{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T10:05:34Z","timestamp":1790762734765,"version":"4.1.0"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100010609","name":"Medical University of Gdansk","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010609","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004569","name":"Polish Ministry of Science and Higher Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004569","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicon"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1016\/j.toxicon.2021.02.007","type":"journal-article","created":{"date-parts":[[2021,2,20]],"date-time":"2021-02-20T23:32:35Z","timestamp":1613863955000},"page":"90-97","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Presence of \u00df-N-methylamino-L-alanine in cyanobacteria and aquatic organisms from waters of Northern Poland; BMAA toxicity studies"],"prefix":"10.1016","volume":"194","author":[{"given":"Agata","family":"B\u0142aszczyk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6313-0799","authenticated-orcid":false,"given":"Kamila","family":"Siedlecka-Kroplewska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micha\u0142","family":"Wo\u017aniak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna","family":"Mazur-Marzec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxicon.2021.02.007_bib1","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.jpba.2018.11.033","article-title":"Reactive intermediates and bioactivation pathways characterization of avitinib by LC-MS\/MS: in vitro metabolic investigation","volume":"164","author":"Attwa","year":"2019","journal-title":"J. Pharmaceut. Biomed. Anal."},{"issue":"4","key":"10.1016\/j.toxicon.2021.02.007_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/10937404.2017.1297592","article-title":"A critical review of the postulated role of the non-essential amino acid, \u03b2-N-methylamino-L-alanine, in neurodegenerative disease in humans","volume":"20","author":"Chernoff","year":"2017","journal-title":"J. Toxicol. Environ. Health B."},{"issue":"23","key":"10.1016\/j.toxicon.2021.02.007_bib3","doi-asserted-by":"crossref","first-page":"13380","DOI":"10.1073\/pnas.2235808100","article-title":"Biomagnification of cyanobacterial neurotoxins and neurodegenerative disease among the Chamorro people of Guam","volume":"100","author":"Cox","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"14","key":"10.1016\/j.toxicon.2021.02.007_bib4","doi-asserted-by":"crossref","first-page":"5074","DOI":"10.1073\/pnas.0501526102","article-title":"Diverse taxa of cyanobacteria produce \u03b2-N-methylamino-L-alanine, a neurotoxic amino acid","volume":"102","author":"Cox","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"9","key":"10.1016\/j.toxicon.2021.02.007_bib5","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0075376","article-title":"The non-protein amino acid BMAA is misincorporated into human proteins in place of l-serine causing protein misfolding and aggregation","volume":"8","author":"Dunlop","year":"2013","journal-title":"PloS One"},{"issue":"2","key":"10.1016\/j.toxicon.2021.02.007_bib6","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.ecoenv.2008.04.010","article-title":"\u03b2-N-methylamino-L-alanine (BMAA) in novel South African cyanobacterial isolates","volume":"71","author":"Esterhuizen","year":"2008","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.toxicon.2021.02.007_bib7","first-page":"439","article-title":"SOP 23. Extraction and LC-MS\/MS analysis of underivatised BMAA","author":"Faassen","year":"2017","journal-title":"Handbook of Cyanobacterial Monitoring and Cyanotoxin Analysis"},{"issue":"45","key":"10.1016\/j.toxicon.2021.02.007_bib8","first-page":"1","article-title":"A collaborative evaluation of LC-MS\/MS based methods for BMAA analysis: soluble bound BMAA found to be an important fraction","volume":"14","author":"Faassen","year":"2016","journal-title":"Mar. Drugs"},{"issue":"s2","key":"10.1016\/j.toxicon.2021.02.007_bib9","doi-asserted-by":"crossref","first-page":"79","DOI":"10.3109\/17482960903272967","article-title":"Determination of the neurotoxins BMAA (\u03b2-N-methylamino-L-alanine) and DAB (\u03b1-,\u03b3-, diaminobutyric acid) by LC-MS\/MS in Dutch urban waters with cyanobacterial blooms","volume":"10","author":"Faassen","year":"2009","journal-title":"Amyotroph Lateral Scler."},{"issue":"3\u20134","key":"10.1016\/j.toxicon.2021.02.007_bib10","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/BF00290938","article-title":"Acute bioassays with control mortality","volume":"35","author":"Hoekstra","year":"1987","journal-title":"Water Air Soil Pollut."},{"issue":"1","key":"10.1016\/j.toxicon.2021.02.007_bib11","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0084578","article-title":"Diatoms: a novel source for the neurotoxin BMAA in aquatic environments","volume":"9","author":"Jiang","year":"2014","journal-title":"PloS One"},{"issue":"20","key":"10.1016\/j.toxicon.2021.02.007_bib12","doi-asserted-by":"crossref","first-page":"9252","DOI":"10.1073\/pnas.0914417107","article-title":"Transfer of cyanobacterial neurotoxin within a temperate aquatic ecosystem suggests pathways for human exposure","volume":"107","author":"Jonasson","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.toxicon.2021.02.007_bib13","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1016\/S0043-1354(01)00417-1","article-title":"Toxicity and microcystin content of extracts from a Planktothrix bloom and two laboratory strains","volume":"36","author":"Keil","year":"2002","journal-title":"Water Res."},{"issue":"7","key":"10.1016\/j.toxicon.2021.02.007_bib15","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1016\/j.neurobiolaging.2010.11.024","article-title":"Weak BMAA toxicity compares with that of the dietary supplement beta-alanine","volume":"33","author":"Lee","year":"2012","journal-title":"Neurobiol. Aging"},{"issue":"2","key":"10.1016\/j.toxicon.2021.02.007_bib16","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.nbd.2006.10.002","article-title":"\u03b2-N-methylamino-l-alanine enhances neurotoxicity through multiple mechanisms","volume":"25","author":"Lobner","year":"2007","journal-title":"Neurobiol. Dis."},{"issue":"2","key":"10.1016\/j.toxicon.2021.02.007_bib17","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1093\/plankt\/fbq130","article-title":"Effects of the cyanobacterial neurotoxin\u03b2-N-methylamino-L-alanine (BMAA) on the survival, mobility and reproduction of Daphnia magna","volume":"33","author":"L\u00fcrling","year":"2011","journal-title":"J. Plankton Res."},{"issue":"3","key":"10.1016\/j.toxicon.2021.02.007_bib18","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1111\/j.1462-2920.2007.01492.x","article-title":"Co-occurrence of \u03b2-N-methylamino-L-alanine, a neurotoxic amino acid with other cyanobacterial toxins in British waterbodies, 1990-2004","volume":"10","author":"Metcalf","year":"2008","journal-title":"Environ. Microbiol."},{"issue":"3","key":"10.1016\/j.toxicon.2021.02.007_bib19","doi-asserted-by":"crossref","first-page":"425","DOI":"10.2131\/jts.38.425","article-title":"\u03b2-N-methylamino-L-alanine induces changes in both GSK3 and TDP-43 in human neuroblastoma","volume":"38","author":"Mu\u00f1oz-Saez","year":"2013","journal-title":"J. Toxicol. Sci."},{"issue":"33","key":"10.1016\/j.toxicon.2021.02.007_bib20","doi-asserted-by":"crossref","first-page":"12228","DOI":"10.1073\/pnas.0404926101","article-title":"A mechanism for slow release of biomagnified cyanobacterial neurotoxins and neurodegenerative disease in Guam","volume":"101","author":"Murch","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"4","key":"10.1016\/j.toxicon.2021.02.007_bib21","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.1600-0404.2004.00320.x","article-title":"Occurrence of \u03b2-methylamino-L-alanine (BMAA) in ALS\/PDC patients from Guam","volume":"110","author":"Murch","year":"2004","journal-title":"Acta Neurol. Scand."},{"issue":"5","key":"10.1016\/j.toxicon.2021.02.007_bib22","first-page":"1473","article-title":"Distribution and toxicity of \u03b1-amino-\u03b2-methylamino propionic acid","volume":"31","author":"Polsky","year":"1972","journal-title":"Fed. Proc."},{"key":"10.1016\/j.toxicon.2021.02.007_bib24","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.toxicon.2015.11.008","article-title":"BMAA detected as neither free nor protein bound amino acid in blue mussels","volume":"109","author":"Ros\u00e9n","year":"2016","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2021.02.007_bib25","first-page":"241","article-title":"3-Fluoromethcathinone, a structural analog of mephedrone, inhibits growth and induces cell cycle arrest in HT22 mouse hippocampal cells","volume":"65","author":"Siedlecka-Kroplewska","year":"2014","journal-title":"J. Physiol. Pharmacol."},{"issue":"4814","key":"10.1016\/j.toxicon.2021.02.007_bib27","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1126\/science.3603037","article-title":"Guam amyotrophic lateral sclerosis-parkinsonism-dementia linked to a plant excitant neurotoxin","volume":"237","author":"Spencer","year":"1987","journal-title":"Science"},{"key":"10.1016\/j.toxicon.2021.02.007_bib28","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/S0031-9422(00)86018-5","article-title":"\u03b1-amino-\u03b2-methylaminopropionic acid, a new amino acid from seeds of Cycas circinalis","volume":"6","author":"Vega","year":"1967","journal-title":"Phytochemistry"},{"key":"10.1016\/j.toxicon.2021.02.007_bib29","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-46815-3","article-title":"Insufficient evidence for BMAA transfer in the pelagic and benthic food webs in the Baltic Sea","volume":"9","author":"Zguna","year":"2019","journal-title":"Sci. Rep."},{"issue":"Suppl. 2","key":"10.1016\/j.toxicon.2021.02.007_bib30","doi-asserted-by":"crossref","first-page":"61","DOI":"10.3109\/17482960903273445","article-title":"BMAA neurotoxicity in Drosophila","volume":"10","author":"Zhou","year":"2009","journal-title":"Amyotroph Lateral Scler."}],"container-title":["Toxicon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004101012100057X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004101012100057X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T21:18:11Z","timestamp":1758575891000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S004101012100057X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":27,"alternative-id":["S004101012100057X"],"URL":"https:\/\/doi.org\/10.1016\/j.toxicon.2021.02.007","relation":{},"ISSN":["0041-0101"],"issn-type":[{"value":"0041-0101","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Presence of \u00df-N-methylamino-L-alanine in cyanobacteria and aquatic organisms from waters of Northern Poland; BMAA toxicity studies","name":"articletitle","label":"Article Title"},{"value":"Toxicon","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxicon.2021.02.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}