{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T05:08:46Z","timestamp":1794373726668,"version":"4.9.0"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicon"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.toxicon.2024.107652","type":"journal-article","created":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T11:21:21Z","timestamp":1708514481000},"page":"107652","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Betulinic acid attenuates T-2 toxin-induced lung injury by activating Nrf2 signaling pathway and inhibiting MAPK\/NF-\u03baB signaling pathway"],"prefix":"10.1016","volume":"241","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-2086-5340","authenticated-orcid":false,"given":"Chunlin","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoping","family":"Ou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjiang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayu","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingqi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siting","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9837-0565","authenticated-orcid":false,"given":"Jine","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxicon.2024.107652_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111410","article-title":"Galangin attenuates diabetic cardiomyopathy through modulating oxidative stress, inflammation and apoptosis in rats","volume":"138","author":"Abukhalil","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.toxicon.2024.107652_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2021.109568","article-title":"Nuclear factor-kappa B and its role in inflammatory lung disease","volume":"345","author":"Alharbi","year":"2021","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.toxicon.2024.107652_bib3","doi-asserted-by":"crossref","first-page":"51180","DOI":"10.1007\/s11356-023-25917-6","article-title":"Betulinic acid protects against cardiotoxicity of the organophosphorus pesticide chlorpyrifos by suppressing oxidative stress, inflammation, and apoptosis in rats","volume":"30","author":"Alruhaimi","year":"2023","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.toxicon.2024.107652_bib4","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1056\/NEJM199704103361506","article-title":"Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases","volume":"336","author":"Barnes","year":"1997","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.toxicon.2024.107652_bib5","doi-asserted-by":"crossref","first-page":"3347","DOI":"10.1007\/s12035-021-02344-7","article-title":"Divulging the intricacies of crosstalk between NF-Kb and Nrf2-Keap1 pathway in neurological complications of COVID-19","volume":"58","author":"Bhandari","year":"2021","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.toxicon.2024.107652_bib6","doi-asserted-by":"crossref","first-page":"3041","DOI":"10.1007\/s00204-019-02577-5","article-title":"T-2 toxin neurotoxicity: role of oxidative stress and mitochondrial dysfunction","volume":"93","author":"Dai","year":"2019","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.toxicon.2024.107652_bib7","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1089\/ars.2013.5674","article-title":"Signaling function of heme oxygenase proteins","volume":"20","author":"Dennery","year":"2014","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.toxicon.2024.107652_bib8","doi-asserted-by":"crossref","first-page":"2773","DOI":"10.1080\/10408398.2019.1658570","article-title":"Worldwide contamination of food-crops with mycotoxins: validity of the widely cited 'FAO estimate' of 25","volume":"60","author":"Eskola","year":"2020","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.toxicon.2024.107652_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.107230","article-title":"Pinocembrin relieves lipopolysaccharide and bleomycin induced lung inflammation via inhibiting TLR4-NF-\u03baB-NLRP3 inflammasome signaling pathway","volume":"90","author":"Gan","year":"2021","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.toxicon.2024.107652_bib10","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.ijbiomac.2018.02.009","article-title":"Prdx1 alleviates cardiomyocyte apoptosis through ROS-activated MAPK pathway during myocardial ischemia\/reperfusion injury","volume":"112","author":"Guo","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.toxicon.2024.107652_bib11","article-title":"T-2 toxin-induced testicular impairment by triggering oxidative stress and ferroptosis","volume":"270","author":"He","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.toxicon.2024.107652_bib12","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.ejphar.2018.02.044","article-title":"Oridonin inhibits vascular inflammation by blocking NF-\u03baB and MAPK activation","volume":"826","author":"Huang","year":"2018","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.toxicon.2024.107652_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.108210","article-title":"Betulinic acid protects against renal damage by attenuation of oxidative stress and inflammation via Nrf2 signaling pathway in T-2 toxin-induced mice","volume":"101","author":"Huang","year":"2021","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.toxicon.2024.107652_bib14","doi-asserted-by":"crossref","first-page":"52098","DOI":"10.1007\/s11356-022-19498-z","article-title":"Betulinic acid attenuates cognitive dysfunction, oxidative stress, and inflammation in a model of T-2 toxin-induced brain damage","volume":"29","author":"Huang","year":"2022","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.toxicon.2024.107652_bib15","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.bbi.2021.09.021","article-title":"From dried bear bile to molecular investigation: a systematic review of the effect of bile acids on cell apoptosis, oxidative stress and inflammation in the brain, across pre-clinical models of neurological, neurodegenerative and neuropsychiatric disorders","volume":"99","author":"Huang","year":"2022","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.toxicon.2024.107652_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2020.111138","article-title":"Cardiomyopathy induced by T-2 toxin in rats","volume":"137","author":"Ja\u0107evi\u0107","year":"2020","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.toxicon.2024.107652_bib17","doi-asserted-by":"crossref","first-page":"6868","DOI":"10.3390\/molecules26226868","article-title":"T-2 toxin-the most toxic trichothecene mycotoxin: metabolism, toxicity, and decontamination strategies","volume":"26","author":"Janik","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.toxicon.2024.107652_bib18","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1165\/rcmb.2010-0339TR","article-title":"A20 regulation of nuclear factor-\u03baB: perspectives for inflammatory lung disease","volume":"44","author":"Kelly","year":"2011","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.toxicon.2024.107652_bib19","doi-asserted-by":"crossref","first-page":"158","DOI":"10.3390\/antiox10020158","article-title":"Betulinic acid alleviates spleen oxidative damage induced by acute intraperitoneal exposure to T-2 toxin by activating Nrf2 and inhibiting MAPK signaling pathways","volume":"10","author":"Kong","year":"2021","journal-title":"Antioxidants"},{"key":"10.1016\/j.toxicon.2024.107652_bib20","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1142\/S0192415X17500422","article-title":"Baicalein attenuates lung injury induced by myocardial ischemia and reperfusion","volume":"45","author":"Lai","year":"2017","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.toxicon.2024.107652_bib21","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.taap.2006.08.007","article-title":"T-2 toxin impairs murine immune response to respiratory reovirus and exacerbates viral bronchiolitis","volume":"217","author":"Li","year":"2006","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.toxicon.2024.107652_bib22","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1016\/j.bcp.2008.07.017","article-title":"Activation of Nrf2-antioxidant signaling attenuates NFkappaB-inflammatory response and elicits apoptosis","volume":"76","author":"Li","year":"2008","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.toxicon.2024.107652_bib23","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/s41419-019-1728-5","article-title":"Adrenomedullin alleviates the pyroptosis of Leydig cells by promoting autophagy via the ROS-AMPK-mTOR axis","volume":"10","author":"Li","year":"2019","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.toxicon.2024.107652_bib24","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/s12967-021-02745-1","article-title":"Panaxydol attenuates ferroptosis against LPS-induced acute lung injury in mice by Keap1-Nrf2\/HO-1 pathway","volume":"19","author":"Li","year":"2021","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.toxicon.2024.107652_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.113561","article-title":"Ameliorative effect of betulinic acid against zearalenone exposure triggers testicular dysfunction and oxidative stress in mice via p38\/ERK MAPK inhibition and Nrf2-mediated antioxidant defense activation","volume":"238","author":"Lin","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.toxicon.2024.107652_bib26","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.ejps.2015.01.001","article-title":"Betulinic acid attenuates renal oxidative stress and inflammation in experimental model of murine polymicrobial sepsis","volume":"70","author":"Lingaraju","year":"2015","journal-title":"Eur. J. Pharmaceut. Sci."},{"key":"10.1016\/j.toxicon.2024.107652_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2019.110661","article-title":"DNA methylation is involved in pro-inflammatory cytokines expression in T-2 toxin-induced liver injury","volume":"132","author":"Liu","year":"2019","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.toxicon.2024.107652_bib28","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1007\/s12011-020-02279-5","article-title":"Protective effect of organic selenium on oxidative damage and inflammatory reaction of rabbit kidney induced by T-2 toxin","volume":"199","author":"Liu","year":"2021","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.toxicon.2024.107652_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111552","article-title":"Hesperetin modulates the Sirt1\/Nrf2 signaling pathway in counteracting myocardial ischemia through suppression of oxidative stress, inflammation, and apoptosis","volume":"139","author":"Liu","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.toxicon.2024.107652_bib30","doi-asserted-by":"crossref","first-page":"5583","DOI":"10.3390\/molecules26185583","article-title":"A review on preparation of betulinic acid and its biological activities","volume":"26","author":"Lou","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.toxicon.2024.107652_bib31","doi-asserted-by":"crossref","first-page":"794","DOI":"10.3390\/toxins12120794","article-title":"Betulinic acid ameliorates the T-2 toxin-triggered intestinal impairment in mice by inhibiting inflammation and mucosal barrier dysfunction through the NF-\u03baB signaling pathway","volume":"12","author":"Luo","year":"2020","journal-title":"Toxins"},{"key":"10.1016\/j.toxicon.2024.107652_bib32","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.3382\/ps\/pev115","article-title":"Experimental pathology of T-2 toxicosis and mycoplasma infection on performance and hepatic functions of broiler chickens","volume":"94","author":"Manafi","year":"2015","journal-title":"Poultry Sci."},{"key":"10.1016\/j.toxicon.2024.107652_bib33","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/6757154","article-title":"Thyroid hormones, oxidative stress, and inflammation","volume":"2016","author":"Mancini","year":"2016","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.toxicon.2024.107652_bib34","doi-asserted-by":"crossref","first-page":"481","DOI":"10.3390\/toxins15080481","article-title":"T-2 and HT-2 toxins: toxicity, occurrence and analysis: a review","volume":"15","author":"Meneely","year":"2023","journal-title":"Toxins"},{"key":"10.1016\/j.toxicon.2024.107652_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.112653","article-title":"The protective effect of Nigella sativa extract on lung inflammation and oxidative stress induced by lipopolysaccharide in rats","volume":"253","author":"Mokhtari-Zaer","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.toxicon.2024.107652_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112746","article-title":"Betulinic acid attenuates cyclophosphamide-induced intestinal mucosa injury by inhibiting the NF-\u03baB\/MAPK signalling pathways and activating the Nrf2 signalling pathway","volume":"225","author":"Ou","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.toxicon.2024.107652_bib37","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1177\/019262338701500309","article-title":"Experimental T-2 toxicosis in swine following inhalation exposure: effects on pulmonary and systemic immunity, and morphologic changes","volume":"15","author":"Pang","year":"1987","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.toxicon.2024.107652_bib38","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.mib.2020.07.012","article-title":"PANoptosis in microbial infection","volume":"59","author":"Place","year":"2021","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.toxicon.2024.107652_bib39","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/8880651","article-title":"Beneficial effects of rosmarinic acid on IPEC-J2 cells exposed to the combination of deoxynivalenol and T-2 toxin","volume":"2020","author":"Pomothy","year":"2020","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.toxicon.2024.107652_bib40","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1016\/j.bcp.2004.05.042","article-title":"Redox modulation of chromatin remodeling: impact on histone acetylation and deacetylation, NF-kappaB and pro-inflammatory gene expression","volume":"68","author":"Rahman","year":"2004","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.toxicon.2024.107652_bib41","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/s41467-020-14478-8","article-title":"Chronic activation of endothelial MAPK disrupts hematopoiesis via NFKB dependent inflammatory stress reversible by SCGF","volume":"11","author":"Ramalingam","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.toxicon.2024.107652_bib42","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1016\/j.freeradbiomed.2010.09.006","article-title":"Oxidative stress, inflammation, and cancer: how are they linked?","volume":"49","author":"Reuter","year":"2010","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.toxicon.2024.107652_bib43","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/nt.2620030404","article-title":"Role of mycotoxins in human and animal nutrition and health","volume":"3","author":"Smith","year":"1995","journal-title":"Nat. Toxins"},{"key":"10.1016\/j.toxicon.2024.107652_bib44","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1289\/ehp.866645","article-title":"Toxicity of mycotoxins for the rat pulmonary macrophage in vitro","volume":"66","author":"Sorenson","year":"1986","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.toxicon.2024.107652_bib45","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1046\/j.1523-1755.2003.00324.x","article-title":"Activation and cellular localization of the p38 and JNK MAPK pathways in rat crescentic glomerulonephritis","volume":"64","author":"Stambe","year":"2003","journal-title":"Kidney Int."},{"key":"10.1016\/j.toxicon.2024.107652_bib46","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1097\/01.ASN.0000108520.63445.E0","article-title":"p38 Mitogen-activated protein kinase activation and cell localization in human glomerulonephritis: correlation with renal injury","volume":"15","author":"Stambe","year":"2004","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.toxicon.2024.107652_bib47","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1007\/s11064-016-2147-y","article-title":"Betulinic acid induces apoptosis in differentiated PC12 cells via ROS-mediated mitochondrial pathway","volume":"42","author":"Wang","year":"2017","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.toxicon.2024.107652_bib48","doi-asserted-by":"crossref","first-page":"393","DOI":"10.3390\/toxics11040393","article-title":"Nrf2: a main responsive element of the toxicity effect caused by trichothecene (T-2) Mycotoxin","volume":"11","author":"Wang","year":"2023","journal-title":"Toxics"},{"key":"10.1016\/j.toxicon.2024.107652_bib49","doi-asserted-by":"crossref","DOI":"10.1002\/ardp.202200418","article-title":"Synthesis of benzylated amine-substituted xanthone derivatives and their antioxidant and anti-inflammatory activities","volume":"356","author":"Wong","year":"2023","journal-title":"Arch. Pharm. (Weinheim)"},{"key":"10.1016\/j.toxicon.2024.107652_bib50","doi-asserted-by":"crossref","first-page":"3645","DOI":"10.1007\/s00204-020-02899-9","article-title":"An update on T-2 toxin and its modified forms: metabolism, immunotoxicity mechanism, and human exposure assessment","volume":"94","author":"Wu","year":"2020","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.toxicon.2024.107652_bib51","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.7150\/ijbs.57825","article-title":"Betulinic acid inhibits pyroptosis in spinal cord injury by augmenting autophagy via the AMPK-mTOR-TFEB signaling pathway","volume":"17","author":"Wu","year":"2021","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.toxicon.2024.107652_bib52","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.toxicon.2020.02.023","article-title":"Distribution and persistence of residual T-2 and HT-2 toxins from moldy feed in broiler chickens","volume":"178","author":"Yang","year":"2020","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2024.107652_bib53","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1007\/s00264-010-0966-z","article-title":"Study on the effect of T-2 toxin combined with low nutrition diet on rat epiphyseal plate growth and development","volume":"34","author":"Yao","year":"2010","journal-title":"Int. Orthop."},{"key":"10.1016\/j.toxicon.2024.107652_bib54","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.intimp.2015.04.050","article-title":"Ameliorative effect of betulinic acid on oxidative damage and apoptosis in the splenocytes of dexamethasone treated mice","volume":"27","author":"Yi","year":"2015","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.toxicon.2024.107652_bib55","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/1518738","article-title":"Propofol suppressed hypoxia\/reoxygenation-induced apoptosis in HBVSMC by regulation of the expression of Bcl-2, Bax, Caspase 3, Kir 6.1, and p-JNK","volume":"2016","author":"Zhang","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.toxicon.2024.107652_bib56","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.fct.2018.02.010","article-title":"T-2 toxin-induced toxicity in neuroblastoma-2a cells involves the generation of reactive oxygen, mitochondrial dysfunction and inhibition of Nrf2\/HO-1 pathway","volume":"114","author":"Zhang","year":"2018","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.toxicon.2024.107652_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112286","article-title":"Bacillus amyloliquefaciens B10 can alleviate aflatoxin B1-induced kidney oxidative stress and apoptosis in mice","volume":"218","author":"Zhao","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.toxicon.2024.107652_bib58","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1111\/j.2042-7158.2010.01239.x","article-title":"Betulinic acid prevention of d-galactosamine\/lipopolysaccharide liver toxicity is triggered by activation of Bcl-2 and antioxidant mechanisms","volume":"63","author":"Zheng","year":"2011","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.toxicon.2024.107652_bib59","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.intimp.2015.10.012","article-title":"Melatonin prevents lung injury induced by hepatic ischemia-reperfusion through anti-inflammatory and anti-apoptosis effects","volume":"29","author":"Zhou","year":"2015","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.toxicon.2024.107652_bib60","doi-asserted-by":"crossref","first-page":"540","DOI":"10.3390\/toxins12090540","article-title":"Betulinic acid attenuates oxidative stress in the thymus induced by acute exposure to T-2 toxin via regulation of the MAPK\/Nrf2 signaling pathway","volume":"12","author":"Zhu","year":"2020","journal-title":"Toxins"}],"container-title":["Toxicon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010124002241?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010124002241?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T21:24:22Z","timestamp":1758576262000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041010124002241"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":60,"alternative-id":["S0041010124002241"],"URL":"https:\/\/doi.org\/10.1016\/j.toxicon.2024.107652","relation":{},"ISSN":["0041-0101"],"issn-type":[{"value":"0041-0101","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Betulinic acid attenuates T-2 toxin-induced lung injury by activating Nrf2 signaling pathway and inhibiting MAPK\/NF-\u03baB signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Toxicon","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxicon.2024.107652","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"107652"}}