{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T03:44:14Z","timestamp":1773978254815,"version":"3.50.1"},"reference-count":72,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["88887.909464\/2023-00"],"award-info":[{"award-number":["88887.909464\/2023-00"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicon"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.toxicon.2026.109002","type":"journal-article","created":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T07:42:08Z","timestamp":1769240528000},"page":"109002","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Evaluation of embryotoxicity and teratogenicity of Cenostigma pyramidale (Tul.) fruit extract in zebrafish (Danio rerio)"],"prefix":"10.1016","volume":"273","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-6027-1406","authenticated-orcid":false,"given":"Cain\u00e3 Aill\u00e9n Ouriques","family":"Oliveira","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thailan Arlindo da","family":"Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1310-7662","authenticated-orcid":false,"given":"Rafael David Souto de","family":"Azevedo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5823-9848","authenticated-orcid":false,"given":"Josefa Gerlane da","family":"Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7555-484X","authenticated-orcid":false,"given":"Jaianne Keitt Alves de","family":"Melo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8826-1683","authenticated-orcid":false,"given":"Pedro Greg\u00f3rio Vieira","family":"Aquino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taciana Rabelo Ramalho","family":"Ramos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxicon.2026.109002_bib1","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0076-6879(84)05016-3","article-title":"Catalase in vitro","volume":"105","author":"Aebi","year":"1984","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.toxicon.2026.109002_bib2","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/3807207","article-title":"Phytochemical evaluation, embryotoxicity, and teratogenic effects of Curcuma longa extract on zebrafish (Danio rerio)","volume":"2019","author":"Alafiatayo","year":"2019","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"10.1016\/j.toxicon.2026.109002_bib3","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.fct.2013.02.040","article-title":"Relative expression of cholesterol transport-related proteins and inflammation markers through the induction of 7-ketosterol-mediated stress in Caco-2 cells","volume":"56","author":"Alemany","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.toxicon.2026.109002_bib4","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1093\/jexbot\/53.372.1331","article-title":"Role of superoxide dismutases (SODs) in controlling oxidative stress in plants","volume":"53","author":"Alscher","year":"2002","journal-title":"J. Exp. Bot."},{"key":"10.1016\/j.toxicon.2026.109002_bib5","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1590\/S1519-69842012000300013","article-title":"Bioactivity evaluation against Artemia salina Leach of medicinal plants used in Brazilian Northeastern folk medicine","volume":"72","author":"Arcanjo","year":"2012","journal-title":"Braz. J. Biol."},{"key":"10.1016\/j.toxicon.2026.109002_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbagen.2020.129634","article-title":"Mitochondria as targets for toxicity and metabolism research using zebrafish","volume":"1864","author":"Azevedo","year":"2020","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"key":"10.1016\/j.toxicon.2026.109002_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.mito.2024.101901","article-title":"The tissue-specific nature of physiological zebrafish mitochondrial bioenergetics","volume":"77","author":"Azevedo","year":"2024","journal-title":"Mitochondrion"},{"key":"10.1016\/j.toxicon.2026.109002_bib8","series-title":"Subsecretaria De Ci\u00eancia E Tecnologia","article-title":"Invent\u00e1rio de plantas medicinais do estado da Bahia. Secretaria do Planejamento, Ci\u00eancia e Tecnologia","year":"1979"},{"key":"10.1016\/j.toxicon.2026.109002_bib9","article-title":"Poisonings in ruminants by Cenostigma pyramidale (Tul.) Gagnon & GP Lewis (Fabaceae)","volume":"246","author":"Bezerra","year":"2024","journal-title":"A mini-review of teratogenic potential and phytochemical evidence. Toxicon"},{"key":"10.1016\/j.toxicon.2026.109002_bib10","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-025-13154-5","article-title":"Zebrafish model of palmitic acid induced MAFLD recapitulates pathways conserved in mice and humans","volume":"15","author":"Bhattacharya","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.toxicon.2026.109002_bib11","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.1002\/etc.5620180927","article-title":"Toxicity of retene to early life stages of two freshwater fish species","volume":"18","author":"Billiard","year":"1999","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.toxicon.2026.109002_bib12","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1177\/1040638716682564","article-title":"Embryotoxic effects of Poincianella (Caesalpinia) pyramidalis leaves on pregnant rats","volume":"29","author":"C\u00e2mara","year":"2017","journal-title":"J. Vet. Diagn. Invest."},{"key":"10.1016\/j.toxicon.2026.109002_bib13","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.fsi.2018.05.025","article-title":"Palmitate induces nitric oxide production and inflammatory cytokine expression in zebrafish","volume":"79","author":"Cha","year":"2018","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.toxicon.2026.109002_bib14","doi-asserted-by":"crossref","first-page":"3382","DOI":"10.1080\/14786419.2019.1566724","article-title":"Phytochemical characterization and mutagenicity, cytotoxicity, antimicrobial and modulatory activities of Poincianella pyramidalis (Tul.) LP Queiroz","volume":"34","author":"Chaves","year":"2020","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.toxicon.2026.109002_bib15","first-page":"1","article-title":"Comparative cardio and developmental toxicity induced by the popular medicinal extract of Sutherlandia frutescens (L.) R.Br. detected using a zebrafish Tuebingen embryo model","volume":"18","author":"Chen","year":"2018","journal-title":"BMC Compl. Alternative Med."},{"key":"10.1016\/j.toxicon.2026.109002_bib16","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1111\/j.1432-1033.1996.0623w.x","article-title":"The mitochondrial permeability transition pore is modulated by oxidative agents through both pyridine nucleotides and glutathione at two separate sites","volume":"238","author":"Chernyak","year":"1996","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.toxicon.2026.109002_bib17","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/S0022-2275(20)38875-1","article-title":"Placental transfer of cholesterol-4-14C into rabbit and Guinea pig fetus","volume":"8","author":"Connor","year":"1967","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.toxicon.2026.109002_bib18","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1590\/s0100-736x2017001200012","article-title":"Malforma\u00e7\u00f5es cong\u00eanitas e abortos induzidos experimentalmente pela ingest\u00e3o de Poincianella pyramidalis (Tul.) LP Queiroz (catingueira) em ovelhas","volume":"37","author":"Correia","year":"2017","journal-title":"Pesqui. Vet. Bras."},{"key":"10.1016\/j.toxicon.2026.109002_bib19","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1016\/S0022-2275(20)37421-6","article-title":"Saturated but not mono-unsaturated fatty acids induce apoptotic cell death in neonatal rat ventricular myocytes","volume":"38","author":"De Vries","year":"1997","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.toxicon.2026.109002_bib20","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.plipres.2017.06.002","article-title":"Emerging roles for conjugated sterols in plants","volume":"67","author":"Ferrer","year":"2017","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.toxicon.2026.109002_bib21","series-title":"Oxygen and Living Processes","first-page":"250","article-title":"Superoxide radical and superoxide dismutases","author":"Fridovich","year":"1981"},{"key":"10.1016\/j.toxicon.2026.109002_bib22","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1177\/1091581814523142","article-title":"Toxicity assessment of 7 anticancer compounds in zebrafish","volume":"33","author":"Gao","year":"2014","journal-title":"Int. J. Toxicol."},{"key":"10.1016\/j.toxicon.2026.109002_bib23","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/S1360-1385(98)01233-3","article-title":"Plant sterols and the membrane environment","volume":"3","author":"Hartmann","year":"1998","journal-title":"Trends Plant Sci."},{"key":"10.1016\/j.toxicon.2026.109002_bib24","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1093\/toxsci\/kfi110","article-title":"Zebrafish as a model vertebrate for investigating chemical toxicity","volume":"86","author":"Hill","year":"2005","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.toxicon.2026.109002_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.mocell.2024.100090","article-title":"Brief guidelines for zebrafish embryotoxicity tests","volume":"47","author":"Hong","year":"2024","journal-title":"Mol. Cells"},{"key":"10.1016\/j.toxicon.2026.109002_bib26","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1002\/1097-0185(20001001)260:2<148::AID-AR50>3.0.CO;2-X","article-title":"Structure and function of the developing zebrafish heart","volume":"260","author":"Hu","year":"2000","journal-title":"Anat. Rec."},{"key":"10.1016\/j.toxicon.2026.109002_bib27","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1095\/biolreprod.111.092148","article-title":"Preimplantation exposure of mouse embryos to palmitic acid results in fetal growth restriction followed by catch-up growth in the offspring","volume":"85","author":"Jungheim","year":"2011","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.toxicon.2026.109002_bib28","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1002\/ddrr.1114","article-title":"Sterol metabolism disorders and neurodevelopment\u2014an update","volume":"17","author":"Kanungo","year":"2013","journal-title":"Dev. Disabil. Res. Rev."},{"key":"10.1016\/j.toxicon.2026.109002_bib29","doi-asserted-by":"crossref","first-page":"755","DOI":"10.3389\/fphys.2020.00755","article-title":"Manganese superoxide dismutase dysfunction and the pathogenesis of kidney disease","volume":"11","author":"Kitada","year":"2020","journal-title":"Front. Physiol."},{"key":"10.1016\/j.toxicon.2026.109002_bib30","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.tiv.2009.03.007","article-title":"Cytotoxic and apoptotic effects of single and mixed oxides of \u03b2-sitosterol on HepG2-cells","volume":"23","author":"Koschutnig","year":"2009","journal-title":"Toxicol. Vitro"},{"key":"10.1016\/j.toxicon.2026.109002_bib31","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.plaphy.2015.07.014","article-title":"Role of phytosterols in drought stress tolerance in rice","volume":"96","author":"Kumar","year":"2015","journal-title":"Plant Physiol. Biochem."},{"key":"10.1016\/j.toxicon.2026.109002_bib32","doi-asserted-by":"crossref","first-page":"14890","DOI":"10.1074\/jbc.M010286200","article-title":"Palmitate-induced apoptosis can occur through a ceramide-independent pathway","volume":"276","author":"Listenberger","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxicon.2026.109002_bib33","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.toxicon.2017.08.020","article-title":"Reproductive losses caused by the ingestion of Poincianella pyramidalis in sheep","volume":"138","author":"Lopes","year":"2017","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2026.109002_bib34","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1079\/BJN2003956","article-title":"Comparison of the cytotoxic effects of \u03b2-sitosterol oxides and a cholesterol oxide, 7\u03b2-hydroxycholesterol, in cultured mammalian cells","volume":"90","author":"Maguire","year":"2003","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.toxicon.2026.109002_bib35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1590\/S0100-736X2010000100001","article-title":"Plantas t\u00f3xicas para ruminantes e eq\u00fc\u00eddeos no Norte Piauiense","volume":"30","author":"Mello","year":"2010","journal-title":"Pesqui. Vet. Bras."},{"key":"10.1016\/j.toxicon.2026.109002_bib36","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1055\/s-2007-971236","article-title":"Brine shrimp: a convenient general bioassay for active plant constituents","volume":"45","author":"Meyer","year":"1982","journal-title":"Planta Med."},{"key":"10.1016\/j.toxicon.2026.109002_bib37","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.freeradbiomed.2009.05.018","article-title":"Regulation of superoxide dismutase genes: implications in disease","volume":"47","author":"Miao","year":"2009","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.toxicon.2026.109002_bib38","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.1016\/S0021-9258(19)45228-9","article-title":"The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase","volume":"247","author":"Misra","year":"1972","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxicon.2026.109002_bib39","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1016\/j.toxrep.2019.10.020","article-title":"Toxicity study on Clinacanthus nutans leaf hexane fraction using Danio rerio embryos","volume":"6","author":"Murugesu","year":"2019","journal-title":"Toxicol. Rep."},{"key":"10.1016\/j.toxicon.2026.109002_bib40","first-page":"38","article-title":"DarT: the embryo test with the Zebrafish Danio rerio-a general model in ecotoxicology and toxicology","volume":"19","author":"Nagel","year":"2002","journal-title":"ALTEX"},{"key":"10.1016\/j.toxicon.2026.109002_bib41","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/9613090","article-title":"Role of catalase in oxidative stress\u2010and age\u2010associated degenerative diseases","volume":"2019","author":"Nandi","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.toxicon.2026.109002_bib42","doi-asserted-by":"crossref","first-page":"30","DOI":"10.2174\/2210289201203010030","article-title":"Evaluation of acute toxicity of crude plant extracts from Kenyan biodiversity using brine shrimp, Artemia salina L. (Artemiidae)","volume":"3","author":"Nguta","year":"2012","journal-title":"Open Conf. Proc. J."},{"key":"10.1016\/j.toxicon.2026.109002_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.113538","article-title":"Developmental toxicity of Clerodendrum cyrtophyllum turcz ethanol extract in zebrafish embryo","volume":"267","author":"Nguyen","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.toxicon.2026.109002_bib44","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/j.bbrc.2014.01.148","article-title":"Recent advances in phytosterol oxidation products","volume":"446","author":"O'Callaghan","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.toxicon.2026.109002_bib45","series-title":"Test No. 236: Fish Embryo","year":"2013"},{"key":"10.1016\/j.toxicon.2026.109002_bib46","first-page":"189","article-title":"Composi\u00e7\u00e3o qu\u00edmica das cascas das ra\u00edzes e flores de Poincianella pyramidalis (Fabaceae)","volume":"39","author":"Oliveira","year":"2016","journal-title":"Quim. Nova"},{"key":"10.1016\/j.toxicon.2026.109002_bib47","series-title":"An Introduction to Interdisciplinary Toxicology","first-page":"525","article-title":"The zebrafish (Danio rerio) model in toxicity testing","author":"Padilla","year":"2020"},{"key":"10.1016\/j.toxicon.2026.109002_bib48","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1530\/jrf.0.0460461","article-title":"Abortifacient effect of steroids from Ananas comosus and their analogues on mice","volume":"46","author":"Pakrashi","year":"1976","journal-title":"Reproduction"},{"key":"10.1016\/j.toxicon.2026.109002_bib49","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.freeradbiomed.2017.02.022","article-title":"Real-time quantification of subcellular H2O2 and glutathione redox potential in living cardiovascular tissues","volume":"109","author":"Panieri","year":"2017","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.toxicon.2026.109002_bib50","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1089\/zeb.2019.1758","article-title":"Palmitic acid-enriched diet induces hepatic steatosis and injury in adult zebrafish","volume":"16","author":"Park","year":"2019","journal-title":"Zebrafish"},{"key":"10.1016\/j.toxicon.2026.109002_bib51","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1590\/S0100-736X2013000600011","article-title":"Import\u00e2ncia econ\u00f4mica, epidemiologia e controle das intoxica\u00e7\u00f5es por plantas no Brasil","volume":"33","author":"Pessoa","year":"2013","journal-title":"Pesqui. Vet. Bras."},{"key":"10.1016\/j.toxicon.2026.109002_bib52","doi-asserted-by":"crossref","first-page":"2584","DOI":"10.1172\/JCI107075","article-title":"Cholesterol metabolism and placental transfer in the pregnant rhesus monkey","volume":"51","author":"Pitkin","year":"1972","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.toxicon.2026.109002_bib53","series-title":"Leguminosas Da Caatinga. Feira De Santana: Universidade Estadual De Feira De Santana","author":"Queiroz","year":"2009"},{"key":"10.1016\/j.toxicon.2026.109002_bib54","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.scitotenv.2018.04.012","article-title":"Mechanisms of developmental toxicity in zebrafish embryos (Danio rerio) induced by boscalid","volume":"634","author":"Qian","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.toxicon.2026.109002_bib55","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.toxicon.2016.04.043","article-title":"Congenital malformations and other reproductive losses in goats due to poisoning by Poincianella pyramidalis (Tul.) LP Queiroz (= Caesalpinia pyramidalis Tul.)","volume":"118","author":"Reis","year":"2016","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2026.109002_bib56","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1007\/s11101-020-09708-2","article-title":"The role of sterols in plant response to abiotic stress","volume":"19","author":"Rogowska","year":"2020","journal-title":"Phytochem. Rev."},{"key":"10.1016\/j.toxicon.2026.109002_bib57","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1002\/jbt.20007","article-title":"Generation of an oxidative stress precedes caspase activation during 7\u03b2\u2010hydroxycholesterol\u2010induced apoptosis in U937 cells","volume":"18","author":"Ryan","year":"2004","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.toxicon.2026.109002_bib58","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1590\/1678-5150-pvb-5480","article-title":"Embryonic mortality and abortion in goats caused by ingestion of Poincianella pyramidalis","volume":"38","author":"Santos","year":"2018","journal-title":"Pesqui. Vet. Bras."},{"key":"10.1016\/j.toxicon.2026.109002_bib59","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1104\/pp.101.1.7","article-title":"Oxygen stress and superoxide dismutases","volume":"101","author":"Scandalios","year":"1993","journal-title":"Plant Physiol."},{"key":"10.1016\/j.toxicon.2026.109002_bib60","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1177\/0300985812467471","article-title":"Zebrafish models for human cancer","volume":"50","author":"Shive","year":"2013","journal-title":"Vet. Pathol."},{"issue":"1","key":"10.1016\/j.toxicon.2026.109002_bib61","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/0003-2697(85)90442-7","article-title":"Measurement of protein using bicinchoninic acid","volume":"150","author":"Smith","year":"1985","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.toxicon.2026.109002_bib62","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.113181","article-title":"Poincianella pyramidalis (Tul) LP Queiroz: a review on traditional uses, phytochemistry and biological-pharmacological activities","volume":"264","author":"Sousa","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.toxicon.2026.109002_bib63","first-page":"179","article-title":"Qualidade nutricional de plantas forrageiras de ocorr\u00eancia natural na Caatinga","volume":"9","author":"Souza","year":"2013","journal-title":"Enciclop. Biosfera, Goi\u00e2nia"},{"key":"10.1016\/j.toxicon.2026.109002_bib64","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1590\/1678-5150-pvb-5243","article-title":"Abortos, malforma\u00e7\u00f5es cong\u00eanitas e falhas reprodutivas espont\u00e2neas em caprinos causados na intoxica\u00e7\u00e3o pelas folhas da catingueira, Poincianella pyramidalis (sin. Caesalpinia pyramidalis)","volume":"38","author":"Souza","year":"2018","journal-title":"Pesqui. Vet. Bras."},{"key":"10.1016\/j.toxicon.2026.109002_bib65","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1093\/jxb\/erv054","article-title":"Membrane nanodomains in plants: capturing form, function, and movement","volume":"66","author":"Tapken","year":"2015","journal-title":"J. Exp. Bot."},{"key":"10.1016\/j.toxicon.2026.109002_bib66","doi-asserted-by":"crossref","first-page":"16","DOI":"10.18782\/2320-7051.2293","article-title":"Embryo-toxicity and teratogenicity of Derris elliptica leaf extract on zebrafish (Danio rerio) embryos","volume":"4","author":"Tolentino","year":"2016","journal-title":"Int. J. Pure Appl. Biosci."},{"key":"10.1016\/j.toxicon.2026.109002_bib67","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/978-1-60761-849-2_16","article-title":"Evaluation of embryotoxicity using the zebrafish model","volume":"691","author":"Truong","year":"2011","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.toxicon.2026.109002_bib68","article-title":"Saturated palmitic acid induces myocardial inflammatory injuries through direct binding to TLR4 accessory protein MD2","volume":"8","author":"Wang","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.toxicon.2026.109002_bib69","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.cbpc.2003.08.013","article-title":"Apoptosis in zebrafish development. Comparative Biochemistry and Physiology Part B","volume":"136","author":"Yamashita","year":"2003","journal-title":"Biochem. Mol. Biol."},{"key":"10.1016\/j.toxicon.2026.109002_bib70","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1093\/cvr\/cvs370","article-title":"\u03b2-Sitosterol oxidation products attenuate vasorelaxation by increasing reactive oxygen species and cyclooxygenase-2","volume":"97","author":"Yang","year":"2013","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.toxicon.2026.109002_bib71","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1002\/ptr.906","article-title":"Isolation of an antimicrobial compound from Impatiens balsamina L. using bioassay\u2010guided fractionation","volume":"15","author":"Yang","year":"2001","journal-title":"Phytother Res."},{"key":"10.1016\/j.toxicon.2026.109002_bib72","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1080\/02772248.2015.1093750","article-title":"Evaluation of developmental toxicity and apoptotic induction of the aqueous extract of Millettia pachycarpa using zebrafish as model organism","volume":"97","author":"Yumnamcha","year":"2015","journal-title":"Toxicol. Environ. Chem."}],"container-title":["Toxicon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010126000206?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010126000206?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T02:54:43Z","timestamp":1773975283000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041010126000206"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":72,"alternative-id":["S0041010126000206"],"URL":"https:\/\/doi.org\/10.1016\/j.toxicon.2026.109002","relation":{},"ISSN":["0041-0101"],"issn-type":[{"value":"0041-0101","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluation of embryotoxicity and teratogenicity of Cenostigma pyramidale (Tul.) fruit extract in zebrafish (Danio rerio)","name":"articletitle","label":"Article Title"},{"value":"Toxicon","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxicon.2026.109002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"109002"}}