{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:11:46Z","timestamp":1791475906345,"version":"4.3.4"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001839","name":"University Grants Committee","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001839","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicon"],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.1016\/j.toxicon.2017.08.003","type":"journal-article","created":{"date-parts":[[2017,8,9]],"date-time":"2017-08-09T08:32:37Z","timestamp":1502267557000},"page":"1-17","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"special_numbering":"C","title":["Aristolochic acid and its derivatives as inhibitors of snake venom L-amino acid oxidase"],"prefix":"10.1016","volume":"138","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1116-5877","authenticated-orcid":false,"given":"Payel","family":"Bhattacharjee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indrani","family":"Bera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhamoy","family":"Chakraborty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanda","family":"Ghoshal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debasish","family":"Bhattacharyya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxicon.2017.08.003_bib1","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1007\/s10495-006-7959-9","article-title":"Mechanisms of cell death induction by L-amino acid oxidase, a major component of ophidian venom","volume":"11","author":"Ande","year":"2006","journal-title":"Apoptosis"},{"key":"10.1016\/j.toxicon.2017.08.003_bib2","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1093\/mutage\/17.4.265","article-title":"Aristolochic acid as a probable human cancer hazard in herbal remedies: a review","volume":"17","author":"Arlt","year":"2002","journal-title":"Mutagenesis"},{"key":"10.1016\/j.toxicon.2017.08.003_bib3","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.jep.2012.10.056","article-title":"Characterization of the aqueous extract of the root of Aristolochia indica: evaluation of its traditional use as an antidote for snake bites","volume":"145","author":"Bhattacharjee","year":"2013","journal-title":"J.\u00a0Ethnopharmacol."},{"key":"10.1016\/j.toxicon.2017.08.003_bib4","first-page":"156","article-title":"Medicinal plants as snake venom antidotes","volume":"1","author":"Bhattacharjee","year":"2014","journal-title":"J.\u00a0Exp. Appl. Ani. Sci."},{"key":"10.1016\/j.toxicon.2017.08.003_bib5","series-title":"Toxins and Drug Discovery","first-page":"1","article-title":"L-amino acid oxidase from venoms","author":"Bhattacharjee","year":"2015"},{"key":"10.1016\/j.toxicon.2017.08.003_bib6","unstructured":"Cerius2, Version 4.6. AccelrysInc, San Diego, CA, USA."},{"key":"10.1016\/j.toxicon.2017.08.003_bib7","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1016\/S0041-0101(99)00243-3","article-title":"Haemorrhagic protein of Russell's viper venom with fibrinolytic and esterolytic activities","volume":"38","author":"Chakrabarty","year":"2000","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2017.08.003_bib8","doi-asserted-by":"crossref","first-page":"3735","DOI":"10.1002\/rcm.3791","article-title":"Characterization of the DNA adducts induced by aristolochic acids in oligonucleotides by electrospray ionization tandem mass spectrometry","volume":"22","author":"Chan","year":"2008","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"10.1016\/j.toxicon.2017.08.003_bib9","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.biochi.2011.07.022","article-title":"Cloning, characterization and mutagenesis of Russell's viper venom L-amino acid oxidase: insights into its catalytic mechanism","volume":"94","author":"Chen","year":"2012","journal-title":"Biochimie"},{"key":"10.1016\/j.toxicon.2017.08.003_bib10","doi-asserted-by":"crossref","first-page":"42673","DOI":"10.1038\/srep42673","article-title":"CR-LAAO, an L-amino acid oxidase from Calloselasma rhodostoma venom, as a potential tool for developing novel immunotherapeutic strategies against cancer","volume":"7","author":"Costa","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.toxicon.2017.08.003_bib11","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/ki.2011.428","article-title":"Chinese herbs nephropathy and Balkan endemic nephropathy: toward a single entity, aristolochic acid nephropathy","volume":"81","author":"De Broe","year":"2012","journal-title":"Kidney Int."},{"key":"10.1016\/j.toxicon.2017.08.003_bib12","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/S0041-0101(02)00102-2","article-title":"Snake venom L-amino acid oxidases","volume":"40","author":"Du","year":"2002","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2017.08.003_bib13","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1042\/BJ20111779","article-title":"First identification of small-molecule inhibitors of Pontin by combining virtual screening and enzymatic assay","volume":"443","author":"Elkaim","year":"2012","journal-title":"Biochem. J."},{"key":"10.1016\/j.toxicon.2017.08.003_bib14","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/978-1-60761-411-1_4","article-title":"Identification of ROS using oxidized DCFDA and flow-cytometry","volume":"594","author":"Eruslanov","year":"2010","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.toxicon.2017.08.003_bib15","doi-asserted-by":"crossref","first-page":"8577","DOI":"10.1063\/1.470117","article-title":"A\u00a0smooth particle mesh Ewald method","volume":"103","author":"Essmann","year":"1995","journal-title":"J.\u00a0Chem. Phys."},{"key":"10.1016\/j.toxicon.2017.08.003_bib16","doi-asserted-by":"crossref","first-page":"4044","DOI":"10.1046\/j.1432-1327.2001.02321.x","article-title":"Structure and characterization of the glycan moiety of L-amino-acid oxidase from the Malayan pit viper Calloselasma rhodostoma","volume":"268","author":"Geyer","year":"2001","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.toxicon.2017.08.003_bib17","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.bmcl.2003.10.006","article-title":"3-D-QSAR of N-substituted 4-amino-3,3-dialkyl-2(3H)-furanone GABA receptor modulators using molecular field analysis and receptor surface modelling study","volume":"14","author":"Ghoshal","year":"2004","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.toxicon.2017.08.003_bib18","doi-asserted-by":"crossref","first-page":"469","DOI":"10.7326\/0003-4819-158-6-201303190-00006","article-title":"The epidemiology, diagnosis, and management of aristolochic acid nephropathy: a narrative review","volume":"158","author":"Gokmen","year":"2013","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.toxicon.2017.08.003_bib19","doi-asserted-by":"crossref","first-page":"12129","DOI":"10.1073\/pnas.0701248104","article-title":"Aristolochic acid and the etiology of endemic (Balkan) nephropathy","volume":"104","author":"Grollman","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.toxicon.2017.08.003_bib20","first-page":"1","article-title":"LINCS: a linear constraint solver for molecular simulations","author":"Berk Hess","year":"1997","journal-title":"J.\u00a0Comput. Chem."},{"key":"10.1016\/j.toxicon.2017.08.003_bib21","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1021\/ct700301q","article-title":"GROMACS 4: algorithms for highly efficient, load-balanced, and scalable molecular simulation","volume":"4","author":"Hess","year":"2008","journal-title":"J.\u00a0Chem. Theory Comput."},{"key":"10.1016\/j.toxicon.2017.08.003_bib22","unstructured":"Hyperchem 7.5. Hypercube, Inc, Gainesville, FL, USA."},{"key":"10.1016\/j.toxicon.2017.08.003_bib23","series-title":"Insight II, Homology User Guide","year":"2000"},{"key":"10.1016\/j.toxicon.2017.08.003_bib24","doi-asserted-by":"crossref","first-page":"196754","DOI":"10.1155\/2014\/196754","article-title":"Snake venom L-amino acid oxidases: trends in pharmacology and biochemistry","volume":"2014","author":"Izidoro","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.toxicon.2017.08.003_bib25","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1111\/j.1440-1746.2010.06592.x","article-title":"Reactive oxygen and mechanisms of inflammatory liver injury: present concepts","volume":"26","author":"Jaeschke","year":"2011","journal-title":"J.\u00a0Gastroenterol. Hepatol."},{"issue":"Pt 17","key":"10.1016\/j.toxicon.2017.08.003_bib26","doi-asserted-by":"crossref","first-page":"2941","DOI":"10.1242\/jcs.113.17.2941","article-title":"Effector caspases are dispensable for the early nuclear morphological changes during chemical-induced apoptosis","volume":"113","author":"Johnson","year":"2000","journal-title":"J.\u00a0Cell. Sci."},{"key":"10.1016\/j.toxicon.2017.08.003_bib27","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1006\/jmbi.1996.0897","article-title":"Development and validation of a genetic algorithm for flexible docking","volume":"267","author":"Jones","year":"1997","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.toxicon.2017.08.003_bib28","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1107\/S0021889892009944","article-title":"PROCHECK: a program to check the stereochemical quality of protein structures","volume":"26","author":"Laskowski","year":"1993","journal-title":"J.\u00a0Appl. Crystallogr."},{"key":"10.1016\/j.toxicon.2017.08.003_bib29","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.3390\/molecules14041404","article-title":"Molecular docking studies and anti-enzymatic activities of Thai mango seed kernel extract against snake venoms","volume":"14","author":"Leanpolchareanchai","year":"2009","journal-title":"Molecules"},{"key":"10.1016\/j.toxicon.2017.08.003_bib30","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.1093\/nar\/gkr1094","article-title":"Structure and stability of DNA containing an aristolactam II-dA lesion: implications for the NER recognition of bulky adducts","volume":"40","author":"Lukin","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.toxicon.2017.08.003_bib31","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1111\/j.1742-4658.2008.06362.x","article-title":"Two L-amino acid oxidase isoenzymes from Russell's viper (Daboia russelli russelli) venom with different mechanisms of inhibition by substrate analogs","volume":"275","author":"Mandal","year":"2008","journal-title":"FEBS J."},{"key":"10.1016\/j.toxicon.2017.08.003_bib32","doi-asserted-by":"crossref","first-page":"3070","DOI":"10.1021\/bi00659a021","article-title":"Vinylglycine and proparglyglycine: complementary suicide substrates for L-amino acid oxidase and D-amino acid oxidase","volume":"15","author":"Marcotte","year":"1976","journal-title":"Biochemistry"},{"key":"10.1016\/j.toxicon.2017.08.003_bib33","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.fob.2013.01.010","article-title":"Irreversible inactivation of snake venom L-amino acid oxidase by covalent modification during catalysis of L-propargylglycine","volume":"3","author":"Mitra","year":"2013","journal-title":"FEBS Open Bio"},{"key":"10.1016\/j.toxicon.2017.08.003_bib34","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1155\/2012\/465897","article-title":"Induction of oxidative stress in kidney","volume":"2012","author":"Ozbek","year":"2012","journal-title":"Int. J. Nephrol."},{"key":"10.1016\/j.toxicon.2017.08.003_bib35","doi-asserted-by":"crossref","first-page":"4204","DOI":"10.1093\/emboj\/19.16.4204","article-title":"The structure of L-amino acid oxidase reveals the substrate trajectory into an enantiomerically conserved active site","volume":"19","author":"Pawelek","year":"2000","journal-title":"Embo J."},{"key":"10.1016\/j.toxicon.2017.08.003_bib36","doi-asserted-by":"crossref","first-page":"S56","DOI":"10.1002\/ptr.2903","article-title":"Inhibitory effect of tea polyphenols on local tissue damage induced by snake venoms","volume":"24","author":"Pithayanukul","year":"2010","journal-title":"Phytother. Res."},{"key":"10.1016\/j.toxicon.2017.08.003_bib37","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.toxicon.2013.12.013","article-title":"Effect of L-amino acid oxidase from Calloselasma rhodosthoma snake venom on human neutrophils","volume":"80","author":"Pontes","year":"2014","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2017.08.003_bib38","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.toxicon.2016.05.013","article-title":"p38 MAPK is involved in human neutrophil chemotaxis induced by L-amino acid oxidase from Calloselasma rhodosthoma","volume":"119","author":"Pontes","year":"2016","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2017.08.003_bib39","doi-asserted-by":"crossref","first-page":"7546","DOI":"10.1073\/pnas.93.15.7546","article-title":"Glycerol-induced development of catalytically active conformation of Crotalus adamanteus L-amino acid oxidase in\u00a0vitro","volume":"93","author":"Raibekas","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.toxicon.2017.08.003_bib40","series-title":"Aristolochic Acid","year":"2016"},{"key":"10.1016\/j.toxicon.2017.08.003_bib41","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1046\/j.1471-4159.1995.65010218.x","article-title":"The intracellular component of cellular 3-(4,5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) reduction is specifically inhibited by beta-amyloid peptides","volume":"65","author":"Shearman","year":"1995","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.toxicon.2017.08.003_bib42","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.mrrev.2007.07.003","article-title":"Metabolic activation of carcinogenic aristolochic acid, a risk factor for Balkan endemic nephropathy","volume":"658","author":"Stiborova","year":"2008","journal-title":"Mutat. Res."},{"key":"10.1016\/j.toxicon.2017.08.003_bib43","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1006\/bbrc.1996.0996","article-title":"Identification of the snake venom substance that induces apoptosis","volume":"224","author":"Suhr","year":"1996","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.toxicon.2017.08.003_bib44","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/0041-0101(94)90166-X","article-title":"The edema-inducing activity of Ophiophagus hannah (king cobra) venom L-amino acid oxidase","volume":"32","author":"Tan","year":"1994","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2017.08.003_bib45","series-title":"The Merck Index","year":"1989"},{"key":"10.1016\/j.toxicon.2017.08.003_bib46","doi-asserted-by":"crossref","first-page":"28968","DOI":"10.1074\/jbc.M300905200","article-title":"The mechanism of gamma-secretase: multiple inhibitor binding sites for transition state analogs and small molecule inhibitors","volume":"278","author":"Tian","year":"2003","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.toxicon.2017.08.003_bib47","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/nsmb.1743","article-title":"An APP inhibitory domain containing the Flemish mutation residue modulates gamma-secretase activity for Abeta production","volume":"17","author":"Tian","year":"2010","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.toxicon.2017.08.003_bib48","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.bbrc.2012.03.129","article-title":"Structural insights into selectivity and cofactor binding in snake venom L-amino acid oxidases","volume":"421","author":"Ullah","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.toxicon.2017.08.003_bib49","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1002\/ptr.1951","article-title":"The anti-snake venom properties of Tamarindus indica (leguminosae) seed extract","volume":"20","author":"Ushanandini","year":"2006","journal-title":"Phytother. Res."},{"key":"10.1016\/j.toxicon.2017.08.003_bib50","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1111\/j.1432-1033.1993.tb18041.x","article-title":"Extensive accumulation of an extracellular L-amino-acid oxidase during gametogenesis of Chlamydomonas reinhardtii","volume":"215","author":"Vallon","year":"1993","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.toxicon.2017.08.003_bib51","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1016\/j.toxicon.2007.07.022","article-title":"Purification, characterization and potent lung lesion activity of an L-amino acid oxidase from Agkistrodon blomhoffii ussurensis snake venom","volume":"50","author":"Wei","year":"2007","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2017.08.003_bib52","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.toxicon.2009.04.017","article-title":"Purification, characterization and biological activities of the L-amino acid oxidase from Bungarus fasciatus snake venom","volume":"54","author":"Wei","year":"2009","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2017.08.003_bib53","doi-asserted-by":"crossref","first-page":"W407","DOI":"10.1093\/nar\/gkm290","article-title":"ProSA-web: interactive web service for the recognition of errors in three-dimensional structures of proteins","volume":"35","author":"Wiederstein","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.toxicon.2017.08.003_bib54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12010-012-9611-1","article-title":"Advances in non-snake venom L-amino acid oxidase","volume":"167","author":"Yu","year":"2012","journal-title":"Appl. Biochem. Biotechnol."},{"key":"10.1016\/j.toxicon.2017.08.003_bib55","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1016\/S0041-0101(01)00123-4","article-title":"Bothrops asper and Bothrops jararaca snake venoms trigger microbicidal functions of peritoneal leukocytes in\u00a0vivo","volume":"39","author":"Zamuner","year":"2001","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2017.08.003_bib56","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1107\/S0907444904000046","article-title":"Purification, partial characterization, crystallization and structural determination of AHP-LAAO, a novel L-amino-acid oxidase with cell apoptosis-inducing activity from Agkistrodon halys pallas venom","volume":"60","author":"Zhang","year":"2004","journal-title":"Acta Crystallogr. D. Biol. Crystallogr."},{"key":"10.1016\/j.toxicon.2017.08.003_bib57","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.toxicon.2004.11.004","article-title":"Inflammatory events induced by Lys-49 and Asp-49 phospholipases A2 isolated from Bothrops asper snake venom: role of catalytic activity","volume":"45","author":"Zuliani","year":"2005","journal-title":"Toxicon"}],"container-title":["Toxicon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010117302398?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010117302398?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,7,31]],"date-time":"2022-07-31T22:33:14Z","timestamp":1659306794000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041010117302398"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11]]},"references-count":57,"alternative-id":["S0041010117302398"],"URL":"https:\/\/doi.org\/10.1016\/j.toxicon.2017.08.003","relation":{},"ISSN":["0041-0101"],"issn-type":[{"value":"0041-0101","type":"print"}],"subject":[],"published":{"date-parts":[[2017,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Aristolochic acid and its derivatives as inhibitors of snake venom L-amino acid oxidase","name":"articletitle","label":"Article Title"},{"value":"Toxicon","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxicon.2017.08.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}