{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:11:13Z","timestamp":1792033873419,"version":"4.4.0"},"reference-count":20,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"QREN","award":["n\u00b016872"],"award-info":[{"award-number":["n\u00b016872"]}]},{"name":"QREN","award":["PEst-OE\/SAU\/UI0177\/2011"],"award-info":[{"award-number":["PEst-OE\/SAU\/UI0177\/2011"]}]},{"name":"QREN","award":["FCT Project UID\/Multi\/04423\/2013"],"award-info":[{"award-number":["FCT Project UID\/Multi\/04423\/2013"]}]},{"name":"QREN","award":["FCT UID\/QUI\/00313\/2013"],"award-info":[{"award-number":["FCT UID\/QUI\/00313\/2013"]}]},{"name":"Structured Program of R&D&I INNOVMAR - Innovation and Sustainability in the Management and Exploitation of Marine Resources","award":["NORTE-01-0145-FEDER-000035"],"award-info":[{"award-number":["NORTE-01-0145-FEDER-000035"]}]},{"name":"Northern Regional Operational Program","award":["NORTE2020"],"award-info":[{"award-number":["NORTE2020"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicon"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1016\/j.toxicon.2018.05.022","type":"journal-article","created":{"date-parts":[[2018,5,29]],"date-time":"2018-05-29T12:42:17Z","timestamp":1527597737000},"page":"207-211","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":44,"special_numbering":"C","title":["Hepatotoxicity induced by paclitaxel interaction with turmeric in association with a microcystin from a contaminated dietary supplement"],"prefix":"10.1016","volume":"150","author":[{"given":"Maria Lu\u00edsa","family":"Costa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 A.","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joana","family":"Azevedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3585-2417","authenticated-orcid":false,"given":"Vitor","family":"Vasconcelos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Eiras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Gra\u00e7a","family":"Campos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.toxicon.2018.05.022_bib1","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s13318-014-0180-2","article-title":"Effect of Curcuma longa on CYP2D6- and CYP3A4-mediated metabolism of dextromethorphan in human liver microsomes and healthy human subjects","volume":"40","author":"Al-Jenoobi","year":"2015","journal-title":"Eur. J. Drug Metab. Pharmacokinet."},{"issue":"9","key":"10.1016\/j.toxicon.2018.05.022_bib2","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1139\/Y07-091","article-title":"Modulation of human cytochrome P450 3A4 (CYP3A4) and P-glycoprotein (P-gp) in Caco-2 cell monolayers by selected commercial-source milk thistle and goldenseal products","volume":"85","author":"Budzinski","year":"2007","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.toxicon.2018.05.022_bib3","first-page":"62","article-title":"Herbal Supplement sales rise in all channels in 2009","volume":"86","author":"Cavaliere","year":"2010","journal-title":"HerbalGram"},{"issue":"8","key":"10.1016\/j.toxicon.2018.05.022_bib4","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1055\/s-2007-981550","article-title":"An in vitro evaluation of cytochrome P450 inhibition and P-glycoprotein interaction with goldenseal, Ginkgo biloba, grape seed, milk thistle, and ginseng extracts and their constituents","volume":"73","author":"Etheridge","year":"2007","journal-title":"Planta Med."},{"key":"10.1016\/j.toxicon.2018.05.022_bib5","series-title":"Marine Toxins as Research Tools","first-page":"221","article-title":"Carcinogenic aspects of protein phosphatase 1 and 2A inhibitors","author":"Fujiki","year":"2009"},{"key":"10.1016\/j.toxicon.2018.05.022_bib6","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1289\/ehp.00108435","article-title":"Assessing potential health risks from microcystin toxins in blue-green algae dietary supplements","volume":"108","author":"Gilroy","year":"2000","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.toxicon.2018.05.022_bib7","doi-asserted-by":"crossref","first-page":"381","DOI":"10.3109\/07357909509031919","article-title":"Taxanes: a new class of antitumor agents","volume":"13","author":"Huizing","year":"1995","journal-title":"Canc. Invest."},{"key":"10.1016\/j.toxicon.2018.05.022_bib8","doi-asserted-by":"crossref","first-page":"3212","DOI":"10.1111\/j.1572-0241.2002.07145.x","article-title":"Spirulina-associated hepatotoxicity","volume":"97","author":"Iwasa","year":"2002","journal-title":"Am. J. Gastroenterol."},{"issue":"16","key":"10.1016\/j.toxicon.2018.05.022_bib9","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.2217\/pgs.12.165","article-title":"Pharmacogenetics of taxanes: impact of gene polymorphisms of drug transporters on pharmacokinetics and toxicity","volume":"13","author":"Jabir","year":"2012","journal-title":"Pharmacogenomics"},{"key":"10.1016\/j.toxicon.2018.05.022_bib10","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1634\/theoncologist.6-2-162","article-title":"Hepatotoxicity of chemotherapy","volume":"6","author":"King","year":"2001","journal-title":"Oncol."},{"key":"10.1016\/j.toxicon.2018.05.022_bib11","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1039\/an9941901525","article-title":"Extraction and high-performance liquid chromatographic method for the determination of microcystins in raw and treated waters","volume":"119","author":"Lawton","year":"1994","journal-title":"Analyst"},{"issue":"2","key":"10.1016\/j.toxicon.2018.05.022_bib12","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1023\/A:1015868809990","article-title":"Protection against microcystin-LR-induced hepatotoxicity by Silymarin: biochemistry, histopathology, and lethality","volume":"8","author":"Mereish","year":"1991","journal-title":"Pharmaceut. Res."},{"issue":"1","key":"10.1016\/j.toxicon.2018.05.022_bib13","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.critrevonc.2008.10.013","article-title":"Drug interactions between antineoplastic and antiretroviral therapies: implications and management for clinical practice","volume":"72","author":"Mounier","year":"2009","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"10.1016\/j.toxicon.2018.05.022_bib14","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s10750-012-1372-x","article-title":"Absence of negative allelopathic effects of cylindrospermopsin and microcystin-LR on selected marine and freshwater phytoplankton species","volume":"705","author":"Pinheiro","year":"2013","journal-title":"Hydrobiologia"},{"key":"10.1016\/j.toxicon.2018.05.022_bib15","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0021-9673(00)00378-2","article-title":"Isolation and preparative purification of microcystin variants","volume":"883","author":"Ramanan","year":"2000","journal-title":"J. Chromatogr. A"},{"issue":"1","key":"10.1016\/j.toxicon.2018.05.022_bib16","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1159\/000073224","article-title":"Inhibition of cytochrome P450 3A: relevant drug interactions in gastroenterology","volume":"68","author":"Sagir","year":"2003","journal-title":"Digestion"},{"key":"10.1016\/j.toxicon.2018.05.022_bib17","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1093\/toxsci\/44.1.87","article-title":"Prolonged sublethal exposure to the protein phosphatase inhibitor microcystin-LR results in multiple dose-dependent hepatotoxic effects","volume":"44","author":"Solter","year":"1998","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.toxicon.2018.05.022_bib18","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0021-9673(03)00428-X","article-title":"Screening for cyanobacterial hepatotoxins, microcystins and nodularin in environmental water samples by reversed-phase liquid chromatography\u2013electrospray ionisation mass spectrometry","volume":"1020","author":"Spoof","year":"2003","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.toxicon.2018.05.022_bib19","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.toxicon.2016.01.059","article-title":"Proteomic and Real-Time PCR analyses of Saccharomyces cerevisiae VL3 exposed to microcystin-LR reveals a set of protein alterations transversal to several eukaryotic models","volume":"112","author":"Val\u00e9rio","year":"2016","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2018.05.022_bib20","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.talanta.2003.07.001","article-title":"Determination of microcystin-LR in surface water using high-performance liquid chromatography\/tandem electrospray ionization mass detector","volume":"62","author":"Zhang","year":"2004","journal-title":"Talanta"}],"container-title":["Toxicon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010118302113?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010118302113?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T21:12:18Z","timestamp":1758575538000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041010118302113"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":20,"alternative-id":["S0041010118302113"],"URL":"https:\/\/doi.org\/10.1016\/j.toxicon.2018.05.022","relation":{},"ISSN":["0041-0101"],"issn-type":[{"value":"0041-0101","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hepatotoxicity induced by paclitaxel interaction with turmeric in association with a microcystin from a contaminated dietary supplement","name":"articletitle","label":"Article Title"},{"value":"Toxicon","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxicon.2018.05.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}