{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T13:49:30Z","timestamp":1767707370184,"version":"3.44.0"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100005930","name":"Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005930","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicon"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.toxicon.2020.08.027","type":"journal-article","created":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T16:33:54Z","timestamp":1598978034000},"page":"116-121","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Modulatory effect of botulinum toxin type A on the microglial P2X7\/CatS\/FKN activated-pathway in antigen-induced arthritis of the temporomandibular joint of rats"],"prefix":"10.1016","volume":"187","author":[{"given":"Victor Ricardo","family":"Manuel Mu\u00f1oz-Lora","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrique Ballassini","family":"Abdalla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Altair Antoninha","family":"Del Bel Cury","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana Trindade","family":"Clemente-Napimoga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.toxicon.2020.08.027_bib1","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1111\/bcpt.12657","article-title":"Pharmacological value of murine delayed-type hypersensitivity arthritis: a robust mouse model of rheumatoid arthritis in C57BL\/6 mice","volume":"120","author":"Atkinson","year":"2017","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"issue":"2","key":"10.1016\/j.toxicon.2020.08.027_bib2","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.pbb.2009.08.012","article-title":"Central origin of the antinociceptive action of botulinum toxin type A","volume":"94","author":"Bach-Rojecky","year":"2009","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"6","key":"10.1016\/j.toxicon.2020.08.027_bib3","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1189\/jlb.70.6.849","article-title":"Modes of action of Freund's adjuvants in experimental models of autoimmune diseases","volume":"70","author":"Billiau","year":"2001","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.toxicon.2020.08.027_bib4","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.neuroscience.2018.09.005","article-title":"The P2X7 receptor, cathepsin S and fractalkine in the trigeminal subnucleus caudalis signal persistent hypernociception in temporomandibular rat joints","volume":"391","author":"Bonfante","year":"2018","journal-title":"Neuroscience"},{"issue":"4","key":"10.1016\/j.toxicon.2020.08.027_bib5","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1046\/j.0953-816x.2001.01686.x","article-title":"Rat microglial cells secrete predominantly the precursor of interleukin-1beta in response to lipopolysaccharide","volume":"14","author":"Chauvet","year":"2001","journal-title":"Eur. J. Neurosci."},{"issue":"2","key":"10.1016\/j.toxicon.2020.08.027_bib6","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.expneurol.2011.09.012","article-title":"Microglial signalling mechanisms: cathepsin S and fractalkine","volume":"234","author":"Clark","year":"2012","journal-title":"Exp. Neurol."},{"issue":"2","key":"10.1016\/j.toxicon.2020.08.027_bib7","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.ejpain.2006.02.003","article-title":"Role of spinal microglia in rat models of peripheral nerve injury and inflammation","volume":"11","author":"Clark","year":"2007","journal-title":"Eur. J. Pain"},{"issue":"14","key":"10.1016\/j.toxicon.2020.08.027_bib8","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1002\/glia.21042","article-title":"Cathepsin S release from primary cultured microglia is regulated by the P2X7 receptor","volume":"58","author":"Clark","year":"2010","journal-title":"Glia"},{"issue":"9","key":"10.1016\/j.toxicon.2020.08.027_bib9","doi-asserted-by":"crossref","first-page":"3411","DOI":"10.1007\/s00784-019-03026-4","article-title":"Botulinum toxin type A applications for masticatory myofascial pain and trigeminal neuralgia: what is the evidence regarding adverse effects?","volume":"23","author":"De la Torre Canales","year":"2019","journal-title":"Clin. Oral Invest."},{"issue":"6","key":"10.1016\/j.toxicon.2020.08.027_bib10","doi-asserted-by":"crossref","first-page":"395","DOI":"10.3390\/toxins12060395","article-title":"Efficacy and safety of botulinum toxin type A on persistent myofascial pain: a randomized clinical trial","volume":"12","author":"De la Torre Canales","year":"2020","journal-title":"Toxins"},{"issue":"1","key":"10.1016\/j.toxicon.2020.08.027_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0029803","article-title":"Central action of peripherally applied botulinum toxin type a on pain and dural protein extravasation in rat model of trigeminal neuropathy","volume":"7","author":"Filipovi\u0107","year":"2012","journal-title":"PloS One"},{"issue":"4","key":"10.1016\/j.toxicon.2020.08.027_bib12","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/nri3621","article-title":"Pathological pain and the neuroimmune interface","volume":"14","author":"Grace","year":"2014","journal-title":"Nat. Rev. Immunol."},{"issue":"2","key":"10.1016\/j.toxicon.2020.08.027_bib13","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1002\/(SICI)1098-1136(199908)27:2<181::AID-GLIA8>3.0.CO;2-9","article-title":"Cultured glial cells express the SNAP-25 analogue SNAP-23","volume":"27","author":"Hepp","year":"1999","journal-title":"Glia"},{"issue":"1","key":"10.1016\/j.toxicon.2020.08.027_bib14","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1939-165X.2012.00418.x","article-title":"Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research","volume":"41","author":"Kilkenny","year":"2012","journal-title":"Vet. Clin. Pathol."},{"issue":"4","key":"10.1016\/j.toxicon.2020.08.027_bib15","first-page":"1","article-title":"Botulinum neurotoxin type a induces TLR2- mediated inflammatory responses in macrophages","volume":"10","author":"Kim","year":"2015","journal-title":"PloS One"},{"issue":"1","key":"10.1016\/j.toxicon.2020.08.027_bib16","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.pain.2005.02.009","article-title":"Minocycline attenuates mechanical allodynia and proinflammatory cytokine expression in rat models of pain facilitation","volume":"115","author":"Ledeboer","year":"2005","journal-title":"Pain"},{"issue":"10","key":"10.1016\/j.toxicon.2020.08.027_bib17","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0047977","article-title":"The analgesic effect on neuropathic pain of retrogradely transported botulinum neurotoxin A involves schwann cells and astrocytes","volume":"7","author":"Marinelli","year":"2012","journal-title":"PloS One"},{"key":"10.1016\/j.toxicon.2020.08.027_bib18","series-title":"Mechanisms of Botulinum Toxin Type A Action on Pain","first-page":"1","author":"Matak","year":"2019"},{"issue":"1","key":"10.1016\/j.toxicon.2020.08.027_bib19","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.neuron.2009.09.033","article-title":"Current challenges in glia-pain Biology","volume":"64","author":"McMahon","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.toxicon.2020.08.027_bib20","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.neuroscience.2010.11.040","article-title":"The effect of botulinum neurotoxin A on sciatic nerve injury-induced neuroimmunological changes in rat dorsal root ganglia and spinal cord","volume":"175","author":"Mika","year":"2011","journal-title":"Neuroscience"},{"issue":"13","key":"10.1016\/j.toxicon.2020.08.027_bib21","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1177\/0022034519875053","article-title":"Botulinum toxin type A in dental medicine","volume":"98","author":"Mu\u00f1oz Lora","year":"2019","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.toxicon.2020.08.027_bib22","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.toxicon.2017.02.010","article-title":"Botulinum toxin type A reduces inflammatory hypernociception induced by arthritis in the temporomadibular joint of rats","volume":"129","author":"Mu\u00f1oz-Lora","year":"2017","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2020.08.027_bib24","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.neuropharm.2016.04.024","article-title":"Maraviroc reduces neuropathic pain through polarization of microglia and astroglia \u2013 evidence from in vivo and in vitro studies","volume":"108","author":"Piotrowska","year":"2016","journal-title":"Neuropharmacology"},{"issue":"APR","key":"10.1016\/j.toxicon.2020.08.027_bib25","first-page":"1","article-title":"Comparison of the expression changes after botulinum toxin type a and minocycline administration in lipopolysaccharide-stimulated rat microglial and astroglial cultures","volume":"7","author":"Piotrowska","year":"2017","journal-title":"Front Cell Infect Microbiol"},{"issue":"4","key":"10.1016\/j.toxicon.2020.08.027_bib26","doi-asserted-by":"crossref","DOI":"10.3390\/toxins10040145","article-title":"Botulinum toxin type A\u2014a modulator of spinal neuron\u2013glia interactions under neuropathic pain conditions","volume":"10","author":"Rojewska","year":"2018","journal-title":"Toxins"},{"issue":"11","key":"10.1016\/j.toxicon.2020.08.027_bib27","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1038\/nn1992","article-title":"The neuropathic pain triad: neurons, immune cells and glia","volume":"10","author":"Scholz","year":"2007","journal-title":"Nat. Neurosci."},{"issue":"December","key":"10.1016\/j.toxicon.2020.08.027_bib28","first-page":"1","article-title":"The CD40-ATP-P2X7 receptor pathway: cell to cell cross-talk to promote inflammation and programmed cell death of endothelial cells","volume":"10","author":"Subauste","year":"2019","journal-title":"Front. Immunol."},{"year":"2004","series-title":"Brain Maps: Structure of the Rat Brain.","author":"Swanson","key":"10.1016\/j.toxicon.2020.08.027_bib37"},{"issue":"3","key":"10.1016\/j.toxicon.2020.08.027_bib29","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1016\/S0022-3565(24)29652-X","article-title":"Propentofylline, a glial modulating agent, exhibits antiallodynic properties in a rat model of neuropathic pain","volume":"297","author":"Sweitzer","year":"2001","journal-title":"J. Pharmacol. Exp. Therapeut."},{"issue":"2","key":"10.1016\/j.toxicon.2020.08.027_bib30","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1111\/j.1365-2249.2007.03354.x","article-title":"Administration of anti-type II collagen antibody sustains footpad swelling of mice caused by a delayed-type hypersensitivity reaction and induces severe arthritis","volume":"148","author":"Tanaka","year":"2007","journal-title":"Clin. Exp. Immunol."},{"issue":"2","key":"10.1016\/j.toxicon.2020.08.027_bib31","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.bbi.2006.07.001","article-title":"Efficacy of propentofylline, a glial modulating agent, on existing mechanical allodynia following peripheral nerve injury","volume":"21","author":"Tawfik","year":"2007","journal-title":"Brain Behav. Immun."},{"issue":"6950","key":"10.1016\/j.toxicon.2020.08.027_bib32","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1038\/nature01786","article-title":"P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury","volume":"424","author":"Tsuda","year":"2003","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.toxicon.2020.08.027_bib33","doi-asserted-by":"crossref","first-page":"124","DOI":"10.3109\/s10165-006-0471-9","article-title":"Fractalkine in rheumatoid arthritis and allied conditions","volume":"16","author":"Umehara","year":"2006","journal-title":"Mod. Rheumatol."},{"key":"10.1016\/j.toxicon.2020.08.027_bib34","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.bbi.2013.01.088","article-title":"Botulinum toxin A increases analgesic effects of morphine , counters development of morphine tolerance and modulates glia activation and l opioid receptor expression in neuropathic mice","volume":"32","author":"Vacca","year":"2013","journal-title":"Brain Behav. Immun."},{"issue":"1","key":"10.1016\/j.toxicon.2020.08.027_bib35","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/sj.cr.7290257","article-title":"Activation and signaling of the p38 MAP kinase pathway","volume":"15","author":"Zarubin","year":"2005","journal-title":"Cell Res."},{"issue":"2","key":"10.1016\/j.toxicon.2020.08.027_bib36","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0304-3959(83)90201-4","article-title":"Ethical guidelines for investigations of experimental pain in conscious animals","volume":"16","author":"Zimmermann","year":"1983","journal-title":"Pain"}],"container-title":["Toxicon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010120303767?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010120303767?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T21:16:31Z","timestamp":1758575791000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041010120303767"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":36,"alternative-id":["S0041010120303767"],"URL":"https:\/\/doi.org\/10.1016\/j.toxicon.2020.08.027","relation":{},"ISSN":["0041-0101"],"issn-type":[{"type":"print","value":"0041-0101"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Modulatory effect of botulinum toxin type A on the microglial P2X7\/CatS\/FKN activated-pathway in antigen-induced arthritis of the temporomandibular joint of rats","name":"articletitle","label":"Article Title"},{"value":"Toxicon","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxicon.2020.08.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}