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Toxicol."},{"key":"10.1016\/j.toxicon.2020.12.015_bib39","series-title":"Beyond the 'big four': venom profiling of the medically important yet neglected Indian snakes reveals disturbing antivenom deficiencies. PLoS Negl. Trop. 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Chem."},{"key":"10.1016\/j.toxicon.2020.12.015_bib43","doi-asserted-by":"crossref","first-page":"26778","DOI":"10.1038\/srep26778","article-title":"Efficacy of Indian polyvalent snake antivenoms against Sri Lankan snake venoms: lethality studies or clinically focussed in vitro studies","volume":"6","author":"Maduwage","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.toxicon.2020.12.015_bib44","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1016\/S0140-6736(00)04868-6","article-title":"Tackling venomous snake bites worldwide","volume":"357","author":"McNamee","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.toxicon.2020.12.015_bib45","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1590\/S1678-91992009000100002","article-title":"Snake antivenoms: adverse reactions and production technology","volume":"15","author":"Morais","year":"2009","journal-title":"J. Venom. Anim. Toxins Incl. Trop. 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Med","volume":"84","author":"Theakston","year":"1990","journal-title":"Hyg"},{"key":"10.1016\/j.toxicon.2020.12.015_bib76","first-page":"e1144","article-title":"Preclinical evaluation of caprylic acid-fractionated IgG antivenom for the treatment of Taipan (Oxyuranus scutellatus) envenoming in Papua New Guinea. PLoS Negl. Trop","volume":"5","author":"Vargas","year":"2011","journal-title":"Dis"},{"key":"10.1016\/j.toxicon.2020.12.015_bib77","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1002\/jps.20065","article-title":"Effect of collapse on the stability of freeze-dried recombinant factor VIII and \u03b1-amylase","volume":"93","author":"Wang","year":"2004","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.toxicon.2020.12.015_bib78","first-page":"38","article-title":"New approaches & technologies of venomics to meet the challenge of human envenoming by snakebites in India. Indian J","volume":"138","author":"Warrell","year":"2013","journal-title":"Med. 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