{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T19:20:49Z","timestamp":1792092049311,"version":"4.4.0"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Hubei Natural Sciences Foundation","award":["2017CFB449"],"award-info":[{"award-number":["2017CFB449"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Sciences Foundation of China","doi-asserted-by":"crossref","award":["81773746"],"award-info":[{"award-number":["81773746"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"School Natural Science Fund of Hubei University of Medicine","award":["FDFR201606"],"award-info":[{"award-number":["FDFR201606"]}]},{"name":"School Natural Science Fund of Hubei University of Medicine","award":["FDFR201604"],"award-info":[{"award-number":["FDFR201604"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicon"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1016\/j.toxicon.2018.07.014","type":"journal-article","created":{"date-parts":[[2018,7,19]],"date-time":"2018-07-19T11:54:29Z","timestamp":1532001269000},"page":"9-15","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["The Kv1.3 channel-inhibitory toxin BF9 also displays anticoagulant activity via inhibition of factor XIa"],"prefix":"10.1016","volume":"152","author":[{"given":"Li","family":"Ding","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinbo","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xudong","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangfang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianli","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuzhi","family":"Ruan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongyun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxicon.2018.07.014_bib1","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.thromres.2015.04.017","article-title":"Allosteric inhibition of factor XIa. Sulfated non-saccharide glycosaminoglycan mimetics as promising anticoagulants","volume":"136","author":"Al-Horani","year":"2015","journal-title":"Thromb. Res."},{"key":"10.1016\/j.toxicon.2018.07.014_bib2","doi-asserted-by":"crossref","first-page":"2864","DOI":"10.1182\/blood-2016-11-709873","article-title":"Heparin-induced thrombocytopenia","volume":"129","author":"Arepally","year":"2017","journal-title":"Blood"},{"key":"10.1016\/j.toxicon.2018.07.014_bib3","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1038\/nrcardio.2014.204","article-title":"Balancing ischaemia and bleeding risks with novel oral anticoagulants","volume":"12","author":"Baber","year":"2014","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.toxicon.2018.07.014_bib4","doi-asserted-by":"crossref","first-page":"4329","DOI":"10.1074\/jbc.M110.191163","article-title":"Engineering kunitz domain 1 (KD1) of human tissue factor pathway inhibitor-2 to selectively inhibit fibrinolysis: properties of KD1-L17R variant","volume":"286","author":"Bajaj","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxicon.2018.07.014_bib5","doi-asserted-by":"crossref","first-page":"17414","DOI":"10.1073\/pnas.0605136103","article-title":"Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases","volume":"103","author":"Beeton","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.toxicon.2018.07.014_bib6","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1042\/BJ20041705","article-title":"An unusual fold for potassium channel blockers: NMR structure of three toxins from the scorpion Opisthacanthus madagascariensis","volume":"388","author":"Chagot","year":"2005","journal-title":"Biochem. J."},{"key":"10.1016\/j.toxicon.2018.07.014_bib7","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.cbpa.2017.02.015","article-title":"Peptide blockers of Kv1.3 channels in T cells as therapeutics for autoimmune disease","volume":"38","author":"Chandy","year":"2017","journal-title":"Curr. Opin. Chem. Biol."},{"key":"10.1016\/j.toxicon.2018.07.014_bib8","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.ijbiomac.2015.05.027","article-title":"SjAPI-2 is the first member of a new neurotoxin family with Ascaris-type fold and KCNQ1 inhibitory activity","volume":"79","author":"Chen","year":"2015","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.toxicon.2018.07.014_bib9","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1111\/jth.12797","article-title":"Fasxiator, a novel factor XIa inhibitor from snake venom, and its site-specific mutagenesis to improve potency and selectivity","volume":"13","author":"Chen","year":"2015","journal-title":"J. Thromb. Haemostasis : JTH"},{"key":"10.1016\/j.toxicon.2018.07.014_bib10","doi-asserted-by":"crossref","first-page":"9881","DOI":"10.1038\/srep09881","article-title":"Toxin acidic residue evolutionary function-guided design of de novo peptide drugs for the immunotherapeutic target, the Kv1.3 channel","volume":"5","author":"Chen","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.toxicon.2018.07.014_bib11","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.bbrc.2014.03.101","article-title":"Unusual binding mode of scorpion toxin BmKTX onto potassium channels relies on its distribution of acidic residues","volume":"447","author":"Chen","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.toxicon.2018.07.014_bib12","article-title":"Genomic and structural characterization of Kunitz-type peptide LmKTT-1a highlights diversity and evolution of scorpion potassium channel toxins","volume":"8","author":"Chen","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.toxicon.2018.07.014_bib13","article-title":"SjAPI, the first functionally characterized Ascaris-type protease inhibitor from animal venoms","volume":"8","author":"Chen","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.toxicon.2018.07.014_bib14","doi-asserted-by":"crossref","first-page":"13813","DOI":"10.1074\/jbc.M112.343996","article-title":"Hg1, novel peptide inhibitor specific for Kv1.3 channels from first scorpion Kunitz-type potassium channel toxin family","volume":"287","author":"Chen","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxicon.2018.07.014_bib15","doi-asserted-by":"crossref","first-page":"32","DOI":"10.2174\/187152810791292890","article-title":"Blood coagulation as an intrinsic pathway for proinflammation: a mini review","volume":"9","author":"Chu","year":"2010","journal-title":"Inflamm. Allergy - Drug Targets"},{"key":"10.1016\/j.toxicon.2018.07.014_bib16","doi-asserted-by":"crossref","first-page":"4302","DOI":"10.1074\/jbc.272.7.4302","article-title":"On the convergent evolution of animal toxins. Conservation of a diad of functional residues in potassium channel-blocking toxins with unrelated structures","volume":"272","author":"Dauplais","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxicon.2018.07.014_bib17","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1113\/jphysiol.2010.190132","article-title":"Kv1.3: the perfect opening of the platelet voltage gate","volume":"588","author":"Emerson","year":"2010","journal-title":"J. Physiol."},{"key":"10.1016\/j.toxicon.2018.07.014_bib18","doi-asserted-by":"crossref","first-page":"2507","DOI":"10.1161\/ATVBAHA.107.155952","article-title":"Intrinsic pathway of coagulation and arterial thrombosis","volume":"27","author":"Gailani","year":"2007","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.toxicon.2018.07.014_bib19","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1111\/j.1538-7836.2007.02446.x","article-title":"The intrinsic pathway of coagulation: a target for treating thromboembolic disease?","volume":"5","author":"Gailani","year":"2007","journal-title":"J. Thromb. Haemostasis : JTH"},{"key":"10.1016\/j.toxicon.2018.07.014_bib20","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/jid.2010.245","article-title":"The beneficial effect of blocking Kv1.3 in the psoriasiform SCID mouse model","volume":"131","author":"Gilhar","year":"2011","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.toxicon.2018.07.014_bib21","doi-asserted-by":"crossref","first-page":"19058","DOI":"10.1074\/jbc.M802054200","article-title":"Structural basis of a potent peptide inhibitor designed for Kv1.3 channel, a therapeutic target of autoimmune disease","volume":"283","author":"Han","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxicon.2018.07.014_bib22","first-page":"B4946","article-title":"The role of T cell potassium channels, KV1.3 and KCa3.1, in the inflammatory cascade in ulcerative colitis","volume":"61","author":"Hansen","year":"2014","journal-title":"Dan Med. J."},{"key":"10.1016\/j.toxicon.2018.07.014_bib23","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/S0076-6879(99)94037-5","article-title":"Interactions of snake dendrotoxins with potassium channels","volume":"294","author":"Hopkins","year":"1999","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.toxicon.2018.07.014_bib24","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.peptides.2015.07.002","article-title":"Engineering a peptide inhibitor towards the KCNQ1\/KCNE1 potassium channel (IKs)","volume":"71","author":"Hu","year":"2015","journal-title":"Peptides"},{"key":"10.1016\/j.toxicon.2018.07.014_bib25","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1006\/jmbi.2000.3522","article-title":"Energetic and structural interactions between delta-dendrotoxin and a voltage-gated potassium channel","volume":"296","author":"Imredy","year":"2000","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.toxicon.2018.07.014_bib26","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1002\/jmr.1031","article-title":"Molecular mechanism of delta-dendrotoxin-potassium channel recognition explored by docking and molecular dynamic simulations","volume":"24","author":"Jin","year":"2011","journal-title":"J. Mol. Recogn."},{"key":"10.1016\/j.toxicon.2018.07.014_bib27","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.mehy.2015.03.023","article-title":"Roles of lymphocyte Kv1.3-channels in gut mucosal immune system: novel therapeutic implications for inflammatory bowel disease","volume":"85","author":"Kazama","year":"2015","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.toxicon.2018.07.014_bib28","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.toxicon.2018.05.006","article-title":"Synthesis, folding, structure and activity of a predicted peptide from the sea anemone Oulactis sp. with an ShKT fold","volume":"150","author":"Krishnarjuna","year":"2018","journal-title":"Toxicon : Official J. Int. Soc. Toxinol."},{"key":"10.1016\/j.toxicon.2018.07.014_bib29","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/nsb0494-246","article-title":"Proteinase inhibitor homologues as potassium channel blockers","volume":"1","author":"Lancelin","year":"1994","journal-title":"Nat. Struct. Biol."},{"key":"10.1016\/j.toxicon.2018.07.014_bib30","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/nrcardio.2017.223","article-title":"Reversal agents for non-vitamin K antagonist oral anticoagulants","volume":"15","author":"Levy","year":"2018","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.toxicon.2018.07.014_bib31","doi-asserted-by":"crossref","first-page":"4094","DOI":"10.1182\/blood-2013-08-517474","article-title":"Desmolaris, a novel factor XIa anticoagulant from the salivary gland of the vampire bat (Desmodus rotundus) inhibits inflammation and thrombosis in vivo","volume":"122","author":"Ma","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.toxicon.2018.07.014_bib32","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1113\/jphysiol.2010.188136","article-title":"Kv1.3 is the exclusive voltage-gated K+ channel of platelets and megakaryocytes: roles in membrane potential, Ca2+ signalling and platelet count","volume":"588","author":"McCloskey","year":"2010","journal-title":"J. Physiol."},{"key":"10.1016\/j.toxicon.2018.07.014_bib33","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0140-6736(15)60243-4","article-title":"Pharmacology of antithrombotic drugs: an assessment of oral antiplatelet and anticoagulant treatments","volume":"386","author":"Mega","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.toxicon.2018.07.014_bib34","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1124\/pr.115.011247","article-title":"Pharmacology of heparin and related drugs","volume":"68","author":"Mulloy","year":"2016","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.toxicon.2018.07.014_bib35","doi-asserted-by":"crossref","DOI":"10.1002\/med.21489","article-title":"Heparin mimetics with anticoagulant activity","author":"Nahain","year":"2018","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.toxicon.2018.07.014_bib36","doi-asserted-by":"crossref","first-page":"2882","DOI":"10.2174\/092986710792065072","article-title":"Use of Kv1.3 blockers for inflammatory skin conditions","volume":"17","author":"Nguyen","year":"2010","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.toxicon.2018.07.014_bib37","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1177\/1076029608329580","article-title":"Aptamers influence the hemostatic system by activating the intrinsic coagulation pathway in an in vitro Chandler-Loop model","volume":"16","author":"Paul","year":"2010","journal-title":"Clin. Appl. Thrombosis\/hemostasis: Official J. Int. Acad. Clin. Appl. Thrombosis\/Hemostasis"},{"key":"10.1016\/j.toxicon.2018.07.014_bib38","doi-asserted-by":"crossref","first-page":"10609","DOI":"10.1523\/JNEUROSCI.2802-10.2010","article-title":"A novel role for Kv1.3 blockers: protecting neural progenitor cells from a hostile inflammatory environment","volume":"30","author":"Peng","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.toxicon.2018.07.014_bib39","doi-asserted-by":"crossref","DOI":"10.1111\/bcp.13520","article-title":"First-in-human study to assess the safety, pharmacokinetics and pharmacodynamics of BMS-962212, a direct, reversible, small molecule factor XIa inhibitor in non-Japanese and Japanese healthy subjects","author":"Perera","year":"2018","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.toxicon.2018.07.014_bib40","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.dci.2012.10.005","article-title":"Structure and function of invertebrate Kunitz serine protease inhibitors","volume":"39","author":"Ranasinghe","year":"2013","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.toxicon.2018.07.014_bib41","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1517\/14728220903018957","article-title":"Kv1.3 potassium channels as a therapeutic target in multiple sclerosis","volume":"13","author":"Rangaraju","year":"2009","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.toxicon.2018.07.014_bib42","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1002\/(SICI)1097-0134(20000101)38:1<70::AID-PROT8>3.0.CO;2-5","article-title":"Solution structure of BmKTX, a K+ blocker toxin from the Chinese scorpion Buthus Martensi","volume":"38","author":"Renisio","year":"2000","journal-title":"Proteins"},{"key":"10.1016\/j.toxicon.2018.07.014_bib43","doi-asserted-by":"crossref","first-page":"25121","DOI":"10.1074\/jbc.270.42.25121","article-title":"Kalicludines and kaliseptine. Two different classes of sea anemone toxins for voltage sensitive K+ channels","volume":"270","author":"Schweitz","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxicon.2018.07.014_bib44","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1080\/14712598.2017.1346606","article-title":"Treating autoimmune disorders with venom-derived peptides","volume":"17","author":"Shen","year":"2017","journal-title":"Expet Opin. Biol. Ther."},{"key":"10.1016\/j.toxicon.2018.07.014_bib45","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.clim.2017.03.014","article-title":"Prolonged immunomodulation in inflammatory arthritis using the selective Kv1.3 channel blocker HsTX1[R14A] and its PEGylated analog","volume":"180","author":"Tanner","year":"2017","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.toxicon.2018.07.014_bib46","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/nsb0496-317","article-title":"Solution structure of ShK toxin, a novel potassium channel inhibitor from a sea anemone","volume":"3","author":"Tudor","year":"1996","journal-title":"Nat. Struct. Biol."},{"key":"10.1016\/j.toxicon.2018.07.014_bib47","doi-asserted-by":"crossref","first-page":"24776","DOI":"10.1074\/jbc.270.42.24776","article-title":"The alpha-dendrotoxin footprint on a mammalian potassium channel","volume":"270","author":"Tytgat","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxicon.2018.07.014_bib48","doi-asserted-by":"crossref","first-page":"E2239","DOI":"10.1073\/pnas.1221206110","article-title":"Selective Kv1.3 channel blocker as therapeutic for obesity and insulin resistance","volume":"110","author":"Upadhyay","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.toxicon.2018.07.014_bib49","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/j.hoc.2016.05.007","article-title":"The intrinsic pathway of coagulation as a target for antithrombotic therapy","volume":"30","author":"Wheeler","year":"2016","journal-title":"Hematol. Oncol. Clin. N. Am."},{"key":"10.1016\/j.toxicon.2018.07.014_bib50","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1182\/blood-2012-03-419523","article-title":"The kunitz protease inhibitor domain of protease nexin-2 inhibits factor XIa and murine carotid artery and middle cerebral artery thrombosis","volume":"120","author":"Wu","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.toxicon.2018.07.014_bib51","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1002\/jbt.21538","article-title":"BF9, the first functionally characterized snake toxin peptide with Kunitz-type protease and potassium channel inhibiting properties","volume":"28","author":"Yang","year":"2014","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.toxicon.2018.07.014_bib52","doi-asserted-by":"crossref","first-page":"4684","DOI":"10.1182\/blood-2010-04-277798","article-title":"Inhibition of the intrinsic coagulation pathway factor XI by antisense oligonucleotides: a novel antithrombotic strategy with lowered bleeding risk","volume":"116","author":"Zhang","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.toxicon.2018.07.014_bib53","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.intimp.2015.12.032","article-title":"Blockage of K(Ca)3.1 and Kv1.3 channels of the B lymphocyte decreases the inflammatory monocyte chemotaxis","volume":"31","author":"Zhang","year":"2016","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.toxicon.2018.07.014_bib54","doi-asserted-by":"crossref","first-page":"147","DOI":"10.3892\/etm.2017.4490","article-title":"T-lymphocyte Kv1.3 channel activation triggers the NLRP3 inflammasome signaling pathway in hypertensive patients","volume":"14","author":"Zhu","year":"2017","journal-title":"Exp. Ther. Med."}],"container-title":["Toxicon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010118303106?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010118303106?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T21:10:27Z","timestamp":1758575427000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041010118303106"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":54,"alternative-id":["S0041010118303106"],"URL":"https:\/\/doi.org\/10.1016\/j.toxicon.2018.07.014","relation":{},"ISSN":["0041-0101"],"issn-type":[{"value":"0041-0101","type":"print"}],"subject":[],"published":{"date-parts":[[2018,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Kv1.3 channel-inhibitory toxin BF9 also displays anticoagulant activity via inhibition of factor XIa","name":"articletitle","label":"Article Title"},{"value":"Toxicon","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxicon.2018.07.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}