{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:52:12Z","timestamp":1781139132682,"version":"3.54.1"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100006418","name":"Yarmouk University","doi-asserted-by":"publisher","award":["3\/2016"],"award-info":[{"award-number":["3\/2016"]}],"id":[{"id":"10.13039\/501100006418","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicon"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1016\/j.toxicon.2017.12.052","type":"journal-article","created":{"date-parts":[[2017,12,30]],"date-time":"2017-12-30T23:06:21Z","timestamp":1514675181000},"page":"45-51","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Biochemical and histopathological effects of the stonefish (Synanceia\u00a0verrucosa) venom in rats"],"prefix":"10.1016","volume":"142","author":[{"given":"Ahmad M.","family":"Khalil","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2722-9350","authenticated-orcid":false,"given":"Mohammad A.","family":"Wahsha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalid M.","family":"Abu Khadra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maroof A.","family":"Khalaf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tariq H.","family":"Al-Najjar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxicon.2017.12.052_bib1","series-title":"Biological, Biochemical and Immunological Studies of the Venom of the Stone Fish Synanceja Verrucosa from the Gulf of Aqaba","author":"Abu-Helu","year":"1989"},{"issue":"2","key":"10.1016\/j.toxicon.2017.12.052_bib2","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.toxicon.2010.12.005","article-title":"Histopathological changes induced by extracts from the tissue covering the stingers of Potamotrygon falkneri freshwater stingrays","volume":"57","author":"Antoniazzi","year":"2011","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2017.12.052_bib3","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/icb.1965.6","article-title":"Stonefish venom: some biochemical and chemical observations","volume":"43","author":"Austin","year":"1965","journal-title":"Aust. J. Exp. Biol. Med. Sci."},{"key":"10.1016\/j.toxicon.2017.12.052_bib4","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1080\/15376510600803573","article-title":"In\u00a0vivo and in\u00a0vitro characterization of the biochemical and pathological changes induced by lionfish [Pterios volitans] venom in mice","volume":"16","author":"Balasubashini","year":"2006","journal-title":"Toxicol. Mech. Meth."},{"issue":"4","key":"10.1016\/j.toxicon.2017.12.052_bib5","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.toxicon.2007.11.011","article-title":"Systemic response induced by Scorpaena plumieri fish venom initiates acute lung injury in mice","volume":"51","author":"Boletini-Santos","year":"2008","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2017.12.052_bib6","first-page":"305","article-title":"Evidence for a neurotoxic activity in crude venom of stonefish (Synanceja verrucosa)","volume":"11","author":"Breton","year":"2002","journal-title":"J.\u00a0Nat. Toxins"},{"key":"10.1016\/j.toxicon.2017.12.052_bib7","series-title":"Cecil Medicine","article-title":"Muscle Diseases","author":"Chinnery","year":"2011"},{"issue":"3","key":"10.1016\/j.toxicon.2017.12.052_bib8","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S0041-0101(99)00169-5","article-title":"Dose-dependent cardiovascular and neuromuscular effects of stonefish (Synanceja trachynis) venom","volume":"38","author":"Church","year":"2000","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2017.12.052_bib9","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/S0041-0101(02)00126-5","article-title":"The pharmacological activity of fish venoms","volume":"40","author":"Church","year":"2002","journal-title":"Toxicon"},{"issue":"6","key":"10.1016\/j.toxicon.2017.12.052_bib10","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/S0041-0101(03)00038-2","article-title":"Modulation of intracellular Ca2+ levels by Scorpaenidae venoms","volume":"41","author":"Church","year":"2003","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2017.12.052_bib11","doi-asserted-by":"crossref","first-page":"163","DOI":"10.3109\/01480547809034433","article-title":"Serum enzymes as indicators of chemical induced liver damage","volume":"1","author":"Drotman","year":"1978","journal-title":"Drug Chem. Toxicol."},{"key":"10.1016\/j.toxicon.2017.12.052_bib12","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1071\/MF9610177","article-title":"A\u00a0study of distribution, habitat, behaviour, venom apparatus, and venom of the stone-fish","volume":"12","author":"Endean","year":"1961","journal-title":"Mar. Freshw. Res."},{"key":"10.1016\/j.toxicon.2017.12.052_bib13","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/978-1-4613-0361-9_28","article-title":"Biochemical studies on the effect of Plotosus lineatus crude venom (in\u00a0vivo) and its effect on Eac-cells (in\u00a0vitro)","volume":"91","author":"Fahim","year":"1996","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.toxicon.2017.12.052_bib14","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1177\/096032719901800305","article-title":"The toxicity of cyanobacterial toxins: I. Microcystin-LR","volume":"18","author":"Fawell","year":"1999","journal-title":"Hum. Exp. Toxicol"},{"key":"10.1016\/j.toxicon.2017.12.052_bib15","series-title":"Fishbase","author":"Froese","year":"2017"},{"key":"10.1016\/j.toxicon.2017.12.052_bib16","first-page":"846","article-title":"Premieres sur un poisson marin venimeux de la Nouvelle-Caledonie: la synancee (Synanceia verrucosa Bloch)","volume":"19","author":"Gail","year":"1956","journal-title":"Bull. Soc. Pathol. Exotique."},{"key":"10.1016\/j.toxicon.2017.12.052_bib17","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0041-0101(94)00151-W","article-title":"Enzymatic properties of the stonefish [Synanceia verrucosa Bloch and Schneider, 1801] venom and purification of a lethal, hypotensive and cytolytic factor","volume":"33","author":"Garnier","year":"1995","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2017.12.052_bib18","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.toxicon.2009.10.012","article-title":"Cardiovascular effects of scorpionfish (Scorpaena plumieri) venom","volume":"55","author":"Gomes","year":"2010","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2017.12.052_bib19","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.toxicon.2013.07.023","article-title":"Molecular and biochemical characterization of a cytolysin from the Scorpaena plumieri (scorpionfish) venom: evidence of pore formation on erythrocyte cell membrane","volume":"74","author":"Gomes","year":"2013","journal-title":"Toxicon"},{"issue":"3","key":"10.1016\/j.toxicon.2017.12.052_bib20","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/0163-7258(94)90022-1","article-title":"A\u00a0review of stonefish venoms and toxins","volume":"64","author":"Gwee","year":"1994","journal-title":"Pharmacol. Ther."},{"issue":"1","key":"10.1016\/j.toxicon.2017.12.052_bib21","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0041-0101(03)00103-X","article-title":"Injuries caused by scorpionfishes (Scorpaena plumieri Bloch, 1789 and Scorpaena brasiliensis Cuvier, 1829) in the Southwestern Atlantic Ocean (Brazilian coast): epidemiologic, clinic and therapeutic aspects of 23 stings in humans","volume":"42","author":"Haddad","year":"2003","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2017.12.052_bib22","doi-asserted-by":"crossref","first-page":"381","DOI":"10.2307\/3223610","article-title":"Stonefish stings, and the venom apparatus of Synanceja horrida (Linnaeus) Trans","volume":"75","author":"Halstead","year":"1956","journal-title":"Am. Microsc. Soc."},{"key":"10.1016\/j.toxicon.2017.12.052_bib23","first-page":"67","article-title":"The cardiovascular and neurotoxic effects of the venoms of six bony and cartilaginous fish species","volume":"9(2)","author":"Han","year":"2017"},{"key":"10.1016\/j.toxicon.2017.12.052_bib24","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/S0041-0101(97)00167-0","article-title":"Enzyme and biochemical studies of stonefish (Synanceja trachynis) and soldierfish (Gymnapistes marmoratus) venoms","volume":"36","author":"Hopkins","year":"1998","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2017.12.052_bib25","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/S0041-0101(98)00009-9","article-title":"Cardiovascular studies on venom from the soldierfish (Gymnapistes marmoratus)","volume":"36","author":"Hopkins","year":"1998","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2017.12.052_bib26","series-title":"Fishes of the Gulf of Aqaba","author":"Khalaf","year":"1997"},{"issue":"1","key":"10.1016\/j.toxicon.2017.12.052_bib27","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1002\/nt.2620010111","article-title":"Biological activities of Synanceja horrida (stonefish) venom","volume":"1","author":"Khoo","year":"1992","journal-title":"Nat. Toxins"},{"issue":"9","key":"10.1016\/j.toxicon.2017.12.052_bib28","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1046\/j.1440-1681.2002.03727.x","article-title":"Bioactive proteins from stonefish venom","volume":"29","author":"Khoo","year":"2002","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.toxicon.2017.12.052_bib29","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/0041-0101(91)90065-Y","article-title":"The detection of a cytolytic toxin in the venom of the stonefish [Synanceja trachynis]","volume":"29","author":"Kreger","year":"1991","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2017.12.052_bib30","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/0041-0101(93)90148-C","article-title":"Effects of stonefish (Synanceia trachynis) venom on murine and frog neuromuscular junctions","volume":"31","author":"Kreger","year":"1993","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2017.12.052_bib31","doi-asserted-by":"crossref","first-page":"515","DOI":"10.47102\/annals-acadmedsg.V33N4p515","article-title":"Stonefish envenomations of the hand-a local marine hazard: a series of 8 cases and review of the literature","volume":"33","author":"Lee","year":"2004","journal-title":"Ann. Acad. Med. Singapore"},{"key":"10.1016\/j.toxicon.2017.12.052_bib32","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1046\/j.1365-2613.2001.00181.x","article-title":"Skeletal muscle necrosis and regeneration after injection of Thalassophryne nattereri [niquim] fish venom in mice","volume":"82","author":"Lopes-Ferreira","year":"2001","journal-title":"Int. J. Clin. Exp. Pathol."},{"issue":"1","key":"10.1016\/j.toxicon.2017.12.052_bib33","first-page":"69","article-title":"High creatine kinase (CK)-MB and lactate dehydrogenase in the absence of myocardial injury or infarction: a case report","volume":"6","author":"Maghamiour","year":"2014","journal-title":"J.\u00a0Cardiovasc. Thorac. Res."},{"issue":"6","key":"10.1016\/j.toxicon.2017.12.052_bib34","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/0736-4679(91)90223-3","article-title":"Marine envenomations; part 1: Vertebrates","volume":"9","author":"McGoldrick","year":"1991","journal-title":"J.\u00a0Emerg. Med"},{"key":"10.1016\/j.toxicon.2017.12.052_bib35","series-title":"Venomous and Poisonous Animals: a Handbook for Biologists, Toxicologists and Toxinologists, Physicians and Pharmacists","first-page":"102","author":"Mebs","year":"2002"},{"key":"10.1016\/j.toxicon.2017.12.052_bib36","first-page":"69","article-title":"Serum biochemical and hormonal parameters for the toxic effects of Egyptian Cobra (Naja haje) envenomation","volume":"6","author":"Omran","year":"1997","journal-title":"J.\u00a0Nat. Toxins"},{"issue":"4","key":"10.1016\/j.toxicon.2017.12.052_bib37","first-page":"492","article-title":"Sublethal effects of an organophosphorus insecticide (RPR-II) on biochemical parameters of tilapia, Oreochromis mossambicus","volume":"143","author":"Rao","year":"2006","journal-title":"Comp. Biochem. Pharmacol. C."},{"issue":"2","key":"10.1016\/j.toxicon.2017.12.052_bib38","first-page":"329","article-title":"Effects of different doses of Cerastes cerastes crude venom on biochemical parameters in serum of Guinea pigs at different times","volume":"6","author":"Salman","year":"2014","journal-title":"Biol. Forum"},{"key":"10.1016\/j.toxicon.2017.12.052_bib39","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.actatropica.2005.09.001","article-title":"Clinico-toxinological characterization of the acute effects of the venom of the marine snail","volume":"97","author":"Saminathan","year":"2006","journal-title":"Conus loroisii. Acta Trop"},{"issue":"4","key":"10.1016\/j.toxicon.2017.12.052_bib40","first-page":"233","article-title":"Neuromuscular modulatory activity of lion fish Pterois russelii venom in mice","volume":"1","author":"Saravanamurugan","year":"2015","journal-title":"Life Sci. Adv."},{"key":"10.1016\/j.toxicon.2017.12.052_bib41","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1152\/ajplegacy.1962.203.3.429","article-title":"Cardiovascular actions of venom of the stonefish Synanceja horrida","volume":"203","author":"Saunders","year":"1962","journal-title":"Am. J. of Physiol"},{"issue":"1","key":"10.1016\/j.toxicon.2017.12.052_bib42","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/0041-0101(71)90045-6","article-title":"Some chemical properties of the venom of the scorpionfish Scorpaena guttata","volume":"9","author":"Schaeffer","year":"1971","journal-title":"Toxicon"},{"issue":"11","key":"10.1016\/j.toxicon.2017.12.052_bib43","first-page":"717","article-title":"Life threatening envenoming by the Saharan horned viper (Cerastes cerastes) causing micro- angiopathic haemolysis, coagulopathy and acute renal failure","volume":"97","author":"Schneemann","year":"2004","journal-title":"Clin. Canc. Res."},{"key":"10.1016\/j.toxicon.2017.12.052_bib44","doi-asserted-by":"crossref","first-page":"135","DOI":"10.21608\/ejhm.2003.18238","article-title":"Ability of gamma\u2013irradiated polyvalent antivenin to neutralize the toxicity of the Egyptian Cobra (Naja haje) venom","volume":"13","author":"Shaban","year":"2003","journal-title":"Egypt. J. Hosp. Med"},{"issue":"2","key":"10.1016\/j.toxicon.2017.12.052_bib45","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1111\/j.1467-2979.2008.00309.x","article-title":"Fish venom: pharmacological features and biological significance","volume":"10","author":"Sivan","year":"2009","journal-title":"Fish Fish."},{"key":"10.1016\/j.toxicon.2017.12.052_bib46","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1016\/j.toxicon.2010.06.014","article-title":"Characterization of biological activity of Scatophagus argus venom","volume":"56","author":"Sivan","year":"2010","journal-title":"Toxicon"},{"issue":"3","key":"10.1016\/j.toxicon.2017.12.052_bib47","doi-asserted-by":"crossref","first-page":"207","DOI":"10.2307\/1439098","article-title":"A\u00a0Case of poisoning by the stonefish, Synanceja verrucosa","volume":"1951","author":"Smith","year":"1951","journal-title":"Copeia"},{"key":"10.1016\/j.toxicon.2017.12.052_bib48","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1093\/icb\/icw070","article-title":"Evolution of venomous cartilaginous and ray-finned fishes","volume":"56","author":"Smith","year":"2016","journal-title":"Integr. Comp. Biol."},{"issue":"1B","key":"10.1016\/j.toxicon.2017.12.052_bib49","first-page":"83","article-title":"Haematological and biochemical changes in lionfish (Pterois russelii) venom treated Swiss albino mice","volume":"7","author":"Subramaniyan","year":"2016","journal-title":"Bar Int. J. Pharma. Bio. Sci."},{"key":"10.1016\/j.toxicon.2017.12.052_bib50","series-title":"Australian Animal Toxins: the Creatures, Their Venoms and Care of the Poisoned Patient","author":"Sutherland","year":"2001"},{"key":"10.1016\/j.toxicon.2017.12.052_bib51","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1016\/j.bbagen.2006.08.017","article-title":"Purification, properties and cDNA cloning of neoverrucotoxin (neoVTX), a hemolytic lethal factor from the stonefish Synanceja verrucosa venom","volume":"1760","author":"Ueda","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.toxicon.2017.12.052_bib52","first-page":"368","article-title":"Australia's dangerous creatures","author":"Underhill","year":"1987","journal-title":"Readers Dig."},{"key":"10.1016\/j.toxicon.2017.12.052_bib53","first-page":"7204","article-title":"Biochemical and histological observations of lung injury after Stonefish (Synanceia verrucosa) envenomation in BALB\/c mice","volume":"12","author":"Wahsha","year":"2017","journal-title":"Fresen. Environ. Bull."},{"issue":"5","key":"10.1016\/j.toxicon.2017.12.052_bib54","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.3390\/toxins7051497","article-title":"Bioactive components in fish venoms","volume":"7","author":"Ziegman","year":"2015","journal-title":"Toxins"}],"container-title":["Toxicon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004101011730418X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004101011730418X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,30]],"date-time":"2024-06-30T06:17:02Z","timestamp":1719728222000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S004101011730418X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":54,"alternative-id":["S004101011730418X"],"URL":"https:\/\/doi.org\/10.1016\/j.toxicon.2017.12.052","relation":{},"ISSN":["0041-0101"],"issn-type":[{"value":"0041-0101","type":"print"}],"subject":[],"published":{"date-parts":[[2018,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Biochemical and histopathological effects of the stonefish (Synanceia\u00a0verrucosa) venom in rats","name":"articletitle","label":"Article Title"},{"value":"Toxicon","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxicon.2017.12.052","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}