{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T15:59:39Z","timestamp":1790351979058,"version":"4.1.0"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001501","name":"University Grants Commission","doi-asserted-by":"publisher","award":["6242-P59\/RGCB\/PMD\/DBT\/ANSR\/2015"],"award-info":[{"award-number":["6242-P59\/RGCB\/PMD\/DBT\/ANSR\/2015"]}],"id":[{"id":"10.13039\/501100001501","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicon"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1016\/j.toxicon.2016.12.013","type":"journal-article","created":{"date-parts":[[2017,1,5]],"date-time":"2017-01-05T18:58:17Z","timestamp":1483642697000},"page":"11-21","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"special_numbering":"C","title":["Daboialectin, a C-type lectin from Russell's viper venom induces cytoskeletal damage and apoptosis in human lung cancer cells in\u00a0vitro"],"prefix":"10.1016","volume":"127","author":[{"given":"Jigni","family":"Pathan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sukanta","family":"Mondal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angshuman","family":"Sarkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dibakar","family":"Chakrabarty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxicon.2016.12.013_bib1","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0041-0101(03)00138-7","article-title":"Fractionation and characterization of Cerastes cerastes cerastes snake venom and the antitumor action of its lethal and non-lethal fractions","volume":"42","author":"Abu-Sinna","year":"2003","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2016.12.013_bib2","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/1477-3163-5-27","article-title":"FV peptide induces apoptosis in HEp 2 and HeLa cells: an insight into the mechanism of induction","volume":"5","author":"Balasubashini","year":"2006","journal-title":"J.\u00a0Carcinog."},{"key":"10.1016\/j.toxicon.2016.12.013_bib3","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1113\/jphysiol.1963.sp007185","article-title":"The aggregation of blood platelets","volume":"168","author":"Born","year":"1963","journal-title":"J.\u00a0Physiol."},{"key":"10.1016\/j.toxicon.2016.12.013_bib4","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1016\/S0041-0101(99)00243-3","article-title":"Haemorrhagic protein of Russell's viper venom with fibrinolytic and esterolytic activities","volume":"11","author":"Chakrabarty","year":"2000","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2016.12.013_bib5","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.etp.2008.09.006","article-title":"Apoptosis of human hepatocellular carcinoma cell (HepG2) induced by cardiotoxin III through S-phase arrest","volume":"61","author":"Chen","year":"2009","journal-title":"Exp. Toxicol. Pathol."},{"key":"10.1016\/j.toxicon.2016.12.013_bib6","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1098\/rstb.2000.0632","article-title":"Rho GTPases: molecular switches that control the organization and dynamics of the actin cytoskeleton","volume":"355","author":"Hall","year":"2000","journal-title":"Philos. Trans. R. Soc. Lond B Biol. Sci."},{"key":"10.1016\/j.toxicon.2016.12.013_bib7","doi-asserted-by":"crossref","first-page":"167","DOI":"10.3923\/ijcr.2007.167.173","article-title":"Antitumor effect of snake venom (Hydrophis spiralis) on Ehrlich ascites carcinoma bearing mice","volume":"3","author":"Karthikeyan","year":"2007","journal-title":"Int. J. Cancer Res."},{"key":"10.1016\/j.toxicon.2016.12.013_bib8","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/0041-0101(94)00133-S","article-title":"A\u00a0major lethal factor of the venom of Burmese Russell's viper (Daboia russelli siamensis): isolation, N-terminal sequencing and biological activities of daboiatoxin","volume":"1","author":"Maung-Maung-Thwin","year":"1995","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2016.12.013_bib9","first-page":"3569","article-title":"Alteration of Bax-to-Bcl-2 ratio modulates the anticancer activity of methanolic extract of Commelina benghalensis (Commelinaceae) in Jurkat T cells","volume":"7","author":"Mbazima","year":"2008","journal-title":"Afr. J. Biotechnol."},{"key":"10.1016\/j.toxicon.2016.12.013_bib10","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/j.toxicon.2005.02.021","article-title":"Structures and functions of snake venom CLPs (C-type lectin-like proteins) with anticoagulant-, procoagulant-, and platelet-modulating activities","volume":"45","author":"Morita","year":"2005","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2016.12.013_bib11","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays","volume":"65","author":"Mosmann","year":"1983","journal-title":"J.\u00a0Immunol. Methods"},{"key":"10.1016\/j.toxicon.2016.12.013_bib12","doi-asserted-by":"crossref","first-page":"e86823","DOI":"10.1371\/journal.pone.0086823","article-title":"The pro-coagulant fibrinogenolytic serine protease isoenzymes purified from Daboia russelii russelii venom coagulate the blood through factor V activation: role of glycosylation on enzymatic activity","volume":"2","author":"Mukherjee","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.toxicon.2016.12.013_bib13","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.toxicon.2015.10.011","article-title":"Russell's viper venom affects regulation of small GTPases and causes nuclear damage","volume":"108","author":"Pathan","year":"2015","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2016.12.013_bib26","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.1093\/nar\/gkn072","article-title":"PROMALS3D: a tool for multiple protein sequence and structure alignments","volume":"36","author":"Pei","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.toxicon.2016.12.013_bib14","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1023\/A:1007429904664","article-title":"Apoptosis: identification of dying cells","volume":"14","author":"Renvoize","year":"1998","journal-title":"Cell Biol. Toxicol."},{"key":"10.1016\/j.toxicon.2016.12.013_bib15","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1146\/annurev.me.31.020180.001335","article-title":"Snake venom poisoning in the United States","volume":"31","author":"Russell","year":"1980","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.toxicon.2016.12.013_bib16","first-page":"123","article-title":"Increased Bax\/Bcl-2 ratio up-regulates caspase-3 and increases apoptosis in the thymus of patients with myasthenia gravis","volume":"21","author":"Salakou","year":"2007","journal-title":"In\u00a0Vivo"},{"issue":"21","key":"10.1016\/j.toxicon.2016.12.013_bib17","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s40409-015-0038-3","article-title":"Snake venom galactoside-binding lectins: a structural and functional overview","volume":"24","author":"Sartim","year":"2015","journal-title":"J.\u00a0Venom. Anim. Toxins Incl. Trop. Dis."},{"key":"10.1016\/j.toxicon.2016.12.013_bib18","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1002\/jcb.10440","article-title":"Apoptosis and lung cancer: a review","volume":"88","author":"Shivapurkar","year":"2003","journal-title":"J.\u00a0Cell Biochem."},{"key":"10.1016\/j.toxicon.2016.12.013_bib19","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1158\/1535-7163.MCT-06-0328","article-title":"Inhibitory effect of snake venom toxin from Vipera lebetina turanica on hormone-refractory human prostate cancer cell growth: induction of apoptosis through inactivation of nuclear factor kappaB","volume":"6","author":"Son","year":"2007","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.toxicon.2016.12.013_bib20","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1093\/carcin\/17.2.239","article-title":"Apoptotic and anti-proliferative effects of fumonisin B1 in human keratinocytes, fibroblasts, esophageal epithelial cells and hepatoma cells","volume":"17","author":"Tolleson","year":"1996","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.toxicon.2016.12.013_bib21","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1159\/000438612","article-title":"The role of RhoA, RhoB and RhoC GTPases in cell morphology, proliferation and migration in human cytomegalovirus (HCMV) infected glioblastoma cells","volume":"38","author":"Tseliou","year":"2016","journal-title":"Cell Physiol. Biochem."},{"key":"10.1016\/j.toxicon.2016.12.013_bib22","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/emm.2006.51","article-title":"Up-regulation of Bax and endonuclease G, and down-modulation of Bcl-XL involved in cardiotoxin III-induced apoptosis in K562 cells","volume":"31","author":"Yang","year":"2006","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.toxicon.2016.12.013_bib23","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s11010-006-9382-5","article-title":"Effects of cardiotoxin III on expression of genes and proteins related to G2\/M arrest and apoptosis in K562 cells","volume":"300","author":"Yang","year":"2007","journal-title":"Mol. Cell Biochem."},{"key":"10.1016\/j.toxicon.2016.12.013_bib24","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1590\/S1678-91992008000400005","article-title":"Cytotoxic effect of ICD-85 (venom-derived peptides) on MDA-MB-231 cell line","volume":"14","author":"Zare Mirakabadi","year":"2008","journal-title":"J.\u00a0Venom. Anim. Toxins Incl. Trop. Dis."},{"key":"10.1016\/j.toxicon.2016.12.013_bib25","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.toxicon.2005.10.002","article-title":"Characterization and molecular cloning of dabocetin, a potent antiplatelet C-type lectin-like protein from Daboia russellii siamensis venom","volume":"47","author":"Zhong","year":"2006","journal-title":"Toxicon"}],"container-title":["Toxicon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010116308704?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010116308704?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,6,18]],"date-time":"2022-06-18T20:22:24Z","timestamp":1655583744000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041010116308704"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":26,"alternative-id":["S0041010116308704"],"URL":"https:\/\/doi.org\/10.1016\/j.toxicon.2016.12.013","relation":{},"ISSN":["0041-0101"],"issn-type":[{"value":"0041-0101","type":"print"}],"subject":[],"published":{"date-parts":[[2017,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Daboialectin, a C-type lectin from Russell's viper venom induces cytoskeletal damage and apoptosis in human lung cancer cells in\u00a0vitro","name":"articletitle","label":"Article Title"},{"value":"Toxicon","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxicon.2016.12.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}