{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T16:13:58Z","timestamp":1759940038240,"version":"3.44.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81472924","81620108026"],"award-info":[{"award-number":["81472924","81620108026"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicon"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1016\/j.toxicon.2017.06.014","type":"journal-article","created":{"date-parts":[[2017,7,3]],"date-time":"2017-07-03T12:46:27Z","timestamp":1499085987000},"page":"38-44","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Gene expression profiles and molecular mechanism of cultured human chondrocytes' exposure to T-2 toxin and deoxynivalenol"],"prefix":"10.1016","volume":"140","author":[{"given":"Lei","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guanghui","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cuiyan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yujie","family":"Ning","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikko J.","family":"Lammi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiong","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxicon.2017.06.014_bib1","first-page":"4759","article-title":"Application of complementary DNA microarray technology to carcinogen identification, toxicology, and drug safety evaluation","volume":"59","author":"Afshari","year":"1999","journal-title":"Cancer Res."},{"key":"10.1016\/j.toxicon.2017.06.014_bib2","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1128\/CMR.16.3.497-516.2003","article-title":"Mycotoxins","volume":"16","author":"Bennett","year":"2003","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.toxicon.2017.06.014_bib3","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.tox.2009.07.020","article-title":"Pathway of deoxynivalenol-induced apoptosis in human colon carcinoma cells","volume":"264","author":"Bensassi","year":"2009","journal-title":"Toxicology"},{"key":"10.1016\/j.toxicon.2017.06.014_bib4","doi-asserted-by":"crossref","first-page":"37758","DOI":"10.1074\/jbc.M111.248039","article-title":"Cartilage intermediate layer protein 2 (CILP-2) is expressed in articular and meniscal cartilage and down-regulated in experimental osteoarthritis","volume":"286","author":"Bernardo","year":"2011","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.toxicon.2017.06.014_bib5","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1016\/j.cell.2006.10.043","article-title":"Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair","volume":"127","author":"Botuyan","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.toxicon.2017.06.014_bib6","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.tiv.2010.12.001","article-title":"Effects of T-2 toxin and selenium on chondrocyte expression of matrix metalloproteinases (MMP-1, MMP-13), alpha2-macroglobulin (alpha2M) and TIMPs","volume":"25","author":"Chen","year":"2011","journal-title":"Toxicol. In\u00a0Vitro"},{"key":"10.1016\/j.toxicon.2017.06.014_bib7","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1007\/s002640100235","article-title":"Skeletal deformities induced by the intraperitoneal administration of deoxynivalenol (vomitoxin) in mice","volume":"25","author":"Debouck","year":"2001","journal-title":"Int. Orthop."},{"key":"10.1016\/j.toxicon.2017.06.014_bib8","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.etap.2016.02.002","article-title":"Deoxynivalenol inhibits proliferation and induces apoptosis in human umbilical vein endothelial cells","volume":"43","author":"Deng","year":"2016","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.toxicon.2017.06.014_bib9","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1128\/mr.57.3.595-604.1993","article-title":"Trichothecene biosynthesis in Fusarium species: chemistry, genetics, and significance","volume":"57","author":"Desjardins","year":"1993","journal-title":"Microbiol. Rev."},{"key":"10.1016\/j.toxicon.2017.06.014_bib10","doi-asserted-by":"crossref","first-page":"46906","DOI":"10.1074\/jbc.M307254200","article-title":"In\u00a0vivo recruitment of XPC to UV-induced cyclobutane pyrimidine dimers by the DDB2 gene product","volume":"278","author":"Fitch","year":"2003","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.toxicon.2017.06.014_bib11","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s002640100240","article-title":"The prevalence of mycotoxins in Kashin-Beck disease","volume":"25","author":"Haubruge","year":"2001","journal-title":"Int. Orthop."},{"key":"10.1016\/j.toxicon.2017.06.014_bib12","doi-asserted-by":"crossref","first-page":"6228","DOI":"10.1038\/sj.onc.1205774","article-title":"Genomic instability, centrosome amplification, cell cycle checkpoints and Gadd45a","volume":"21","author":"Hollander","year":"2002","journal-title":"Oncogene"},{"key":"10.1016\/j.toxicon.2017.06.014_bib13","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1093\/biostatistics\/4.2.249","article-title":"Exploration, normalization, and summaries of high density oligonucleotide array probe level data","volume":"4","author":"Irizarry","year":"2003","journal-title":"Biostatistics"},{"key":"10.1016\/j.toxicon.2017.06.014_bib14","doi-asserted-by":"crossref","first-page":"210","DOI":"10.3109\/02656736.2014.906048","article-title":"Evaluation of reference genes for human chondrocytes cultured in several different thermal environments","volume":"30","author":"Ito","year":"2014","journal-title":"Int. J. Hyperth."},{"key":"10.1016\/j.toxicon.2017.06.014_bib15","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1007\/s12011-015-0495-0","article-title":"Prevalence of selenium, T-2 toxin, and deoxynivalenol in Kashin-Beck disease areas in Qinghai province, northwest China","volume":"171","author":"Lei","year":"2016","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.toxicon.2017.06.014_bib16","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.etap.2013.06.002","article-title":"Gene expression profiling analysis of deoxynivalenol-induced inhibition of mouse thymic epithelial cell proliferation","volume":"36","author":"Li","year":"2013","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.toxicon.2017.06.014_bib17","doi-asserted-by":"crossref","first-page":"e109536","DOI":"10.1371\/journal.pone.0109536","article-title":"Effects of the mycotoxin nivalenol on bovine articular chondrocyte metabolism in\u00a0vitro","volume":"9","author":"Li","year":"2014","journal-title":"PloS One"},{"key":"10.1016\/j.toxicon.2017.06.014_bib18","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1631\/jzus.B071322","article-title":"Promotion of the articular cartilage proteoglycan degradation by T-2 toxin and selenium protective effect","volume":"9","author":"Li","year":"2008","journal-title":"J.\u00a0Zhejiang Univ. Sci. B"},{"key":"10.1016\/j.toxicon.2017.06.014_bib19","doi-asserted-by":"crossref","first-page":"e108394","DOI":"10.1371\/journal.pone.0108394","article-title":"The role of mitochondria in T-2 toxin-induced human chondrocytes apoptosis","volume":"9","author":"Liu","year":"2014","journal-title":"PloS One"},{"key":"10.1016\/j.toxicon.2017.06.014_bib20","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1159\/000335046","article-title":"The effects of mycotoxins and selenium deficiency on tissue-engineered cartilage","volume":"196","author":"Lu","year":"2012","journal-title":"Cells Tissues Organs"},{"key":"10.1016\/j.toxicon.2017.06.014_bib21","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.fct.2013.07.047","article-title":"Mycotoxins: occurrence, toxicology, and exposure assessment","volume":"60","author":"Marin","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.toxicon.2017.06.014_bib22","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1080\/02652030500058403","article-title":"Effects of trichothecene mycotoxins on eukaryotic cells: a review","volume":"22","author":"Rocha","year":"2005","journal-title":"Food Addit. Contam."},{"key":"10.1016\/j.toxicon.2017.06.014_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/009841096161447","article-title":"Toxicology of deoxynivalenol (vomitoxin)","volume":"48","author":"Rotter","year":"1996","journal-title":"J.\u00a0Toxicol. Environ. Health"},{"key":"10.1016\/j.toxicon.2017.06.014_bib24","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.etp.2005.02.005","article-title":"Microarray analysis of T-2 toxin-induced liver, placenta and fetal liver lesions in pregnant rats","volume":"57","author":"Sehata","year":"2005","journal-title":"Exp. Toxicol. Pathol."},{"key":"10.1016\/j.toxicon.2017.06.014_bib25","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1016\/j.fct.2004.06.006","article-title":"Morphological and microarray analysis of T-2 toxin-induced rat fetal brain lesion","volume":"42","author":"Sehata","year":"2004","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.toxicon.2017.06.014_bib26","first-page":"731","article-title":"Cell sensitivity assay: the MTT assay","author":"van Meerloo","year":"2011","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.toxicon.2017.06.014_bib27","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/s10555-005-5130-7","article-title":"Integrin-dependent signal transduction regulating cyclin D1 expression and G1 phase cell cycle progression","volume":"24","author":"Walker","year":"2005","journal-title":"Cancer Metastasis Rev."},{"key":"10.1016\/j.toxicon.2017.06.014_bib28","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1177\/0192623310396902","article-title":"T-2 toxin induces degenerative articular changes in rodents: link to Kaschin-Beck disease","volume":"39","author":"Wang","year":"2011","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.toxicon.2017.06.014_bib29","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1093\/toxsci\/kfs106","article-title":"JAK\/STAT pathway plays a critical role in the proinflammatory gene expression and apoptosis of RAW264.7 cells induced by trichothecenes as DON and T-2 toxin","volume":"127","author":"Wang","year":"2012","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.toxicon.2017.06.014_bib30","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1007\/s00204-016-1872-y","article-title":"Evaluation of the cytotoxic properties, gene expression profiles and secondary signalling responses of cultured cells exposed to fumonisin B1, deoxynivalenol and zearalenone mycotoxins","volume":"91","author":"Wentzel","year":"2016","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.toxicon.2017.06.014_bib31","doi-asserted-by":"crossref","first-page":"250","DOI":"10.3109\/03602530903125807","article-title":"Metabolic pathways of thichothecenes","volume":"42","author":"Wu","year":"2010","journal-title":"Drug Metab. Rev."},{"key":"10.1016\/j.toxicon.2017.06.014_bib32","doi-asserted-by":"crossref","first-page":"641","DOI":"10.2174\/1389200211314060002","article-title":"Trichothecenes: structure-toxic activity relationships","volume":"14","author":"Wu","year":"2013","journal-title":"Curr. Drug Metab."},{"key":"10.1016\/j.toxicon.2017.06.014_bib33","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1007\/s00204-014-1280-0","article-title":"Oxidative stress-mediated cytotoxicity and metabolism of T-2 toxin and deoxynivalenol in animals and humans: an update","volume":"88","author":"Wu","year":"2014","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.toxicon.2017.06.014_bib34","first-page":"201","article-title":"Research report on the etiology of Kashin-Beck disease (KBD)","volume":"14","author":"Yang","year":"1995","journal-title":"Chin. J. Endem."},{"key":"10.1016\/j.toxicon.2017.06.014_bib35","doi-asserted-by":"crossref","first-page":"8592","DOI":"10.1021\/acs.jafc.5b03281","article-title":"Simultaneous determination of type A and B trichothecenes and their main metabolites in food animal tissues by ultraperformance liquid chromatography coupled with triple-quadrupole mass spectrometry","volume":"63","author":"Yang","year":"2015","journal-title":"J.\u00a0Agric. Food Chem."}],"container-title":["Toxicon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010117302039?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010117302039?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T21:10:25Z","timestamp":1758575425000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041010117302039"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":35,"alternative-id":["S0041010117302039"],"URL":"https:\/\/doi.org\/10.1016\/j.toxicon.2017.06.014","relation":{},"ISSN":["0041-0101"],"issn-type":[{"type":"print","value":"0041-0101"}],"subject":[],"published":{"date-parts":[[2017,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gene expression profiles and molecular mechanism of cultured human chondrocytes' exposure to T-2 toxin and deoxynivalenol","name":"articletitle","label":"Article Title"},{"value":"Toxicon","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxicon.2017.06.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}