{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T23:08:51Z","timestamp":1789945731926,"version":"4.0.1"},"reference-count":20,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Tunisian Ministry of Research and Technology (MERST)"},{"name":"Associazione Italiana per la Ricerca sul Cancro (AIRC)","award":["14095"],"award-info":[{"award-number":["14095"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicon"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1016\/j.toxicon.2016.12.001","type":"journal-article","created":{"date-parts":[[2016,12,8]],"date-time":"2016-12-08T17:45:16Z","timestamp":1481219116000},"page":"38-46","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"special_numbering":"C","title":["The small subunit of Hemilipin2, a new heterodimeric phospholipase A2 from  Hemiscorpius lepturus  scorpion venom, mediates the antiangiogenic effect of the whole protein"],"prefix":"10.1016","volume":"126","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9816-1811","authenticated-orcid":false,"given":"Imen","family":"Jridi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana","family":"Catacchio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hafed","family":"Majdoub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delavar","family":"Shahbazzadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"El Ayeb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Antonia","family":"Frassanito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Giovanni","family":"Solimando","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Ribatti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Vacca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lamia","family":"Borchani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxicon.2016.12.001_bib1","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1002\/ptr.5179","article-title":"Antiangiogenic activity of xanthomicrol and calycopterin, two polymethoxylatedhydroxyflavones in both in\u00a0vitro and ex\u00a0vivo models","volume":"28","author":"Abbaszadeh","year":"2014","journal-title":"Phytother. Res."},{"key":"10.1016\/j.toxicon.2016.12.001_bib2","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.matbio.2009.03.007","article-title":"MVL-PLA2, a phospholipase A2 from Macrovipera lebetina transmediterranea venom, inhibits tumor cells adhesion and migration","volume":"28","author":"Bazaa","year":"2009","journal-title":"Matrix Biol."},{"key":"10.1016\/j.toxicon.2016.12.001_bib3","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.toxicon.2011.05.016","article-title":"Heminecrolysin, the first hemolytic dermonecrotic toxin purified from scorpion venom","volume":"58","author":"Borchani","year":"2011","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2016.12.001_bib4","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/S0014-5793(99)01392-7","article-title":"Phospholipin, a novel heterodimeric phospholipase A2 from Pandinus imperator scorpion venom","volume":"460","author":"Conde","year":"1999","journal-title":"FEBS Lett."},{"key":"10.1016\/j.toxicon.2016.12.001_bib5","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/S0006-8993(03)03326-2","article-title":"Group III secreted phospholipase A2 causes apoptosis in rat primary cortical neuronal cultures","volume":"988","author":"De Coster","year":"2003","journal-title":"Brain Res."},{"key":"10.1016\/j.toxicon.2016.12.001_bib6","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1002\/pmic.201100409","article-title":"Molecular diversity of the telson and venom components from Pandinuscavimanus (Scorpionidae Latreille 1802): transcriptome, venomics and function","volume":"12","author":"Diego-Garc\u00eda","year":"2012","journal-title":"Proteomics"},{"key":"10.1016\/j.toxicon.2016.12.001_bib7","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/nm0195-27","article-title":"Angiogenesis in cancer, vascular, rheumatoid and other disease","volume":"1","author":"Folkman","year":"1995","journal-title":"Nat. Med."},{"issue":"3","key":"10.1016\/j.toxicon.2016.12.001_bib21","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.ijbiomac.2011.01.004","article-title":"Structural analysis of a group III Glu62-phospholipase A2 from the scorpion, Mesobuthus tamulus: targeting and reversible inhibition by native peptides","volume":"48","author":"Hariprasad","year":"2011","journal-title":"Int. J. Biol. Macromol."},{"issue":"3","key":"10.1016\/j.toxicon.2016.12.001_bib8","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1080\/10425170701243294","article-title":"Cloning, sequence analysis and homology modeling of a novel phospholipase A2 from Heterometrus fulvipes (Indian black scorpion)","volume":"18","author":"Hariprasad","year":"2007","journal-title":"DNA Seq."},{"key":"10.1016\/j.toxicon.2016.12.001_bib9","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.toxicon.2012.10.012","article-title":"Heteromtoxin (HmTx), a novel heterodimeric phospholipase A(2) from Heterometruslaoticus scorpion venom","volume":"61","author":"Incamnoi","year":"2013","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2016.12.001_bib10","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.toxicon.2009.09.012","article-title":"A\u00a0review of epidemiological, clinical and in\u00a0vitro physiological studies of envenomation by the scorpion Hemiscorpius lepturus (Hemiscorpiidae) in Iran","volume":"55","author":"Jalali","year":"2010","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2016.12.001_bib11","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.toxicon.2015.08.022","article-title":"Hemilipin, a novel Hemiscorpiuslepturus venom heterodimeric phospholipase A2, which inhibits angiogenesis in\u00a0vitro and in\u00a0vivo","volume":"105","author":"Jridi","year":"2015","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2016.12.001_bib12","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1038\/labinvest.2009.137","article-title":"CCPLA2-1 and CC-PLA2-2, two Cerastescerastes venom-derived phospholipases A2, inhibit angiogenesis both in\u00a0vitro and in\u00a0vivo","volume":"90","author":"Kessentini-Zouari","year":"2010","journal-title":"Lab. Invest"},{"key":"10.1016\/j.toxicon.2016.12.001_bib13","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/j.toxicon.2003.11.002","article-title":"Excitement ahead: structure, function and mechanism of snake venom phospholipase A2 enzymes","volume":"42","author":"Kini","year":"2003","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2016.12.001_bib14","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.jep.2010.05.064","article-title":"Anti-angiogenic activity of methanol extract of Phellinus linteus and its fractions","volume":"9","author":"Lee","year":"2010","journal-title":"J.\u00a0Ethnopharmacol."},{"key":"10.1016\/j.toxicon.2016.12.001_bib15","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1016\/j.bbalip.2006.07.011","article-title":"The phospholipase A2 superfamily and its group numbering system","volume":"1761","author":"Schaloske","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.toxicon.2016.12.001_bib16","first-page":"8","article-title":"Transcriptome analysis of the venom gland of the Mexican scorpion Hadrurus gertschi(Arachnida: Scorpiones)","volume":"16","author":"Schwartz","year":"2007","journal-title":"BMC Genomics"},{"key":"10.1016\/j.toxicon.2016.12.001_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1388-1981(00)00105-0","article-title":"The expanding superfamily of phospholipase A2 enzymes: classification and characterization","volume":"1488","author":"Six","year":"2000","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.toxicon.2016.12.001_bib18","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1111\/j.1432-1033.2004.04047.x","article-title":"Phaiodactylipin a glycosylated heterodimeric phospholipase A from the venom of the scorpion Anuroctonusphaiodactylus","volume":"271","author":"Valdez-Cruz","year":"2004","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.toxicon.2016.12.001_bib19","doi-asserted-by":"crossref","first-page":"11886","DOI":"10.1074\/jbc.272.18.11886","article-title":"The mechanism of inhibition of ryanodine receptor channels by imperatoxin I, a heterodimeric protein from the scorpion Pandinus imperator","volume":"272","author":"Zamudio","year":"1997","journal-title":"J.\u00a0Biol. Chem"}],"container-title":["Toxicon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010116306146?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010116306146?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,7,2]],"date-time":"2018-07-02T16:37:36Z","timestamp":1530549456000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041010116306146"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":20,"alternative-id":["S0041010116306146"],"URL":"https:\/\/doi.org\/10.1016\/j.toxicon.2016.12.001","relation":{},"ISSN":["0041-0101"],"issn-type":[{"value":"0041-0101","type":"print"}],"subject":[],"published":{"date-parts":[[2017,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The small subunit of Hemilipin2, a new heterodimeric phospholipase A2 from Hemiscorpius lepturus scorpion venom, mediates the antiangiogenic effect of the whole protein","name":"articletitle","label":"Article Title"},{"value":"Toxicon","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxicon.2016.12.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}