{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:30:51Z","timestamp":1768869051324,"version":"3.49.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2004,2,1]],"date-time":"2004-02-01T00:00:00Z","timestamp":1075593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicology Letters"],"published-print":{"date-parts":[[2004,2]]},"DOI":"10.1016\/j.toxlet.2003.10.010","type":"journal-article","created":{"date-parts":[[2003,12,11]],"date-time":"2003-12-11T12:47:40Z","timestamp":1071146860000},"page":"27-33","source":"Crossref","is-referenced-by-count":48,"title":["Impact of nitrate intake in drinking water on the thyroid gland activity in male rat"],"prefix":"10.1016","volume":"147","author":[{"given":"A.","family":"Zaki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Ait Chaoui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Talibi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.F.","family":"Derouiche","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Aboussaouira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Zarrouck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Chait","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Himmi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxlet.2003.10.010_BIB1","unstructured":"Alary, J., Vergnes, M.F., Cantin, D., 1980. Dosage des nitrates et des nitrites dans les l\u00e9gumes. Soci\u00e9t\u00e9 de Pharmacie de Lyon, 30\u201334."},{"key":"10.1016\/j.toxlet.2003.10.010_BIB2","first-page":"537","article-title":"Le goitre end\u00e9mique au Cameroun (Provinces de l\u2019Est et du Nord Ouest)","volume":"26","author":"Aquaron","year":"1985","journal-title":"Rev. Franc. Endocrinol."},{"key":"10.1016\/j.toxlet.2003.10.010_BIB3","doi-asserted-by":"crossref","first-page":"5283","DOI":"10.1210\/en.136.12.5283","article-title":"Expression of nitric oxide synthase isoforms in the thyroid gland: evidence for a role of nitric oxide in vascular control during goiter formation","volume":"136","author":"Colin","year":"1995","journal-title":"Endocrinology"},{"key":"10.1016\/j.toxlet.2003.10.010_BIB4","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1530\/eje.0.1360649","article-title":"Expression of nitric oxide synthase III in human thyroid follicular cells: evidence for increased expression in hyperthyroidism","volume":"136","author":"Colin","year":"1997","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.toxlet.2003.10.010_BIB5","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1089\/thy.1998.8.1127","article-title":"Nitric oxide donors inhibit iodide transport and organification and induce morphological changes in cultured bovine thyroid cells","volume":"8","author":"Costamagna","year":"1998","journal-title":"Thyroid"},{"key":"10.1016\/j.toxlet.2003.10.010_BIB6","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1152\/physrev.2000.80.3.1083","article-title":"Molecular analysis of the sodium\/iodide symporter: impact on thyroid and extrathyroide pathophysiology","volume":"80","author":"De La Vieja","year":"2000","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.toxlet.2003.10.010_BIB7","first-page":"1097","article-title":"Nuritional and toxicologic impact of nitrates and nitrites administered chronically (6 months) in the rat","volume":"34","author":"Fritsch","year":"1980","journal-title":"Ann. Nutr. Aliment"},{"key":"10.1016\/j.toxlet.2003.10.010_BIB8","first-page":"75","article-title":"Experimental data on the effect of nitrates entering the organism with the drinking water","volume":"37","author":"Gatseva","year":"1996","journal-title":"Folia Medica"},{"key":"10.1016\/j.toxlet.2003.10.010_BIB9","first-page":"19","article-title":"Incidence of goiter among children in a village with nitrate contamination of drinking water","volume":"40","author":"Gatseva","year":"1998","journal-title":"Folia Medica"},{"key":"10.1016\/j.toxlet.2003.10.010_BIB10","first-page":"43","article-title":"Changes in the thyroid and other internal organs of experimental animals exposed to a drinking regimen with a high nitrate content","volume":"17","author":"Gatseva","year":"1992","journal-title":"Probl. Khig."},{"key":"10.1016\/j.toxlet.2003.10.010_BIB11","first-page":"45","article-title":"Pathomorphological study of rats submitted to a drinking water regime with high nitrate content","volume":"8","author":"Gatseva","year":"1999","journal-title":"Fresenius Environ. Bull."},{"key":"10.1016\/j.toxlet.2003.10.010_BIB12","first-page":"58","article-title":"Dynamics of thyroid hormones and hematological and biochemical indices in chronic nitrate poisoning in sheep","volume":"24","author":"Georgiev","year":"1987","journal-title":"Vet. Med. Nauki."},{"key":"10.1016\/j.toxlet.2003.10.010_BIB13","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1289\/ehp.00108363","article-title":"Recurrent acute respiratory tract infections in areas with high nitrate concentrations in drinking water","volume":"108","author":"Gupta","year":"2000","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.toxlet.2003.10.010_BIB14","first-page":"58","article-title":"Methaemoglobinaemia in areas with high nitrate concentration in drinking water","volume":"13","author":"Gupta","year":"2000","journal-title":"Natl. Med. J. India"},{"key":"10.1016\/j.toxlet.2003.10.010_BIB15","first-page":"713","article-title":"The action of phenylmercuriacetate and nitrate in combined application in rats: the thyroid Gland, liver enzymes and morphologic findings in the brain and kidney","volume":"30","author":"Horing","year":"1986","journal-title":"Nahrung"},{"key":"10.1016\/j.toxlet.2003.10.010_BIB16","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/BF03348673","article-title":"Study of an endemic goiter area in northern Campania","volume":"15","author":"Iodice","year":"1992","journal-title":"J. Endocrinol. Invest."},{"key":"10.1016\/j.toxlet.2003.10.010_BIB17","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1159\/000139421","article-title":"Nitric oxide-donating compounds and cyclic GMP depress the spontaneous contractile activity of the isolated rabbit jejunum","volume":"53","author":"Izzo","year":"1996","journal-title":"Pharmacology"},{"key":"10.1016\/j.toxlet.2003.10.010_BIB18","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1055\/s-0029-1211049","article-title":"Nitrate-induced hypothyroidism is associated with a reduced concentration of growth hormone-releasing factor in hypothalamic tissue of rats","volume":"97","author":"Jahreis","year":"1991","journal-title":"Exp. Clin. Endocrinol."},{"key":"10.1016\/j.toxlet.2003.10.010_BIB19","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1055\/s-0029-1210603","article-title":"Effect of chronic dietary nitrate and different iodine supply on porcine thyroid function, somatomedin-C-level and growth","volume":"88","author":"Jahreis","year":"1986","journal-title":"Exp. Clin. Endocrinol."},{"key":"10.1016\/j.toxlet.2003.10.010_BIB20","first-page":"171","article-title":"Growth impairment caused by dietary nitrate intake regulated via hypothyroidism and decreased somatomedin","volume":"21","author":"Jahreis","year":"1987","journal-title":"Endocrinol. Exp."},{"key":"10.1016\/j.toxlet.2003.10.010_BIB21","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1677\/jme.0.0100163","article-title":"Nitric oxide stimulates cyclic GMP in human thyrocytes","volume":"10","author":"Millatt","year":"1993","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.toxlet.2003.10.010_BIB22","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1210\/en.133.3.1197","article-title":"Iodine deficiency induces thyroid autoimmune reactivity in Wistar rats","volume":"133","author":"Mooij","year":"1993","journal-title":"Endocrinology"},{"key":"10.1016\/j.toxlet.2003.10.010_BIB23","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/BF01719941","article-title":"Impact of nitrates in drinking water on cancer mortality in Valancia, Spain","volume":"11","author":"Morales-Suarez-Varela","year":"1995","journal-title":"Eur. J. Epidemiol."},{"key":"10.1016\/j.toxlet.2003.10.010_BIB24","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1515\/JBCPP.2000.11.1.47","article-title":"Effects of high nitrate intake in rats","volume":"11","author":"Ogur","year":"2000","journal-title":"J. Basic. Clin. Physiol. Pharmacol."},{"key":"10.1016\/j.toxlet.2003.10.010_BIB25","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/S0026-0495(99)90167-1","article-title":"Role of chloride and inhibitory action of inorganic nitrate on gonadotropin-stimilated steroidogenesis in mouse leydig tumor cells","volume":"48","author":"Panesar","year":"1999","journal-title":"Metabolism"},{"key":"10.1016\/j.toxlet.2003.10.010_BIB26","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1006\/taap.2000.9079","article-title":"Decreased steroid hormone Synthesis from inorganic nitrite and nitrate: studies in vitro and in vivo","volume":"169","author":"Panesar","year":"2000","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.toxlet.2003.10.010_BIB27","first-page":"339","article-title":"Le goitre end\u00e9mique au Mali","volume":"19","author":"Roux","year":"1983","journal-title":"Med. Nut. T."},{"key":"10.1016\/j.toxlet.2003.10.010_BIB28","first-page":"12","article-title":"Incidence of goiter in children of the tarnobrzeg district and environemental factors","volume":"43","author":"Rybakowa","year":"1992","journal-title":"Endokrynol. Pol."},{"key":"10.1016\/j.toxlet.2003.10.010_BIB29","first-page":"116 537","article-title":"Hypertrophy and hyperplasia during goitre growth and involution in rats-separate bioeffects of TSH and Iodine","volume":"116","author":"Stubner","year":"1987","journal-title":"Acta Endocrinol. (Copenh.)"},{"key":"10.1016\/j.toxlet.2003.10.010_BIB30","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/0378-4274(94)90050-7","article-title":"Consumption of drinking water with high nitrate levels causes hypertrophy of the thyroid","volume":"72","author":"van Maanen","year":"1994","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.toxlet.2003.10.010_BIB31","first-page":"179","article-title":"Comparative analysis of results from studies of goitre in children from Bulgarian villages with nitrate pollution of drinking water in 1995 and 1998","volume":"8","author":"Vladeva","year":"2000","journal-title":"Cent. Eur. J. Public Health"},{"key":"10.1016\/j.toxlet.2003.10.010_BIB32","first-page":"345","article-title":"Effects of oral intake of nitrates on reproductive functions of bulls","volume":"42","author":"Zraly","year":"1997","journal-title":"Vet. Med. Praha."}],"container-title":["Toxicology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427403003825?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427403003825?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,3,28]],"date-time":"2020-03-28T00:30:11Z","timestamp":1585355411000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378427403003825"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,2]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,2]]}},"alternative-id":["S0378427403003825"],"URL":"https:\/\/doi.org\/10.1016\/j.toxlet.2003.10.010","relation":{},"ISSN":["0378-4274"],"issn-type":[{"value":"0378-4274","type":"print"}],"subject":[],"published":{"date-parts":[[2004,2]]}}}