{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T10:48:05Z","timestamp":1762253285731,"version":"3.44.0"},"reference-count":11,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100005299","name":"Vicerrector\u00eda de Investigaci\u00f3n, Universidad de Costa Rica","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005299","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicon"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1016\/j.toxicon.2020.02.011","type":"journal-article","created":{"date-parts":[[2020,2,12]],"date-time":"2020-02-12T05:46:32Z","timestamp":1581486392000},"page":"1-3","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Hemorrhagic and procoagulant P-III snake venom metalloproteinases differ in their binding to the microvasculature of mouse cremaster muscle"],"prefix":"10.1016","volume":"178","author":[{"given":"Cristina","family":"Herrera","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"Escalante","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Rucavado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Mar\u00eda","family":"Guti\u00e9rrez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxicon.2020.02.011_bib1","doi-asserted-by":"crossref","first-page":"e727","DOI":"10.1371\/journal.pntd.0000727","article-title":"Mechanisms of vascular damage by hemorrhagic snake venom metalloproteinases: tissue distribution and in situ hydrolysis","volume":"4","author":"Baldo","year":"2010","journal-title":"PLoS Neglected Trop. Dis."},{"key":"10.1016\/j.toxicon.2020.02.011_bib2","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1016\/j.jprot.2011.03.026","article-title":"Key events in microvascular damage induced by snake venom hemorrhagic metalloproteinases","volume":"74","author":"Escalante","year":"2011","journal-title":"J. Proteomics"},{"year":"2010","series-title":"Snake Venom Metalloproteinases, Handbook of Venoms and Toxins of Reptiles","author":"Fox","key":"10.1016\/j.toxicon.2020.02.011_bib3"},{"key":"10.1016\/j.toxicon.2020.02.011_bib4","doi-asserted-by":"crossref","first-page":"17063","DOI":"10.1038\/nrdp.2017.63","article-title":"Snakebite envenoming","volume":"3","author":"Guti\u00e9rrez","year":"2017","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.toxicon.2020.02.011_bib5","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/j.toxicon.2005.02.029","article-title":"Hemorrhage induced by snake venom metalloproteinases: biochemical and biophysical mechanisms involved in microvessel damage","volume":"45","author":"Guti\u00e9rrez","year":"2005","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2020.02.011_bib6","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0003731","article-title":"Tissue localization and extracellular matrix degradation by PI, PII and PIII snake venom metalloproteinases: clues on the mechanisms of venom-induced hemorrhage","volume":"9","author":"Herrera","year":"2015","journal-title":"PLoS Neglected Trop. Dis."},{"key":"10.1016\/j.toxicon.2020.02.011_bib7","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/j.toxicon.2005.02.019","article-title":"The intriguing world of prothrombin activators from snake venom","volume":"45","author":"Kini","year":"2005","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2020.02.011_bib8","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0003-9861(03)00385-0","article-title":"Characterization of \u201cbasparin A,\u201d a prothrombin-activating metalloproteinase, from the venom of the snake Bothrops asper that inhibits platelet aggregation and induces defibrination and thrombosis","volume":"418","author":"Lor\u00eda","year":"2003","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.toxicon.2020.02.011_bib9","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.biochi.2007.11.009","article-title":"Collagen binding is a key factor for the hemorrhagic activity of snake venom metalloproteinases","volume":"90","author":"Moura-da-Silva","year":"2008","journal-title":"Biochimie"},{"key":"10.1016\/j.toxicon.2020.02.011_bib10","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1160\/TH09-12-0855","article-title":"New insights into the structural elements involved in the skin haemorrhage induced by snake venom metalloproteinases","volume":"104","author":"Oliveira","year":"2010","journal-title":"Thromb. Haemostasis"},{"key":"10.1016\/j.toxicon.2020.02.011_bib11","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0140-6736(09)61754-2","article-title":"Snake bite","volume":"375","author":"Warrell","year":"2010","journal-title":"Lancet"}],"container-title":["Toxicon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010120300428?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010120300428?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T21:13:39Z","timestamp":1758575619000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041010120300428"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":11,"alternative-id":["S0041010120300428"],"URL":"https:\/\/doi.org\/10.1016\/j.toxicon.2020.02.011","relation":{},"ISSN":["0041-0101"],"issn-type":[{"type":"print","value":"0041-0101"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hemorrhagic and procoagulant P-III snake venom metalloproteinases differ in their binding to the microvasculature of mouse cremaster muscle","name":"articletitle","label":"Article Title"},{"value":"Toxicon","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxicon.2020.02.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}