{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:03:33Z","timestamp":1787238213501,"version":"build-2736575974"},"reference-count":65,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicon"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1016\/j.toxicon.2022.106934","type":"journal-article","created":{"date-parts":[[2022,10,3]],"date-time":"2022-10-03T02:18:41Z","timestamp":1664763521000},"page":"106934","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Kochiae Fructus: Evaluation on the antioxidant properties and oral safety of its water decoction"],"prefix":"10.1016","volume":"219","author":[{"given":"Xue-Lin","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-hong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han-Lei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Mei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxicon.2022.106934_bib1","first-page":"286","article-title":"Use of Strychnos nux-vomica (Azraqi) seeds in Unani system of medicine: role of detoxification","volume":"7","author":"Akbar","year":"2010","journal-title":"Afr. J. Tradit., Complementary Altern. Med."},{"key":"10.1016\/j.toxicon.2022.106934_bib2","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.jsps.2012.05.002","article-title":"Review on in vivo and in vitro methods evaluation of antioxidant activity","volume":"21","author":"Alam","year":"2013","journal-title":"Saudi Pharmaceut. J."},{"key":"10.1016\/j.toxicon.2022.106934_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/bs.afnr.2019.02.011","article-title":"Natural antioxidants of plant origin","volume":"90","author":"Amarowicz","year":"2019","journal-title":"Adv. Food Nutr. Res."},{"key":"10.1016\/j.toxicon.2022.106934_bib4","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1177\/0960327120952140","article-title":"An approach to evaluating the potential teratogenic and neurotoxic mechanism of BHA based on apoptosis induced by oxidative stress in zebrafish embryo (Danio rerio)","volume":"40","author":"Baran","year":"2021","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.toxicon.2022.106934_bib5","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.forsciint.2012.06.016","article-title":"Aconite poisoning following the percutaneous absorption of Aconitum alkaloids","volume":"223","author":"Chan","year":"2012","journal-title":"Forensic Sci. Int."},{"key":"10.1016\/j.toxicon.2022.106934_bib6","first-page":"91","article-title":"The antioxidant activity of Kochia scoparia extracts and their ferulic acid derivatives in vitro","volume":"37","author":"Cheng","year":"2016","journal-title":"J. Henan Univ. Technol., Nat. Sci. Ed."},{"key":"10.1016\/j.toxicon.2022.106934_bib7","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.3390\/molecules21101378","article-title":"The inhibition effect of cell DNA oxidative damage and LDL oxidation by bovine colostrums","volume":"21","author":"Chen","year":"2016","journal-title":"Molecules"},{"key":"10.1016\/j.toxicon.2022.106934_bib8","first-page":"8","article-title":"Inhibition of immediate and delayed type hypersensitivity by the 70% ethanolic extract from Fructus Kochiae","volume":"1","author":"Dai","year":"2001","journal-title":"Chin. J. Mod. Appl. Pharm."},{"key":"10.1016\/j.toxicon.2022.106934_bib9","first-page":"21","article-title":"Studies on the hypoglycemic mechanism of n-butanol fraction from Fructus Kochiae","volume":"19","author":"Dai","year":"2003","journal-title":"Pharmacol. Clin. Chin. Mater. Med."},{"key":"10.1016\/j.toxicon.2022.106934_bib10","article-title":"The relationship between traditional Chinese medicine and modern medicine","volume":"2013","author":"Dong","year":"2013","journal-title":"J. Evidence-Based Complementary Altern. Med."},{"key":"10.1016\/j.toxicon.2022.106934_bib11","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.xphs.2017.09.022","article-title":"The Use of a 2,2\u2019-Azobis (2-Amidinopropane) Dihydrochloride stress model as an indicator of oxidation susceptibility for monoclonal antibodies","volume":"107","author":"Dion","year":"2018","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.toxicon.2022.106934_bib12","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.foodchem.2014.08.016","article-title":"Structural characterisation, physicochemical properties and antioxidant activity of polysaccharide from Lilium lancifolium Thunb","volume":"169","author":"Gao","year":"2015","journal-title":"Food Chem."},{"key":"10.1016\/j.toxicon.2022.106934_bib13","first-page":"900","article-title":"Antioxidative effect of water decoction of Broom cypress Fruit on D-galactose model mice","author":"Guan","year":"2016","journal-title":"J. Hunan Univ. Chin. Med."},{"key":"10.1016\/j.toxicon.2022.106934_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115270","article-title":"Aconitine: a review of its pharmacokinetics, pharmacology, toxicology and detoxification","volume":"293","author":"Gao","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.toxicon.2022.106934_bib15","first-page":"64","article-title":"Bio-molecules damage protective effect and free radical scavenging capacity of Coriandrum sativum L","volume":"1","author":"Han","year":"2017","journal-title":"J. Food Sci. Technol."},{"key":"10.1016\/j.toxicon.2022.106934_bib16","series-title":"Alkaloid Content of Nux Vomica Seeds Saeng Yak Hak","first-page":"189","author":"Han","year":"1988"},{"key":"10.1016\/j.toxicon.2022.106934_bib17","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0218104","article-title":"Water-soluble exudates from seeds of Kochia scoparia exhibit antifungal activity against Colletotrichum graminicola","volume":"14","author":"Houlihan","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.toxicon.2022.106934_bib18","first-page":"1","article-title":"Are antioxidants helpful for disease prevention?","volume":"5","author":"Hajhashemi","year":"2010","journal-title":"Res. Pharm. Sci."},{"key":"10.1016\/j.toxicon.2022.106934_bib19","doi-asserted-by":"crossref","first-page":"281","DOI":"10.4067\/S0716-97602006000200010","article-title":"Antioxidant activity of extract from Polygonum aviculare L","volume":"39","author":"Hsu","year":"2006","journal-title":"Biol. Res."},{"key":"10.1016\/j.toxicon.2022.106934_bib20","first-page":"3","article-title":"Measuring of the total flavonoid content and anti-oxidation in polygonum aviculare and its processing products","volume":"17","author":"Hai","year":"2008","journal-title":"Chin. J. Ethnomed. Ethnopharmacy"},{"key":"10.1016\/j.toxicon.2022.106934_bib21","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1016\/j.biopha.2017.09.038","article-title":"Toxic effects of Tripterygium wilfordii Hook F on the reproductive system of adolescent male rats","volume":"95","author":"Jing","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.toxicon.2022.106934_bib22","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.3892\/mmr.2015.4698","article-title":"Anti-inflammatory activity of Kochia scoparia fruit on contact dermatitis in mice","volume":"13","author":"Jo","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.toxicon.2022.106934_bib23","doi-asserted-by":"crossref","DOI":"10.4172\/2329-6836.1000341","article-title":"Determination of DPPH free radical scavenging activity by RP-HPLC, rapid sensitive method for the screening of berry fruit juice freeze dried extract","volume":"6","author":"Kumara","year":"2018","journal-title":"Nat. Prod. Chem. Res."},{"key":"10.1016\/j.toxicon.2022.106934_bib24","first-page":"2601","article-title":"Study on background reference value range of hematology, serum biochemistry and hemagglutination indexes of SD rats and Beagle dogs","volume":"44","author":"Kong","year":"2021","journal-title":"Drug. Eval. Res."},{"key":"10.1016\/j.toxicon.2022.106934_bib25","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1248\/yakushi1947.117.4_193","article-title":"Studies on Kochiae Fructus. I. Antipruritogenic effect of 70% ethanol extract from Kochiae Fructus and its active component","volume":"117","author":"Kubo","year":"1997","journal-title":"Yakugaku Zasshi"},{"key":"10.1016\/j.toxicon.2022.106934_bib26","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1089\/jmf.2005.8.177","article-title":"Momordin Ic and oleanolic acid from Kochiae Fructus reduce carbon tetrachloride-induced hepatotoxicity in rats","volume":"8","author":"Kim","year":"2005","journal-title":"J. Med. Food"},{"key":"10.1016\/j.toxicon.2022.106934_bib27","first-page":"97","article-title":"Phytochemical antioxidants for health and medicine \u2013 a move towards nature","volume":"1","author":"Krishnaiah","year":"2007","journal-title":"Biotechnol. Mol. Biol. Rev."},{"key":"10.1016\/j.toxicon.2022.106934_bib28","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.carbpol.2010.02.011","article-title":"Antioxidant activities of water-soluble polysaccharide extracted from mung bean (Vigna radiata L.) hull with ultrasonic assisted treatment","volume":"81","author":"Lai","year":"2010","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.toxicon.2022.106934_bib29","first-page":"338","article-title":"Study on chemical constituents of Kochia scoparia","volume":"5","author":"Lu","year":"2012","journal-title":"J. Chin. Med. Mater."},{"key":"10.1016\/j.toxicon.2022.106934_bib30","article-title":"Free radicals, antioxidants and functional foods: impact on human health","volume":"4","author":"Lobo","year":"2010","journal-title":"Pharm. Rev."},{"key":"10.1016\/j.toxicon.2022.106934_bib31","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.biotechadv.2008.07.001","article-title":"Plant in vitro culture for the production of antioxidants \u2014 a review","volume":"26","author":"Matkowski","year":"2008","journal-title":"Biotechnol. Adv."},{"key":"10.1016\/j.toxicon.2022.106934_bib66","doi-asserted-by":"crossref","first-page":"704","DOI":"10.2307\/3800856","article-title":"Test methods for vertebrate pest control and management materials","volume":"42","author":"Mclean","year":"1977","journal-title":"J. Wildl. Manage."},{"key":"10.1016\/j.toxicon.2022.106934_bib32","article-title":"Tropical protozoan diseases: natural product drug discovery and development","volume":"2013","author":"Muschietti","year":"2013","journal-title":"J. Evidence-Based Complementary Altern. Med."},{"key":"10.1016\/j.toxicon.2022.106934_bib33","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1248\/cpb.46.1399","article-title":"Antidiabetic principles of natural medicines. III. Structure-related inhibitory activity and action mode of oleanolic acid glycosides on hypoglycemic activity","volume":"46","author":"Matsuda","year":"1998","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.toxicon.2022.106934_bib34","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1248\/bpb.20.1165","article-title":"Studies on Kochiae Fructus. IV. Anti-allergic effects of 70% ethanol extract and its component, momordin Ic from dried fruits of Kochia scoparia L","volume":"20","author":"Matsuda","year":"1997","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.toxicon.2022.106934_bib36","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1111\/j.1365-2621.2006.01431.x","article-title":"Antioxidant properties of methanolic extracts from Diospyros mespiliformis (jackal berry), Flacourtia indica (Batoka plum), Uapaca kirkiana (wild loquat) and Ziziphus mauritiana (yellow berry) fruits","volume":"43","author":"Ndhlala","year":"2008","journal-title":"Int. J. Food Sci. Technol."},{"key":"10.1016\/j.toxicon.2022.106934_bib37","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aan6446","article-title":"Aristolochic acids and their derivatives are widely implicated in liver cancers in Taiwan and throughout Asia","volume":"9","author":"Ng","year":"2017","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.toxicon.2022.106934_bib38","series-title":"The Pharmacopoeia of the People's Republic of China","year":"2020"},{"key":"10.1016\/j.toxicon.2022.106934_bib39","series-title":"Guidelines for Testing of Chemical. Acute Oral Toxicity - Up-And-Down - Procedure","year":"2008"},{"key":"10.1016\/j.toxicon.2022.106934_bib40","series-title":"Guidelines for Testing of Chemical. Repeated Dose 28-day Oral Toxicity Study in Rodents","year":"2008"},{"key":"10.1016\/j.toxicon.2022.106934_bib41","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/bs.mie.2015.10.005","article-title":"Bioconjugation of antibodies and enzyme labels onto magnetic beads","volume":"571","author":"Otieno","year":"2016","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.toxicon.2022.106934_bib42","doi-asserted-by":"crossref","first-page":"9618","DOI":"10.1021\/acs.jafc.9b02899","article-title":"Butylated hydroxyanisole exerts neurotoxic effects by promoting cytosolic calcium accumulation and endoplasmic reticulum stress in astrocytes","volume":"67","author":"Park","year":"2019","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.toxicon.2022.106934_bib43","doi-asserted-by":"crossref","first-page":"3839","DOI":"10.1111\/are.14732","article-title":"Toxicity of a synthetic phenolic antioxidant, butyl hydroxytoluene (BHT), in vertebrate model zebrafish embryo (Danio rerio)","volume":"51","author":"Sarmah","year":"2020","journal-title":"Aquacult. Res."},{"key":"10.1016\/j.toxicon.2022.106934_bib44","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.etp.2011.02.002","article-title":"Antioxidant ability and total phenolic content of aqueous leaf extract of Stevia rebaudiana Bert","volume":"64","author":"Shukla","year":"2012","journal-title":"Exp. Toxicol. Pathol."},{"key":"10.1016\/j.toxicon.2022.106934_bib45","series-title":"Chapter 27: Spondias Pinnata (L.F.) Kurz. (Anacardiaceae): Profiles and Applications to Diabetes","article-title":"Bioactive food as dietary interventions for diabetes","author":"Sujarwo","year":"2019"},{"key":"10.1016\/j.toxicon.2022.106934_bib46","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-99264-2","article-title":"Extract from Dioscorea bulbifera L. rhizomes aggravate pirarubicin-induced cardiotoxicity by inhibiting the expression of P-glycoprotein and multidrug resistance-associated protein 2 in the mouse liver","volume":"11","author":"Sun","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.toxicon.2022.106934_bib47","series-title":"Handbook of Antioxidants for Food Preservation","author":"Shahidi","year":"2015"},{"key":"10.1016\/j.toxicon.2022.106934_bib48","doi-asserted-by":"crossref","first-page":"570","DOI":"10.3329\/bjp.v11i3.27663","article-title":"Ferric reducing anti-oxidant power assay in plant extract","volume":"11","author":"Vijayalakshmi","year":"2016","journal-title":"Bangladesh J. Pharmacol."},{"key":"10.1016\/j.toxicon.2022.106934_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114100","article-title":"Evaluation of the toxic potential of the aqueous extract from Mangifera indica Linn. (Anacardiaceae) in rats submitted to experimental models of acute and subacute oral toxicity","volume":"275","author":"Villas-Boas","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.toxicon.2022.106934_bib50","doi-asserted-by":"crossref","first-page":"383","DOI":"10.3920\/QAS2012.0218","article-title":"Antioxidant capacity and antitumor activity of Fructus Kochiae extracts","volume":"6","author":"Wang","year":"2014","journal-title":"Qual. Assur. Saf. Crop Foods"},{"key":"10.1016\/j.toxicon.2022.106934_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.tiv.2020.104784","article-title":"Natural triterpenoid saponin Momordin Ic suppresses HepG2 cell invasion via COX-2 inhibition and PPAR\u03b3 activation","volume":"65","author":"Wang","year":"2020","journal-title":"Toxicol. Vitro"},{"key":"10.1016\/j.toxicon.2022.106934_bib52","first-page":"1974","article-title":"Normative research on bacteriostasis and relieving itching external therapeutic function of Kochiae Fructus","volume":"12","author":"Wang","year":"2012","journal-title":"J. Chin. Med. Mater."},{"key":"10.1016\/j.toxicon.2022.106934_bib53","first-page":"29","article-title":"Study on the volatile oil components of Fructus Kochiae","volume":"2","author":"Wen","year":"1992","journal-title":"J. Chin. Med. Mater."},{"key":"10.1016\/j.toxicon.2022.106934_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2021.129488","article-title":"Synthetic phenolic antioxidants: metabolism, hazards and mechanism of action","volume":"353","author":"Xu","year":"2021","journal-title":"Food Chem."},{"key":"10.1016\/j.toxicon.2022.106934_bib55","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1080\/10286020.2013.824427","article-title":"Studies on the flavone glycosides from Fructus Kochiae","volume":"16","author":"Xu","year":"2014","journal-title":"J. Asian Nat. Prod. Res."},{"key":"10.1016\/j.toxicon.2022.106934_bib65","first-page":"29","article-title":"Screening chemical constituents with antioxidative activity from the Kochiae Fructus","volume":"33","author":"Yan","year":"2019","journal-title":"Chin. Med. J. Res. Prac.,"},{"key":"10.1016\/j.toxicon.2022.106934_bib56","series-title":"Chemical Constituents and Biological Activities of Strawberry and Carambola Fruits","author":"Yang","year":"2015"},{"key":"10.1016\/j.toxicon.2022.106934_bib57","doi-asserted-by":"crossref","first-page":"199","DOI":"10.3844\/ajbbsp.2020.199.207","article-title":"Inhibitory effect of crude walnut leaf polysaccharides on oxidative damage of proteins and proliferation of SGC-7901 cells","volume":"16","author":"Yang","year":"2020","journal-title":"Am. J. Biochem. Biotechnol."},{"issue":"6","key":"10.1016\/j.toxicon.2022.106934_bib67","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1248\/cpb.45.1052","article-title":"Studies on Kochiae Fructus. Part 2. On the Saponin constituents from the fruit of Chinese Kochia scoparia (Chenopodiaceae): chemical structures of Kochianosides I, II, III, and IV","volume":"45","author":"Yoshikawa","year":"1997","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.toxicon.2022.106934_bib58","doi-asserted-by":"crossref","first-page":"559","DOI":"10.3390\/molecules21050559","article-title":"The traditional medicine and modern medicine from natural products","volume":"21","author":"Yuan","year":"2016","journal-title":"Molecules"},{"key":"10.1016\/j.toxicon.2022.106934_bib59","first-page":"119","article-title":"Investigation on the relativity between flavonoid content and antioxidant activation for eleven kinds of Chinese herbal medicine","volume":"1","author":"Yang","year":"2008","journal-title":"Sci. Technol. Food Ind."},{"key":"10.1016\/j.toxicon.2022.106934_bib61","article-title":"Kochiae Fructus, the fruit of common potherb Kochia scoparia (L.) Schrad: a review on phytochemistry, pharmacology, toxicology, quality control, and pharmacokinetics","volume":"2021","author":"Zou","year":"2021","journal-title":"J. Evidence-Based Complementary Altern. Med."},{"key":"10.1016\/j.toxicon.2022.106934_bib62","first-page":"48","article-title":"Interpretation of the \u2018Shennong's classic of Materia Medica\u2019 42","volume":"6","author":"Zhong","year":"2016","journal-title":"Journal for Beneficial Readines Drug Informations & Medical Advices"},{"key":"10.1016\/j.toxicon.2022.106934_bib63","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.toxicon.2021.08.015","article-title":"In vivo toxicity assessment of 4\u2019-O-methylpyridoxine from Ginkgo biloba seeds: growth, hematology, metabolism, and oxidative parameters","volume":"201","author":"Zhu","year":"2021","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2022.106934_bib64","doi-asserted-by":"crossref","first-page":"3381","DOI":"10.3390\/molecules27113381","article-title":"Hypoglycemic and antioxidant properties of extracts and fractions from polygoni avicularis herba","volume":"27","author":"Zhang","year":"2022","journal-title":"Molecules"}],"container-title":["Toxicon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010122002859?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010122002859?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T21:23:04Z","timestamp":1758576184000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041010122002859"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":65,"alternative-id":["S0041010122002859"],"URL":"https:\/\/doi.org\/10.1016\/j.toxicon.2022.106934","relation":{},"ISSN":["0041-0101"],"issn-type":[{"value":"0041-0101","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Kochiae Fructus: Evaluation on the antioxidant properties and oral safety of its water decoction","name":"articletitle","label":"Article Title"},{"value":"Toxicon","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxicon.2022.106934","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"106934"}}