{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T00:54:09Z","timestamp":1793408049956,"version":"4.5.0"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Helmholtz-Gemeinschaft Deutscher Forschungszentren"},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012774","name":"Innovation Fund Denmark","doi-asserted-by":"publisher","award":["0603-00449B"],"award-info":[{"award-number":["0603-00449B"]}],"id":[{"id":"10.13039\/100012774","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012774","name":"Innovation Fund Denmark","doi-asserted-by":"publisher","award":["4097-00007B"],"award-info":[{"award-number":["4097-00007B"]}],"id":[{"id":"10.13039\/100012774","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicon"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1016\/j.toxicon.2018.10.007","type":"journal-article","created":{"date-parts":[[2018,10,12]],"date-time":"2018-10-12T13:37:51Z","timestamp":1539351471000},"page":"51-60","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Development of a LC-MS\/MS method for the quantification of goniodomins A and B and its application to Alexandrium pseudogonyaulax strains and plankton field samples of Danish coastal waters"],"prefix":"10.1016","volume":"155","author":[{"given":"Bernd","family":"Krock","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urban","family":"Tillmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per Juel","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas Ostenfeld","family":"Larsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3876-7480","authenticated-orcid":false,"given":"Aaron J.C.","family":"Andersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.toxicon.2018.10.007_bib1","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1002\/jcp.10040","article-title":"Goniodomin A, an antifungal polyether macrolide, exhibits antiangiogenic activities via inhibition of actin reorganization in endothelial cells","volume":"190","author":"Abe","year":"2002","journal-title":"J. Cell. Physiol."},{"issue":"3","key":"10.1016\/j.toxicon.2018.10.007_bib2","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1080\/09670260600810360","article-title":"Resting cysts of the toxigenic dinofiagellate genus Alexandrium in recent sediments from the Western Mediterranean coast, including the first description of cysts of A. kutnerae and A. peruvianum","volume":"41","author":"Bravo","year":"2006","journal-title":"Eur. J. Phycol."},{"key":"10.1016\/j.toxicon.2018.10.007_bib3","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.toxlet.2016.04.001","article-title":"Cytotoxicity of goniodomin A and B in non contractile cells","volume":"250\u2013251","author":"Espi\u00f1a","year":"2016","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.toxicon.2018.10.007_bib4","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.chroma.2012.12.021","article-title":"The implementation of liquid chromatography tandem mass spectrometry for the official control of lipophilic toxins in seafood: single-laboratory validation under four chromatographic conditions","volume":"1275","author":"Garc\u00eda-Altares","year":"2013","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.toxicon.2018.10.007_bib5","doi-asserted-by":"crossref","first-page":"363","DOI":"10.2983\/035.028.0219","article-title":"Mortality of the veined rapa whelk, Rapana venosa, in relation to a bloom of Alexandrium monilatum in the York River, United States","volume":"28","author":"Harding","year":"2009","journal-title":"J. Shellfish Res."},{"issue":"3","key":"10.1016\/j.toxicon.2018.10.007_bib6","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.hal.2005.08.004","article-title":"Production of goniodomin A by the planktonic, chain-forming dinoflagellate Alexandrium monilatum (Howell) balech isolated from the Gulf coast of the United States","volume":"5","author":"Hsia","year":"2006","journal-title":"Harmful Algae"},{"key":"10.1016\/j.toxicon.2018.10.007_bib7","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jembe.2015.08.011","article-title":"Development of phytoplankton communities: implications of nutrient injections on phytoplankton composition, pH and ecosystem production","volume":"473","author":"Jakobsen","year":"2015","journal-title":"J. Exp. Mar. Biol. Ecol."},{"key":"10.1016\/j.toxicon.2018.10.007_bib8","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1111\/j.1529-8817.1987.tb04217.x","article-title":"Media for the culture of oceanic ultraphytoplankton","volume":"23","author":"Keller","year":"1987","journal-title":"J. Phycol."},{"issue":"1","key":"10.1016\/j.toxicon.2018.10.007_bib9","first-page":"1","article-title":"Description of the gonyaulacoid dinoflagellate Alexandrium hiranoi sp. nov. inhabiting tidepools on Japanese Pacific coast","volume":"35","author":"Kita","year":"1988","journal-title":"Bull. Plankton Soc. Jpn."},{"key":"10.1016\/j.toxicon.2018.10.007_bib50","unstructured":"Kremp A., Hansen P.J., Tillmann U., Savela, H., Suikkanen, S., Vo\u00df, D., Barrera, F., Jakobsen H.H., Krock, B., Distribution of three Alexandrium species across a salinity transition system suggests an increasing impact of A. pseudogonyaulax in shallow and brackish waters of Northern Europe, manuscript in preparation."},{"issue":"5","key":"10.1016\/j.toxicon.2018.10.007_bib10","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/j.hal.2007.02.005","article-title":"Toxin profile of Alexandrium catenella from the Chilean coast as determined by liquid chromatography with fluorescence detection and liquid chromatography coupled with tandem mass spectrometry","volume":"6","author":"Krock","year":"2007","journal-title":"Harmful Algae"},{"issue":"5","key":"10.1016\/j.toxicon.2018.10.007_bib11","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1007\/s00216-008-2221-7","article-title":"LC-MS-MS aboard ship: tandem mass spectrometry in the search for phycotoxins and novel toxigenic plankton from the North Sea","volume":"392","author":"Krock","year":"2008","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.toxicon.2018.10.007_bib12","series-title":"Physical Oceanography during UTH\u00d6RN Cruise UT201606 (HAB-DK\/Limfjord)","author":"Krock","year":"2017"},{"issue":"5","key":"10.1016\/j.toxicon.2018.10.007_bib13","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1093\/plankt\/fbw053","article-title":"Salinity effects on growth and toxin production in an Alexandrium ostenfeldii (Dinophyceae) isolate from The Netherlands","volume":"38","author":"Martens","year":"2016","journal-title":"J. Plankton Res."},{"issue":"1","key":"10.1016\/j.toxicon.2018.10.007_bib14","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.hal.2003.09.001","article-title":"The dinoflagellate genus Alexandrium (Halim) in New Zealand coastal waters: comparative morphology, toxicity and molecular genetics","volume":"3","author":"MacKenzie","year":"2004","journal-title":"Harmful Algae"},{"issue":"10","key":"10.1016\/j.toxicon.2018.10.007_bib15","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/S0040-4039(00)86674-5","article-title":"Goniodomin a, a novel polyether macrolide from the dinoflagellate Goniodoma pseudogoniaulax","volume":"29","author":"Murakami","year":"1988","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.toxicon.2018.10.007_bib16","series-title":"Mycotoxins and Phycotoxins in Perspective at the Turn of the Century. Proceedings of the Xth International IUPAC Symposium on Mycotoxins and Phycotoxins, Sao Paulo, Brazil, May 22-25, 2000","first-page":"383","article-title":"Recent developments in the analysis of phycotoxins by liquid chromatography-mass spectrometry","author":"Quilliam","year":"2001"},{"issue":"11","key":"10.1016\/j.toxicon.2018.10.007_bib17","doi-asserted-by":"crossref","first-page":"659","DOI":"10.7164\/antibiotics.21.659","article-title":"Goniodomin, a new antibiotic from a dinoflagellate","volume":"21","author":"Sharma","year":"1968","journal-title":"J. Antibiot."},{"issue":"2","key":"10.1016\/j.toxicon.2018.10.007_bib18","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.hal.2008.06.001","article-title":"LC-MS\/MS analysis of okadaic acid analogues and other lipophilic toxins in single-cell isolates of several Dinophysis species collected in Hokkaido, Japan","volume":"8","author":"Suzuki","year":"2009","journal-title":"Harmful Algae"},{"issue":"5","key":"10.1016\/j.toxicon.2018.10.007_bib19","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1021\/ol8000377","article-title":"Assignment of the absolute configuration of goniodomin A by NMR spectroscopy and synthesis of model compounds","volume":"10","author":"Takeda","year":"2008","journal-title":"Org. Lett."},{"issue":"11\u201312","key":"10.1016\/j.toxicon.2018.10.007_bib20","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1016\/0041-0101(86)90140-6","article-title":"Histopathological studies on experimental marine toxin poisoning. I. Ultrastructural changes in the small intestine and liver of suckling mice induced by dinophysistoxin-1 and pectenotoxin-1","volume":"24","author":"Terao","year":"1986","journal-title":"Toxicon"},{"issue":"5","key":"10.1016\/j.toxicon.2018.10.007_bib21","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.hal.2009.03.005","article-title":"Intra-population clonal variability in allelochemical potency of the toxigenic dinoflagellate Alexandrium tamarense","volume":"8","author":"Tillmann","year":"2009","journal-title":"Harmful Algae"},{"key":"10.1016\/j.toxicon.2018.10.007_bib22","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.toxicon.2015.12.018","article-title":"First report of goniodomin A production by the dinoflagellate Alexandrium pseudogonyaulax developing in southern Mediterranean (Bizerte Lagoon, Tunisia)","volume":"111","author":"Zmerli Triki","year":"2016","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2018.10.007_bib23","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.marpolbul.2014.05.014","article-title":"Distribution of resting cysts of the potentially toxic dinoflagellate Alexandrium pseudogonyaulax in recently-deposited sediment within Bizerte Lagoon (Mediterranean coast, Tunisia)","volume":"84","author":"Zmerli Triki","year":"2014","journal-title":"Mar. Pollut. Bull."}],"container-title":["Toxicon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010118304069?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010118304069?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,11,5]],"date-time":"2018-11-05T20:04:13Z","timestamp":1541448253000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041010118304069"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":24,"alternative-id":["S0041010118304069"],"URL":"https:\/\/doi.org\/10.1016\/j.toxicon.2018.10.007","relation":{},"ISSN":["0041-0101"],"issn-type":[{"value":"0041-0101","type":"print"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development of a LC-MS\/MS method for the quantification of goniodomins A and B and its application to Alexandrium pseudogonyaulax strains and plankton field samples of Danish coastal waters","name":"articletitle","label":"Article Title"},{"value":"Toxicon","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxicon.2018.10.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}