{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T02:06:08Z","timestamp":1793066768318,"version":"4.5.0"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["SFRH\/BPD\/98304\/2013"],"award-info":[{"award-number":["SFRH\/BPD\/98304\/2013"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005639","name":"Universidade de S\u00e3o Paulo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005639","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015621","name":"Applied Molecular Biosciences Unit","doi-asserted-by":"publisher","award":["UIDP\/04378\/2020"],"award-info":[{"award-number":["UIDP\/04378\/2020"]}],"id":[{"id":"10.13039\/501100015621","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015621","name":"Applied Molecular Biosciences Unit","doi-asserted-by":"publisher","award":["UIDB\/04378\/2020"],"award-info":[{"award-number":["UIDB\/04378\/2020"]}],"id":[{"id":"10.13039\/501100015621","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2017\/25532-6"],"award-info":[{"award-number":["2017\/25532-6"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicon"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.toxicon.2021.07.003","type":"journal-article","created":{"date-parts":[[2021,7,12]],"date-time":"2021-07-12T01:49:30Z","timestamp":1626054570000},"page":"69-77","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["The anti-cancer potential of crotoxin in estrogen receptor-positive breast cancer: Its effects and mechanism of action"],"prefix":"10.1016","volume":"200","author":[{"given":"Cristina Ferreira","family":"Almeida","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Amaral","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiago V.","family":"Augusto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgina","family":"Correia-da-Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila","family":"Marques de Andrade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Regina","family":"Torqueti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nat\u00e9rcia","family":"Teixeira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxicon.2021.07.003_bib1","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.biochi.2020.11.023","article-title":"Discovery of a multi-target compound for estrogen receptor-positive (ER(+)) breast cancer: involvement of aromatase and ERs","volume":"181","author":"Almeida","year":"2021","journal-title":"Biochimie"},{"key":"10.1016\/j.toxicon.2021.07.003_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2019.165661","article-title":"The potential clinical benefit of targeting androgen receptor (AR) in estrogen-receptor positive breast cancer cells treated with Exemestane","volume":"1866","author":"Amaral","year":"2020","journal-title":"Biochim. Biophys. Acta (BBA) - Mol. Basis Dis."},{"key":"10.1016\/j.toxicon.2021.07.003_bib3","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jsbmb.2018.05.006","article-title":"Hormone-dependent breast cancer: targeting autophagy and PI3K overcomes Exemestane-acquired resistance","volume":"183","author":"Amaral","year":"2018","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.toxicon.2021.07.003_bib4","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0042398","article-title":"Apoptosis and autophagy in breast cancer cells following exemestane treatment","volume":"7","author":"Amaral","year":"2012","journal-title":"PloS One"},{"key":"10.1016\/j.toxicon.2021.07.003_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.jsbmb.2021.105876","article-title":"Unveiling the mechanism of action behind the anti-cancer properties of cannabinoids in ER(+) breast cancer cells: impact on aromatase and steroid receptors","volume":"210","author":"Amaral","year":"2021","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.toxicon.2021.07.003_bib6","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.jsbmb.2017.04.002","article-title":"Anti-tumor efficacy of new 7alpha-substituted androstanes as aromatase inhibitors in hormone-sensitive and resistant breast cancer cells","volume":"171","author":"Amaral","year":"2017","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.toxicon.2021.07.003_bib7","doi-asserted-by":"crossref","first-page":"R283","DOI":"10.1530\/ERC-17-0425","article-title":"Acquired resistance to aromatase inhibitors: where we stand!","volume":"25","author":"Augusto","year":"2018","journal-title":"Endocr. Relat. Canc."},{"key":"10.1016\/j.toxicon.2021.07.003_bib8","doi-asserted-by":"crossref","first-page":"285","DOI":"10.3747\/co.25.4139","article-title":"Endocrine therapy for breast cancer in the primary care setting","volume":"25","author":"Awan","year":"2018","journal-title":"Curr. Oncol."},{"key":"10.1016\/j.toxicon.2021.07.003_bib9","doi-asserted-by":"crossref","first-page":"308","DOI":"10.3389\/fonc.2018.00308","article-title":"Current landscape of targeted therapies for hormone-receptor positive, HER2 negative metastatic breast cancer","volume":"8","author":"Ballinger","year":"2018","journal-title":"Front Oncol"},{"key":"10.1016\/j.toxicon.2021.07.003_bib10","doi-asserted-by":"crossref","first-page":"2496","DOI":"10.1073\/pnas.83.8.2496","article-title":"Phenol red in tissue culture media is a weak estrogen: implications concerning the study of estrogen-responsive cells in culture","volume":"83","author":"Berthois","year":"1986","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.toxicon.2021.07.003_bib11","first-page":"394","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.toxicon.2021.07.003_bib12","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/2457532","article-title":"Walker 256 tumor growth suppression by crotoxin involves formyl peptide receptors and lipoxin A4","volume":"2016","author":"Brigatte","year":"2016","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.toxicon.2021.07.003_bib13","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/203639","article-title":"Antitumoral activity of snake venom proteins: new trends in cancer therapy","volume":"2014","author":"Calderon","year":"2014","journal-title":"BioMed Res. Int."},{"issue":"12","key":"10.1016\/j.toxicon.2021.07.003_bib14","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1016\/j.annonc.2020.09.010","article-title":"5th ESO-ESMO international consensus guidelines for advanced breast cancer (ABC 5)(dagger)","volume":"31","author":"Cardoso","year":"2020","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.toxicon.2021.07.003_bib15","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1093\/annonc\/mdy192","article-title":"4th ESO-ESMO international consensus guidelines for advanced breast cancer (ABC 4)dagger","volume":"29","author":"Cardoso","year":"2018","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.toxicon.2021.07.003_bib16","first-page":"429","article-title":"Effect of crotapotin on the biological activity of Asp49 and Lys49 phospholipases A(2) from Bothrops snake venoms. Comparative biochemistry and physiology","volume":"138","author":"Cecchini","year":"2004","journal-title":"Toxicology & pharmacology : CBP"},{"key":"10.1016\/j.toxicon.2021.07.003_bib17","first-page":"1571","article-title":"Effects of animal venoms and toxins on hallmarks of cancer","volume":"7","author":"Chaisakul","year":"2016","journal-title":"J. Canc."},{"key":"10.1016\/j.toxicon.2021.07.003_bib18","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.jsbmb.2015.07.018","article-title":"Structural and functional characterization of aromatase, estrogen receptor, and their genes in endocrine-responsive and -resistant breast cancer cells","volume":"161","author":"Chan","year":"2016","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.toxicon.2021.07.003_bib19","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1038\/sj.leu.2402824","article-title":"Involvement of PI3K\/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy","volume":"17","author":"Chang","year":"2003","journal-title":"Leukemia"},{"key":"10.1016\/j.toxicon.2021.07.003_bib20","first-page":"119","article-title":"Aromatase inhibitors and breast cancer","volume":"9","author":"Chumsri","year":"2012","journal-title":"Horm. Mol. Biol. Clin. Invest."},{"key":"10.1016\/j.toxicon.2021.07.003_bib21","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/BF00873905","article-title":"Cytotoxicity of crotoxin on murine erythroleukemia cells in vitro","volume":"11","author":"Corin","year":"1993","journal-title":"Invest. N. Drugs"},{"key":"10.1016\/j.toxicon.2021.07.003_bib22","first-page":"1033","article-title":"Phase I and pharmacokinetics study of crotoxin (cytotoxic PLA(2), NSC-624244) in patients with advanced cancer","volume":"8","author":"Cura","year":"2002","journal-title":"Clin. Canc. Res."},{"key":"10.1016\/j.toxicon.2021.07.003_bib23","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.ijbiomac.2019.05.018","article-title":"Crotoxin, a neurotoxin from Crotalus durissus terrificus snake venom, as a potential tool against thrombosis development","volume":"134","author":"de Andrade","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.toxicon.2021.07.003_bib24","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.ijbiomac.2019.05.019","article-title":"Effects of crotoxin, a neurotoxin from Crotalus durissus terrificus snake venom, on human endothelial cells","volume":"134","author":"de Andrade","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.toxicon.2021.07.003_bib25","first-page":"3512","article-title":"To arrest or not to G(2)-M Cell-cycle arrest : commentary re: A. K. Tyagi et al., Silibinin strongly synergizes human prostate carcinoma DU145 cells to doxorubicin-induced growth inhibition, G(2)-M arrest, and apoptosis","volume":"8","author":"DiPaola","year":"2002","journal-title":"Clin. Canc. Res."},{"key":"10.1016\/j.toxicon.2021.07.003_bib26","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1083\/jcb.200804038","article-title":"Erk1\/2 MAP kinases are required for epidermal G2\/M progression","volume":"185","author":"Dumesic","year":"2009","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.toxicon.2021.07.003_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2020.113989","article-title":"Estrogen receptor-positive (ER(+)) breast cancer treatment: are multi-target compounds the next promising approach?","volume":"177","author":"Ferreira Almeida","year":"2020","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.toxicon.2021.07.003_bib28","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1038\/aps.2014.62","article-title":"Crotoxin induces apoptosis and autophagy in human lung carcinoma cells in vitro via activation of the p38MAPK signaling pathway","volume":"35","author":"Han","year":"2014","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.toxicon.2021.07.003_bib29","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/aps.2012.156","article-title":"Growth inhibitory effects and molecular mechanisms of crotoxin treatment in esophageal Eca-109 cells and transplanted tumors in nude mice","volume":"34","author":"He","year":"2013","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.toxicon.2021.07.003_bib30","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1073\/pnas.68.7.1560","article-title":"Biological roles of the two components of crotoxin","volume":"68","author":"Hendon","year":"1971","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.toxicon.2021.07.003_bib31","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1111\/j.1749-6632.2009.03703.x","article-title":"Molecular characterization of aromatase","volume":"1155","author":"Hong","year":"2009","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.toxicon.2021.07.003_bib32","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1158\/1541-7786.MCR-04-0122","article-title":"Letrozole-, anastrozole-, and tamoxifen-responsive genes in MCF-7aro cells: a microarray approach","volume":"3","author":"Itoh","year":"2005","journal-title":"Mol. Canc. Res."},{"key":"10.1016\/j.toxicon.2021.07.003_bib33","doi-asserted-by":"crossref","first-page":"4855","DOI":"10.7314\/APJCP.2012.13.10.4855","article-title":"Snake venom: a potent anticancer agent","volume":"13","author":"Jain","year":"2012","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"10.1016\/j.toxicon.2021.07.003_bib34","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1073\/pnas.75.2.600","article-title":"Search for relationships among the hemolytic, phospholipolytic, and neurotoxic activities of snake venoms","volume":"75","author":"Jeng","year":"1978","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.toxicon.2021.07.003_bib35","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1186\/s12964-019-0438-z","article-title":"Distribution, dynamics and functional roles of phosphatidylserine within the cell","volume":"17","author":"Kay","year":"2019","journal-title":"Cell Commun. Signal. : CCS"},{"key":"10.1016\/j.toxicon.2021.07.003_bib36","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/0041-0101(94)90111-2","article-title":"Crotoxin induces aggregation of human washed platelets","volume":"32","author":"Landucci","year":"1994","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2021.07.003_bib37","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s10549-005-9011-0","article-title":"EGFR signaling pathway in breast cancers: from traditional signal transduction to direct nuclear translocalization","volume":"95","author":"Lo","year":"2006","journal-title":"Breast Canc. Res. Treat."},{"key":"10.1016\/j.toxicon.2021.07.003_bib38","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.molonc.2013.11.003","article-title":"pERK 1\/2 inhibit Caspase-8 induced apoptosis in cancer cells by phosphorylating it in a cell cycle specific manner","volume":"8","author":"Mandal","year":"2014","journal-title":"Mol. Oncol."},{"key":"10.1016\/j.toxicon.2021.07.003_bib39","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.ejca.2018.06.009","article-title":"Prevalence and risk factors for fatigue among breast cancer survivors on aromatase inhibitors","volume":"101","author":"Mao","year":"2018","journal-title":"Eur. J. Canc."},{"key":"10.1016\/j.toxicon.2021.07.003_bib40","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1002\/prot.21980","article-title":"Insights into the role of oligomeric state on the biological activities of crotoxin: crystal structure of a tetrameric phospholipase A2 formed by two isoforms of crotoxin B from Crotalus durissus terrificus venom","volume":"72","author":"Marchi-Salvador","year":"2008","journal-title":"Proteins"},{"key":"10.1016\/j.toxicon.2021.07.003_bib41","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a008656","article-title":"Caspase functions in cell death and disease","volume":"5","author":"McIlwain","year":"2013","journal-title":"Cold Spring Harb Perspect. Biol."},{"key":"10.1016\/j.toxicon.2021.07.003_bib42","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.conctc.2017.07.008","article-title":"Innovative design for a phase 1 trial with intra-patient dose escalation: the Crotoxin study","volume":"7","author":"Medioni","year":"2017","journal-title":"Contemp. Clin. Trials Commun."},{"key":"10.1016\/j.toxicon.2021.07.003_bib43","doi-asserted-by":"crossref","first-page":"2897","DOI":"10.1007\/s00018-008-8113-3","article-title":"Cellular pathology induced by snake venom phospholipase A2 myotoxins and neurotoxins: common aspects of their mechanisms of action","volume":"65","author":"Montecucco","year":"2008","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.toxicon.2021.07.003_bib44","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s10495-005-6076-5","article-title":"Dynamics of membrane translocation of phosphatidylserine during apoptosis detected by a monoclonal antibody","volume":"10","author":"Mourdjeva","year":"2005","journal-title":"Apoptosis : an international journal on programmed cell death"},{"key":"10.1016\/j.toxicon.2021.07.003_bib45","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.toxicon.2018.10.306","article-title":"Crotoxin from Crotalus durissus terrificus venom: in vitro cytotoxic activity of a heterodimeric phospholipase A2 on human cancer-derived cell lines","volume":"156","author":"Muller","year":"2018","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2021.07.003_bib46","doi-asserted-by":"crossref","first-page":"894","DOI":"10.2174\/092986609788923266","article-title":"Snake venom phospholipases A2: a new class of antitumor agents","volume":"16","author":"Rodrigues","year":"2009","journal-title":"Protein Pept. Lett."},{"key":"10.1016\/j.toxicon.2021.07.003_bib47","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.toxicon.2010.01.011","article-title":"Crotoxin: novel activities for a classic beta-neurotoxin","volume":"55","author":"Sampaio","year":"2010","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2021.07.003_bib48","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1038\/cdd.2014.216","article-title":"Old, new and emerging functions of caspases","volume":"22","author":"Shalini","year":"2015","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.toxicon.2021.07.003_bib49","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.toxicon.2003.11.004","article-title":"Chemical modifications of phospholipases A2 from snake venoms: effects on catalytic and pharmacological properties","volume":"42","author":"Soares","year":"2003","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2021.07.003_bib50","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1590\/S1678-91992010000300015","article-title":"Crotalus durissus terrificus venom as a source of antitumoral agents","volume":"16","author":"Soares Ma","year":"2010","journal-title":"J. Venom. Anim. Toxins Incl. Trop. Dis."},{"key":"10.1016\/j.toxicon.2021.07.003_bib51","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.2174\/1389201017666160808154250","article-title":"Antitumoral potential of snake venom phospholipases A2 and synthetic peptides","volume":"17","author":"Sobrinho","year":"2016","journal-title":"Curr. Pharmaceut. Biotechnol."},{"key":"10.1016\/j.toxicon.2021.07.003_bib52","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1023\/A:1016119328968","article-title":"Poly(ADP-ribose) polymerase-1 cleavage during apoptosis: an update","volume":"7","author":"Soldani","year":"2002","journal-title":"Apoptosis : an international journal on programmed cell death"},{"key":"10.1016\/j.toxicon.2021.07.003_bib53","first-page":"35","article-title":"The expression patterns of ER, PR, HER2, CK5\/6, EGFR, Ki-67 and AR by immunohistochemical analysis in breast cancer cell lines","volume":"4","author":"Subik","year":"2010","journal-title":"Breast Canc. Basic Clin. Res."},{"key":"10.1016\/j.toxicon.2021.07.003_bib54","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0960-0760(97)00068-X","article-title":"Autocrine and paracrine actions of breast tumor aromatase. A three-dimensional cell culture study involving aromatase transfected MCF-7 and T-47D cells","volume":"63","author":"Sun","year":"1997","journal-title":"J. Steroid Biochem. Mol. Biol."},{"issue":"3","key":"10.1016\/j.toxicon.2021.07.003_bib55","first-page":"209","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.toxicon.2021.07.003_bib56","doi-asserted-by":"crossref","first-page":"3009","DOI":"10.3892\/mmr.2014.2620","article-title":"Crotoxin suppresses the tumorigenic properties and enhances the antitumor activity of Iressa\u00ae (gefinitib) in human lung adenocarcinoma SPCA-1 cells","volume":"10","author":"Wang","year":"2014","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.toxicon.2021.07.003_bib57","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.toxicon.2006.01.010","article-title":"Contributions of autophagic and apoptotic mechanisms to CrTX-induced death of K562 cells","volume":"47","author":"Yan","year":"2006","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2021.07.003_bib58","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1111\/j.1745-7254.2007.00530.x","article-title":"Autophagy is involved in cytotoxic effects of crotoxin in human breast cancer cell line MCF-7 cells","volume":"28","author":"Yan","year":"2007","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.toxicon.2021.07.003_bib59","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1038\/aps.2011.116","article-title":"Anti-tumor activity of CrTX in human lung adenocarcinoma cell line A549","volume":"32","author":"Ye","year":"2011","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.toxicon.2021.07.003_bib60","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/sj.cr.7290105","article-title":"MAPK signal pathways in the regulation of cell proliferation in mammalian cells","volume":"12","author":"Zhang","year":"2002","journal-title":"Cell Res."},{"key":"10.1016\/j.toxicon.2021.07.003_bib61","first-page":"6949","article-title":"Stable expression of human aromatase complementary DNA in mammalian cells: a useful system for aromatase inhibitor screening","volume":"50","author":"Zhou","year":"1990","journal-title":"Canc. Res."}],"container-title":["Toxicon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010121001999?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010121001999?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:22:07Z","timestamp":1777458127000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041010121001999"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":61,"alternative-id":["S0041010121001999"],"URL":"https:\/\/doi.org\/10.1016\/j.toxicon.2021.07.003","relation":{},"ISSN":["0041-0101"],"issn-type":[{"value":"0041-0101","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The anti-cancer potential of crotoxin in estrogen receptor-positive breast cancer: Its effects and mechanism of action","name":"articletitle","label":"Article Title"},{"value":"Toxicon","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxicon.2021.07.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}