{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T22:02:27Z","timestamp":1771020147973,"version":"3.50.1"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100010072","name":"Animal Toxins Research Support Center","doi-asserted-by":"crossref","award":["12.1.17615.1.5"],"award-info":[{"award-number":["12.1.17615.1.5"]}],"id":[{"id":"10.13039\/501100010072","id-type":"DOI","asserted-by":"crossref"}]},{"name":"gs2:S\u00e3o Paulo Research Foundation","award":["2011\/23236-4, 2015\/25637-7 and 2015\/23555-3"],"award-info":[{"award-number":["2011\/23236-4, 2015\/25637-7 and 2015\/23555-3"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicon"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1016\/j.toxicon.2016.07.008","type":"journal-article","created":{"date-parts":[[2016,7,15]],"date-time":"2016-07-15T14:15:23Z","timestamp":1468592123000},"page":"9-14","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["The L-amino acid oxidase from Calloselasma rhodostoma snake venom modulates apoptomiRs expression in Bcr-Abl-positive cell lines"],"prefix":"10.1016","volume":"120","author":[{"given":"Sandra Mara","family":"Burin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Gabriela","family":"Berzoti-Coelho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ju\u00e7ara Gastaldi","family":"Cominal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciana","family":"Ambrosio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Regina","family":"Torqueti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suely Vilela","family":"Sampaio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fab\u00edola Atti\u00e9","family":"de Castro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxicon.2016.07.008_bib1","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.cbpa.2008.07.007","article-title":"Evidence of caspase-mediated apoptosis induced by L-amino acid oxidase isolated from Bothrops atrox venom","volume":"151","author":"Alves","year":"2008","journal-title":"Comp. Biochem. Physiol. A Mol. Integr. Physiol."},{"key":"10.1016\/j.toxicon.2016.07.008_bib2","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.biochi.2011.01.009","article-title":"Cell cycle arrest evidence, parasiticidal and bactericidal properties induced by l-amino acid oxidase from Bothrops atrox snake venom","volume":"93","author":"Alves-Paiva","year":"2011","journal-title":"Biochimie"},{"key":"10.1016\/j.toxicon.2016.07.008_bib3","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1007\/s10495-006-7959-9","article-title":"Mechanism cell death induction by L-amino acid oxidase, a major component of ophidian venom","volume":"11","author":"Ande","year":"2006","journal-title":"Apoptosis"},{"key":"10.1016\/j.toxicon.2016.07.008_bib4","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s00277-015-2322-2","article-title":"A\u00a0review of the European leukemia net recommendations for the management of CML","volume":"94","author":"Baccarani","year":"2015","journal-title":"Ann. Hematol."},{"key":"10.1016\/j.toxicon.2016.07.008_bib5","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0014-5793(03)00299-0","article-title":"Comparison of the anti-apoptotic effects of Bcr-Abl, Bcl-2 and Bcl-x(L) following diverse apoptogenic stimuli","volume":"541","author":"Brumatti","year":"2003","journal-title":"FEBS Lett."},{"key":"10.1016\/j.toxicon.2016.07.008_bib6","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/bcpt.12073","article-title":"L-amino acid oxidase isolated from Bothrops pirajai induces apoptosis in BCR-ABL-positive cells and potentiates imatinib mesylate effect","volume":"113","author":"Burin","year":"2013","journal-title":"Basic. Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.toxicon.2016.07.008_bib7","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.ijbiomac.2016.01.069","article-title":"CR-LAAO antileukemic effect against Bcr-Abl+ cells is mediated by apoptosis and hydrogen peroxide","volume":"86","author":"Burin","year":"2016","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.toxicon.2016.07.008_bib8","doi-asserted-by":"crossref","first-page":"371","DOI":"10.5732\/cjc.30.0371","article-title":"Apoptosis and the target genes of microRNA-21","volume":"30","author":"Buscaglia","year":"2011","journal-title":"Chin. J. Cancer"},{"key":"10.1016\/j.toxicon.2016.07.008_bib9","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1038\/nrc1997","article-title":"MicroRNA signatures in human cancers","volume":"6","author":"Calin","year":"2006","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.toxicon.2016.07.008_bib10","doi-asserted-by":"crossref","first-page":"15524","DOI":"10.1073\/pnas.242606799","article-title":"Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia","volume":"99","author":"Calin","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.toxicon.2016.07.008_bib11","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.yjmcc.2009.01.008","article-title":"MicroRNA-21 protects against the H2O2-induced injury on cardiac myocytes via its target gene PDCD4","volume":"47","author":"Cheng","year":"2009","journal-title":"J.\u00a0Mol. Cell. Cardiol."},{"key":"10.1016\/j.toxicon.2016.07.008_bib12","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s00277-015-2325-z","article-title":"Natural course and biology of CML","volume":"94","author":"Chereda","year":"2015","journal-title":"Ann. Hematol."},{"key":"10.1016\/j.toxicon.2016.07.008_bib13","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.molcel.2010.01.025","article-title":"The BCL-2 family reunion","volume":"37","author":"Chipuk","year":"2010","journal-title":"Mol. Cell."},{"key":"10.1016\/j.toxicon.2016.07.008_bib14","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1678-9199-20-23","article-title":"Snake venom L-amino acid oxidases: an overview on their antitumor effects","volume":"20","author":"Costa","year":"2014","journal-title":"J.\u00a0Venom. Anim. Toxins Incl. Trop. Dis."},{"key":"10.1016\/j.toxicon.2016.07.008_bib15","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.ijbiomac.2015.07.004","article-title":"Evaluating the microbicidal, antiparasitic and antitumor effects of CR-LAAO from Calloselasma rhodostoma venom","volume":"80","author":"Costa","year":"2015","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.toxicon.2016.07.008_bib16","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.cell.2012.03.003","article-title":"MYC on the path to cancer","volume":"149","author":"Dang","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.toxicon.2016.07.008_bib17","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.bcmd.2014.02.008","article-title":"ApoptomiRs expression modulated by BCR-ABL is linked to CML progression and imatinib resistance","volume":"53","author":"Ferreira","year":"2014","journal-title":"Blood Cells Mol. Dis."},{"key":"10.1016\/j.toxicon.2016.07.008_bib18","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.toxicon.2015.01.012","article-title":"Molecular mechanism of cell death induced by king cobra (Ophiophagus hannah) venom L-amino acid oxidase","volume":"96","author":"Fung","year":"2015","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2016.07.008_bib19","doi-asserted-by":"crossref","first-page":"4044","DOI":"10.1046\/j.1432-1327.2001.02321.x","article-title":"Structure and characterization of the glycan moiety of L-amino acid oxidase from the Malayan pit viper Calloselasma rhodostoma","volume":"268","author":"Geyer","year":"2001","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.toxicon.2016.07.008_bib20","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.toxicon.2012.05.001","article-title":"Past decade study of snake venom L-amino acid oxidase","volume":"60","author":"Guo","year":"2012","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2016.07.008_bib21","doi-asserted-by":"crossref","first-page":"4696","DOI":"10.1002\/cncr.26096","article-title":"Functional implications of microRNAs in acute myeloid leukemia by integrating microRNA and messenger RNA expression profiling","volume":"117","author":"Havelange","year":"2011","journal-title":"Cancer"},{"key":"10.1016\/j.toxicon.2016.07.008_bib22","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1038\/35037710","article-title":"The biochemistry of apoptosis","volume":"407","author":"Hengartner","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.toxicon.2016.07.008_bib23","doi-asserted-by":"crossref","first-page":"7034","DOI":"10.1016\/j.bmc.2006.06.025","article-title":"Biochemical and functional characterization of an L-amino acid oxidase isolated from Bothrops pirajai snake venom","volume":"14","author":"Izidoro","year":"2006","journal-title":"Bioorg. Med Chem."},{"key":"10.1016\/j.toxicon.2016.07.008_bib24","article-title":"MiR-146a regulates SOD2 expression in H2O2-stimulated PC12 cells","author":"Ji","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.toxicon.2016.07.008_bib25","doi-asserted-by":"crossref","first-page":"7903","DOI":"10.1074\/jbc.M806920200","article-title":"Involvement of microRNAs in hydrogen peroxide-mediated gene regulation and cellular injury response in vascular smooth muscle cells","volume":"284","author":"Lin","year":"2009","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.toxicon.2016.07.008_bib26","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1046\/j.1432-1327.2001.02042.x","article-title":"L-amino-acid oxidase from Malayan pit viper Calloselasma rhodostoma. Comparative sequence analysis and characterization of active and inactive forms of the enzyme","volume":"268","author":"Macheroux","year":"2001","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.toxicon.2016.07.008_bib27","first-page":"891934","article-title":"Cerium oxide nanoparticles induced toxicity in human lung cells: role of ROS mediated DNA damage and apoptosis","author":"Mittal","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.toxicon.2016.07.008_bib28","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.jmb.2006.09.032","article-title":"Crystal structure of LAAO from Calloselasma rhodostoma with an L-phenylalanine substrate: insights into structure and mechanism","volume":"364","author":"Moustafa","year":"2006","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.toxicon.2016.07.008_bib29","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1007\/s10495-015-1157-6","article-title":"Apoptosis induction in human breast cancer (MCF-7) cells by a novel venom L-amino acid oxidase (Rusvinoxidase) is independent of its enzymatic activity and is accompanied by caspase-7 activation and reactive oxygen species production","volume":"20","author":"Mukherjee","year":"2015","journal-title":"Apoptosis"},{"key":"10.1016\/j.toxicon.2016.07.008_bib30","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1016\/j.bbamcr.2011.07.021","article-title":"Activation of ER stress and apoptosis by hydrogen peroxide in HeLa cells: protective role of mild heat preconditioning at 40\u00b0C","volume":"1813","author":"Pallepati","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.toxicon.2016.07.008_bib31","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1042\/bse0470099","article-title":"Mitochondria in cell death","volume":"47","author":"Parsons","year":"2010","journal-title":"Essays Biochem."},{"key":"10.1016\/j.toxicon.2016.07.008_bib32","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.bbapap.2006.01.021","article-title":"Isolation and characterization of an apoptotic and platelet aggregation inhibiting L-amino acid oxidase from Vipera berus berus (common viper) venom","volume":"1764","author":"Samel","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.toxicon.2016.07.008_bib33","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s00277-009-0822-7","article-title":"Response to imatinib mesylate in chronic myeloid leukemia patients with variant BCR-ABL fusion transcripts","volume":"89","author":"Sharma","year":"2010","journal-title":"Ann. Hematol."},{"key":"10.1016\/j.toxicon.2016.07.008_bib34","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1111\/j.1365-2141.1995.tb08362.x","article-title":"Analysis of molecular breakpoint and m-RNA transcripts in a prospective randomized trial of interferon in chronic myeloid leukaemia: no correlation with clinical features, cytogenetic response, duration of chronic phase or survival","volume":"89","author":"Shephered","year":"1995","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.toxicon.2016.07.008_bib35","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1006\/abbi.1999.1287","article-title":"Isolation and structural characterization of a cytotoxic L-amino acid oxidase from Agkistrodon contortrix laticinctus snake venom: preliminary crystallographic data","volume":"368","author":"Souza","year":"1999","journal-title":"Arch. Bioch. Bioph."},{"key":"10.1016\/j.toxicon.2016.07.008_bib36","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s12079-011-0139-x","article-title":"MicroRNAs 130a\/130b are regulated by BCR\u2013ABL and downregulate expression of CCN3 in CML","volume":"5","author":"Suresh","year":"2011","journal-title":"J.\u00a0Cell Commun. Signal"},{"key":"10.1016\/j.toxicon.2016.07.008_bib37","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1006\/bbrc.1996.0996","article-title":"Identification of the snake venom substance that induces apoptosis","volume":"224","author":"Suhr","year":"1996","journal-title":"Bioch. Biop. Res. Comm."},{"key":"10.1016\/j.toxicon.2016.07.008_bib38","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1159\/000358700","article-title":"MiR-142-3p functions as a potential tumor suppressor in human osteosarcoma by targeting HMGA1","volume":"33","author":"Xu","year":"2014","journal-title":"Cell Physiol. Biochem."},{"key":"10.1016\/j.toxicon.2016.07.008_bib39","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.ygyno.2011.10.013","article-title":"Epigenetic silencing of miR-130b in ovarian cancer promotes the development of multidrug resistance by targeting colony-stimulating factor 1","volume":"124","author":"Yang","year":"2012","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.toxicon.2016.07.008_bib40","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1186\/1477-7819-12-254","article-title":"Prognostic role of microRNA-145 in various human malignant neoplasms: a meta-analysis of 18 related studies","volume":"12","author":"Yang","year":"2014","journal-title":"World J. Surg. Oncol."},{"key":"10.1016\/j.toxicon.2016.07.008_bib41","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1093\/abbs\/gmt113","article-title":"Downregulation of miR-130a contributes to cisplatin resistance in ovarian cancer cells by targeting X-linked inhibitor of apoptosis (XIAP) directly","volume":"45","author":"Zhang","year":"2013","journal-title":"Acta. Biochim. Biophys. Sin."},{"key":"10.1016\/j.toxicon.2016.07.008_bib42","first-page":"8","article-title":"MiR-130b is a prognostic marker and inhibits cell proliferation and invasion in pancreatic cancer through targeting STAT3","author":"Zhao","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.toxicon.2016.07.008_bib43","doi-asserted-by":"crossref","first-page":"11","DOI":"10.2174\/138161210789941883","article-title":"The role of apoptosis in cancer development and treatment: focusing on the development and treatment of hematologic malignancies","volume":"16","author":"Zivny","year":"2010","journal-title":"Curr. Pharm. Des."}],"container-title":["Toxicon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010116302100?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010116302100?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,16]],"date-time":"2020-05-16T21:23:11Z","timestamp":1589664191000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041010116302100"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":43,"alternative-id":["S0041010116302100"],"URL":"https:\/\/doi.org\/10.1016\/j.toxicon.2016.07.008","relation":{},"ISSN":["0041-0101"],"issn-type":[{"value":"0041-0101","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The L-amino acid oxidase from Calloselasma rhodostoma snake venom modulates apoptomiRs expression in Bcr-Abl-positive cell lines","name":"articletitle","label":"Article Title"},{"value":"Toxicon","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxicon.2016.07.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}