{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T01:54:38Z","timestamp":1771034078738,"version":"3.50.1"},"reference-count":35,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2004,3,1]],"date-time":"2004-03-01T00:00:00Z","timestamp":1078099200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicology Letters"],"published-print":{"date-parts":[[2004,3]]},"DOI":"10.1016\/j.toxlet.2003.11.009","type":"journal-article","created":{"date-parts":[[2004,1,27]],"date-time":"2004-01-27T10:23:12Z","timestamp":1075198992000},"page":"11-20","source":"Crossref","is-referenced-by-count":23,"title":["\u03b11-Microglobulin as a promising marker of cadmium-induced tubular dysfunction, possibly better than \u03b22-microglobulin"],"prefix":"10.1016","volume":"148","author":[{"given":"J","family":"Moriguchi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Ezaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Tsukahara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Furuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Fukui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Okamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Ukai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Sakurai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxlet.2003.11.009_BIB1","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/BF00378371","article-title":"Reliability of urinary creatinine as a parameter used to adjust values of urinary biological indicators","volume":"55","author":"Alessio","year":"1985","journal-title":"Int. Arch. Occup. Environ. Health"},{"key":"10.1016\/j.toxlet.2003.11.009_BIB2","unstructured":"American Conference of Governmental Industrial Hygienists, 2003. Documentation of TLVs\u00ae and BEIs\u00ae. American Conference of Governmental Industrial Hygienists, Cincinnati, OH."},{"key":"10.1016\/j.toxlet.2003.11.009_BIB3","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1080\/15298669391355134","article-title":"Interpretation of urinary results used to assess chemical exposure with emphasis on creatinine adjustment: a review","volume":"54","author":"Boeniger","year":"1993","journal-title":"Am. Ind. Hyg. Assoc. J."},{"key":"10.1016\/j.toxlet.2003.11.009_BIB4","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1007\/s00420-002-0389-2","article-title":"No clear-cut evidence for cadmium-induced renal tubular dysfunction among over 10,000 women in the Japanese general population a nationwide large-scale survey","volume":"76","author":"Ezaki","year":"2003","journal-title":"Int. Arch. Occup. Environ. Health"},{"key":"10.1016\/j.toxlet.2003.11.009_BIB5","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s002280050619","article-title":"Renal handling of drugs in the healthy elderly. Creatinine clearance underestimates renal function and pharmacokinetics remain virtually unchanged","volume":"55","author":"Fliser","year":"1999","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"10.1016\/j.toxlet.2003.11.009_BIB6","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1515\/CCLM.1998.162","article-title":"Physiopathology of proteinuria and laboratory diagnostic strategy based on single protein analysis","volume":"36","author":"Guder","year":"1998","journal-title":"Clin. Chem. Lab. Med."},{"key":"10.1016\/j.toxlet.2003.11.009_BIB7","doi-asserted-by":"crossref","first-page":"520","DOI":"10.2169\/internalmedicine.34.520","article-title":"Changes in renal function with aging among Japanese","volume":"34","author":"Hosoya","year":"1995","journal-title":"Intern. Med."},{"key":"10.1016\/j.toxlet.2003.11.009_BIB8","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1006\/enrs.1995.1044","article-title":"Urinary \u03b11-microglobulin, \u03b22-microglobulin, and retinal-binding protein levels in general populations in Japan with references to cadmium in urine, blood and 24-h food duplicates","volume":"70","author":"Ikeda","year":"1995","journal-title":"Environ. Res."},{"key":"10.1016\/j.toxlet.2003.11.009_BIB9","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0378-4274(99)00084-3","article-title":"Background exposure of general women populations in Japan to cadmium in the environment and possible health effects","volume":"108","author":"Ikeda","year":"1999","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.toxlet.2003.11.009_BIB10","doi-asserted-by":"crossref","unstructured":"Ikeda, M., Ezaki, T., Tsukahara, T., Moriguchi, J., Furuki, K., Fukui, Y., Ukai, H., Okamoto, S., Sakurai, H., 2003a. Bias induced by the use of creatinine-corrected values in evaluation of \u03b22-microglobulin levels. Toxicol. Lett. 145, 197\u2013207.","DOI":"10.1016\/S0378-4274(03)00320-5"},{"key":"10.1016\/j.toxlet.2003.11.009_BIB11","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0378-4274(02)00389-2","article-title":"Threshold levels of urinary cadmium in relation to increase in urinary \u03b22-microglobulin among general Japanese populations","volume":"137","author":"Ikeda","year":"2003","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.toxlet.2003.11.009_BIB12","unstructured":"International Programme on Chemical Safety, 1992a. Environmental Health Criteria. 134. Cadmium. World Health Organization, Geneva."},{"key":"10.1016\/j.toxlet.2003.11.009_BIB13","unstructured":"International Programme on Chemical Safety, 1992b. Environmental Health Criteria. 135. Cadmium\u2014Environmental Aspects. World Health Organization, Geneva."},{"key":"10.1016\/j.toxlet.2003.11.009_BIB14","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1097\/00004032-196606000-00014","article-title":"Creatinine in urine as an index of urinary excretion rate","volume":"12","author":"Jackson","year":"1966","journal-title":"Health Phys."},{"key":"10.1016\/j.toxlet.2003.11.009_BIB15","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1093\/clinchem\/39.5.757","article-title":"Urinary proteins and enzymes as early indicators of renal dysfunction in chronic exposure to cadmium","volume":"39","author":"Jung","year":"1993","journal-title":"Clin. Chem."},{"key":"10.1016\/j.toxlet.2003.11.009_BIB16","unstructured":"Kasuya, M., Aoshima, K., Katoh, T., Teranishi, H., Horiguchi, H., Kitagawa, M., Hagino, S., 1992. Natural history of Itai\u2013itai disease: a long-term observation on the clinical and laboratory findings in patients with itai\u2013itai disease. In: Cook, M.E., Hiscock, S.A., Morrow, H., Volpe, R.A. (Eds.), Proceedings of the Seventh International Cadmium Conference. Cadmium Association, London. pp. 180\u2013192."},{"key":"10.1016\/j.toxlet.2003.11.009_BIB17","first-page":"69","article-title":"Indicators of renal effects of exposure to cadmium: N-acetyl-\u03b2-D-glucosaminidase and others","volume":"37","author":"Kawada","year":"1995","journal-title":"J. Occup. Health"},{"key":"10.1016\/j.toxlet.2003.11.009_BIB18","first-page":"251","article-title":"Human \u03b11-microglobuline. Its physico-chemical properties and clinical significance","volume":"25","author":"Kawai","year":"1982","journal-title":"Asian Med. J."},{"key":"10.1016\/j.toxlet.2003.11.009_BIB19","first-page":"217","article-title":"Evaluation of urinary lead concentrations. I. The significance of the specific gravity","volume":"27","author":"Levine","year":"1945","journal-title":"J. Ind. Hyg. Toxicol."},{"key":"10.1016\/j.toxlet.2003.11.009_BIB20","first-page":"122","article-title":"Renal function in the elderly","volume":"25","author":"Lubran","year":"1995","journal-title":"Ann. Clin. Lab. Sci."},{"key":"10.1016\/j.toxlet.2003.11.009_BIB21","first-page":"283","article-title":"\u03b11-microglobulin as a marker of proximal tubular damage in urinary tract infection in children","volume":"53","author":"Mantur","year":"2000","journal-title":"Clin. Nephrol."},{"key":"10.1016\/j.toxlet.2003.11.009_BIB22","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0378-4274(03)00181-4","article-title":"Comparative evaluation of four urinary tubular dysfunction makers, with special references to the effects of aging and correction for creatinine concentration","volume":"143","author":"Moriguchi","year":"2003","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.toxlet.2003.11.009_BIB23","unstructured":"Moriguchi, J., Ezaki, T., Tsukahara, T., Furuki, K., Fukui, Y, Okamoto, S., Ukai, H., Sakurai, H., Shimbo, S., Ikeda, M., 2003b. Levels of urinary a1-microglobulin in general populations in Japan. Submitted for publication."},{"key":"10.1016\/j.toxlet.2003.11.009_BIB24","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0048-9697(02)00646-0","article-title":"Effects of low-dose cadmium exposure on biological examinations","volume":"308","author":"Nakadaira","year":"2003","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.toxlet.2003.11.009_BIB25","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/0378-4274(84)90046-8","article-title":"\u03b11-Microglobulin in urine as an indicator of renal tubular damage caused by environmental cadmium exposure","volume":"22","author":"Nogawa","year":"1984","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.toxlet.2003.11.009_BIB26","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1046\/j.1523-1755.2000.00847.x","article-title":"Tubular proteinuria defined by a study of Dent\u2019s (CLCN5 mutation) and other tubular diseases","volume":"57","author":"Norden","year":"2000","journal-title":"Kidney Int."},{"key":"10.1016\/j.toxlet.2003.11.009_BIB27","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1093\/clinchem\/48.7.1136","article-title":"\u03b11-Microglobulin is stable in human urine ex vivo","volume":"48","author":"Payn","year":"2002","journal-title":"Clin. Chem."},{"key":"10.1016\/j.toxlet.2003.11.009_BIB28","first-page":"21","article-title":"Urinary excretion of phenol by men exposed to benzene a screening test","volume":"22","author":"Rainsford","year":"1965","journal-title":"Brit. J. Ind. Med."},{"key":"10.1016\/j.toxlet.2003.11.009_BIB29","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1080\/104732299302323","article-title":"Measurement of specific gravity as a surrogate of urinary flow rate\u2014a singular study","volume":"14","author":"Sherwood","year":"1999","journal-title":"Appl. Occup. Environ. Hyg."},{"key":"10.1016\/j.toxlet.2003.11.009_BIB30","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/jat.2550060307","article-title":"Urinary \u03b11-Microglobulin as an indicator protein of renal tubular dysfunction caused by environmental cadmium exposure","volume":"6","author":"Tohyama","year":"1986","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.toxlet.2003.11.009_BIB31","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s00420-003-0432-y","article-title":"No significant effect of iron deficiency on cadmium body burden on kidney dysfunction among women in the general population in Japan","volume":"76","author":"Tsukahara","year":"2003","journal-title":"Int. Arch. Occup. Environ. Health"},{"key":"10.1016\/j.toxlet.2003.11.009_BIB32","unstructured":"World Health Organization, 1996. Biological Monitoring of Chemical Exposure in Workplace. Selected Metals 3.1. Cadmium, Vol. 1. World Health Organization, Geneva (Chapter 3), pp. 52\u201390."},{"key":"10.1016\/j.toxlet.2003.11.009_BIB33","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1007\/s002239900576","article-title":"Age-related changes in body composition, hydroxyproline, and creatinine excretion in normal women","volume":"64","author":"Worsfold","year":"1999","journal-title":"Calcified Tissue Int."},{"key":"10.1016\/j.toxlet.2003.11.009_BIB34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/enrs.1998.3839","article-title":"Association between renal effects and cadmium exposure in cadmium-non-polluted areas in Japan","volume":"77","author":"Yamanaka","year":"1998","journal-title":"Environ. Res."},{"key":"10.1016\/j.toxlet.2003.11.009_BIB35","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1136\/jcp.36.3.253","article-title":"Alpha-1-microglobulin an indicator protein for renal tubular function","volume":"36","author":"Yu","year":"1983","journal-title":"J. Clin. Pathol."}],"container-title":["Toxicology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427403004296?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427403004296?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,3,29]],"date-time":"2020-03-29T11:05:33Z","timestamp":1585479933000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378427403004296"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,3]]},"references-count":35,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2004,3]]}},"alternative-id":["S0378427403004296"],"URL":"https:\/\/doi.org\/10.1016\/j.toxlet.2003.11.009","relation":{},"ISSN":["0378-4274"],"issn-type":[{"value":"0378-4274","type":"print"}],"subject":[],"published":{"date-parts":[[2004,3]]}}}