{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:18:10Z","timestamp":1790209090285,"version":"4.1.0"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,8,5]],"date-time":"2023-08-05T00:00:00Z","timestamp":1691193600000},"content-version":"vor","delay-in-days":308,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicon"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.toxicon.2022.07.009","type":"journal-article","created":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T11:32:16Z","timestamp":1659439936000},"page":"5-12","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Utilization of gallic acid to inhibit some toxic activities caused by Bothrops jararaca or B. jararacussu snake venoms"],"prefix":"10.1016","volume":"217","author":[{"given":"Luiz Carlos","family":"Simas Pereira Junior","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenifer Frouche","family":"Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Cl\u00e1udia","family":"Rodrigues da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Coriolano de Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eladio Flores","family":"Sanchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 Lopes","family":"Fuly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.toxicon.2022.07.009_bib1","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1590\/s1984-82502016000300015","article-title":"Formulation and evaluation of topical herbal gel for the treatment of arthritis in animal model","volume":"52","author":"Aiyalu","year":"2016","journal-title":"Braz J Pharmac Scienc"},{"key":"10.1016\/j.toxicon.2022.07.009_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2020.114135","article-title":"Snake antivenom: challenges and alternate approaches","volume":"181","author":"Alangode","year":"2020","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.toxicon.2022.07.009_bib3","doi-asserted-by":"crossref","first-page":"27540","DOI":"10.1039\/C5RA01911G","article-title":"Gallic acid: a versatile antioxidant with promising therapeutic and industrial applications","volume":"5","author":"Badhani","year":"2015","journal-title":"RSC Adv."},{"key":"10.1016\/j.toxicon.2022.07.009_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110985","article-title":"Gallic acid: pharmacological activities and molecular mechanisms involved in inflammation-related diseases","volume":"133","author":"Bai","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.toxicon.2022.07.009_bib5","doi-asserted-by":"crossref","first-page":"708\u00f1711","DOI":"10.1590\/S1517-83822008000400021","article-title":"A new approach to microbial production of gallic acid","volume":"39","author":"Bajpai","year":"2008","journal-title":"Braz. J. Microbiol."},{"key":"10.1016\/j.toxicon.2022.07.009_bib6","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1002\/mabi.201200017","article-title":"Poly(2-ethyl-2-oxazoline) as alternative for the stealth polymer poly(ethylene glycol): comparison of in vitro cytotoxicity and hemocompatibility","volume":"12","author":"Bauer","year":"2012","journal-title":"Macromol. Biosci."},{"key":"10.1016\/j.toxicon.2022.07.009_bib7","series-title":"Farmacopeia Brasileira. Ag\u00eancia Nacional de Vigil\u00e2ncia Sanit\u00e1ria","first-page":"546","year":"2010"},{"key":"10.1016\/j.toxicon.2022.07.009_bib8","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/683872","article-title":"Gallic acid attenuates platelet activation and platelet-leukocyte aggregation: involving pathways of Akt and GSK3","volume":"2012","author":"Chang","year":"2012","journal-title":"Evid Based Complement Alternat Med"},{"key":"10.1016\/j.toxicon.2022.07.009_bib9","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.2174\/1389557518666180330114010","article-title":"Probing gallic acid for its broad spectrum applications","volume":"18","author":"Choubey","year":"2018","journal-title":"Mini Rev. Med. Chem."},{"key":"10.1016\/j.toxicon.2022.07.009_bib10","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.ijbiomac.2021.06.163","article-title":"Gallic acid anti-myotoxic activity and mechanism of action, a snake venom phospholipase A2 toxin inhibitor, isolated from the medicinal plant Anacardium humile","volume":"185","author":"Costa","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"issue":"2","key":"10.1016\/j.toxicon.2022.07.009_bib11","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.toxicon.2007.03.010","article-title":"Evaluation of three Brazilian antivenom ability to antagonize myonecrosis and hemorrhage induced by Bothrops snake venoms in a mouse model","volume":"50","author":"da Silva","year":"2007","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2022.07.009_bib12","article-title":"Potential use of extract of the plant Schwartiza brasiliensis (choisy) bedell exgir.-Ca\u00f1as against the toxic effects of the venom of Bothrops jararaca or","volume":"125","author":"de Souza","year":"2020","journal-title":"B. jararacussu. Biomed Pharmacother."},{"key":"10.1016\/j.toxicon.2022.07.009_bib13","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/180981","article-title":"Medicinal plants in the prevention and treatment of chronic diseases","volume":"2014","author":"Eddouks","year":"2014","journal-title":"Evid Based Complement Alternat Med"},{"key":"10.1016\/j.toxicon.2022.07.009_bib14","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1055\/s-0038-1665414","article-title":"Mechanism of inhibitory action on platelet activation of a phospholipase A2 isolated from Lachesis muta (Bushmaster) snake venom","volume":"78","author":"Fuly","year":"1997","journal-title":"Thromb. Haemostasis"},{"key":"10.1016\/j.toxicon.2022.07.009_bib15","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S0003-9861(78)80015-0","article-title":"Purification and characterization of a sulfhydryl-dependent protease from Rhodnius prolixus midgut","volume":"188","author":"Garcia","year":"1978","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.toxicon.2022.07.009_bib16","series-title":"Handbook of Venoms and Toxins of Reptiles","first-page":"471","article-title":"Snakebite envenomation as a neglected tropical disease: new impetus for confronting an old scourge","author":"Gutierrez","year":"2021"},{"key":"10.1016\/j.toxicon.2022.07.009_bib17","first-page":"1","article-title":"Snakebite envenoming","volume":"3","author":"Guti\u00e9rrez","year":"2017","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.toxicon.2022.07.009_bib18","article-title":"Snakebite envenoming in different national contexts: Costa Rica, Sri Lanka, and Nigeria","volume":"9\u201310","author":"Guti\u00e9rrez","year":"2021","journal-title":"Toxicon X"},{"key":"10.1016\/j.toxicon.2022.07.009_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.toxcx.2021.100079","article-title":"Clinical management of snakebite envenoming: future perspectives","volume":"11","author":"Hamza","year":"2021","journal-title":"Toxicon X"},{"key":"10.1016\/j.toxicon.2022.07.009_bib20","first-page":"225","article-title":"Pharmacological effects of gallic acid in health and diseases: a mechanistic review","volume":"22","author":"Kahkeshani","year":"2019","journal-title":"Iran J Basic Med Sci"},{"key":"10.1016\/j.toxicon.2022.07.009_bib21","doi-asserted-by":"crossref","first-page":"43","DOI":"10.7883\/yoken1952.13.43","article-title":"Studies on the quantitative method for determination of hemorrhagic activity of Habu snake venom","volume":"13","author":"Kondo","year":"1960","journal-title":"Jpn. J. Med. Sci. Biol."},{"key":"10.1016\/j.toxicon.2022.07.009_bib22","doi-asserted-by":"crossref","first-page":"2520","DOI":"10.2174\/156802611797633447","article-title":"The polyphenol 3, 4, 5 - tri-hydroxy benzoic acid inhibits indian daboia russelli venom and its hemorrhagic complex induced local toxicity","volume":"11","author":"Mahadeswaraswamy","year":"2011","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.toxicon.2022.07.009_bib23","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/S0031-9422(00)00229-6","article-title":"Plant natural products active against snake bite--the molecular approach","volume":"55","author":"Mors","year":"2000","journal-title":"Phytochemistry"},{"issue":"3","key":"10.1016\/j.toxicon.2022.07.009_bib24","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1021\/acs.jnatprod.9b01285","article-title":"Natural products as sources of new drugs over the nearly four decades from 01\/1981 to 09\/2019","volume":"27;83","author":"Newman","year":"2020","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.toxicon.2022.07.009_bib25","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/S0278-6915(01)00054-0","article-title":"Subchronic toxicity study of gallic acid by oral administration in F344 rats","volume":"39","author":"Niho","year":"2001","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.toxicon.2022.07.009_bib26","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1080\/15563650.2020.1837386","article-title":"Acute hypersensitivity reaction from administration of crotalidae immune F(ab\u00ed)2 antivenom","volume":"59","author":"Ontiveros","year":"2021","journal-title":"Clin. Toxicol."},{"key":"10.1016\/j.toxicon.2022.07.009_bib27","first-page":"1","article-title":"Improving bioavailability of gallic acid and quercetin by designing polymeric nanoparticle formulation","volume":"21","author":"Patil","year":"2021","journal-title":"Drug Dev. Ind. Pharm."},{"key":"10.1016\/j.toxicon.2022.07.009_bib28","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.toxicon.2020.08.011","article-title":"The plant Stryphnodendron adstringens (Mart.) Coville as a neutralizing source against some toxic activities of Bothrops jararacussu snake venom","volume":"186","author":"Pereira","year":"2020","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2022.07.009_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4103\/0973-7847.95849","article-title":"Historical review of medicinal plants\u00ed usage","volume":"6","author":"Petrovska","year":"2012","journal-title":"Phcog. Rev."},{"key":"10.1016\/j.toxicon.2022.07.009_bib30","doi-asserted-by":"crossref","first-page":"2662","DOI":"10.3390\/molecules23102662","article-title":"Inhibition of a snake venom metalloproteinase by the flavonoid myricetin","volume":"23","author":"Preciado","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.toxicon.2022.07.009_bib31","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/j.toxicon.2008.10.002","article-title":"Interspecific variation in venom composition and toxicity of Brazilian snakes from Bothrops genus","volume":"52","author":"Queiroz","year":"2008","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2022.07.009_bib32","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.2174\/138945011798109473","article-title":"Biodiversity and chemodiversity: future perspectives in bioprospecting","volume":"12","author":"Ramesha","year":"2011","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.toxicon.2022.07.009_bib33","doi-asserted-by":"crossref","DOI":"10.1590\/1678-9199-jvatitd-1493-18","article-title":"Effects of copaiba oil on dermonecrosis induced by Loxosceles intermedia venom","volume":"25","author":"Ribeiro","year":"2019","journal-title":"J. Venom. Anim. Toxins Incl. Trop. Dis."},{"key":"10.1016\/j.toxicon.2022.07.009_bib34","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.828269","article-title":"The bioflavonoids rutin and rutin succinate neutralize the toxins of B. jararaca venom and inhibit its lethality","volume":"13","author":"Sachetto","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"113","key":"10.1016\/j.toxicon.2022.07.009_bib35","first-page":"1000113","article-title":"Therapeutic effects of gallic acid: current scenario","volume":"2","author":"Samad","year":"2018","journal-title":"J Phytochem Biochem"},{"key":"10.1016\/j.toxicon.2022.07.009_bib36","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1038\/nm.2382","article-title":"A pharmacological approach to first aid treatment for snakebite","volume":"17","author":"Saul","year":"2011","journal-title":"Nat Med"},{"key":"10.1016\/j.toxicon.2022.07.009_bib37","article-title":"Snakebite crisis gets US$100-million boost for better antivenoms","volume":"16","author":"Schiermeier","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.toxicon.2022.07.009_bib39","doi-asserted-by":"crossref","first-page":"368","DOI":"10.3390\/pharmaceutics14020368","article-title":"Gallic acid as a non-selective inhibitor of -hydrolase fold enzymes involved in the inflammatory process: the two sides of the same coin","volume":"14","author":"Toyama","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.toxicon.2022.07.009_bib40","doi-asserted-by":"crossref","first-page":"5020","DOI":"10.1007\/s11356-015-4098-2","article-title":"Acute toxicity and sublethal effects of gallic and pelargonic acids on the zebrafish Danio rerio","volume":"22","author":"Techer","year":"2015","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.toxicon.2022.07.009_bib41","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/j.ijbiomac.2018.03.164","article-title":"Thrombin-like enzymes from snake venom: structural characterization and mechanism of action","volume":"114","author":"Ullah","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"issue":"8","key":"10.1016\/j.toxicon.2022.07.009_bib42","article-title":"Pharmacological approaches that slow lymphatic flow as a snakebite first aid","volume":"27","author":"van Helden","year":"2014","journal-title":"PLoS Neglected Trop. Dis."},{"key":"10.1016\/j.toxicon.2022.07.009_bib43","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/0041-0101(87)90286-8","article-title":"Characterization of three edema-inducing phospholipase A2 enzymes from habu (Trimeresurus flavoviridis) venom and their interaction with the alkaloid aristolochic acid","volume":"25","author":"Vishwanath","year":"1987","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2022.07.009_bib45","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/3208634","article-title":"An ethnobotanical study of traditional knowledge and uses of medicinal wild plants among the Marakwet community in Kenya","author":"Wanjohi","year":"2020","journal-title":"Evid Bas Complement Alternat Med"},{"key":"10.1016\/j.toxicon.2022.07.009_bib46","series-title":"Snakebite Envenoming","author":"Who","year":"2019"},{"key":"10.1016\/j.toxicon.2022.07.009_bib48","article-title":"Functional and binding studies of gallic acid showing platelet aggregation inhibitory effect as a thrombin inhibitor","author":"Zhang","year":"2021","journal-title":"Chin Herbal Medic"},{"key":"10.1016\/j.toxicon.2022.07.009_bib38","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1504\/IJBRA.2015.073239","article-title":"Docking analysis of gallic acid derivatives as HIV-1 protease inhibitors","volume":"11","author":"Singh","year":"2015","journal-title":"Int. J. Bioinf. Res. Appl."},{"key":"10.1016\/j.toxicon.2022.07.009_bib44","doi-asserted-by":"crossref","first-page":"662966","DOI":"10.3389\/fmicb.2021.662966","article-title":"Effects of gallic acid on fermentation parameters, protein fraction, and bacterial community of whole plant soybean silage","volume":"12","author":"Wang","year":"2021","journal-title":"Front. Microbiol."},{"issue":"4","key":"10.1016\/j.toxicon.2022.07.009_bib47","first-page":"482","article-title":"Influence of gallic and tannic acids on enzymatic activity and growth of Pectobacterium chrysanthemi (Dickeya chrysanthemi bv. chrysanthemi)","volume":"7","author":"Zaidi-Yahiaoui","year":"2008","journal-title":"Afr. J. Biotechnol."}],"container-title":["Toxicon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010122002239?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010122002239?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T21:21:11Z","timestamp":1758576071000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041010122002239"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":48,"alternative-id":["S0041010122002239"],"URL":"https:\/\/doi.org\/10.1016\/j.toxicon.2022.07.009","relation":{},"ISSN":["0041-0101"],"issn-type":[{"value":"0041-0101","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Utilization of gallic acid to inhibit some toxic activities caused by Bothrops jararaca or B. jararacussu snake venoms","name":"articletitle","label":"Article Title"},{"value":"Toxicon","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxicon.2022.07.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}