{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T02:20:59Z","timestamp":1768789259854,"version":"3.49.0"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,11,3]],"date-time":"2018-11-03T00:00:00Z","timestamp":1541203200000},"content-version":"vor","delay-in-days":337,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["455161\/2014-3"],"award-info":[{"award-number":["455161\/2014-3"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["23038000825\/2011-63"],"award-info":[{"award-number":["23038000825\/2011-63"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005667","name":"Funda\u00e7\u00e3o de Amparo a Pesquisa do Estado de Santa Catarina","doi-asserted-by":"publisher","award":["FAPESC\/2016TR2239"],"award-info":[{"award-number":["FAPESC\/2016TR2239"]}],"id":[{"id":"10.13039\/501100005667","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo a Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicon"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1016\/j.toxicon.2017.10.024","type":"journal-article","created":{"date-parts":[[2017,10,26]],"date-time":"2017-10-26T13:00:13Z","timestamp":1509022813000},"page":"132-138","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Genotoxicity evaluation induced by Tityus serrulatus scorpion venom in mice"],"prefix":"10.1016","volume":"140","author":[{"given":"Nathalia Coral","family":"Galvani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2986-1715","authenticated-orcid":false,"given":"Thais Ceres\u00e9r","family":"Vilela","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelino Chitoma","family":"Domingos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00edrian \u00cdvens","family":"Fagundes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiza Macarini","family":"Bosa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Indiani Conti","family":"Della Vechia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rahisa","family":"Scussel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1rcia","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bethina Trevisol","family":"Steiner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriani Paganini","family":"Damiani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Ch\u00e1vez-Ol\u00f3rtegui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa Moraes","family":"De Andrade","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo Andrez Machado","family":"de \u00c1vila","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxicon.2017.10.024_bib2","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.toxicon.2013.08.039","article-title":"Lipid-derived inflammatory mediators: their role in pathogenesis of scorpion envenomation","volume":"75","author":"Adi-Bessalem","year":"2013","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2017.10.024_bib3","first-page":"49","article-title":"Effects of Leurus quinquestriatus scorpion venom on histological structure of the liver and kidney","volume":"3","author":"Al-Harbi","year":"2014","journal-title":"Glob. Adv. Res. J. Environ. Sci. Toxicol."},{"issue":"10","key":"10.1016\/j.toxicon.2017.10.024_bib5","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1038\/nrm1493","article-title":"Lukas J Checking on DNA damage in S phase","volume":"5","author":"Bartek","year":"2004","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"4","key":"10.1016\/j.toxicon.2017.10.024_bib6","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/S0041-0101(02)00391-4","article-title":"Effects of Tityus serrulatus scorpion venom and its major toxin, TsTX-I, on the complement system in\u00a0vivo","volume":"41","author":"Bertazzi","year":"2003","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2017.10.024_bib7","first-page":"204","article-title":"Safe antigens: their use in immune sera production and vaccine approach","volume":"135","author":"Boussag-Abib","year":"2011","journal-title":"Immunology"},{"key":"10.1016\/j.toxicon.2017.10.024_bib8","series-title":"Secretaria Vigil\u00e2ncia em Sa\u00fade. Departamento de Vigil\u00e2ncia Epidemi\u00f3logica. Manual de Controle de Escorpi\u00f5es","author":"Brasil - Minist\u00e9rio da Sa\u00fade","year":"2009"},{"key":"10.1016\/j.toxicon.2017.10.024_bib9","series-title":"Novo m\u00e9todo de fracionamento da pe\u00e7onha do escorpi\u00e3o Tityus serrulatus e carateriza\u00e7\u00e3o eletrofisiol\u00f3gica das toxinas Ts6 e Ts7","author":"Cerni","year":"2012"},{"issue":"2","key":"10.1016\/j.toxicon.2017.10.024_bib49","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.actatropica.2008.05.021","article-title":"Epidemiology of scorpionism: a global appraisal","volume":"107","author":"Chippaux","year":"2008","journal-title":"Acta Trop."},{"issue":"1","key":"10.1016\/j.toxicon.2017.10.024_bib10","first-page":"56","article-title":"Evaluation of a new polyvalent antivenom against snakebite envenomation (Inoserp(\u00ae) Panafricain) in two different epidemiological settings: northern Benin and maritime Guinea","volume":"25","author":"Chippaux","year":"2015","journal-title":"Med. Sante Trop."},{"key":"10.1016\/j.toxicon.2017.10.024_bib11","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0024-3205(99)00579-2","article-title":"Toxicity during early development of the mouse nervous system of a scorpion neurotoxin active on sodium channels","volume":"66","author":"Clot-Faybesse","year":"2000","journal-title":"Life Sci."},{"issue":"2","key":"10.1016\/j.toxicon.2017.10.024_bib50","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1002\/(SICI)1098-2280(1997)30:2<139::AID-EM6>3.0.CO;2-I","article-title":"Comet assay in human biomonitoring studies: reliability, validation, and applications","volume":"30","author":"Collins","year":"1997","journal-title":"Environ. Mol. Mutagen."},{"key":"10.1016\/j.toxicon.2017.10.024_bib13","first-page":"56","article-title":"Selected scorpion toxin exposures induce cytokine release in human peripheral blood mononuclear cells","volume":"127","author":"Corzo","year":"2017","journal-title":"Toxicol"},{"key":"10.1016\/j.toxicon.2017.10.024_bib17","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/978-1-59745-548-0_12","article-title":"The micronucleus assay determination of chromosomal level DNA damage","volume":"410","author":"Fenech","year":"2008","journal-title":"Methods Mol. Biol."},{"issue":"1","key":"10.1016\/j.toxicon.2017.10.024_bib51","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0041-0101(02)00208-8","article-title":"Increased plasma levels of IL-1\u03b2, IL-6, IL-8, IL-10 and TNF-\u03b1 in patients moderately or severely envenomed by Tityus serrulatus scorpion sting","volume":"41","author":"Fukuhara","year":"2003","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2017.10.024_bib18","first-page":"93","article-title":"Anticancer potential of animal venoms and toxins","volume":"48","author":"Gomes","year":"2010","journal-title":"Indian J. Exp. Biol."},{"issue":"5","key":"10.1016\/j.toxicon.2017.10.024_bib20","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1056\/NEJMra1401108","article-title":"Scorpion envenomation","volume":"371","author":"Isbister","year":"2014","journal-title":"N.\u00a0Engl. J. Med."},{"issue":"7","key":"10.1016\/j.toxicon.2017.10.024_bib21","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/0041-0101(95)00005-7","article-title":"The scorpion envenoming syndrome","volume":"33","author":"Ismail","year":"1995","journal-title":"Toxicon"},{"issue":"7267","key":"10.1016\/j.toxicon.2017.10.024_bib23","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1038\/nature08467","article-title":"The DNA-damage response in human biology and disease","volume":"461","author":"Jackson","year":"2009","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.toxicon.2017.10.024_bib52","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1016\/S0041-0101(97)00017-2","article-title":"Venomvariability among several Tityus serrulatus specimens","volume":"35","author":"Kalapothakis","year":"1997","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2017.10.024_bib25","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3389\/fgene.2017.00020","article-title":"Inflammation, DNA damage, Helicobacter pylori and gastric Tumorigenesis","volume":"8","author":"Kalisperati","year":"2017","journal-title":"Front. Genet."},{"issue":"5","key":"10.1016\/j.toxicon.2017.10.024_bib27","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1007\/s10753-014-9898-x","article-title":"Modulation of tissue inflammatory response by histamine receptors in scorpion envenomation pathogenesis: involvement of H4 receptor","volume":"37","author":"Lamraoui","year":"2014","journal-title":"Inflammation"},{"issue":"3","key":"10.1016\/j.toxicon.2017.10.024_bib29","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.toxicon.2004.04.015","article-title":"Molecular characterization of protective antibodies raised in mice by Tityus serrulatus scorpion venom toxins conjugated to bovine serum albumin","volume":"44","author":"Machado de Avila","year":"2004","journal-title":"Toxicon"},{"issue":"8","key":"10.1016\/j.toxicon.2017.10.024_bib53","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/S0041-0101(98)00251-7","article-title":"Serum levels of cytokines in patients envenomed by Tityus serrulatus scorpion sting","volume":"37","author":"Magalh\u00e3es","year":"1999","journal-title":"Toxicon"},{"issue":"1","key":"10.1016\/j.toxicon.2017.10.024_bib33","first-page":"39","article-title":"Lethal effect of the scorpion Tityus serrulatus venom: comparative study on adult and weanling rats","volume":"37","author":"Nunan","year":"2001","journal-title":"Braz. J. Pharm. Sci."},{"key":"10.1016\/j.toxicon.2017.10.024_bib34","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1590\/S0100-879X2004000300016","article-title":"Age effects on the pharmacokinetics of tityustoxin from Tityus serrulatus scorpion venom in rats","volume":"37","author":"Nunan","year":"2004","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.toxicon.2017.10.024_bib35","series-title":"Toxicidade da pe\u00e7onha de Tityus serrulatus procedente do distrito federal por meio da avalia\u00e7\u00e3o da DL50, efeitos da pe\u00e7onha e edema pulmonar induzido","author":"Oliveira","year":"2011"},{"issue":"5","key":"10.1016\/j.toxicon.2017.10.024_bib36","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1101\/gad.2021311","article-title":"Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications","volume":"25","author":"Polo","year":"2011","journal-title":"Genes Dev."},{"key":"10.1016\/j.toxicon.2017.10.024_bib54","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.freeradbiomed.2016.01.024","article-title":"Physical exercise, reactive oxygen species and neuroprotection","volume":"98","author":"Radak","year":"2016","journal-title":"Free Radic. Biol. Med."},{"issue":"10","key":"10.1016\/j.toxicon.2017.10.024_bib38","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/0041-0101(96)00074-8","article-title":"Body distribution of tityus serrulatus scorpion venom in mice and effects of scorpion antivenom","volume":"34","author":"Revelo","year":"1996","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2017.10.024_bib55","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.toxicon.2016.07.013","article-title":"Human bronchial epithelial cells injury and cytokine production induced by Tityus serrulatus scorpion venom: An in vitro study","volume":"120","author":"Rigoni","year":"2016","journal-title":"Toxicon"},{"issue":"8","key":"10.1016\/j.toxicon.2017.10.024_bib39","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.toxicon.2005.09.006","article-title":"Overview of scorpion toxins specific for Na+ channels and related peptides: biodiversity, structure-function relationships and evolution","volume":"46","author":"Rodr\u00edguez de la Vega","year":"2005","journal-title":"Toxicon"},{"issue":"4","key":"10.1016\/j.toxicon.2017.10.024_bib40","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1590\/S1678-91992012000400005","article-title":"A\u00a0biodistribution study of Hemiscorpius lepturus scorpion venom and available polyclonal antivenom in rats","volume":"18","author":"Seyedian","year":"2012","journal-title":"J.\u00a0Venom. Aim. Toxin. Incl. Trop."},{"issue":"1","key":"10.1016\/j.toxicon.2017.10.024_bib43","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/0014-4827(88)90265-0","article-title":"A\u00a0simple technique for quantitation of low levels of DNA damage in individual cells","volume":"175","author":"Singh","year":"1988","journal-title":"Exp. Cell Res."},{"issue":"3","key":"10.1016\/j.toxicon.2017.10.024_bib44","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1002\/(SICI)1098-2280(2000)35:3<206::AID-EM8>3.0.CO;2-J","article-title":"Single cell gel\/comet assay: guidelines for in\u00a0vitro and in\u00a0vivo genetic Toxicology testing","volume":"35","author":"Tice","year":"2000","journal-title":"Environ. Mol. Mutagen"},{"issue":"1","key":"10.1016\/j.toxicon.2017.10.024_bib45","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.cca.2005.05.012","article-title":"Effects of voltage-gated Na+ channel toxins from Tityus serrulatus venom on rat arterial blood pressure and plasma catecholamines","volume":"141","author":"Vasconcelos","year":"2005","journal-title":"Comp. Biochem. Phisiol. C Toxicol. Pharmacol."},{"issue":"8","key":"10.1016\/j.toxicon.2017.10.024_bib48","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1016\/j.tiv.2011.09.002","article-title":"Scorpion venom (Odontobuthus doriae) induces apoptosis by depolarization of mitochondria and reduces S-phase population in human breast cancer cells (MCF-7)","volume":"25","author":"Zargan","year":"2011","journal-title":"Toxicol. Vitro"}],"container-title":["Toxicon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010117303288?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010117303288?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T21:11:31Z","timestamp":1758575491000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041010117303288"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":36,"alternative-id":["S0041010117303288"],"URL":"https:\/\/doi.org\/10.1016\/j.toxicon.2017.10.024","relation":{},"ISSN":["0041-0101"],"issn-type":[{"value":"0041-0101","type":"print"}],"subject":[],"published":{"date-parts":[[2017,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genotoxicity evaluation induced by Tityus serrulatus scorpion venom in mice","name":"articletitle","label":"Article Title"},{"value":"Toxicon","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxicon.2017.10.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}