35","author":"Barbosa","year":"2014","journal-title":"Placenta"},{"key":"10.1016\/j.toxicon.2016.05.010_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1095\/biolreprod.114.124115","article-title":"IL-10, TGF Beta1, and IFN gamma modulate intracellular signaling pathways and cytokine production to control Toxoplasma gondii infection in BeWo trophoblast cells","volume":"92","author":"Barbosa","year":"2015","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.toxicon.2016.05.010_bib8","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.exppara.2008.09.008","article-title":"Toxoplasma gondii: effects of neuwiedase, a metalloproteinase from Bothrops neuwiedi snake venom, on the invasion and replication of human fibroblasts in\u00a0vitro","volume":"120","author":"Bastos","year":"2008","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.toxicon.2016.05.010_bib9","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1111\/j.1600-0463.2009.02453.x","article-title":"Communication between Toxoplasma gondii and its host: impact on parasite growth, development, immune evasion, and virulence","volume":"117","author":"Blader","year":"2009","journal-title":"APMIS"},{"key":"10.1016\/j.toxicon.2016.05.010_bib10","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.ijpara.2006.02.008","article-title":"Proteolysis and Toxoplasma invasion","volume":"36","author":"Carruthers","year":"2006","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.toxicon.2016.05.010_bib73","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/S0020-7519(00)00101-6","article-title":"Toxoplasma gondii secretes a calcium-independent phospholipase A2","volume":"30","author":"Cassaing","year":"2000","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.toxicon.2016.05.010_bib11","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.ijbiomac.2014.11.035","article-title":"Insights into anti-parasitism induced by a C-type lectin from Bothrops pauloensis venom on Toxoplasma gondii","volume":"74","author":"Castanheira","year":"2015","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.toxicon.2016.05.010_bib12","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.3390\/toxins4121500","article-title":"In\u00a0vitro antiplasmodial activity of phospholipases A2 and a phospholipase homologue isolated from the venom of the snake Bothrops asper","volume":"4","author":"Castillo","year":"2012","journal-title":"Toxins"},{"key":"10.1016\/j.toxicon.2016.05.010_bib13","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.placenta.2012.12.006","article-title":"Trophoblast cells are able to regulate monocyte activity to control Toxoplasma gondii infection","volume":"34","author":"Castro","year":"2013","journal-title":"Placenta"},{"key":"10.1016\/j.toxicon.2016.05.010_bib14","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.toxicon.2009.05.040","article-title":"Biochemical and functional properties of a thrombin-like enzyme isolated from Bothrops pauloensis snake venom","volume":"54","author":"Costa","year":"2008","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2016.05.010_bib15","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1016\/j.placenta.2009.08.002","article-title":"Azithromycin inhibits vertical transmission of Toxoplasma gondii in Calomys callosus (Rodentia: Cricetidae)","volume":"30","author":"Costa","year":"2009","journal-title":"Placenta"},{"key":"10.1016\/j.toxicon.2016.05.010_bib16","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.toxicon.2009.11.013","article-title":"Antibacterial and antiparasitic effects of Bothrops marajoensis venom and its fractions: phospholipase A2 and l-amino acid oxidase","volume":"55","author":"Costa Torres","year":"2010","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2016.05.010_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/195356","article-title":"Purification and biochemical characterization of three myotoxins from Bothrops mattogrossensis snake venom with toxicity against Leishmania and tumor cells","volume":"2014","author":"de Moura","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.toxicon.2016.05.010_bib18","doi-asserted-by":"crossref","first-page":"39973","DOI":"10.1074\/jbc.M006712200","article-title":"Bee venom phospholipase A2 induces stage-specific growth arrest of the intraerythrocytic Plasmodium falciparum via modifications of human serum components","volume":"275","author":"Deregnaucourt","year":"2000","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.toxicon.2016.05.010_bib19","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/0005-2736(91)90086-N","article-title":"The effect of myotoxins isolated from Bothrops snake venoms on multilamellar liposomes: relationship to phospholipase A2, anticoagulant and myotoxic activities","volume":"1070","author":"D\u00edaz","year":"1991","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.toxicon.2016.05.010_bib20","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1017\/S0031182012000765","article-title":"Toxoplasmosis in humans and animals in Brazil: high prevalence, high burden of disease, and epidemiology","volume":"139","author":"Dubey","year":"2012","journal-title":"Parasitology"},{"key":"10.1016\/j.toxicon.2016.05.010_bib21","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1111\/j.1432-1033.1967.tb00047.x","volume":"1","author":"Edman","year":"1967","journal-title":"Eur. J. Biochem. FEBS"},{"key":"10.1016\/j.toxicon.2016.05.010_bib22","doi-asserted-by":"crossref","first-page":"2772","DOI":"10.1016\/j.bbapap.2013.10.009","article-title":"Structural bases for a complete myotoxic mechanism: crystal structures of two non-catalytic phospholipases A2-like from Bothrops brazili venom","volume":"1834","author":"Fernandes","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.toxicon.2016.05.010_bib23","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1016\/j.bbapap.2014.09.015","article-title":"A\u00a0structure-based proposal for a comprehensive myotoxic mechanism of phospholipase A2-like proteins from viperid snake venoms","volume":"1844","author":"Fernandes","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.toxicon.2016.05.010_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1096\/fj.08-111666","article-title":"Macrophage migration inhibitory factor (MIF) is critical for the host resistance against Toxoplasma gondii","volume":"22","author":"Flores","year":"2008","journal-title":"FASEB J."},{"key":"10.1016\/j.toxicon.2016.05.010_bib25","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.placenta.2011.08.012","article-title":"Azithromycin and spiramycin induce anti-inflammatory response in human trophoblastic (BeWo) cells infected by Toxoplasma gondii but are able to control infection","volume":"32","author":"Franco","year":"2011","journal-title":"Placenta"},{"key":"10.1016\/j.toxicon.2016.05.010_bib26","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0020-7519(01)00322-8","article-title":"Interleukin-6 is required for parasite specific response and host resistance to Trypanosoma cruzi","volume":"32","author":"Gao","year":"2002","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.toxicon.2016.05.010_bib27","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.biologicals.2009.01.010","article-title":"Antitumor effects of snake venom chemically modified Lys49 phospholipase A2-like BthTX-I and a synthetic peptide derived from its C-terminal region","volume":"37","author":"Gebrim","year":"2009","journal-title":"Biologicals"},{"key":"10.1016\/j.toxicon.2016.05.010_bib28","doi-asserted-by":"crossref","first-page":"e277","DOI":"10.1371\/journal.pntd.0000277","article-title":"Ocular sequelae of congenital toxoplasmosis in Brazil compared with Europe","volume":"2","author":"Gilbert","year":"2008","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.toxicon.2016.05.010_bib29","doi-asserted-by":"crossref","first-page":"2792","DOI":"10.1016\/j.ajpath.2011.02.005","article-title":"Effect of macrophage migration inhibitory factor (MIF) in human placental explants infected with Toxoplasma gondii depends on gestational age","volume":"178","author":"Gomes","year":"2011","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.toxicon.2016.05.010_bib30","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1006\/cimm.1996.0112","article-title":"Role of interferon-g against invasion by Toxoplasma gondii in a human monocytic cell line (THP1): involvement of the parasite\u2019s secretory phospholipase A2","volume":"169","author":"Gomez-Marin","year":"1996","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.toxicon.2016.05.010_bib31","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.toxicon.2004.01.006","article-title":"Anti-Plasmodium properties of group IA, IB, IIA and III secreted phospholipases A2 are serum-dependent","volume":"43","author":"Guillaume","year":"2004","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2016.05.010_bib32","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1126\/science.7233198","article-title":"Transbilayer phospholipid asymmetry in Plasmodium knowlesi-infected host cell membrane","volume":"212","author":"Gupta","year":"1981","journal-title":"Science"},{"key":"10.1016\/j.toxicon.2016.05.010_bib33","first-page":"15","article-title":"Isolation of phospholipase A1 from Trypanosoma brucei","volume":"35","author":"Hambrey","year":"1984","journal-title":"Tropenmed. Parasitol."},{"key":"10.1016\/j.toxicon.2016.05.010_bib34","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1046\/j.1365-3024.1998.00152.x","article-title":"A\u00a0protective role for IL-6 during early infection with Toxoplasma gondii","volume":"20","author":"Jebbari","year":"1998","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.toxicon.2016.05.010_bib35","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.exppara.2012.01.003","article-title":"Giardia duodenalis: dendritic cell defects in IL-6 deficient mice contribute to susceptibility to intestinal infection","volume":"130","author":"Kamda","year":"2012","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.toxicon.2016.05.010_bib36","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/j.toxicon.2003.11.002","article-title":"Excitement ahead: structure, function and mechanism of snake venom phospholipase A2 enzymes","volume":"42","author":"Kini","year":"2003","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2016.05.010_bib37","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.rvsc.2012.08.001","article-title":"In\u00a0vivo efficacy of toltrazuril on experimentally induced Toxoplasma gondii tissue cysts in lambs: a novel strategy for prevention of human exposure to meat-borne toxoplasmosis","volume":"94","author":"Kul","year":"2013","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.toxicon.2016.05.010_bib38","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","article-title":"Cleavage of structural proteins during the assembly of the head of bacteriophage T4","volume":"227","author":"Laemmli","year":"1970","journal-title":"Nature"},{"key":"10.1016\/j.toxicon.2016.05.010_bib39","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s00436-006-0306-9","article-title":"Subversion of innate and adaptive immune responses by Toxoplasma gondii","volume":"100","author":"Lang","year":"2007","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.toxicon.2016.05.010_bib40","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.toxicon.2012.02.007","article-title":"Snake venom Lys49 myotoxins: from phospholipases A2 to non-enzymatic membrane disruptors","volume":"60","author":"Lomonte","year":"2012","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2016.05.010_bib41","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0041-0101(03)00149-1","article-title":"Comparative study of synthetic peptides corresponding to region 115-129 in Lys49 myotoxic phospholipases A2 from snake venoms","volume":"42","author":"Lomonte","year":"2003","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2016.05.010_bib42","doi-asserted-by":"crossref","first-page":"3224","DOI":"10.2174\/138161210793292456","article-title":"Synthetic peptides derived from the C-terminal region of Lys49 phospholipase A2 homologues from viperidae snake venoms: biomimetic activities and potential applications","volume":"16","author":"Lomonte","year":"2010","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.toxicon.2016.05.010_bib43","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.bbrc.2003.10.047","article-title":"Crystal structures of BnSP-7 and BnSP-6, two Lys49-phospholipases A2: quaternary structure and inhibition mechanism insights","volume":"311","author":"Magro","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.toxicon.2016.05.010_bib44","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1093\/jac\/dkl180","article-title":"Antiproliferative activities of two novel quinuclidine inhibitors against Toxoplasma gondii tachyzoites in\u00a0vitro","volume":"58","author":"Martins-Duarte","year":"2006","journal-title":"J.\u00a0Antimicrob. Chemother."},{"key":"10.1016\/j.toxicon.2016.05.010_bib45","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1128\/iai.27.2.283-287.1980","article-title":"Enzyme-linked immunosorbent assay for antibodies to Toxoplasma gondii polysaccharides in human toxoplasmosis","volume":"27","author":"Mineo","year":"1980","journal-title":"Infect. Immun."},{"key":"10.1016\/j.toxicon.2016.05.010_bib46","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1016\/S0140-6736(04)16412-X","article-title":"Toxoplasmosis","volume":"363","author":"Montoya","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.toxicon.2016.05.010_bib47","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays","volume":"65","author":"Mosmann","year":"1983","journal-title":"J.\u00a0Immunol. Methods"},{"key":"10.1016\/j.toxicon.2016.05.010_bib48","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1017\/S0031182013000012","article-title":"BnSP-7 toxin, a basic phospholipase A2 from Bothrops pauloensis snake venom, interferes with proliferation, ultrastructure and infectivity of Leishmania (Leishmania) amazonensis","volume":"140","author":"Nunes","year":"2013","journal-title":"Parasitology"},{"key":"10.1016\/j.toxicon.2016.05.010_bib49","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.toxicon.2004.04.013","article-title":"Structural and functional characterization of myotoxin I, a Lys49 phospholipase A2 homologue from the venom of the snake Bothrops atrox","volume":"44","author":"Nu\u00f1ez","year":"2004","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2016.05.010_bib50","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.placenta.2005.06.006","article-title":"BeWo trophoblasts are unable to control replication of Toxoplasma gondii, even in the presence of exogenous IFN-gamma","volume":"27","author":"Oliveira","year":"2006","journal-title":"Placenta"},{"key":"10.1016\/j.toxicon.2016.05.010_bib51","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.exppara.2009.04.010","article-title":"Toxoplasma gondii: effects of Artemisia annua L. on susceptibility to infection in experimental models in\u00a0vitro and in\u00a0vivo","volume":"122","author":"Oliveira","year":"2009","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.toxicon.2016.05.010_bib52","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1007\/s00436-007-0871-6","article-title":"The effect of phospholipase A2 from Crotalus durissus collilineatus on Leishmania (Leishmania) amazonensis infection","volume":"102","author":"Passero","year":"2008","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.toxicon.2016.05.010_bib53","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.siny.2007.01.011","article-title":"Toxoplasmosis","volume":"12","author":"Petersen","year":"2007","journal-title":"Semin. Fetal Neonatal Med."},{"key":"10.1016\/j.toxicon.2016.05.010_bib54","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1128\/IAI.01170-07","article-title":"Highly polymorphic family of glycosylphosphatidylinositol-anchored surface antigens with evidence of developmental regulation in Toxoplasma gondii","volume":"76","author":"Pollard","year":"2008","journal-title":"Infect. Immun."},{"key":"10.1016\/j.toxicon.2016.05.010_bib55","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.1128\/IAI.01648-05","article-title":"Macrophage migration inhibitory factor contributes to host defense against acute Trypanosoma cruzi infection","volume":"74","author":"Reyes","year":"2006","journal-title":"Infect. Immun."},{"key":"10.1016\/j.toxicon.2016.05.010_bib56","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S1095-6433(98)10136-8","article-title":"Geographic variations in the composition of myotoxins from Bothrops neuwiedi snake venoms: biochemical characterization and biological activity","volume":"121","author":"Rodrigues","year":"1998","journal-title":"Comp. Biochem. Physiol. A Mol. Integr. Physiol."},{"key":"10.1016\/j.toxicon.2016.05.010_bib57","doi-asserted-by":"crossref","first-page":"670","DOI":"10.2174\/1568026615666150217120347","article-title":"Bothrops pauloensis snake venom toxins: the search for new therapeutic models","volume":"15","author":"Rodrigues","year":"2015","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.toxicon.2016.05.010_bib58","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1128\/IAI.71.3.1247-1254.2003","article-title":"Macrophage migration inhibitory factor plays a critical role in mediating protection against the helminth parasite Taenia crassiceps","volume":"71","author":"Rodr\u00edgues-Sosa","year":"2003","journal-title":"Infect. Immun."},{"key":"10.1016\/j.toxicon.2016.05.010_bib59","doi-asserted-by":"crossref","first-page":"12424","DOI":"10.1021\/bi00164a018","article-title":"Calcium ion independent membrane leakage induced by phospholipase-like myotoxins","volume":"31","author":"Rufini","year":"1992","journal-title":"Biochemistry"},{"key":"10.1016\/j.toxicon.2016.05.010_bib60","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1111\/j.1550-7408.1991.tb04816.x","article-title":"A\u00a0soluble phospholipase of Toxoplasma gondii associated with host cell penetration","volume":"38","author":"Saffer","year":"1991","journal-title":"J.\u00a0Protozool."},{"key":"10.1016\/j.toxicon.2016.05.010_bib61","doi-asserted-by":"crossref","first-page":"145","DOI":"10.4269\/ajtmh.1989.40.145","article-title":"The role of phospholipase in host cell penetration by Toxoplasma gondii","volume":"40","author":"Saffer","year":"1989","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.toxicon.2016.05.010_bib62","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1128\/AAC.49.4.1340-1345.2005","article-title":"Bactericidal and antiendotoxic properties of short cationic peptides derived from a snake venom Lys49 phospholipase A2","volume":"49","author":"Santamaria","year":"2005","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.toxicon.2016.05.010_bib63","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1128\/IAI.69.2.906-911.2001","article-title":"Migration-inhibitory factor gene-deficient mice are susceptible to cutaneous Leishmania major infection","volume":"69","author":"Satoskar","year":"2001","journal-title":"Infect. Immun."},{"key":"10.1016\/j.toxicon.2016.05.010_bib64","doi-asserted-by":"crossref","first-page":"209","DOI":"10.2307\/3276925","article-title":"The fine structure and reproduction of Toxoplasma gondii","volume":"54","author":"Sheffield","year":"1968","journal-title":"J.\u00a0Parasitol."},{"key":"10.1016\/j.toxicon.2016.05.010_bib65","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s00436-005-0037-3","article-title":"In\u00a0vitro effects of Crotalus durissus terrificus and Bothrops jararaca venoms on Giardia duodenalis trophozoites","volume":"98","author":"Shinohara","year":"2006","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.toxicon.2016.05.010_bib66","first-page":"17","article-title":"Invasion and intracellular survival by Toxoplasma","author":"Sibley","year":"2007","journal-title":"Protozoans Macrophages"},{"key":"10.1016\/j.toxicon.2016.05.010_bib67","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1006\/abbi.2000.1790","article-title":"Structural and functional characterization of BnSP-7, a Lys49 myotoxic phospholipase A2 homologue from Bothrops neuwiedi pauloensis venom","volume":"378","author":"Soares","year":"2000","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.toxicon.2016.05.010_bib68","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.cbpc.2005.11.020","article-title":"Bothrops moojeni myotoxin-II, a Lys49-phospholipase A2 homologue: an example of function versatility of snake venom proteins","volume":"142","author":"St\u00e1beli","year":"2006","journal-title":"Comp. Biochem. Physiol. C Toxicol. Pharmacol."},{"key":"10.1016\/j.toxicon.2016.05.010_bib69","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1046\/j.1365-3024.2003.00641.x","article-title":"Blockade of macrophage migration inhibitory factor (MIF) in Schistosoma japonicum-infected mice results in an increased adult worm burden and reduced fecundity","volume":"25","author":"Stavitsky","year":"2003","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.toxicon.2016.05.010_bib70","article-title":"Trypan blue exclusion test of cell viability","author":"Strober","year":"2001","journal-title":"Curr. Protoc. Immunol"},{"key":"10.1016\/j.toxicon.2016.05.010_bib71","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1128\/AAC.01059-06","article-title":"Cysteine protease inhibitors block Toxoplasma gondii microneme secretion and cell invasion","volume":"51","author":"Teo","year":"2007","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.toxicon.2016.05.010_bib72","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.toxicon.2009.11.013","article-title":"Antibacterial and antiparasitic effects of Bothrops marajoensis venom and its fractions: phospholipase A2 and L-amino acid oxidase","volume":"55","author":"Torres","year":"2010","journal-title":"Toxicon"}],"container-title":["Toxicon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010116301398?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010116301398?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T21:09:50Z","timestamp":1758575390000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041010116301398"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":73,"alternative-id":["S0041010116301398"],"URL":"https:\/\/doi.org\/10.1016\/j.toxicon.2016.05.010","relation":{},"ISSN":["0041-0101"],"issn-type":[{"value":"0041-0101","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anti-parasitic effect on Toxoplasma gondii induced by BnSP-7, a Lys49-phospholipase A2 homologue from Bothrops pauloensis venom","name":"articletitle","label":"Article Title"},{"value":"Toxicon","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxicon.2016.05.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}