{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T09:39:36Z","timestamp":1792489176200,"version":"4.5.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004916","name":"FAPEAM","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004916","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicon"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.toxicon.2024.107682","type":"journal-article","created":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T03:22:33Z","timestamp":1709781753000},"page":"107682","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Long-term hospital care needs after Bothrops atrox envenomation with hemorrhagic stroke in the Brazilian Amazon: \u2018From social to physical death\u2019 \u2013 A case report"],"prefix":"10.1016","volume":"241","author":[{"given":"Tha\u00eds Pinto","family":"Nascimento","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talyson Aparicio","family":"Gomes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e1rbara Juliana Carvalho","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda Braga","family":"Cunha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca Leite","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco Aur\u00e9lio","family":"Sartim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe Le\u00e3o Gomes","family":"Murta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wuelton","family":"Monteiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5723-9977","authenticated-orcid":false,"given":"Jacqueline de Almeida Gon\u00e7alves","family":"Sachett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxicon.2024.107682_bib1","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1093\/oxfordjournals.pubmed.a043090","article-title":"Clinical and epidemiological pattern of long-stay in-patients: an opportunity for the provision of out-reach community services in Saudi Arabia","volume":"17","author":"Al-Shammari","year":"1995","journal-title":"J. Publ. Health Med."},{"issue":"1","key":"10.1016\/j.toxicon.2024.107682_bib2","first-page":"3","volume":"19","author":"An","year":"2017","journal-title":"Epidemiology, Risk Factors, and Clinical Features of Intracerebral Hemorrhage: An Update. J Stroke [Internet]"},{"key":"10.1016\/j.toxicon.2024.107682_bib3","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0202361","article-title":"Predicting acute renal failure in Bothrops snakebite patients in a tertiary reference center, Western Brazilian Amazon","volume":"13","author":"Alves","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.toxicon.2024.107682_bib4","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0000727","article-title":"Mechanisms of vascular damage by hemorrhagic snake venom metalloproteinases: tissue distribution and in situ hydrolysis","volume":"4","author":"Baldo","year":"2010","journal-title":"PLoS Neglected Trop. Dis."},{"key":"10.1016\/j.toxicon.2024.107682_bib5","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0000727","article-title":"Mechanisms of vascular damage by hemorrhagic snake venom metalloproteinases: tissue distribution and in situ hydrolysis","volume":"4","author":"Baldo","year":"2010","journal-title":"PLoS Neglected Trop. Dis."},{"key":"10.1016\/j.toxicon.2024.107682_bib6","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1093\/qjmed\/hcw183","article-title":"Social death","volume":"110","author":"Borgstrom","year":"2017","journal-title":"QJM"},{"key":"10.1016\/j.toxicon.2024.107682_bib7","unstructured":"Brasil. SIGTAP \u2013 Sistema de Gerenciamento da Tabela de Procedimentos, Medicamento e OPM do SUS \u2013 Tratamento de Efeitos do Contato com Animais e Plantas Venenosos. Minist\u00e9rio da Sa\u00fade. www.datasus.gov.br. Access in: Fev 18, 2024."},{"key":"10.1016\/j.toxicon.2024.107682_bib8","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.toxicon.2016.08.005","article-title":"Brainstem ischemic stroke after to Bothrops atrox snakebite","volume":"120","author":"Ca\u00f1as","year":"2016","journal-title":"Toxicon"},{"issue":"5","key":"10.1016\/j.toxicon.2024.107682_bib9","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.4269\/ajtmh.17-0992","article-title":"Accuracy of the lee-white clotting time performed in the hospital routine to detect coagulopathy in Bothrops atrox envenomation","volume":"98","author":"de Brito Sousa","year":"2018","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.toxicon.2024.107682_bib10","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.toxicon.2018.02.041","article-title":"Snakebites as cause of deaths in the Western Brazilian Amazon: why and who dies? Deaths from snakebites in the Amazon","volume":"145","author":"da Silva Souza","year":"2018","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2024.107682_bib11","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0011485","article-title":"Snakebite envenomations and access to treatment in communities of two indigenous areas of the Western Brazilian Amazon: a cross-sectional study","volume":"17","author":"de Farias","year":"2023","journal-title":"PLoS Neglected Trop. Dis."},{"key":"10.1016\/j.toxicon.2024.107682_bib12","article-title":"Hemorrhagic stroke in children caused by Bothrops marajoensis envenoming: a case report","volume":"21","author":"de Oliveira Pardal","year":"2015","journal-title":"J Venomous Animals Toxins incl. Trop. Dis"},{"key":"10.1016\/j.toxicon.2024.107682_bib13","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/S0035-9203(03)00005-1","article-title":"Clinical trial of two antivenoms for the treatment of Bothrops and Lachesis bites in the north eastern Amazon region of Brazil","volume":"98","author":"de Oliveira Pardal","year":"2004","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1016\/j.toxicon.2024.107682_bib14","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0028017","article-title":"Role of collagens and perlecan in microvascular stability: exploring the mechanism of capillary vessel damage by snake venom metalloproteinases","volume":"6","author":"Escalante","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.toxicon.2024.107682_bib15","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.abb.2006.09.018","article-title":"Novel insights into capillary vessel basement membrane damage by snake venom hemorrhagic metalloproteinases: a biochemical and immunohistochemical study","volume":"455","author":"Escalante","year":"2006","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.toxicon.2024.107682_bib16","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.biochi.2015.08.006","article-title":"Comparison of venoms from wild and long-term captive Bothrops atrox snakes and characterization of Batroxrhagin, the predominant class PIII metalloproteinase from the venom of this species","volume":"118","author":"Freitas-De-Sousa","year":"2015","journal-title":"Biochimie"},{"key":"10.1016\/j.toxicon.2024.107682_bib17","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1471-2458-9-306","article-title":"Long-stay in short-stay inpatient facilities: risk factors and barriers to discharge","volume":"9","author":"Gigantesco","year":"2009","journal-title":"BMC Publ. Health"},{"key":"10.1016\/j.toxicon.2024.107682_bib18","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/j.toxicon.2005.02.029","article-title":"Hemorrhage induced by snake venom metalloproteinases: biochemical and biophysical mechanisms involved in microvessel damage","volume":"45","author":"Guti\u00e9rrez","year":"2005","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2024.107682_bib19","series-title":"Cerebral Complications of Snakebite Envenoming: Case Studies. Toxins (Basel) [Internet]","author":"Huang","year":"2022"},{"key":"10.1016\/j.toxicon.2024.107682_bib20","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1002\/brb3.1722","article-title":"Acute kidney injury after a stroke: a PRISMA-compliant meta-analysis","volume":"10","author":"Huang","year":"2020","journal-title":"Brain Behav"},{"key":"10.1016\/j.toxicon.2024.107682_bib21","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/0035-9203(91)90257-Y","article-title":"Fatal extradural haematoma after snake bite (Bothrops moojeni)","volume":"85","author":"Kouyoumdjian","year":"1991","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1016\/j.toxicon.2024.107682_bib22","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1080\/21582041.2015.1114407","article-title":"What is social death?","volume":"10","author":"Kr\u00e1lov\u00e1","year":"2015","journal-title":"Contemp Soc Sci"},{"key":"10.1016\/j.toxicon.2024.107682_bib23","series-title":"Claw Hand. [Updated 2023 Aug 8]. in: StatPearls [Internet]. Treasure Island (FL)","author":"Lane","year":"2024"},{"key":"10.1016\/j.toxicon.2024.107682_bib24","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0009758","article-title":"Snakebites in \u201cInvisible Populations\u201d: a cross-sectional survey in riverine populations in the remote western Brazilian Amazon","volume":"15","author":"Maciel Salazar","year":"2021","journal-title":"PLoS Neglected Trop. Dis."},{"key":"10.1016\/j.toxicon.2024.107682_bib25","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1093\/trstmh\/traa005","article-title":"Snakebite envenomation in the Brazilian Amazon: a cost-of-illness study","volume":"114","author":"Magalh\u00e3es","year":"2020","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1016\/j.toxicon.2024.107682_bib26","series-title":"Cerebral Hemorrhage: Pathophysiology, Treatment, and Future Directions. Circ Res [Internet]","author":"Magid-Bernstein","year":"2022"},{"key":"10.1016\/j.toxicon.2024.107682_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.toxcx.2020.100037","article-title":"Bothrops atrox, the most important snake involved in human envenomings in the amazon: how venomics contributes to the knowledge of snake biology and clinical toxinology","volume":"6","author":"Monteiro","year":"2020","journal-title":"Toxicon X"},{"key":"10.1016\/j.toxicon.2024.107682_bib28","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1212\/01.WNL.0000061614.52580.A1","article-title":"Stroke following Bothrops spp. snakebite","volume":"60","author":"Mosquera","year":"2003","journal-title":"Neurology"},{"key":"10.1016\/j.toxicon.2024.107682_bib29","doi-asserted-by":"crossref","DOI":"10.3390\/toxins12090554","article-title":"Bleeding disorders in Bothrops atrox envenomations in the Brazilian amazon: participation of hemostatic factors and the impact of tissue factor","volume":"12","author":"Oliveira","year":"2020","journal-title":"Toxins"},{"key":"10.1016\/j.toxicon.2024.107682_bib30","doi-asserted-by":"crossref","DOI":"10.1590\/0037-8682-0115-2019","article-title":"Hemorrhagic stroke following viper bites and delayed antivenom administration: three case reports from the Western Brazilian Amazon","volume":"52","author":"P\u00e9rez-G\u00f3mez","year":"2019","journal-title":"Rev. Soc. Bras. Med. Trop."},{"key":"10.1016\/j.toxicon.2024.107682_bib31","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1081\/JDI-100103499","article-title":"Fatal cerebral hemorrhage and acute renal failure after young Bothrops jararacussu snake bite","volume":"23","author":"Pinho","year":"2001","journal-title":"Ren. Fail."},{"key":"10.1016\/j.toxicon.2024.107682_bib32","series-title":"Acidente vascular encef\u00e1lico em v\u00edtimas de acidentes of\u00eddicos: Uma revis\u00e3o sistem\u00e1tica com metan\u00e1lise de dados individuais (Disserta\u00e7\u00e3o de Mestrado)","author":"Priante","year":"2023"},{"key":"10.1016\/j.toxicon.2024.107682_bib33","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1007\/s00068-007-6184-8","article-title":"Evaluation of factors delaying discharge in acute orthopedic wards: a prospective study","volume":"34","author":"Rambani","year":"2008","journal-title":"Eur. J. Trauma Emerg. Surg."},{"key":"10.1016\/j.toxicon.2024.107682_bib34","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1007\/s40475-020-00203-4","article-title":"Bothrops snakebite envenomings in the amazon region","volume":"7","author":"Resiere","year":"2020","journal-title":"Curr Trop Med Rep"},{"key":"10.1016\/j.toxicon.2024.107682_bib35","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.wem.2020.04.009","article-title":"Cerebrovascular accidents related to snakebites in the amazon-two case reports","volume":"31","author":"Sachett","year":"2020","journal-title":"Wilderness Environ. Med."},{"key":"10.1016\/j.toxicon.2024.107682_bib36","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.toxicon.2017.08.021","article-title":"Fatal stroke after Bothrops snakebite in the Amazonas state, Brazil: a case report","volume":"138","author":"Silva de Oliveira","year":"2017","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2024.107682_bib37","doi-asserted-by":"crossref","DOI":"10.1590\/0037-8682-0374-2020","article-title":"Severe tissue complications in patients of Bothrops snakebite at a tertiary health unit in the Brazilian Amazon: clinical characteristics and associated factors","volume":"54","author":"Silva","year":"2021","journal-title":"Rev. Soc. Bras. Med. Trop."},{"key":"10.1016\/j.toxicon.2024.107682_bib38","author":"Unnithan","year":"2022","journal-title":"Hemorrhagic Stroke. StatPearls [Internet]"},{"key":"10.1016\/j.toxicon.2024.107682_bib39","first-page":"321","article-title":"Long-stay institutions for the elderly: the reality in Brazil","volume":"5","author":"Wanderley","year":"2020","journal-title":"Journal Health NPEPS"}],"container-title":["Toxicon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004101012400254X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004101012400254X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T21:25:41Z","timestamp":1758576341000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S004101012400254X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":39,"alternative-id":["S004101012400254X"],"URL":"https:\/\/doi.org\/10.1016\/j.toxicon.2024.107682","relation":{},"ISSN":["0041-0101"],"issn-type":[{"value":"0041-0101","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Long-term hospital care needs after Bothrops atrox envenomation with hemorrhagic stroke in the Brazilian Amazon: \u2018From social to physical death\u2019 \u2013 A case report","name":"articletitle","label":"Article Title"},{"value":"Toxicon","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxicon.2024.107682","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"107682"}}