{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T14:18:11Z","timestamp":1772806691819,"version":"3.50.1"},"reference-count":57,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2004,12,1]],"date-time":"2004-12-01T00:00:00Z","timestamp":1101859200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicology Letters"],"published-print":{"date-parts":[[2004,12]]},"DOI":"10.1016\/j.toxlet.2004.07.004","type":"journal-article","created":{"date-parts":[[2004,8,10]],"date-time":"2004-08-10T19:56:00Z","timestamp":1092167760000},"page":"69-80","source":"Crossref","is-referenced-by-count":29,"title":["Anti-arthritic effect and subacute toxicological evaluation of Baccharis genistelloides aqueous extract"],"prefix":"10.1016","volume":"154","author":[{"given":"M.G.P.","family":"Coelho","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.A.","family":"Reis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.B.","family":"Gava","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.R.","family":"Marques","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.R.","family":"Gayer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.A.T.","family":"Laranja","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Felzenswalb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.C.C.","family":"Sabino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxlet.2004.07.004_bib1","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/S0306-3623(98)00214-6","article-title":"Antiviral activity of Bolivian plant extracts","volume":"32","author":"Abad","year":"1999","journal-title":"Gen. Pharmacol."},{"key":"10.1016\/j.toxlet.2004.07.004_bib2","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1007\/BF01965393","article-title":"The anti-inflammatory action of nepitrin, a flavonoid","volume":"12","author":"Agarwal","year":"1982","journal-title":"Agents Actions"},{"key":"10.1016\/j.toxlet.2004.07.004_bib3","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1006\/bbrc.1998.8748","article-title":"Skin cancer chemopreventive effects of a flavonoid antioxidant silymarin are mediated via impairment of receptor tyrosine kinase signaling and perturbation in cell cycle progression","volume":"247","author":"Ahmad","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.toxlet.2004.07.004_bib4","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1248\/cpb.51.197","article-title":"A new ent-clerodane diterpene from the aerial parts of Baccharis gaudichaudiana","volume":"51","author":"Akaike","year":"2003","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.toxlet.2004.07.004_bib5","unstructured":"Almeida, E.R., 1993. Plantas medicinais brasileiras. Conhecimentos Populares e Cient\u00edficos, Editora Hemus, pp. 124\u2013125."},{"key":"10.1016\/j.toxlet.2004.07.004_bib6","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S1043-6618(02)00253-0","article-title":"Gastroprotective effects of a crude extract of Baccharis illinita DC in rats","volume":"47","author":"Baggio","year":"2003","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.toxlet.2004.07.004_bib7","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s003940070014","article-title":"Absorption and DNA protective effects of flavonoid glycosides from an onion meal","volume":"39","author":"Boyle","year":"2000","journal-title":"Eur. J. Nutr."},{"key":"10.1016\/j.toxlet.2004.07.004_bib8","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/S0031-9422(02)00437-5","article-title":"Clerodane diterpenes from Baccharis sagittalis: insect antifeedant activity","volume":"61","author":"Cifuente","year":"2002","journal-title":"Phytochemistry"},{"key":"10.1016\/j.toxlet.2004.07.004_bib9","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1002\/(SICI)1099-1573(199909)13:6<464::AID-PTR483>3.0.CO;2-4","article-title":"Triptolide is more effective in preventing T cell proliferation and interferon-gamma production than is FK506","volume":"13","author":"Chan","year":"1999","journal-title":"Phytother. Res."},{"key":"10.1016\/j.toxlet.2004.07.004_bib10","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1248\/bpb.26.282","article-title":"Baicalin promoted the repair of DNA single strand breakage caused by H2O2 in cultured NIH3T3 fibroblasts","volume":"26","author":"Chen","year":"2003","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.toxlet.2004.07.004_bib11","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1023\/A:1021624520740","article-title":"Quercetin suppresses proinflammatory cytokines production through MAP kinases and NF-\u03baB pathway in lipopolysaccharide-stimulated macrophage","volume":"243","author":"Cho","year":"2003","journal-title":"Mol. Cell Biochem."},{"key":"10.1016\/j.toxlet.2004.07.004_bib12","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0300-483X(00)00155-4","article-title":"The popliteal lymph node response to streptozotocin is under type 1, MHC class-I restricted CD8(+) T-cell control","volume":"146","author":"Choquet-Kastylevski","year":"2000","journal-title":"Toxicology"},{"key":"10.1016\/j.toxlet.2004.07.004_bib13","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1080\/1071576031000076259","article-title":"Antioxidant activity of Baccharis articulata extracts: isolation of a new compound with antioxidant activity","volume":"37","author":"De Oliveira","year":"2003","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.toxlet.2004.07.004_bib14","unstructured":"Descotes, J., 1999. Assays of humoral immunity. Assays of cell-mediated immunity. In: An Introduction to Immunotoxicology. Taylor & Francis Ltd., London, UK, pp. 101\u2013108."},{"key":"10.1016\/j.toxlet.2004.07.004_bib15","first-page":"2327","article-title":"Long-term predictors of anxiety and depressed mood in early rheumatoid arthritis: a 3 and 5 year follow-up","volume":"29","author":"Evers","year":"2002","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.toxlet.2004.07.004_bib16","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0165-1110(94)00013-3","article-title":"The Comet assay: a comprehensive review","volume":"339","author":"Fairbairn","year":"1995","journal-title":"Mut. Res."},{"key":"10.1016\/j.toxlet.2004.07.004_bib17","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1146\/annurev.immunol.19.1.163","article-title":"Anti-TNF\u03b1 therapy of rheumatoid arthritis: what have we learned?","volume":"19","author":"Feldman","year":"2001","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.toxlet.2004.07.004_bib18","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0378-8741(03)00259-9","article-title":"Constituents of the Argentinian medicinal plant Baccharis grisebachii and their antimicrobial activity","volume":"89","author":"Feresin","year":"2003","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.toxlet.2004.07.004_bib19","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/S0753-3322(03)00095-7","article-title":"Immunomodulatory effects of agents of plant origin","volume":"57","author":"Ganju","year":"2003","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.toxlet.2004.07.004_bib20","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1055\/s-2006-961552","article-title":"Anti-inflammatory effect of aqueous extracts of three species of the genus Baccharis","volume":"58","author":"Gene","year":"1992","journal-title":"Planta Med."},{"key":"10.1016\/j.toxlet.2004.07.004_bib21","first-page":"682","article-title":"Inhibition of type II collagen induced arthritis in mice by an immunosuppressive extract of Tripterygium wilfordii Hook f","volume":"19","author":"Gu","year":"1992","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.toxlet.2004.07.004_bib22","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/S0192-0561(98)00035-6","article-title":"Inhibition of type II collagen-induced arthritis in rats by triptolide","volume":"20","author":"Gu","year":"1998","journal-title":"Int. J. Immunopharmacol."},{"key":"10.1016\/j.toxlet.2004.07.004_bib23","doi-asserted-by":"crossref","first-page":"4524","DOI":"10.1073\/pnas.96.8.4524","article-title":"Prevention of collagen-induced arthritis in mice by a polyphenolic fraction from green tea","volume":"96","author":"Haqqi","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.toxlet.2004.07.004_bib24","doi-asserted-by":"crossref","first-page":"141","DOI":"10.2174\/1568026033392570","article-title":"Ethnobotany and natural products: the search for new molecules, new treatments of old diseases or a better understanding of indigenous cultures?","volume":"3","author":"Heinrich","year":"2003","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.toxlet.2004.07.004_bib25","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0047-6374(01)00371-2","article-title":"The molecular pathogenesis of collagen induced arthritis in mice\u2014a model of rheumatoid arthritis","volume":"1","author":"Holmdhal","year":"2002","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.toxlet.2004.07.004_bib26","first-page":"20","article-title":"A citrus flavonoid, nobiletin, suppresses production and gene expression of matrix metalloproteinase 9\/gelatinase B in rabbit synovial fibroblasts","volume":"27","author":"Ishiwa","year":"2000","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.toxlet.2004.07.004_bib27","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1002\/pca.2800030602","article-title":"Macrocyclic trichothecenes from Brazilian Baccharis species: from microanalysis to large-scale isolation","volume":"3","author":"Jarvis","year":"1992","journal-title":"Phytochem. Anal."},{"key":"10.1016\/j.toxlet.2004.07.004_bib28","doi-asserted-by":"crossref","first-page":"2724","DOI":"10.1248\/cpb.32.2724","article-title":"Studies on Scutellariae radix. VII. Anti-arthritic and anti-inflammatory actions of methanolic extract and flavonoid components from Scutellariae radix","volume":"32","author":"Kubo","year":"1984","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.toxlet.2004.07.004_bib29","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1590\/S0100-879X1999000500020","article-title":"Adhesion of the human pathogen Sporothrix schenckii to several extracellular matrix proteins","volume":"32","author":"Lima","year":"1999","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.toxlet.2004.07.004_bib30","first-page":"782","article-title":"Triptolide: a potent inhibitor of NF-kappa B in T-lymphocytes","volume":"21","author":"Liu","year":"2000","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.toxlet.2004.07.004_bib31","doi-asserted-by":"crossref","first-page":"15703","DOI":"10.1074\/jbc.271.26.15703","article-title":"Reactive oxygen species mediate cytokine activation of c-Jun NH2-terminal kinases","volume":"271","author":"Lo","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxlet.2004.07.004_bib32","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S1383-5718(01)00216-9","article-title":"Effect of the Cymbopogon citrates, Maytenus ilicifolia and Baccharis genistelloides extracts against the stannous chloride oxidative damage in Escherichia coli","volume":"496","author":"Melo","year":"2001","journal-title":"Mut. Res."},{"key":"10.1016\/j.toxlet.2004.07.004_bib33","doi-asserted-by":"crossref","first-page":"371","DOI":"10.3109\/08923978609026495","article-title":"Some effects of flavonoids on lymphocyte proliferative responses","volume":"8","author":"Mookerjee","year":"1986","journal-title":"J. Immunopharmacol."},{"key":"10.1016\/j.toxlet.2004.07.004_bib34","first-page":"1","article-title":"Antioxidative action of flavonoids, quercetin and catechin, mediated by the activation of glutathione peroxidase","volume":"24","author":"Nagata","year":"1999","journal-title":"Tokai J. Exp. Clin. Med."},{"key":"10.1016\/j.toxlet.2004.07.004_bib35","first-page":"457","article-title":"Antigen induced arthritis","volume":"vol. 24","author":"Pettipher","year":"1995"},{"key":"10.1016\/j.toxlet.2004.07.004_bib36","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0378-8741(01)00288-4","article-title":"Subacute toxicity evaluation of a hydroalcoholic extract of Pterodon pubescens seeds in mice with collagen-induced arthritis","volume":"77","author":"Pinto Coelho","year":"2001","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.toxlet.2004.07.004_bib37","unstructured":"Pio Correa, M., 1984. Dicion\u00e1rio das plantas \u00fateis do Brasil e das ex\u00f3ticas cultivadas, vol. III. Minist\u00e9rio da Agricultura, Instituto Brasileiro de Desenvolvimento Florestal, Rio de Janeiro, p. 129."},{"key":"10.1016\/j.toxlet.2004.07.004_bib38","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1124\/mol.57.3.512","article-title":"Hematotoxicity of the Chinese herbal medicine Tripterygium wilfordii Hook f. in positive human bone marrow cells","volume":"57","author":"Pyatt","year":"2000","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.toxlet.2004.07.004_bib39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2165\/00126839-200304010-00001","article-title":"Immunosuppressive and anti-inflammatory mechanisms of triptolide, the principal active diterpenoid from the Chinese medicinal herb Tripterygium wilfordii Hook f.","volume":"4","author":"Qiu","year":"2003","journal-title":"Drugs R. D."},{"key":"10.1016\/j.toxlet.2004.07.004_bib40","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/S0091-3057(03)00156-4","article-title":"Adaptogenic effect of Bacopa monniera (Brahmi)","volume":"75","author":"Rai","year":"2003","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.toxlet.2004.07.004_bib41","doi-asserted-by":"crossref","first-page":"6253","DOI":"10.4049\/jimmunol.159.12.6253","article-title":"Suppression of TNA-\u03b1 expression, inhibition of Th1 activity, and amelioration of collagen-induced arthritis by rolipram","volume":"159","author":"Ross","year":"1997","journal-title":"J. Immunol."},{"key":"10.1016\/j.toxlet.2004.07.004_bib42","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0027-5107(02)00319-6","article-title":"Anticlastogenic, antigenotoxic and apoptotic activity of epigallocatechin gallate green tea polyphenol","volume":"523\u2013524","author":"Roy","year":"2003","journal-title":"Mut. Res."},{"key":"10.1016\/j.toxlet.2004.07.004_bib43","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1002\/(SICI)1099-1573(199911)13:7<613::AID-PTR503>3.0.CO;2-D","article-title":"Successful treatment of collagen-induced arthritis in mice with a hydroalcohol extract of seeds of Pterodon pubescens","volume":"13","author":"Sabino","year":"1999","journal-title":"Phytother. Res."},{"key":"10.1016\/j.toxlet.2004.07.004_bib44","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0378-4274(99)00110-1","article-title":"In vitro and in vivo toxicological study of the Pterodon pubescens seed oil","volume":"108","author":"Sabino","year":"1999","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.toxlet.2004.07.004_bib45","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/S0278-6915(98)00073-8","article-title":"Protective Effects of green tea on hepatotoxicity, oxidative DNA damage and cell proliferation in the rat liver induced by repeated oral administration of 2-nitropropane","volume":"36","author":"Sai","year":"1998","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.toxlet.2004.07.004_bib46","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1248\/bpb.25.1147","article-title":"Screening of South American plants against human immunodeficiency virus: preliminary fractionation of aqueous extract from Bacharis trinervis","volume":"25","author":"Sanchez-Palomino","year":"2002","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.toxlet.2004.07.004_bib47","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1016\/S0891-5849(00)00415-9","article-title":"Phenolic antioxidants attenuate neuronal cell death following uptake of oxidized low-density lipoprotein","volume":"29","author":"Schroeter","year":"2000","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.toxlet.2004.07.004_bib48","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/S0891-5849(98)00040-9","article-title":"Quercetin prevents DNA single strand breakage and citotoxicity caused by tert-butylhydroperoxide: free radical scavenging versus iron chelating mechanism","volume":"25","author":"Sestili","year":"1998","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.toxlet.2004.07.004_bib49","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0304-3835(96)04554-5","article-title":"Evaluation of the mutagenic, cytotoxic, and antitumor potential of triptolide, a oxygenated diterpene isolated from Tripterygium wilfordii","volume":"112","author":"Shamon","year":"1997","journal-title":"Cancer Lett."},{"key":"10.1016\/j.toxlet.2004.07.004_bib50","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1055\/s-2006-962613","article-title":"Characterization of flavonoids from Baccharis trimera and their antihepatotoxic properties","volume":"53","author":"Soicke","year":"1987","journal-title":"Planta Med."},{"key":"10.1016\/j.toxlet.2004.07.004_bib51","unstructured":"Souza, M.P., Mattos, N.E.O., Matos, M.F.J.A., Machado, M.I.L., Craveiro, A.A., 1991. Constituintes ativos de plantas medicinais brasileiras. Fortaleza, UFC."},{"key":"10.1016\/j.toxlet.2004.07.004_bib52","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S0031-9422(00)94778-2","article-title":"Neo-clerodane diterpenoids and other constituents from Baccharis genistelloides","volume":"35","author":"Suttisri","year":"1994","journal-title":"Phytochemistry"},{"key":"10.1016\/j.toxlet.2004.07.004_bib53","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/S0031-9422(00)00223-5","article-title":"Diterpene from Baccharis trimera with a relaxant effect on rat vascular smooth muscle","volume":"55","author":"Torres","year":"2000","journal-title":"Phytochemistry"},{"key":"10.1016\/j.toxlet.2004.07.004_bib54","first-page":"28","article-title":"Physical disability and psychological well being in recent onset rheumatoid arthritis","volume":"21","author":"van der Heide","year":"1994","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.toxlet.2004.07.004_bib55","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1211\/0022357021771797","article-title":"Spasmolytic effects of Baccharis conferta and some of its constituents","volume":"54","author":"Weimann","year":"2002","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.toxlet.2004.07.004_bib56","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1016\/S0026-0495(98)90297-9","article-title":"Arterial compliance, blood pressure, plasma leptin, and plasma lipids in women are improved with weight reduction equally with a meat-based diet and a plant-based diet","volume":"47","author":"Yamashita","year":"1998","journal-title":"Metabolism"},{"key":"10.1016\/j.toxlet.2004.07.004_bib57","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1055\/s-2006-957511","article-title":"Vitexicarpin, a flavonoid from the fruits of Vitex rotundifolia, inhibits mouse lymphocyte proliferation and growth of cell lines in vitro","volume":"64","author":"You","year":"1998","journal-title":"Planta Med."}],"container-title":["Toxicology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037842740400339X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037842740400339X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,29]],"date-time":"2023-04-29T04:53:18Z","timestamp":1682743998000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S037842740400339X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,12]]},"references-count":57,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2004,12]]}},"alternative-id":["S037842740400339X"],"URL":"https:\/\/doi.org\/10.1016\/j.toxlet.2004.07.004","relation":{},"ISSN":["0378-4274"],"issn-type":[{"value":"0378-4274","type":"print"}],"subject":[],"published":{"date-parts":[[2004,12]]}}}