{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:20:29Z","timestamp":1790792429753,"version":"4.1.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2019\/20890\u20137"],"award-info":[{"award-number":["2019\/20890\u20137"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicon"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.toxicon.2022.106941","type":"journal-article","created":{"date-parts":[[2022,10,12]],"date-time":"2022-10-12T06:55:06Z","timestamp":1665557706000},"page":"106941","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Photobiomodulation therapy on local effects induced by juvenile and adult venoms of Bothrops alternatus"],"prefix":"10.1016","volume":"220","author":[{"given":"Amanda Cabral","family":"David","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana Miato Gon\u00e7alves","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Em\u00edlia","family":"Garcia Denegri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura Cristina Ana","family":"Leiva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Ant\u00f4nio","family":"Silva Junior","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana Pavan","family":"Zuliani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4694-7617","authenticated-orcid":false,"given":"Stella Regina","family":"Zamuner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.toxicon.2022.106941_bib1","doi-asserted-by":"crossref","first-page":"148","DOI":"10.3390\/toxins11030148","article-title":"Acute kidney injury induced by Bothrops venom: insights into the pathogenic mechanisms","volume":"11","author":"Albuquerque","year":"2019","journal-title":"Toxins (Basel). Mar 5"},{"issue":"10","key":"10.1016\/j.toxicon.2022.106941_bib2","doi-asserted-by":"crossref","first-page":"3752","DOI":"10.1021\/acs.jproteome.6b00561","article-title":"Dynamic rearrangement in snake venom gland proteome: insights into Bothrops jararaca intraspecific venom variation","volume":"15","author":"Augusto-de-Oliveira","year":"2016","journal-title":"J. Proteome Res."},{"issue":"7","key":"10.1016\/j.toxicon.2022.106941_bib3","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1016\/j.toxicon.2008.02.007","article-title":"Effect of low-level laser therapy in the inflammatory response induced by Bothrops jararacussu snake venom","volume":"51","author":"Barbosa","year":"2008","journal-title":"Toxicon"},{"issue":"4","key":"10.1016\/j.toxicon.2022.106941_bib4","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1089\/pho.2008.2296","article-title":"Effect of low-level laser therapy in the myonecrosis induced by Bothrops jararacussu snake venom","volume":"27","author":"Barbosa","year":"2009","journal-title":"Photomed Laser Surg. Aug"},{"key":"10.1016\/j.toxicon.2022.106941_bib5","series-title":"Biodiversidade: Regi\u00f5es da Lagoa do Casamento e dos Butiazais de Tapes, Plan\u00edcie Costeira do Rio Grande do Sul. Minist\u00e9rio do Meio Ambiente e Fund","author":"Becker","year":"2007"},{"key":"10.1016\/j.toxicon.2022.106941_bib6","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.toxicon.2020.05.028","article-title":"Sexual and ontogenetic variation of Bothrops leucurus venom","volume":"184","author":"Braga","year":"2020","journal-title":"Toxicon. Sep"},{"key":"10.1016\/j.toxicon.2022.106941_bib7","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.toxicon.2018.07.029","article-title":"Light emitting diode (LED) therapy reduces local pathological changes induced by Bothrops asper snake venom","author":"Campos","year":"2018","journal-title":"Toxicon. Sep"},{"key":"10.1016\/j.toxicon.2022.106941_bib8","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2164-11-605","article-title":"A transcriptomic analysis of gene expression in the venom gland of the snake Bothrops alternatus (urutu)","author":"Cardoso","year":"2010","journal-title":"BMC Genom."},{"issue":"3","key":"10.1016\/j.toxicon.2022.106941_bib9","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1590\/S0100-879X2004000300018","article-title":"An electronic pressure-meter nociception paw test for mice","volume":"37","author":"Cunha","year":"2004","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.toxicon.2022.106941_bib10","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1111\/j.1751-1097.2008.00397.x","article-title":"The ability of low level laser therapy to prevent muscle tissue damage induced by snake venom","volume":"85","author":"Doin-Silva","year":"2009","journal-title":"Photochem. Photobiol."},{"key":"10.1016\/j.toxicon.2022.106941_bib11","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.3390\/jcm9061724","article-title":"Photobiomodulation\u2014underlying mechanism and clinical applications","volume":"9","author":"Dompe","year":"2020","journal-title":"J. Clin. Med."},{"issue":"5","key":"10.1016\/j.toxicon.2022.106941_bib12","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1002\/lsm.10237","article-title":"Effects of the GaAs laser irradiation on myonecrosis caused by Bothrops moojeni snake venom","volume":"33","author":"Dourado","year":"2003","journal-title":"Laser Surg. Med."},{"key":"10.1016\/j.toxicon.2022.106941_bib13","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.cbi.2017.12.022","article-title":"Evaluation of proinflammatory events induced by Bothrops alternatus snake venom","volume":"281","author":"Echeverr\u00eda","year":"2018","journal-title":"Chem. Biol. Interact."},{"issue":"5","key":"10.1016\/j.toxicon.2022.106941_bib14","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1007\/s10103-016-1941-8","article-title":"Effect of photobiomodulation on endothelial cell exposed to Bothrops jararaca venom","volume":"31","author":"Franco","year":"2016","journal-title":"Lasers Med Sci. Jul"},{"issue":"3","key":"10.1016\/j.toxicon.2022.106941_bib15","doi-asserted-by":"crossref","DOI":"10.1109\/JSTQE.2016.2561201","article-title":"Proposed mechanisms of photobiomodulation or low-level light therapy","volume":"22","author":"Freitas","year":"2016","journal-title":"IEEE J. Sel. Top. Quant. Electron."},{"key":"10.1016\/j.toxicon.2022.106941_bib16","series-title":"Aspectos sistem\u00e1ticos e biol\u00f3gicos que atuam na diversidade da composi\u00e7\u00e3o de venenos em serpentes pe\u00e7onhentas brasileiras","author":"Furtado","year":"2005"},{"issue":"2","key":"10.1016\/j.toxicon.2022.106941_bib17","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0041-0101(91)90106-2","article-title":"Comparative study of nine Bothrops snake venoms from adult female snakes and their offspring","volume":"29","author":"Furtado","year":"1991","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2022.106941_bib18","article-title":"Efficient muscle regeneration after highly haemorrhagic Bothrops alternatus venom injection","volume":"122","author":"Garcia Denegri","year":"2016","journal-title":"Toxicon. Nov"},{"key":"10.1016\/j.toxicon.2022.106941_bib19","doi-asserted-by":"crossref","first-page":"69","DOI":"10.14409\/fabicib.v12i1.819","article-title":"Serpientes venenosas de Santa Fe, Argentina: conocimientos sobre su historia natural aplicados para la prevenci\u00f3n de ofidismo","volume":"12","author":"Giraudo","year":"2008","journal-title":"Revista FABICIB"},{"issue":"5","key":"10.1016\/j.toxicon.2022.106941_bib20","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1007\/s10103-019-02884-4","article-title":"Photobiomodulation reduces cell death and cytokine production in C2C12 cells exposed to Bothrops venoms","volume":"35","author":"Gouveia","year":"2020","journal-title":"Lasers Med Sci. Jul"},{"key":"10.1016\/j.toxicon.2022.106941_bib21","article-title":"Snakebite envenoming","volume":"3","author":"Guti\u00e9rrez","year":"2017","journal-title":"Nat. Rev. Dis. Prim."},{"issue":"6","key":"10.1016\/j.toxicon.2022.106941_bib22","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0253050","article-title":"From birth to adulthood: an analysis of the Brazilian lancehead (Bothrops moojeni) venom at different life stages","volume":"16","author":"Hatakeyama","year":"2021","journal-title":"PLoS One"},{"key":"10.1016\/j.toxicon.2022.106941_bib23","article-title":"Effects of photobiomodulation therapy on the local experimental envenoming by Bothrops leucurus snake","volume":"214","author":"Lauria","year":"2021","journal-title":"J Photochem Photobiol. Jan"},{"issue":"6","key":"10.1016\/j.toxicon.2022.106941_bib24","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1590\/S0365-05962010000600011","article-title":"Efeitos bioestimulantes do laser de baixa pot\u00eancia no processo de reparo","volume":"85","author":"Lins","year":"2010","journal-title":"An. Bras. Dermatol."},{"key":"10.1016\/j.toxicon.2022.106941_bib25","article-title":"Tabebuia aurea decreases hyperalgesia and neuronal injury induced by snake venom","volume":"233","author":"Malange","year":"2019","journal-title":"J Ethnopharmacol. Apr6"},{"key":"10.1016\/j.toxicon.2022.106941_bib26","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.toxicon.2016.03.006","article-title":"Comparative analysis of local effects caused by Bothrops alternatus and Bothrops moojeni snake venoms: enzymatic contributions and inflammatory modulations","volume":"117","author":"Mamede","year":"2016","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2022.106941_bib27","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.toxicon.2020.08.016","article-title":"Edema, hyperalgesia and myonecrosis induced by Brazilian bothropic venoms: overview of the last decade","volume":"187","author":"Mamede","year":"2020","journal-title":"Toxicon"},{"issue":"5","key":"10.1016\/j.toxicon.2022.106941_bib28","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.toxicon.2006.09.006","article-title":"Bothrops jararaca and Crotalus durissus terrificus venoms elicit distinct responses regarding to production of prostaglandins E2 and D2, and expression of cyclooxygenases","volume":"49","author":"Moreira","year":"2007","journal-title":"Toxicon. Abril"},{"key":"10.1016\/j.toxicon.2022.106941_bib29","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s10103-011-0914-1","article-title":"Effects of photobiostimulation on edema and hemorrhage induced by Bothrops moojeni venom","volume":"27","author":"Nadur-Andrade","year":"2012","journal-title":"Laser Med. Sci."},{"issue":"10","key":"10.1016\/j.toxicon.2022.106941_bib30","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0004998","article-title":"Analgesic effect of photobiomodulation on Bothrops moojeni venom-induced hyperalgesia: a mechanism dependent on neuronal inhibition, cytokines and kinin receptors modulation","volume":"10","author":"Nadur-Andrade","year":"2016","journal-title":"PLoS Neglected Trop. Dis."},{"issue":"5","key":"10.1016\/j.toxicon.2022.106941_bib31","doi-asserted-by":"crossref","first-page":"2422","DOI":"10.1021\/pr901128x","article-title":"The venomics of Bothrops alternatus is a pool of acidic proteins with predominant hemorrhagic and coagulopathic activities","volume":"9","author":"Ohler","year":"2010","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.toxicon.2022.106941_bib32","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.toxicon.2006.11.006","article-title":"Role of cyclooxygenases in oedema-forming activity of bothropic venoms","volume":"49","author":"Olivo","year":"2007","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2022.106941_bib33","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.toxicon.2021.05.009","article-title":"Photobiomodulation induces murine macrophages polarization toward M2 phenotype","volume":"198","author":"Reis","year":"2021","journal-title":"Toxicon. Jul"},{"issue":"4","key":"10.1016\/j.toxicon.2022.106941_bib34","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/S0041-0101(03)00171-5","article-title":"Ontogenetic variability of Bothrops atrox and Bothrops asper snake venoms from Colombia","volume":"42","author":"Saldarriaga","year":"2003","journal-title":"Toxicon"},{"issue":"Pt B","key":"10.1016\/j.toxicon.2022.106941_bib35","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1016\/j.ijbiomac.2017.10.076","article-title":"Photobiomodulation of local alterations induced by BthTX-I, a phospholipase A2 myotoxin from Bothrops jararacussu snake venom: in vivo and in vitro evaluation","volume":"107","author":"Santos","year":"2018","journal-title":"Int J Biol Macromol. Feb"},{"issue":"152","key":"10.1016\/j.toxicon.2022.106941_bib36","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.toxicon.2018.07.006","article-title":"Photobiomodulation therapy on bothrops snake venom induced local pathological effects: a systematic review","volume":"15","author":"Silva","year":"2018","journal-title":"Toxicon. Sep"},{"issue":"3\u20134","key":"10.1016\/j.toxicon.2022.106941_bib37","first-page":"97","article-title":"Low-level laser therapy reduces edema, leukocyte influx and hyperalgesia induced by Bothrops jararacussu snake venom","volume":"52","author":"Souza","year":"2011","journal-title":"Clin. Exp. Med. Lett."},{"issue":"7","key":"10.1016\/j.toxicon.2022.106941_bib39","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.toxicon.2005.08.011","article-title":"Inflammation induced by Bothrops asper venom: release of proinflammatory cytokines and eicosanoids, and role of adhesion molecules in leukocyte infiltration","volume":"46","author":"Zamuner","year":"2005","journal-title":"Toxicon"},{"issue":"5","key":"10.1016\/j.toxicon.2022.106941_bib40","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.1021\/pr901027r","article-title":"Analysis of the ontogenetic variation in the venom proteome\/peptidome of Bothrops jararaca reveals different strategies to deal with prey","volume":"9","author":"Zelanis","year":"2010","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.toxicon.2022.106941_bib41","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.toxicon.2020.09.006","article-title":"Polymorphonuclear neutrophil leukocytes in snakebite envenoming","volume":"187","author":"Zuliani","year":"2020","journal-title":"Toxicon. Nov"}],"container-title":["Toxicon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010122002926?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010122002926?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T21:22:00Z","timestamp":1758576120000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041010122002926"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":40,"alternative-id":["S0041010122002926"],"URL":"https:\/\/doi.org\/10.1016\/j.toxicon.2022.106941","relation":{},"ISSN":["0041-0101"],"issn-type":[{"value":"0041-0101","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Photobiomodulation therapy on local effects induced by juvenile and adult venoms of Bothrops alternatus","name":"articletitle","label":"Article Title"},{"value":"Toxicon","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxicon.2022.106941","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"106941"}}