{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T10:16:05Z","timestamp":1777716965414,"version":"3.51.4"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/K01952X\/1"],"award-info":[{"award-number":["MR\/K01952X\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["15024"],"award-info":[{"award-number":["15024"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["12035"],"award-info":[{"award-number":["12035"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000838","name":"University of Sussex","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000838","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005242","name":"Universit\u00e9 de Montr\u00e9al","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005242","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007903","name":"Bloodwise","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007903","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["CRDPJ 44052-12"],"award-info":[{"award-number":["CRDPJ 44052-12"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicon"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1016\/j.toxicon.2019.06.003","type":"journal-article","created":{"date-parts":[[2019,6,7]],"date-time":"2019-06-07T13:52:53Z","timestamp":1559915573000},"page":"123-133","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["The role of membrane-bound metal ions in toxicity of a human cancer cell-active pore-forming toxin Cry41Aa from Bacillus thuringiensis"],"prefix":"10.1016","volume":"167","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2606-550X","authenticated-orcid":false,"given":"Barbara","family":"Domanska","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Fortea","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle J.","family":"West","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Louis","family":"Schwartz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil","family":"Crickmore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.toxicon.2019.06.003_bib1","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1093\/jb\/mvm220","article-title":"Raft-targeting and oligomerization of parasporin-2, a Bacillus thuringiensis crystal protein with anti-tumour activity","volume":"143","author":"Abe","year":"2008","journal-title":"J. Biochem."},{"key":"10.1016\/j.toxicon.2019.06.003_bib2","series-title":"Advances in Insect Physiology","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/B978-0-12-800197-4.00002-6","article-title":"Chapter two - diversity of Bacillus thuringiensis crystal toxins and mechanism of action","author":"Adang","year":"2014"},{"key":"10.1016\/j.toxicon.2019.06.003_bib3","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1002\/prot.20431","article-title":"Flexibility of metal binding sites in proteins on a database scale","volume":"59","author":"Babor","year":"2005","journal-title":"Proteins: Structure, Function, and Bioinformatics"},{"issue":"3","key":"10.1016\/j.toxicon.2019.06.003_bib4","doi-asserted-by":"crossref","first-page":"C421","DOI":"10.1152\/ajpcell.1990.258.3.C421","article-title":"A nonselective cation channel in rat liver cells is activated by membrane stretch","volume":"258","author":"Bear","year":"1990","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.toxicon.2019.06.003_bib5","first-page":"443","article-title":"A practical guide to the study of calcium in living cells","volume":"vol. 4","author":"Bolsover","year":"1994"},{"issue":"2","key":"10.1016\/j.toxicon.2019.06.003_bib6","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s004240050502","article-title":"Regulation of ion channels in rat hepatocytes","volume":"435","author":"Breit","year":"1997","journal-title":"Pfl\u00fcgers Archiv"},{"key":"10.1016\/j.toxicon.2019.06.003_bib7","series-title":"Interrelations between Essential Metal Ions and Human Diseases","first-page":"81","article-title":"Calcium in health and disease","author":"Brini","year":"2013"},{"key":"10.1016\/j.toxicon.2019.06.003_bib8","series-title":"Neurotoxicity of Metals","first-page":"313","article-title":"Neurotoxicity of copper","author":"Bulcke","year":"2017"},{"issue":"2","key":"10.1016\/j.toxicon.2019.06.003_bib9","first-page":"281","article-title":"The stability of some metal EDTA, DTPA and DOTA complexes: application as tracers in groundwater studies","volume":"241","author":"Byeg\u00e5rd","year":"1999","journal-title":"Journal of Radioanalytical and Nuclear Chemistry. [journal article]"},{"issue":"46","key":"10.1016\/j.toxicon.2019.06.003_bib10","doi-asserted-by":"crossref","first-page":"13717","DOI":"10.1021\/bi026323k","article-title":"Proteolytic cleavage of the developmentally important cadherin BT-R1 in the midgut epithelium of Manduca sexta","volume":"41","author":"Candas","year":"2002","journal-title":"Biochemistry"},{"key":"10.1016\/j.toxicon.2019.06.003_bib11","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1113\/jphysiol.1989.sp017497","article-title":"The properties of calcium-activated potassium ion channels in Guinea-pig isolated hepatocytes","volume":"409","author":"Capiod","year":"1989","journal-title":"J. Physiol."},{"issue":"7","key":"10.1016\/j.toxicon.2019.06.003_bib12","first-page":"503","article-title":"Characterization of Ca(2+)- and voltage-dependent nonselective cation channels in human HepG2 cells","volume":"96","author":"Chen","year":"1997","journal-title":"J. Formos. Med. Assoc."},{"key":"10.1016\/j.toxicon.2019.06.003_bib13","series-title":"CRC Handbook of Organic Analytical Reagents","author":"Cheng KU","year":"1982"},{"issue":"1","key":"10.1016\/j.toxicon.2019.06.003_bib14","doi-asserted-by":"crossref","first-page":"29","DOI":"10.4162\/nrp.2007.1.1.29","article-title":"Cellular Zn depletion by metal ion chelators (TPEN, DTPA and chelex resin) and its application to osteoblastic MC3T3-E1 cells","volume":"1","author":"Cho","year":"2007","journal-title":"Nutrition Research and Practice"},{"issue":"32","key":"10.1016\/j.toxicon.2019.06.003_bib15","doi-asserted-by":"crossref","first-page":"13122","DOI":"10.1074\/jbc.M116.765941","article-title":"Cry6Aa1, a Bacillus thuringiensis nematocidal and insecticidal toxin, forms pores in planar lipid bilayers at extremely low concentrations and without the need of proteolytic processing","volume":"292","author":"Fortea","year":"2017","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.toxicon.2019.06.003_bib16","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s00232-005-0820-1","article-title":"Differential effects of ionic strength, divalent cations and pH on the pore-forming activity of Bacillus thuringiensis insecticidal toxins","volume":"208","author":"Fortier","year":"2005","journal-title":"J. Membr. Biol."},{"key":"10.1016\/j.toxicon.2019.06.003_bib17","series-title":"Paper Presented at: 47th Annual Meeting of the Society for Invertebrate Pathology in Mainz, Germany","article-title":"PS1Aa2 induces ionic channels in lipid bilayer membranes and calcium oscillations in sensitive cells","author":"Gabriel Narvaez","year":"2014"},{"issue":"1","key":"10.1016\/j.toxicon.2019.06.003_bib18","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ejphar.2006.11.010","article-title":"Cytotoxic effects of intra and extracellular zinc chelation on human breast cancer cells","volume":"557","author":"Hashemi","year":"2007","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.toxicon.2019.06.003_bib19","series-title":"Ion Channels of Excitable Membranes","author":"Hille","year":"2001"},{"issue":"4","key":"10.1016\/j.toxicon.2019.06.003_bib20","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1016\/j.bbrc.2006.03.241","article-title":"Differential role of p38 mitogen activated protein kinase for cellular recovery from attack by pore-forming S. aureus alpha-toxin or streptolysin O","volume":"344","author":"Husmann","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"3","key":"10.1016\/j.toxicon.2019.06.003_bib21","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1001314","article-title":"Global functional analyses of cellular responses to pore-forming toxins","volume":"7","author":"Kao","year":"2011","journal-title":"PLoS Pathog."},{"issue":"10","key":"10.1016\/j.toxicon.2019.06.003_bib22","doi-asserted-by":"crossref","first-page":"7742","DOI":"10.1074\/jbc.M611382200","article-title":"Parasporin-1, a novel cytotoxic protein from Bacillus thuringiensis, induces Ca2+ influx and a sustained elevation of the cytoplasmic Ca2+ concentration in toxin-sensitive cells","volume":"282","author":"Katayama","year":"2007","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.toxicon.2019.06.003_bib23","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1128\/AEM.72.1.506-515.2006","article-title":"Protease inhibitors fail to prevent pore formation by the activated Bacillus thuringiensis toxin Cry1Aa in insect brush border membrane vesicles","volume":"72","author":"Kirouac","year":"2006","journal-title":"Appl. Environ. Microbiol."},{"issue":"36","key":"10.1016\/j.toxicon.2019.06.003_bib24","doi-asserted-by":"crossref","first-page":"26350","DOI":"10.1074\/jbc.M602589200","article-title":"Cytocidal actions of parasporin-2, an anti-tumor crystal toxin from Bacillus thuringiensis","volume":"281","author":"Kitada","year":"2006","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.toxicon.2019.06.003_bib25","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.bbrc.2009.05.121","article-title":"Pore-forming toxins activate MAPK p38 by causing loss of cellular potassium","volume":"385","author":"Kloft","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"3","key":"10.1016\/j.toxicon.2019.06.003_bib26","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/0304-4165(87)90167-X","article-title":"Colloid-osmotic lysis is a general feature of the mechanism of action of Bacillus thuringiensis \u03b4-endotoxins with different insect specificity","volume":"924","author":"Knowles","year":"1987","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"key":"10.1016\/j.toxicon.2019.06.003_bib27","doi-asserted-by":"crossref","first-page":"283","DOI":"10.3389\/fpls.2015.00283","article-title":"The food and environmental safety of Bt crops","volume":"6","author":"Koch","year":"2015","journal-title":"Front. Plant Sci."},{"issue":"2","key":"10.1016\/j.toxicon.2019.06.003_bib28","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1085\/jgp.104.2.357","article-title":"Characterization of the calcium-activated chloride channel in isolated Guinea-pig hepatocytes","volume":"104","author":"Koumi","year":"1994","journal-title":"J. Gen. Physiol."},{"issue":"10","key":"10.1016\/j.toxicon.2019.06.003_bib29","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1042\/BCJ20170122","article-title":"The human cancer cell active toxin Cry41Aa from Bacillus thuringiensis acts like its insecticidal counterparts","volume":"474","author":"Krishnan","year":"2017","journal-title":"Biochem. J."},{"issue":"0","key":"10.1016\/j.toxicon.2019.06.003_bib30","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1039\/tf9595501660","article-title":"Metal complexes of histidine","volume":"55","author":"Leberman","year":"1959","journal-title":"Trans. Faraday Soc."},{"issue":"2","key":"10.1016\/j.toxicon.2019.06.003_bib31","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1093\/jee\/90.2.287","article-title":"Synergism of Bacillus thuringiensis by ethylenediamine tetraacetate in susceptible and resistant larvae of diamondback moth (Lepidoptera: plutellidae)","volume":"90","author":"Liu","year":"1997","journal-title":"J. Econ. Entomol."},{"issue":"34","key":"10.1016\/j.toxicon.2019.06.003_bib32","doi-asserted-by":"crossref","first-page":"26050","DOI":"10.1074\/jbc.M001576200","article-title":"KATP channels regulate mitogenically induced proliferation in primary rat hepatocytes and human liver cell lines: implications for liver growth control and potential therapeutic targeting","volume":"275","author":"Malhi","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxicon.2019.06.003_bib33","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1590\/S0100-879X2003000800018","article-title":"Changes in cell shape, cytoskeletal proteins and adhesion sites of cultured cells after extracellular Ca2+ chelation","volume":"36","author":"Mermelstein","year":"2003","journal-title":"Braz. J. Med. Biol. Res."},{"issue":"2","key":"10.1016\/j.toxicon.2019.06.003_bib34","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1128\/aem.63.2.440-447.1997","article-title":"Interaction between calcium ions and Bacillus thuringiensis toxin activity against Sf9 cells (Spodoptera frugiperda, Lepidoptera)","volume":"63","author":"Monette","year":"1997","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.toxicon.2019.06.003_bib35","first-page":"427","article-title":"Parasporin, a new anticancer protein group from Bacillus thuringiensis","volume":"29","author":"Ohba","year":"2009","journal-title":"Anticancer Res."},{"key":"10.1016\/j.toxicon.2019.06.003_bib36","author":"Okumura"},{"issue":"47","key":"10.1016\/j.toxicon.2019.06.003_bib37","doi-asserted-by":"crossref","first-page":"32750","DOI":"10.1074\/jbc.M109.024968","article-title":"Domain II Loop 3 of Bacillus thuringiensis Cry1Ab toxin is involved in a \u201cping pong\u201d binding mechanism with Manduca sexta aminopeptidase-N and cadherin receptors","volume":"284","author":"Pacheco","year":"2009","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.toxicon.2019.06.003_bib38","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1128\/MMBR.00034-06","article-title":"Role of receptors in Bacillus thuringiensis crystal toxin activity","volume":"71","author":"Pigott","year":"2007","journal-title":"Microbiol. Mol. Biol. Rev."},{"issue":"3","key":"10.1016\/j.toxicon.2019.06.003_bib39","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1083\/jcb.96.3.613","article-title":"Effects of extracellular calcium depletion on membrane topography and occluding junctions of mammary epithelial cells in culture","volume":"96","author":"Pitelka","year":"1983","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.toxicon.2019.06.003_bib40","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.3390\/ijerph7041342","article-title":"The essential toxin: impact of zinc on human health","volume":"7","author":"Plum","year":"2010","journal-title":"Int. J. Environ. Res. Public Health"},{"issue":"3","key":"10.1016\/j.toxicon.2019.06.003_bib41","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1111\/j.1432-1033.1994.tb19080.x","article-title":"Conformational changes of the recombinant extracellular domain of E-cadherin upon calcium binding","volume":"223","author":"Pokutta","year":"1994","journal-title":"Eur. J. Biochem."},{"issue":"3","key":"10.1016\/j.toxicon.2019.06.003_bib42","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.peptides.2010.06.012","article-title":"Role of MAPK p38 in the cellular responses to pore-forming toxins","volume":"32","author":"Porta","year":"2011","journal-title":"Peptides"},{"issue":"2","key":"10.1016\/j.toxicon.2019.06.003_bib43","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1002\/jcp.1041070202","article-title":"The effect of calcium chelation on lymphocyte monovalent cation permeability, transport and concentration","volume":"107","author":"Quastel","year":"1981","journal-title":"J. Cell. Physiol."},{"issue":"18","key":"10.1016\/j.toxicon.2019.06.003_bib44","doi-asserted-by":"crossref","first-page":"12994","DOI":"10.1074\/jbc.M511431200","article-title":"Epithelial cells are sensitive detectors of bacterial pore-forming toxins","volume":"281","author":"Ratner","year":"2006","journal-title":"J. Biol. Chem."},{"issue":"1\u20135","key":"10.1016\/j.toxicon.2019.06.003_bib45","first-page":"425","article-title":"Potential of some chemicals to increase the effectiveness of Bacillus thuringiensis Berl. against Spodoptera littoralis (Boisd.)","volume":"100","author":"Salama","year":"1985","journal-title":"Z. Angew. Entomol."},{"issue":"2","key":"10.1016\/j.toxicon.2019.06.003_bib46","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/0005-2736(91)90237-3","article-title":"Early response of cultured lepidopteran cells to exposure to \u03b4-endotoxin from Bacillus thuringiensis: involvement of calcium and anionic channels","volume":"1065","author":"Schwartz","year":"1991","journal-title":"Biochim. Biophys. Acta Biomembr."},{"issue":"2","key":"10.1016\/j.toxicon.2019.06.003_bib47","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/S0014-5793(97)00801-6","article-title":"Ion channels formed in planar lipid bilayers by Bacillus thuringiensis toxins in the presence of Manduca sexta midgut receptors","volume":"412","author":"Schwartz","year":"1997","journal-title":"FEBS (Fed. Eur. Biochem. Soc.) Lett."},{"issue":"13","key":"10.1016\/j.toxicon.2019.06.003_bib48","doi-asserted-by":"crossref","first-page":"6629","DOI":"10.1016\/S0021-9258(19)69036-8","article-title":"The activation of lymphocyte plasma membrane (Na,K)-ATPase by EGTA is explained better by zinc than calcium chelation","volume":"256","author":"Segel","year":"1981","journal-title":"J. Biol. Chem."},{"issue":"01","key":"10.1016\/j.toxicon.2019.06.003_bib49","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1017\/S0025315400014880","article-title":"The Chemistry of ethylenediamine tetra-acetic acid in sea water","volume":"37","author":"Spencer","year":"1958","journal-title":"J. Mar. Biol. Assoc. U. K."},{"key":"10.1016\/j.toxicon.2019.06.003_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.jip.2012.05.001","article-title":"Current models of the mode of action of Bacillus thuringiensis insecticidal crystal proteins: a critical review","volume":"111","author":"Vachon","year":"2012","journal-title":"J. Invertebr. Pathol."},{"key":"10.1016\/j.toxicon.2019.06.003_bib51","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1021\/ar010106e","article-title":"Role of cofactors in protein folding","volume":"35","author":"Wittung-Stafshede","year":"2002","journal-title":"Acc. Chem. Res."},{"issue":"6","key":"10.1016\/j.toxicon.2019.06.003_bib52","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1093\/jb\/mvi177","article-title":"Typical three-domain cry proteins of Bacillus thuringiensis strain A1462 exhibit cytocidal activity on limited human cancer cells","volume":"138","author":"Yamashita","year":"2005","journal-title":"J. Biochem."}],"container-title":["Toxicon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010119301709?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010119301709?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:20:48Z","timestamp":1777458048000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041010119301709"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":52,"alternative-id":["S0041010119301709"],"URL":"https:\/\/doi.org\/10.1016\/j.toxicon.2019.06.003","relation":{},"ISSN":["0041-0101"],"issn-type":[{"value":"0041-0101","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of membrane-bound metal ions in toxicity of a human cancer cell-active pore-forming toxin Cry41Aa from Bacillus thuringiensis","name":"articletitle","label":"Article Title"},{"value":"Toxicon","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxicon.2019.06.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}