{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T18:11:20Z","timestamp":1781115080672,"version":"3.54.1"},"reference-count":63,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100005298","name":"Universidad de Costa Rica","doi-asserted-by":"publisher","award":["VI-741-B7608"],"award-info":[{"award-number":["VI-741-B7608"]}],"id":[{"id":"10.13039\/501100005298","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003562","name":"Ministry of Environment","doi-asserted-by":"publisher","award":["151 RGE: 0205"],"award-info":[{"award-number":["151 RGE: 0205"]}],"id":[{"id":"10.13039\/501100003562","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007637","name":"Departamento Administrativo de Ciencia, Tecnolog\u00eda e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["111577757474"],"award-info":[{"award-number":["111577757474"]}],"id":[{"id":"10.13039\/100007637","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicon"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1016\/j.toxicon.2019.09.017","type":"journal-article","created":{"date-parts":[[2019,9,23]],"date-time":"2019-09-23T11:26:18Z","timestamp":1569237978000},"page":"85-93","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Novel three-finger toxins from Micrurus dumerilii and Micrurus mipartitus coral snake venoms: Phylogenetic relationships and characterization of Clarkitoxin-I-Mdum"],"prefix":"10.1016","volume":"170","author":[{"given":"Paola","family":"Rey-Su\u00e1rez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f3nica","family":"Saldarriaga-C\u00f3rdoba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uday","family":"Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel","family":"Marin-Villa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2419-6469","authenticated-orcid":false,"given":"Bruno","family":"Lomonte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vitelbina","family":"N\u00fa\u00f1ez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxicon.2019.09.017_bib1","first-page":"9","article-title":"Coralsnake venomics: analyses of venom gland transcriptomes and proteomes of six Brazilian taxa","volume":"8","author":"Aird","year":"2017","journal-title":"Toxins"},{"key":"10.1016\/j.toxicon.2019.09.017_bib2","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0014-5793(95)01543-4","article-title":"Characterization of multiple nicotinic acetylcholine receptor binding proteins and phospholipases A2 from the venom of the coral snake Micrurus nigrocinctus nigrocinctus","volume":"380","author":"Alape-Gir\u00f3n","year":"1996","journal-title":"FEBS Lett."},{"key":"10.1016\/j.toxicon.2019.09.017_bib3","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1021\/pr700610z","article-title":"Snake venomics of Central American pitvipers. Clues for rationalizing the distinct envenomation profiles of Atropoides nummifer and Atropoides picadoi","volume":"7","author":"Angulo","year":"2008","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.toxicon.2019.09.017_bib4","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.toxicon.2013.02.006","article-title":"Isolation, characterization, cloning and expression of an alpha-neurotoxin from the venom of the Mexican coral snake Micrurus laticollaris (Squamata: Elapidae)","volume":"66","author":"Carbajal-Saucedo","year":"2013","journal-title":"Toxicon"},{"issue":"D1","key":"10.1016\/j.toxicon.2019.09.017_bib5","doi-asserted-by":"crossref","first-page":"D158","DOI":"10.1093\/nar\/gkw1099","article-title":"UniProt: the universal protein knowledgebase","volume":"45","author":"Consortium","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.toxicon.2019.09.017_bib6","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1016\/j.jprot.2011.04.003","article-title":"Snake venomics and venom gland transcriptomic analysis of Brazilian coral snakes, Micrurus altirostris and M. corallinus","volume":"74","author":"Corr\u00eaa-Netto","year":"2011","journal-title":"J. Proteom."},{"key":"10.1016\/j.toxicon.2019.09.017_bib7","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/j.lfs.2011.09.024","article-title":"Characterization of a new muscarinic toxin from the venom of the Brazilian coral snake Micrurus lemniscatus in rat hippocampus","volume":"89","author":"da Silva","year":"2011","journal-title":"Life Sci."},{"key":"10.1016\/j.toxicon.2019.09.017_bib8","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1002\/jbt.21734","article-title":"Purification and Characterization of Nk-3FTx: a three finger toxin from the venom of North East Indian monocled cobra","volume":"30","author":"Das","year":"2016","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.toxicon.2019.09.017_bib9","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1007\/s00239-017-9825-5","article-title":"Ancient diversification of three-finger toxins in Micrurus coral snakes","volume":"86","author":"Dashevsky","year":"2018","journal-title":"J. Mol. Evol."},{"key":"10.1016\/j.toxicon.2019.09.017_bib10","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1006\/bbrc.1999.2033","article-title":"Cloning and characterization of an \u03b1-neurotoxin-type protein specific for the coral snake Micrurus corallinus","volume":"267","author":"de Oliveira","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.toxicon.2019.09.017_bib11","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1007\/s00726-018-2556-0","article-title":"Short-chain consensus alpha-neurotoxin: a synthetic 60-mer peptide with generic traits and enhanced immunogenic properties","volume":"50","author":"de la Rosa","year":"2018","journal-title":"Amino Acids"},{"key":"10.1016\/j.toxicon.2019.09.017_bib12","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1186\/1471-2148-8-196","article-title":"Accelerated exchange of exon segments in Viperid three-finger toxin genes (Sistrurus catenatus edwardsii; Desert Massasauga)","volume":"8","author":"Doley","year":"2008","journal-title":"BMC Evol. Biol."},{"key":"10.1016\/j.toxicon.2019.09.017_bib13","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.toxicon.2008.12.015","article-title":"Biochemical characterization of the Micrurus pyrrhocryptus venom","volume":"53","author":"Dokmetjian","year":"2009","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2019.09.017_bib14","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.toxicon.2015.08.016","article-title":"Snake venomics of Micrurus alleni and Micrurus mosquitensis from the Caribbean region of Costa Rica reveals two divergent compositional patterns in New World elapids","volume":"107","author":"Fernandez","year":"2015","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2019.09.017_bib15","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1007\/s00239-003-2497-3","article-title":"Isolation of a neurotoxin (\u03b1-colubritoxin) from a nonvenomous colubrid: evidence for early origin of venom in snakes","volume":"57","author":"Fry","year":"2003","journal-title":"J. Mol. Evol."},{"key":"10.1016\/j.toxicon.2019.09.017_bib16","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1101\/gr.3228405","article-title":"From genome to \"venome\": molecular origin and evolution of the snake venom proteome inferred from phylogenetic analysis of toxin sequences and related body proteins","volume":"15","author":"Fry","year":"2005","journal-title":"Genome Res."},{"key":"10.1016\/j.toxicon.2019.09.017_bib17","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1074\/mcp.M700094-MCP200","article-title":"Evolution of an arsenal: structural and functional diversification of the venom system in the advanced snakes (Caenophidia)","volume":"7","author":"Fry","year":"2008","journal-title":"Mol. Cell. Proteom."},{"key":"10.1016\/j.toxicon.2019.09.017_bib18","doi-asserted-by":"crossref","first-page":"3207","DOI":"10.1111\/j.1742-4658.2008.06473.x","article-title":"Conserved structural determinants in three-fingered protein domains","volume":"275","author":"Galat","year":"2008","journal-title":"FEBS J."},{"key":"10.1016\/j.toxicon.2019.09.017_bib65","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.biochi.2018.01.006","article-title":"Cloning and sequencing of three-finger toxins from the venom glands of four Micrurus species from Mexico and heterologous expression of an alpha-neurotoxin from Micrurus diastema","volume":"147","author":"Guerrero-Garz\u00f3n","year":"2018","journal-title":"Biochimie"},{"key":"10.1016\/j.toxicon.2019.09.017_bib21","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1016\/j.biochi.2013.06.025","article-title":"Identification and characterization of a taxon-specific three-finger toxin from the venom of the Green Vinesnake (Oxybelis fulgidus; family Colubridae)","volume":"95","author":"Heyborne","year":"2013","journal-title":"Biochimie"},{"issue":"12","key":"10.1016\/j.toxicon.2019.09.017_bib22","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1093\/bioinformatics\/bts199","article-title":"404 Geneious Basic: an integrated and extendable desktop software platform for the organization and 405 analysis of sequence data","volume":"28","author":"Kearse","year":"2012","journal-title":"Bioinformatics"},{"key":"10.1016\/j.toxicon.2019.09.017_bib23","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/jnc.13975","article-title":"The three-finger toxin fold: a multifunctional structural scaffold able to modulate cholinergic functions","volume":"142","author":"Kessler","year":"2017","journal-title":"J. Neurochem."},{"key":"10.1016\/j.toxicon.2019.09.017_bib24","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.toxicon.2010.07.010","article-title":"Structure, function and evolution of three-finger toxins: mini proteins with multiple targets","volume":"56","author":"Kini","year":"2010","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2019.09.017_bib25","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.toxicon.2008.05.020","article-title":"A rational nomenclature for naming peptide toxins from spiders and other venomous animals","volume":"52","author":"King","year":"2008","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2019.09.017_bib26","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1126\/science.1135308","article-title":"A \u201cSilent\u201d polymorphism in the MDR1 gene changes substrate specificity","volume":"315","author":"Kimchi-Sarfaty","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.toxicon.2019.09.017_bib27","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1093\/molbev\/msw054","article-title":"MEGA7: molecular evolutionary genetics analysis version 7.0 for bigger datasets","volume":"33","author":"Kumar","year":"2016","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.toxicon.2019.09.017_bib28","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","article-title":"Cleavage of structural proteins during the assembly of the head of bacteriophage T4","volume":"227","author":"Laemmli","year":"1970","journal-title":"Nature"},{"key":"10.1016\/j.toxicon.2019.09.017_bib29","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/1471-2164-10-112","article-title":"Transcriptomic basis for an antiserum against Micrurus corallinus (coral snake) venom","volume":"10","author":"Le\u00e3o","year":"2009","journal-title":"BMC Genomics"},{"key":"10.1016\/j.toxicon.2019.09.017_bib30","doi-asserted-by":"crossref","first-page":"150277","DOI":"10.1098\/rsos.150277","article-title":"Diversification rates and phenotypic evolution in venomous snakes (Elapidae)","volume":"3","author":"Lee","year":"2016","journal-title":"R. Soc. Open Sci."},{"key":"10.1016\/j.toxicon.2019.09.017_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.jprot.2019.01.007","article-title":"First look into the venom of Roatan Island's critically endangered coral snake Micrurus ruatanus: proteomic characterization, toxicity, immunorecognition and neutralization by an antivenom","author":"Lippa","year":"2019","journal-title":"J. Proteom."},{"key":"10.1016\/j.toxicon.2019.09.017_bib32","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0041-0101(98)00171-8","article-title":"Comparative study of the cytolytic activity of myotoxic phospholipases A2 on mouse endothelial (tEnd) and skeletal muscle (C2C12) cells in vitro","volume":"37","author":"Lomonte","year":"1999","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2019.09.017_bib33","doi-asserted-by":"crossref","first-page":"138","DOI":"10.3390\/toxins8050138","article-title":"Venom of the coral snake Micrurus clarki: proteomic profile, toxicity, immunological cross-neutralization, and characterization of a three-finger toxin","volume":"8","author":"Lomonte","year":"2016","journal-title":"Toxins"},{"key":"10.1016\/j.toxicon.2019.09.017_bib34","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.toxicon.2016.09.008","article-title":"Calvete JJ Venoms of Micrurus coral snakes: evolutionary trends in compositional patterns emerging from proteomic analyses","volume":"122","author":"Lomonte","year":"2016","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2019.09.017_bib35","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s40409-017-0117-8","article-title":"Strategies in 'snake venomics' aiming at an integrative view of compositional, functional, and immunological characteristics of venoms","volume":"23","author":"Lomonte","year":"2017","journal-title":"J. Venom. Anim. Toxins Incl. Trop. Dis."},{"key":"10.1016\/j.toxicon.2019.09.017_bib36","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.toxicon.2019.06.023","article-title":"Three-finger toxins from the venom of Micrurus tschudii (desert coral snake): isolation and characterization of tschuditoxin-I","volume":"167","author":"Lomonte","year":"2019","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2019.09.017_bib37","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.toxicon.2004.11.003","article-title":"Pharmacological characterisation of a neurotoxin from the venom of Boiga dendrophila (mangrove catsnake)","volume":"45","author":"Lumsden","year":"2005","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2019.09.017_bib64","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1186\/1471-2164-14-531","article-title":"The venom-gland transcriptome of the eastern coral snake (Micrurus fulvius) reveals high venom complexity in the intragenomic evolution of venoms","volume":"14","author":"Margres","year":"2013","journal-title":"BMC Genomics"},{"key":"10.1016\/j.toxicon.2019.09.017_bib38","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0163-7258(85)90049-X","article-title":"Molecular immunology of snake toxins","volume":"30","author":"M\u00e9nez","year":"1985","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.toxicon.2019.09.017_bib39","doi-asserted-by":"crossref","first-page":"55e63","DOI":"10.1016\/j.toxicon.2010.02.030","article-title":"Frontoxins, three-finger toxins from Micrurus frontalis venom, decrease miniature endplate potential amplitude at frog neuromuscular junction","volume":"56","author":"Moreira","year":"2010","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2019.09.017_bib40","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/wics.199","article-title":"The Bayesian information criterion: background, derivation, and applications","volume":"4","author":"Neath","year":"2012","journal-title":"WIREs Comp. Stat."},{"key":"10.1016\/j.toxicon.2019.09.017_bib41","first-page":"14","article-title":"GeneDoc: analysis and visualization of genetic variation","volume":"4","author":"Nicholas","year":"1997","journal-title":"Embnew. News."},{"key":"10.1016\/j.toxicon.2019.09.017_bib42","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/j.toxicon.2003.11.003","article-title":"Molecular evolution of myotoxic phospholipases A2 from snake venom","volume":"42","author":"Ohno","year":"2003","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2019.09.017_bib43","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1002\/pmic.200700668","article-title":"Proteomic analysis of the venom from the fish eating coral snake Micrurus surinamensis: novel toxins, their function and phylogeny","volume":"8","author":"Olamendi-Portugal","year":"2008","journal-title":"Proteomics"},{"key":"10.1016\/j.toxicon.2019.09.017_bib44","series-title":"Clinical Toxinology","first-page":"1e44","article-title":"Snake bites in Colombia","author":"Otero-Pati\u00f1o","year":"2014"},{"key":"10.1016\/j.toxicon.2019.09.017_bib45","doi-asserted-by":"crossref","first-page":"29030","DOI":"10.1074\/jbc.M605850200","article-title":"Denmotoxin, a three-finger toxin from the colubrid snake Boiga dendrophila (Mangrove Catsnake) with bird-specific activity","volume":"281","author":"Pawlak","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxicon.2019.09.017_bib46","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1096\/fj.08-113555","article-title":"Irditoxin, a novel covalently linked heterodimeric three-finger toxin with high taxon-specific neurotoxicity","volume":"23","author":"Pawlak","year":"2009","journal-title":"FASEB J."},{"key":"10.1016\/j.toxicon.2019.09.017_bib47","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1089\/hum.2005.16.292","article-title":"Protective immunity against alpha-cobratoxin following a single administration of a genetic vaccine encoding a non-toxic cobratoxin variant","volume":"16","author":"Pergolizzi","year":"2005","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.toxicon.2019.09.017_bib48","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/nmeth.1701","article-title":"SignalP 4.0: discriminating signal peptides from transmembrane regions","volume":"8","author":"Petersen","year":"2011","journal-title":"Nat. Methods"},{"key":"10.1016\/j.toxicon.2019.09.017_bib49","series-title":"FigTree, a graphical viewer of phylogenetic trees","author":"Rambaut","year":"2009"},{"key":"10.1016\/j.toxicon.2019.09.017_bib50","series-title":"Tracer v1.6","author":"Rambaut","year":"2013"},{"key":"10.1016\/j.toxicon.2019.09.017_bib51","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.jprot.2011.09.003","article-title":"Proteomic and biological characterization of the venom of the redtail coral snake, Micrurus mipartitus (Elapidae), from Colombia and Costa Rica","volume":"75","author":"Rey-Su\u00e1rez","year":"2011","journal-title":"J. Proteom."},{"key":"10.1016\/j.toxicon.2019.09.017_bib52","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/j.toxicon.2012.05.023","article-title":"A novel three-finger toxin, is the major neurotoxic component in the venom of the redtail coral snake Micrurus mipartitus (Elapidae)","volume":"60","author":"Rey-Su\u00e1rez","year":"2012","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2019.09.017_bib53","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.jprot.2016.02.006","article-title":"Integrative characterization of the venom of the coral snake Micrurus dumerilii (Elapidae) from Colombia: proteome, toxicity, and cross-neutralization by antivenom","volume":"136","author":"Rey-Su\u00e1rez","year":"2016","journal-title":"J. Proteom."},{"key":"10.1016\/j.toxicon.2019.09.017_bib54","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1093\/bioinformatics\/btg180","article-title":"Bayesian phylogenetic inference under mixed models","volume":"19","author":"Ronquist","year":"2003","journal-title":"Bioinformatics"},{"key":"10.1016\/j.toxicon.2019.09.017_bib55","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/j.1432-1033.1996.0231q.x","article-title":"Characterization of alpha-neurotoxin and phospholipase A2 activities from Micrurus venoms. Determination of the amino acid sequence and receptor-binding ability of the major alpha-neurotoxin from Micrurus nigrocinctus nigrocinctus","volume":"238","author":"Rosso","year":"1996","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.toxicon.2019.09.017_bib56","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1073\/pnas.1415488112","article-title":"MmTX1 and MmTX2 from coral snake venom potently modulate GABAA receptor activity","volume":"112","author":"Rosso","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.toxicon.2019.09.017_bib57","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/nprot.2010.5","article-title":"I-TASSER: a unified platform for automated protein structure and function prediction","volume":"5","author":"Roy","year":"2010","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.toxicon.2019.09.017_bib58","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.gene.2005.11.039","article-title":"Genetic variation of a disintegrin gene found in the American copperhead snake (Agkistrodon contortrix)","volume":"373","author":"Soto","year":"2006","journal-title":"Gene"},{"key":"10.1016\/j.toxicon.2019.09.017_bib59","doi-asserted-by":"crossref","first-page":"2172","DOI":"10.3390\/toxins5112172","article-title":"Three-fingered RAVERs: rapid accumulation of variations in exposed residues of snake venom toxins","volume":"5","author":"Sunagar","year":"2013","journal-title":"Toxins"},{"key":"10.1016\/j.toxicon.2019.09.017_bib60","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jprot.2015.11.014","article-title":"Unveiling the elusive and exotic: venomics of the Malayan blue coral snake (Calliophis bivirgata flaviceps)","volume":"132","author":"Tan","year":"2016","journal-title":"J. Proteom."},{"key":"10.1016\/j.toxicon.2019.09.017_bib61","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1046\/j.1432-1327.1999.00623.x","article-title":"Snake venom alpha-neurotoxins and other 'three-finger' proteins","volume":"264","author":"Tsetlin","year":"1999","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.toxicon.2019.09.017_bib62","doi-asserted-by":"crossref","first-page":"17","DOI":"10.4331\/wjbc.v10.i1.17","article-title":"Last decade update for three-finger toxins: newly emerging structures and biological activities","volume":"10","author":"Utkin","year":"2019","journal-title":"World J. Biol. Chem."},{"key":"10.1016\/j.toxicon.2019.09.017_bib63","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.jprot.2014.02.027","article-title":"Eastern coralsnake Micrurus fulvius venom toxicity in mice is mainly determined by neurotoxic phospholipases A2","volume":"105","author":"Vergara","year":"2014","journal-title":"J. Proteom."}],"container-title":["Toxicon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010119304593?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010119304593?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T08:05:52Z","timestamp":1778659552000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041010119304593"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":63,"alternative-id":["S0041010119304593"],"URL":"https:\/\/doi.org\/10.1016\/j.toxicon.2019.09.017","relation":{},"ISSN":["0041-0101"],"issn-type":[{"value":"0041-0101","type":"print"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Novel three-finger toxins from Micrurus dumerilii and Micrurus mipartitus coral snake venoms: Phylogenetic relationships and characterization of Clarkitoxin-I-Mdum","name":"articletitle","label":"Article Title"},{"value":"Toxicon","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxicon.2019.09.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}