{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T12:51:37Z","timestamp":1767703897380,"version":"3.44.0"},"reference-count":16,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100007472","name":"University of Kentucky","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007472","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicon"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.toxicon.2022.106975","type":"journal-article","created":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T15:52:35Z","timestamp":1669045955000},"page":"106975","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Brown recluse spider envenomation with systemic loxoscelism and delayed hemolysis: A case report"],"prefix":"10.1016","volume":"222","author":[{"given":"Blake","family":"DiPaola","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason","family":"Davis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Regan A.","family":"Baum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Akpunonu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6243-1776","authenticated-orcid":false,"given":"Andrew","family":"Micciche","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.toxicon.2022.106975_bib1","doi-asserted-by":"crossref","first-page":"e31","DOI":"10.1016\/j.jemermed.2009.08.055","article-title":"Suspected brown recluse envenomation: a case report and review of different treatment modalities","volume":"41","author":"Andersen","year":"2011","journal-title":"J. Emerg. Med."},{"key":"10.1016\/j.toxicon.2022.106975_bib2","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.toxicon.2015.09.041","article-title":"Brown spider (Loxosceles genus) venom toxins: evaluation of biological conservation by immune cross-reactivity","volume":"108","author":"Buch","year":"2015","journal-title":"Toxicon"},{"issue":"6","key":"10.1016\/j.toxicon.2022.106975_bib3","first-page":"869","article-title":"Common spider bites","volume":"75","author":"Diaz","year":"2007","journal-title":"Am. Fam. Physician"},{"key":"10.1016\/j.toxicon.2022.106975_bib4","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.toxicon.2014.02.023","article-title":"Recent advances in the understanding of brown spider venoms: from the biology of spiders to the molecular mechanisms of toxins","volume":"83","author":"Gremski","year":"2014","journal-title":"Toxicon"},{"issue":"3","key":"10.1016\/j.toxicon.2022.106975_bib5","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1177\/0009922810388510","article-title":"Complications and outcomes of brown recluse spider bites in children","volume":"50","author":"Hubbard","year":"2011","journal-title":"Clin. Pediatr."},{"issue":"12","key":"10.1016\/j.toxicon.2022.106975_bib6","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1080\/15563650.2020.1739701","article-title":"Cutaneous-hemolytic loxoscelism following brown recluse spider envenomation: new understandings","volume":"58","author":"Loden","year":"2020","journal-title":"Clin. Toxicol."},{"key":"10.1016\/j.toxicon.2022.106975_bib7","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.molimm.2017.12.009","article-title":"Loxosceles venom Sphingomyelinase D activates human blood leukocytes: role of the complement system","volume":"94","author":"Manzoni-de-Almeida","year":"2018","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.toxicon.2022.106975_bib8","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/4091278","article-title":"Cutaneous and hematologic manifestations","volume":"2019","author":"Nguyen","year":"2019","journal-title":"Adv Hematol"},{"issue":"11","key":"10.1016\/j.toxicon.2022.106975_bib9","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1001\/jamadermatol.2014.605","article-title":"Extreme pain from brown recluse spider bites: model for cytokine-driven pain","volume":"150","author":"Payne","year":"2014","journal-title":"JAMA Dermatol"},{"issue":"4","key":"10.1016\/j.toxicon.2022.106975_bib10","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1067\/mjd.2001.112385","article-title":"Necrotic arachnidism","volume":"44","author":"Sams","year":"2001","journal-title":"J. Am. Acad. Dermatol."},{"issue":"3","key":"10.1016\/j.toxicon.2022.106975_bib11","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.clindermatol.2005.11.006","volume":"24","author":"Swanson","year":"2006","journal-title":"Loxoscelism. Clin Dermatol."},{"issue":"5","key":"10.1016\/j.toxicon.2022.106975_bib12","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1136\/ewjm.173.5.357","article-title":"Myth: idiopathic wounds are often due to brown recluse or other spider bites throughout the United States","volume":"173","author":"Vetter","year":"2000","journal-title":"West. J. Med."},{"issue":"5","key":"10.1016\/j.toxicon.2022.106975_bib13","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1097\/SMJ.0b013e3181a0abb3","article-title":"The distribution of brown recluse spiders in the southeastern quadrant of the United States in relation to loxoscelism diagnoses","volume":"102","author":"Vetter","year":"2009","journal-title":"South. Med. J."},{"issue":"6","key":"10.1016\/j.toxicon.2022.106975_bib14","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1603\/0022-2585-39.6.948","article-title":"An infestation of 2,055 brown recluse spiders (Araneae: sicariidae) and no envenomations in a Kansas home: implications for bite diagnoses in nonendemic areas","volume":"39","author":"Vetter","year":"2002","journal-title":"J. Med. Entomol."},{"key":"10.1016\/j.toxicon.2022.106975_bib15","series-title":"Clinical Toxinology in Australia, Europe, and Americas. Toxinology","article-title":"Envenomations by widow, recluse, and medically implicated spiders","author":"Vetter","year":"2018"},{"issue":"8","key":"10.1016\/j.toxicon.2022.106975_bib16","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1080\/15563650903218724","article-title":"Systemic loxoscelism - not so quick","volume":"47","author":"Wasserman","year":"2009","journal-title":"Clin. Toxicol."}],"container-title":["Toxicon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010122003269?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010122003269?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T21:22:04Z","timestamp":1758576124000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041010122003269"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":16,"alternative-id":["S0041010122003269"],"URL":"https:\/\/doi.org\/10.1016\/j.toxicon.2022.106975","relation":{},"ISSN":["0041-0101"],"issn-type":[{"type":"print","value":"0041-0101"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Brown recluse spider envenomation with systemic loxoscelism and delayed hemolysis: A case report","name":"articletitle","label":"Article Title"},{"value":"Toxicon","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxicon.2022.106975","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"106975"}}