{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T02:22:22Z","timestamp":1793931742164,"version":"4.8.0"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003819","name":"Hubei Province Natural Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicon"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.toxicon.2026.109042","type":"journal-article","created":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T20:33:13Z","timestamp":1772483593000},"page":"109042","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Daidzein attenuates hepatic ischemia\/reperfusion injury via HMGB1-TLR4 signaling pathway"],"prefix":"10.1016","volume":"275","author":[{"given":"Shanglin","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyue","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueqiang","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinke","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangyuan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxicon.2026.109042_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2008.09.029","article-title":"Mouse model of liver ischemia and reperfusion injury: method for studying reactive oxygen and nitrogen metabolites in vivo","volume":"46","author":"Abe","year":"2009","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.toxicon.2026.109042_bib2","first-page":"39","article-title":"Genistein and daidzein: different molecular effects on prostate cancer","volume":"33","author":"Adjakly","year":"2013","journal-title":"Anticancer Res."},{"key":"10.1016\/j.toxicon.2026.109042_bib3","volume":"2021","author":"Alshehri","year":"2021","journal-title":"Therapeutic Potential of Isoflavones with an Emphasis on Daidzein"},{"key":"10.1016\/j.toxicon.2026.109042_bib4","doi-asserted-by":"crossref","first-page":"146","DOI":"10.4103\/1673-5374.150724","article-title":"Neuroprotective effects of daidzein on focal cerebral ischemia injury in rats","volume":"10","author":"Aras","year":"2015","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.toxicon.2026.109042_bib5","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.phrs.2018.12.014","article-title":"Protective effects of curcumin against ischemia-reperfusion injury in the liver","volume":"141","author":"Bavarsad","year":"2019","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.toxicon.2026.109042_bib6","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24032340","article-title":"Experimental and clinical aspects of sevoflurane preconditioning and postconditioning to alleviate hepatic ischemia-reperfusion injury: a scoping review","volume":"24","author":"Benoit","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.toxicon.2026.109042_bib7","doi-asserted-by":"crossref","DOI":"10.1098\/rsob.180002","article-title":"Targeting BCL-2 regulated apoptosis in cancer","volume":"8","author":"Campbell","year":"2018","journal-title":"Open Biol."},{"key":"10.1016\/j.toxicon.2026.109042_bib8","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1024\/0300-9831.73.2.120","article-title":"Potential risks and benefits of phytoestrogen-rich diets","volume":"73","author":"Cassidy","year":"2003","journal-title":"Int. J. Vitam. Nutr. Res."},{"key":"10.1016\/j.toxicon.2026.109042_bib9","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/s12276-022-00736-w","article-title":"The mechanism of HMGB1 secretion and release","volume":"54","author":"Chen","year":"2022","journal-title":"Exp Mol Med"},{"key":"10.1016\/j.toxicon.2026.109042_bib10","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1111\/liv.14091","article-title":"Ischaemia reperfusion injury in liver transplantation: cellular and molecular mechanisms","volume":"39","author":"Dar","year":"2019","journal-title":"Liver Int."},{"key":"10.1016\/j.toxicon.2026.109042_bib12","article-title":"Research progress of nano selenium in the treatment of oxidative stress injury during hepatic ischemia-reperfusion injury","volume":"13","author":"Deng","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.toxicon.2026.109042_bib11","doi-asserted-by":"crossref","first-page":"3409","DOI":"10.1007\/s12035-023-03787-w","article-title":"Targeting NF-\u03baB in Hepatic ischemia-reperfusion alleviation: from signaling networks to therapeutic targeting","volume":"61","author":"Deng","year":"2024","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.toxicon.2026.109042_bib13","doi-asserted-by":"crossref","first-page":"3856","DOI":"10.7150\/thno.82607","article-title":"Hepatocyte HSPA12A inhibits macrophage chemotaxis and activation to attenuate liver ischemia\/reperfusion injury via suppressing glycolysis-mediated HMGB1 lactylation and secretion of hepatocytes","volume":"13","author":"Du","year":"2023","journal-title":"Theranostics"},{"key":"10.1016\/j.toxicon.2026.109042_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2020.115340","article-title":"Octreotide and melatonin alleviate inflammasome-induced pyroptosis through inhibition of TLR4-NF-\u03baB-NLRP3 pathway in hepatic ischemia\/reperfusion injury","volume":"410","author":"El-Sisi","year":"2021","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.toxicon.2026.109042_bib15","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.intimp.2015.04.002","article-title":"Daidzein attenuates lipopolysaccharide-induced acute lung injury via toll-like receptor 4\/NF-kappaB pathway","volume":"26","author":"Feng","year":"2015","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.toxicon.2026.109042_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103255","article-title":"Inhibition of ferroptosis rescues M2 macrophages and alleviates arthritis by suppressing the HMGB1\/TLR4\/STAT3 axis in M1 macrophages","volume":"75","author":"Feng","year":"2024","journal-title":"Redox Biol."},{"key":"10.1016\/j.toxicon.2026.109042_bib17","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.2987","article-title":"HMGB1, angel or devil, in ischemic stroke","volume":"13","author":"Gao","year":"2023","journal-title":"Brain Behav"},{"key":"10.1016\/j.toxicon.2026.109042_bib18","first-page":"1","article-title":"Unveiling the neuroprotective properties of isoflavones: current evidence, molecular mechanisms and future perspectives","author":"Gong","year":"2024","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.toxicon.2026.109042_bib19","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.747911","article-title":"The protective effect of dexmedetomidine Against ischemia-reperfusion injury after hepatectomy: a meta-analysis of randomized controlled trials","volume":"12","author":"Huang","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.toxicon.2026.109042_bib20","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.1002\/jcp.29106","article-title":"Cav-1 participates in the development of diabetic neuropathy pain through the TLR4 signaling pathway","volume":"235","author":"Jia","year":"2020","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.toxicon.2026.109042_bib21","first-page":"38","article-title":"ROS-responsive 18\u03b2-glycyrrhetic acid-conjugated polymeric nanoparticles mediate neuroprotection in ischemic stroke through HMGB1 inhibition and microglia polarization regulation","volume":"19","author":"Jin","year":"2023","journal-title":"Bioact Mater"},{"key":"10.1016\/j.toxicon.2026.109042_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2024.122139","article-title":"RG-I pectin-like polysaccharide from Rosa chinensis inhibits inflammation and fibrosis associated to HMGB1\/TLR4\/NF-\u03baB signaling pathway to improve non-alcoholic steatohepatitis","volume":"337","author":"Jing","year":"2024","journal-title":"Carbohydr Polym"},{"key":"10.1016\/j.toxicon.2026.109042_bib23","volume":"11","author":"Kaltenmeier","year":"2022","journal-title":"Role of Immuno-Inflammatory Signals in Liver Ischemia-Reperfusion Injury"},{"key":"10.1016\/j.toxicon.2026.109042_bib24","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.jss.2018.09.057","article-title":"Effects of hepatic ischemia-reperfusion injuries and NRF2 on transcriptional activities of bile transporters in rats","volume":"235","author":"Kim","year":"2019","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.toxicon.2026.109042_bib25","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.lfs.2008.12.005","article-title":"Daidzein administration in vivo reduces myocardial injury in a rat ischemia\/reperfusion model by inhibiting NF-kappaB activation","volume":"84","author":"Kim","year":"2009","journal-title":"Life Sci."},{"key":"10.1016\/j.toxicon.2026.109042_bib26","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20235899","article-title":"Remote ischemic preconditioning and diazoxide protect from hepatic ischemic reperfusion injury by inhibiting HMGB1-Induced TLR4\/MyD88\/NF-\u03baB signaling","volume":"20","author":"Koh","year":"2019","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.toxicon.2026.109042_bib27","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1007\/s10753-023-01792-8","article-title":"Chlorogenic acid alleviates Hepatic ischemia-reperfusion injury by inhibiting oxidative stress, inflammation, and Mitochondria-Mediated apoptosis In vivo and In vitro","volume":"46","author":"Li","year":"2023","journal-title":"Inflammation"},{"key":"10.1016\/j.toxicon.2026.109042_bib28","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.21037\/atm-21-378","article-title":"Daidzein ameliorated concanavalin A-induced liver injury through the Akt\/GSK-3\u03b2\/Nrf2 pathway in mice","volume":"9","author":"Li","year":"2021","journal-title":"Ann Transl Med"},{"key":"10.1016\/j.toxicon.2026.109042_bib29","doi-asserted-by":"crossref","first-page":"3018","DOI":"10.1096\/fj.201601278R","article-title":"mTOR activation protects liver from ischemia\/reperfusion-induced injury through NF-\u03baB pathway","volume":"31","author":"Li","year":"2017","journal-title":"FASEB J."},{"key":"10.1016\/j.toxicon.2026.109042_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2019.117146","article-title":"HMGB1 upregulates NF-kB by inhibiting IKB-\u03b1 and associates with diabetic retinopathy","volume":"241","author":"Liang","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.toxicon.2026.109042_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110398","article-title":"The effect of Ginsenoside Rg1 in hepatic ischemia reperfusion (I\/R) injury ameliorates ischemia-reperfusion-induced liver injury by inhibiting apoptosis","volume":"129","author":"Lin","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.toxicon.2026.109042_bib32","doi-asserted-by":"crossref","first-page":"585","DOI":"10.3350\/cmh.2024.0222","article-title":"Current status and perspective on molecular targets and therapeutic intervention strategy in hepatic ischemia-reperfusion injury","volume":"30","author":"Liu","year":"2024","journal-title":"Clin Mol Hepatol"},{"key":"10.1016\/j.toxicon.2026.109042_bib33","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s12026-012-8331-5","article-title":"Regulation of the immune response by soybean isoflavones","volume":"54","author":"Masilamani","year":"2012","journal-title":"Immunol. Res."},{"key":"10.1016\/j.toxicon.2026.109042_bib34","doi-asserted-by":"crossref","DOI":"10.3390\/cancers12010167","article-title":"Divergent effects of daidzein and its metabolites on estrogen-induced survival of breast cancer cells","volume":"12","author":"Montalesi","year":"2020","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.toxicon.2026.109042_bib35","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/labinvest.2017.90","article-title":"Neutrophils: a cornerstone of liver ischemia and reperfusion injury","volume":"98","author":"Oliveira","year":"2018","journal-title":"Lab. Invest."},{"key":"10.1016\/j.toxicon.2026.109042_bib36","doi-asserted-by":"crossref","first-page":"221","DOI":"10.7555\/JBR.32.20180087","article-title":"Hepatic ischemia-reperfusion injury in liver transplant setting: mechanisms and protective strategies","volume":"33","author":"Rampes","year":"2019","journal-title":"J Biomed Res"},{"key":"10.1016\/j.toxicon.2026.109042_bib37","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/ki.2014.80","article-title":"Carbon monoxide potently prevents ischemia-induced high-mobility group box 1 translocation and release and protects against lethal renal ischemia-reperfusion injury","volume":"86","author":"Ruan","year":"2014","journal-title":"Kidney Int."},{"key":"10.1016\/j.toxicon.2026.109042_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2019.117120","article-title":"HMGB1 was negatively regulated by HSF1 and mediated the TLR4\/MyD88\/NF-\u03baB signal pathway in asthma","volume":"241","author":"Shang","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.toxicon.2026.109042_bib39","article-title":"Hepatic Ischemia-reperfusion injury: protective approaches and treatment","volume":"17","author":"Singh","year":"2024","journal-title":"Curr. Mol. Pharmacol."},{"key":"10.1016\/j.toxicon.2026.109042_bib40","doi-asserted-by":"crossref","DOI":"10.3892\/mmr.2020.11194","article-title":"Quantitative proteomic characterization of microvesicles\/exosomes from the cerebrospinal fluid of patients with acute bilirubin encephalopathy","author":"Tan","year":"2020","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.toxicon.2026.109042_bib41","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/s00281-022-00910-2","article-title":"TNF in the liver: targeting a central player in inflammation","volume":"44","author":"Tiegs","year":"2022","journal-title":"Semin Immunopathol"},{"key":"10.1016\/j.toxicon.2026.109042_bib42","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1084\/jem.20042614","article-title":"The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion","volume":"201","author":"Tsung","year":"2005","journal-title":"J Exp Med"},{"key":"10.1016\/j.toxicon.2026.109042_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.117387","article-title":"Synergetic inhibition of daidzein and regular exercise on breast cancer in bearing-4T1 mice by regulating NK cells and apoptosis pathway","volume":"245","author":"Wang","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.toxicon.2026.109042_bib44","first-page":"1043","article-title":"Emerging Roles of High-mobility Group Box-1 in liver disease","volume":"12","author":"Wang","year":"2024","journal-title":"J. Clin. Transl. Hepatol."},{"key":"10.1016\/j.toxicon.2026.109042_bib45","doi-asserted-by":"crossref","DOI":"10.1155\/grp\/5587859","article-title":"FTO alleviates hepatic ischemia-reperfusion injury by regulating apoptosis and autophagy","volume":"2025","author":"Wang","year":"2025","journal-title":"Gastroenterol. Res. Pract."},{"key":"10.1016\/j.toxicon.2026.109042_bib46","doi-asserted-by":"crossref","first-page":"3056","DOI":"10.1038\/s41598-022-06848-7","article-title":"Endothelial cell ferroptosis mediates monocrotaline-induced pulmonary hypertension in rats by modulating NLRP3 inflammasome activation","volume":"12","author":"Xie","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.toxicon.2026.109042_bib47","article-title":"Sevoflurane postconditioning Attenuates Hepatic ischemia-reperfusion injury by limiting HMGB1\/TLR4\/NF-\u03baB pathway via modulating microRNA-142 in vivo and in vitro","volume":"12","author":"Xu","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.toxicon.2026.109042_bib48","doi-asserted-by":"crossref","first-page":"5224","DOI":"10.1111\/bph.15261","article-title":"Arctigenin protects against depression by inhibiting microglial activation and neuroinflammation via HMGB1\/TLR4\/NF-\u03baB and TNF-\u03b1\/TNFR1\/NF-\u03baB pathways","volume":"177","author":"Xu","year":"2020","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.toxicon.2026.109042_bib49","doi-asserted-by":"crossref","first-page":"484","DOI":"10.3389\/fimmu.2020.00484","article-title":"Targeting inflammation driven by HMGB1","volume":"11","author":"Yang","year":"2020","journal-title":"Front Immunol"},{"key":"10.1016\/j.toxicon.2026.109042_bib50","article-title":"Induction of IL-25 secretion from tumour-associated fibroblasts suppresses mammary tumour metastasis","volume":"7","author":"Yin","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.toxicon.2026.109042_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.toxicon.2023.107561","article-title":"Roles of Cyt-c\/Caspase-9\/Caspase-3\/Bax\/Bcl-2 pathway in Cd-induced testicular injury in rats and the protective effect of quercetin","volume":"237","author":"Yu","year":"2024","journal-title":"Toxicon"},{"key":"10.1016\/j.toxicon.2026.109042_bib52","volume":"14","author":"Zhang","year":"2019","journal-title":"Dexmedetomidine-induced cardioprotection is mediated by inhibition of high mobility group box-1 and the cholinergic anti-inflammatory pathway in myocardial ischemia-reperfusion injury"}],"updated-by":[{"DOI":"10.1016\/j.toxicon.2026.109339","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:00:00Z","timestamp":1792800000000}}],"container-title":["Toxicon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010126000607?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041010126000607?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:28:24Z","timestamp":1777458504000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041010126000607"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":52,"alternative-id":["S0041010126000607"],"URL":"https:\/\/doi.org\/10.1016\/j.toxicon.2026.109042","relation":{},"ISSN":["0041-0101"],"issn-type":[{"value":"0041-0101","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Daidzein attenuates hepatic ischemia\/reperfusion injury via HMGB1-TLR4 signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Toxicon","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxicon.2026.109042","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"109042"}}