{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T07:26:48Z","timestamp":1791444408247,"version":"4.3.3"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100008323","name":"Zanjan University of Medical Sciences","doi-asserted-by":"publisher","award":["A-12-769-30"],"award-info":[{"award-number":["A-12-769-30"]}],"id":[{"id":"10.13039\/501100008323","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicon"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.toxicon.2019.12.154","type":"journal-article","created":{"date-parts":[[2019,12,27]],"date-time":"2019-12-27T11:10:56Z","timestamp":1577445056000},"page":"57-63","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["The effects of Hemiscorpius lepturus induced-acute kidney injury on PGC-1\u03b1 gene expression: From induction to suppression in mice"],"prefix":"10.1016","volume":"174","author":[{"given":"Rana","family":"Dizaji","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Sharafi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jalal","family":"Pourahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saba","family":"Vatanpour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4469-9488","authenticated-orcid":false,"given":"Mir-Jamal","family":"Hosseini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossein","family":"Vatanpour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxicon.2019.12.154_bib1","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.pnpbp.2017.02.022","article-title":"Oxytocin mitigated the depressive-like behaviors of maternal separation stress through modulating mitochondrial function and neuroinflammation","volume":"76","author":"Amini-Khoei","year":"2017","journal-title":"Prog. Neuro Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.toxicon.2019.12.154_bib2","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1038\/nrneph.2017.107","article-title":"Mitochondrial energetics in the kidney","volume":"13","author":"Bhargava","year":"2017","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.toxicon.2019.12.154_bib3","doi-asserted-by":"crossref","first-page":"F385","DOI":"10.1152\/ajprenal.00335.2015","article-title":"Proximal tubule-targeted heme oxygenase-1 in cisplatin-induced acute kidney injury","volume":"310","author":"Bolisetty","year":"2015","journal-title":"Am. J. Physiol. Renal. Physiol."},{"key":"10.1016\/j.toxicon.2019.12.154_bib4","doi-asserted-by":"crossref","first-page":"3426","DOI":"10.1016\/j.bbamcr.2013.04.014","article-title":"Induction of mitochondrial biogenesis protects against caspase-dependent and caspase-independent apoptosis in L6 myoblasts","volume":"1833","author":"Dam","year":"2013","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"10.1016\/j.toxicon.2019.12.154_bib5","first-page":"495","article-title":"Uranyl acetate induces oxidative stress and mitochondrial membrane potential collapse in the human dermal fibroblast primary cells","volume":"11","author":"Daraie","year":"2012","journal-title":"Iran. J. Pharm. Res. (IJPR): IJPR"},{"key":"10.1016\/j.toxicon.2019.12.154_bib6","article-title":"Hemoglobinuria-related acute kidney injury is driven by intrarenal oxidative reactions triggering a heme toxicity response","volume":"7","author":"Deuel","year":"2017","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.toxicon.2019.12.154_bib7","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.toxicon.2019.03.011","article-title":"Induction of two independent immunological cell death signaling following hemoglobinuria-induced acute kidney injury: in vivo study","volume":"163","author":"Dizaji","year":"2019","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2019.12.154_bib8","doi-asserted-by":"crossref","first-page":"E4110","DOI":"10.1073\/pnas.1405023111","article-title":"Hemolysis-induced lethality involves inflammasome activation by heme","volume":"111","author":"Dutra","year":"2014","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.toxicon.2019.12.154_bib9","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/nrneph.2015.214","article-title":"Mitochondrial dysfunction in inherited renal disease and acute kidney injury","volume":"12","author":"Emma","year":"2016","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.toxicon.2019.12.154_bib10","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1172\/JCI27794","article-title":"PGC-1 coactivators: inducible regulators of energy metabolism in health and disease","volume":"116","author":"Finck","year":"2006","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.toxicon.2019.12.154_bib11","doi-asserted-by":"crossref","first-page":"3322","DOI":"10.1016\/j.bbadis.2018.07.019","article-title":"Laz3 protects cardiac remodeling in diabetic cardiomyopathy via regulating miR-21\/PPARa signaling","volume":"1864","author":"Gao","year":"2018","journal-title":"Biochim. Biophys. Acta (BBA) - Mol. Basis Dis."},{"key":"10.1016\/j.toxicon.2019.12.154_bib12","doi-asserted-by":"crossref","first-page":"3508","DOI":"10.1016\/j.febslet.2009.10.010","article-title":"Prolonged cigarette smoke exposure decreases heme oxygenase\u20101 and alters Nrf2 and Bach 1 expression in human macrophages: roles of the MAP kinases ERK1\/2 and JNK","volume":"583","author":"Goven","year":"2009","journal-title":"FEBS Lett."},{"key":"10.1016\/j.toxicon.2019.12.154_bib14","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/ki.2011.120","article-title":"Apoptosis and acute kidney injury","volume":"80","author":"Havasi","year":"2011","journal-title":"Kidney Int."},{"key":"10.1016\/j.toxicon.2019.12.154_bib15","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.diabres.2013.03.036","article-title":"PGC-1\u03b1 prevents apoptosis in adipose-derived stem cells by reducing reactive oxygen species production in a diabetic microenvironment","volume":"100","author":"Jiang","year":"2013","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1016\/j.toxicon.2019.12.154_bib16","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.celrep.2015.06.006","article-title":"Suppression of PGC-1\u03b1 is critical for reprogramming oxidative metabolism in renal cell carcinoma","volume":"12","author":"LaGory","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.toxicon.2019.12.154_bib17","series-title":"The Role of Peroxisome Proliferator-Activated Receptor \u03b3 Coactivator 1\u03b1 (PGC-1\u03b1) in Kidney Disease, Seminars in Nephrology","first-page":"121","author":"Li","year":"2018"},{"key":"10.1016\/j.toxicon.2019.12.154_bib18","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1038\/ki.2009.330","article-title":"Transgenic expression of proximal tubule peroxisome proliferator\u2013activated receptor-\u03b1 in mice confers protection during acute kidney injury","volume":"76","author":"Li","year":"2009","journal-title":"Kidney Int."},{"key":"10.1016\/j.toxicon.2019.12.154_bib19","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/s12013-014-9823-9","article-title":"Heme induces IL-1\u03b2 secretion through activating NLRP3 in kidney inflammation","volume":"69","author":"Li","year":"2014","journal-title":"Cell Biochem. Biophys."},{"key":"10.1016\/j.toxicon.2019.12.154_bib20","doi-asserted-by":"crossref","first-page":"F1","DOI":"10.1152\/ajprenal.00263.2017","article-title":"PGC1\u03b1 in the kidney","volume":"314","author":"Lynch","year":"2017","journal-title":"Am. J. Physiol. Renal. Physiol."},{"key":"10.1016\/j.toxicon.2019.12.154_bib21","doi-asserted-by":"crossref","first-page":"44892","DOI":"10.1038\/srep44892","article-title":"Double knockout of Bax and Bak from kidney proximal tubules reduces unilateral urethral obstruction associated apoptosis and renal interstitial fibrosis","volume":"7","author":"Mei","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.toxicon.2019.12.154_bib22","first-page":"581","article-title":"Protective effect of ozone against Hemiscorpius lepturus envenomation in mice","volume":"30","author":"Naserzadeh","year":"2017","journal-title":"Biomed. Environ. Sci."},{"key":"10.1016\/j.toxicon.2019.12.154_bib23","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1097\/01.mnh.0000437613.88158.d3","article-title":"Heme oxygenase-1 and acute kidney injury","volume":"23","author":"Nath","year":"2014","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"10.1016\/j.toxicon.2019.12.154_bib24","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.exger.2014.01.021","article-title":"Mitochondrial homeostasis: the interplay between mitophagy and mitochondrial biogenesis","volume":"56","author":"Palikaras","year":"2014","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.toxicon.2019.12.154_bib25","doi-asserted-by":"crossref","first-page":"16374","DOI":"10.1074\/jbc.M110.207738","article-title":"Heme oxygenase-1 couples activation of mitochondrial biogenesis to anti-inflammatory cytokine expression","author":"Piantadosi","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxicon.2019.12.154_bib26","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.toxicon.2006.04.017","article-title":"In vitro and in vivo studies on some toxic effects of the venom from Hemiscorpious lepturus scorpion","volume":"48","author":"Pipelzadeh","year":"2006","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2019.12.154_bib27","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1016\/j.toxicon.2007.07.018","article-title":"An epidemiological and a clinical study on scorpionism by the Iranian scorpion Hemiscorpius lepturus","volume":"50","author":"Pipelzadeh","year":"2007","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2019.12.154_bib28","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.toxicon.2015.03.023","article-title":"A forward to optimization of antivenom therapy: an in vivo study upon the effectiveness of the antivenom against early and delayed nephrotoxicity induced by the venom of the Iranian scorpion Hemiscorpius lepturus in rat","volume":"100","author":"Pipelzadeh","year":"2015","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2019.12.154_bib29","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.cellsig.2013.11.029","article-title":"Bilirubin mediated oxidative stress involves antioxidant response activation via Nrf2 pathway","volume":"26","author":"Qaisiya","year":"2014","journal-title":"Cell. Signal."},{"key":"10.1016\/j.toxicon.2019.12.154_bib30","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1002\/path.5011","article-title":"Podocytes are new cellular targets of haemoglobin\u2010mediated renal damage","volume":"244","author":"Rubio\u2010Navarro","year":"2018","journal-title":"J. Pathol."},{"key":"10.1016\/j.toxicon.2019.12.154_bib31","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/ki.2015.332","article-title":"The inflammatory cytokine TWEAK decreases PGC-1\u03b1 expression and mitochondrial function in acute kidney injury","volume":"89","author":"Ruiz-Andres","year":"2016","journal-title":"Kidney Int."},{"key":"10.1016\/j.toxicon.2019.12.154_bib32","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1124\/jpet.114.221085","article-title":"Suppression of mitochondrial biogenesis through toll-like receptor 4\u2013dependent mitogen-activated protein kinase kinase\/extracellular signal-regulated kinase signaling in endotoxin-induced acute kidney injury","volume":"352","author":"Smith","year":"2015","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.toxicon.2019.12.154_bib33","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.cell.2006.09.024","article-title":"Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators","volume":"127","author":"St-Pierre","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.toxicon.2019.12.154_bib34","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1096\/fasebj.13.13.1800","article-title":"Reversal of HO-1 related cytoprotection with increased expression is due to reactive iron","volume":"13","author":"Suttner","year":"1999","journal-title":"FASEB J."},{"key":"10.1016\/j.toxicon.2019.12.154_bib35","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1089\/ars.2007.1957","article-title":"Redox regulation of cell survival","volume":"10","author":"Trachootham","year":"2008","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.toxicon.2019.12.154_bib36","doi-asserted-by":"crossref","DOI":"10.1172\/JCI58662","article-title":"PGC-1\u03b1 promotes recovery after acute kidney injury during systemic inflammation in mice","volume":"121","author":"Tran","year":"2011","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.toxicon.2019.12.154_bib37","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1097\/SHK.0000000000000390","article-title":"Resveratrol rescues kidney mitochondrial function following hemorrhagic shock","volume":"44","author":"Wang","year":"2015","journal-title":"Shock"},{"key":"10.1016\/j.toxicon.2019.12.154_bib38","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.bcp.2018.01.034","article-title":"Regulation on SIRT1-PGC-1\u03b1\/Nrf2 pathway together with selective inhibition of aldose reductase makes compound hr5F a potential agent for the treatment of diabetic complications","volume":"150","author":"Wang","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.toxicon.2019.12.154_bib39","article-title":"The transcriptional coactivator PGC1\u03b1 protects against hyperthermic stress via cooperation with the heat shock factor HSF1","volume":"7","author":"Xu","year":"2017","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.toxicon.2019.12.154_bib40","doi-asserted-by":"crossref","first-page":"12150","DOI":"10.18632\/oncotarget.7859","article-title":"PGC-1\u03b1 overexpression protects against aldosterone-induced podocyte depletion: role of mitochondria","volume":"7","author":"Zhao","year":"2016","journal-title":"Oncotarget"}],"container-title":["Toxicon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004101011930916X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004101011930916X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T21:13:33Z","timestamp":1758575613000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S004101011930916X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":39,"alternative-id":["S004101011930916X"],"URL":"https:\/\/doi.org\/10.1016\/j.toxicon.2019.12.154","relation":{},"ISSN":["0041-0101"],"issn-type":[{"value":"0041-0101","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The effects of Hemiscorpius lepturus induced-acute kidney injury on PGC-1\u03b1 gene expression: From induction to suppression in mice","name":"articletitle","label":"Article Title"},{"value":"Toxicon","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxicon.2019.12.154","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}