{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T09:30:08Z","timestamp":1773307808109,"version":"3.50.1"},"reference-count":30,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicology Letters"],"published-print":{"date-parts":[[2009,2]]},"DOI":"10.1016\/j.toxlet.2008.11.017","type":"journal-article","created":{"date-parts":[[2008,12,7]],"date-time":"2008-12-07T10:34:17Z","timestamp":1228646057000},"page":"16-22","source":"Crossref","is-referenced-by-count":20,"title":["Gene profiles of a human alveolar epithelial cell line after in vitro exposure to respiratory (non-)sensitizing chemicals: Identification of discriminating genetic markers and pathway analysis"],"prefix":"10.1016","volume":"185","author":[{"given":"Sandra","family":"Verstraelen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inge","family":"Nelissen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jef","family":"Hooyberghs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hilda","family":"Witters","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Greet","family":"Schoeters","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Van Cauwenberge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosette","family":"Van Den Heuvel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxlet.2008.11.017_bib1","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.cyto.2007.01.001","article-title":"Modulation of eotaxin-3 (CCL26) in alveolar type II epithelial cells","volume":"36","author":"Abonyo","year":"2006","journal-title":"Cytokine"},{"key":"10.1016\/j.toxlet.2008.11.017_bib2","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1007\/BF02041244","article-title":"The human leukemia cell line, THP-1: a multifacetted model for the study of monocyte-macrophage differentiation","volume":"47","author":"Auwerx","year":"1991","journal-title":"Experientia"},{"key":"10.1016\/j.toxlet.2008.11.017_bib3","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1097\/01.mcp.0000144502.50149.e0","article-title":"Chemokines and their receptors in the pathogenesis of allergic asthma: progress and perspective","volume":"11","author":"Bisset","year":"2005","journal-title":"Curr. Opin. Pulm. Med."},{"key":"10.1016\/j.toxlet.2008.11.017_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.taap.2007.10.008","article-title":"Respiratory sensitization and allergy: current research approaches and needs","volume":"226","author":"Boverhof","year":"2008","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.toxlet.2008.11.017_bib5","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1165\/ajrcmb.24.5.4375","article-title":"CD28 and CTLA4 coordinately regulate airway inflammatory cell recruitment and T-helper cell differentiation after inhaled allergen","volume":"24","author":"Burr","year":"2001","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.toxlet.2008.11.017_bib6","doi-asserted-by":"crossref","first-page":"5713","DOI":"10.4049\/jimmunol.174.9.5713","article-title":"TLR2 signaling is critical for Mycoplasma pneumoniae-induced airway mucin expression","volume":"174","author":"Chu","year":"2005","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.toxlet.2008.11.017_bib7","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1186\/1745-6673-3-S1-S5","article-title":"Modulation of asthma and allergy by addressing toll-like receptor 2","volume":"3","author":"Fuchs","year":"2008","journal-title":"J. Occup. Med. Toxicol."},{"key":"10.1016\/j.toxlet.2008.11.017_bib8","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1517\/14728222.11.7.869","article-title":"STAT3 and suppressor of cytokine signaling 3: potential targets in lung inflammatory responses","volume":"11","author":"Gao","year":"2007","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.toxlet.2008.11.017_bib9","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1002\/1521-4141(200202)32:2<585::AID-IMMU585>3.0.CO;2-U","article-title":"Blockade of CTLA-4 enhances allergic sensitization and eosinophilic airway inflammation in genetically predisposed mice","volume":"32","author":"Hellings","year":"2002","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.toxlet.2008.11.017_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2008.03.014","article-title":"A cell-based in vitro alternative to identify skin sensitizers by gene expression","author":"Hooyberghs","year":"2008","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.toxlet.2008.11.017_bib11","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1067\/mai.2002.128723","article-title":"Fine mapping of an IgE-controlling gene on chromosome 2q: analysis of CTLA4 and CD28","volume":"110","author":"Howard","year":"2002","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.toxlet.2008.11.017_bib12","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.taap.2005.03.019","article-title":"Relationship of CD86 surface marker expression and cytotoxicity on dendritic cells exposed to chemical allergen","volume":"209","author":"Hulette","year":"2005","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.toxlet.2008.11.017_bib13","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1111\/j.0906-6705.2006.00420.x","article-title":"Skin irritants and contact sensitizers induce Langerhans cell migration and maturation at irritant concentration","volume":"15","author":"Jacobs","year":"2006","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.toxlet.2008.11.017_bib14","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1084\/jem.182.2.459","article-title":"CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation","volume":"182","author":"Krummel","year":"1995","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.toxlet.2008.11.017_bib15","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1126\/science.271.5256.1734","article-title":"Enhancement of antitumor immunity by CTLA-4 blockade","volume":"271","author":"Leach","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.toxlet.2008.11.017_bib16","first-page":"90","article-title":"Effect of macrophage inflammatory protein-1alpha and its mRNA on airway inflammation of mouse asthma model","volume":"42","author":"Li","year":"2004","journal-title":"Zhonghua Er Ke Za Zhi"},{"key":"10.1016\/j.toxlet.2008.11.017_bib17","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1084\/jem.174.3.561","article-title":"CTLA-4 is a second receptor for the B cell activation antigen B7","volume":"174","author":"Linsley","year":"1991","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.toxlet.2008.11.017_bib18","first-page":"180","article-title":"Role of eotaxin in the pathophysiology of asthma","volume":"75","author":"Paplinska","year":"2007","journal-title":"Pneumonol. Alergol. Pol."},{"key":"10.1016\/j.toxlet.2008.11.017_bib19","doi-asserted-by":"crossref","first-page":"e251","DOI":"10.1371\/journal.pmed.0020251","article-title":"Up-regulation and profibrotic role of osteopontin in human idiopathic pulmonary fibrosis","volume":"2","author":"Pardo","year":"2005","journal-title":"PLoS Med."},{"key":"10.1016\/j.toxlet.2008.11.017_bib20","doi-asserted-by":"crossref","first-page":"4154","DOI":"10.4049\/jimmunol.156.11.4154","article-title":"Regulation of CTLA-4 expression during T cell activation","volume":"156","author":"Perkins","year":"1996","journal-title":"J. Immunol."},{"key":"10.1016\/j.toxlet.2008.11.017_bib21","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/j.1365-2222.2006.02414.x","article-title":"Sequence variants of the secreted phosphoprotein 1 gene are associated with total serum immunoglobulin E levels in a Japanese population","volume":"36","author":"Tanino","year":"2006","journal-title":"Clin. Exp. Allergy"},{"key":"10.1016\/j.toxlet.2008.11.017_bib22","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/1074-7613(95)90125-6","article-title":"Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4","volume":"3","author":"Tivol","year":"1995","journal-title":"Immunity"},{"key":"10.1016\/j.toxlet.2008.11.017_bib23","doi-asserted-by":"crossref","first-page":"5116","DOI":"10.1073\/pnas.091062498","article-title":"Significance analysis of microarrays applied to the ionizing radiation response","volume":"98","author":"Tusher","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.toxlet.2008.11.017_bib24","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1016\/j.tiv.2008.05.008","article-title":"Cell types involved in allergic asthma and their use in in vitro models to assess respiratory sensitization","volume":"22","author":"Verstraelen","year":"2008","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.toxlet.2008.11.017_bib25","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1016\/j.tiv.2008.02.015","article-title":"Gene expression profiling of in vitro cultured macrophages after exposure to the respiratory sensitizer hexamethylene diisocyanate","volume":"22","author":"Verstraelen","year":"2008","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.toxlet.2008.11.017_bib26","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/1074-7613(94)90071-X","article-title":"CTLA-4 can function as a negative regulator of T cell activation","volume":"1","author":"Walunas","year":"1994","journal-title":"Immunity"},{"key":"10.1016\/j.toxlet.2008.11.017_bib27","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.4049\/jimmunol.156.3.1006","article-title":"CD28 expression is not essential for positive and negative selection of thymocytes or peripheral T cell tolerance","volume":"156","author":"Walunas","year":"1996","journal-title":"J. Immunol."},{"key":"10.1016\/j.toxlet.2008.11.017_bib28","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1126\/science.270.5238.985","article-title":"Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4","volume":"270","author":"Waterhouse","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.toxlet.2008.11.017_bib29","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1111\/j.1365-2222.2005.02185.x","article-title":"Glutathione protects human airway proteins and epithelial cells from isocyanates","volume":"35","author":"Wisnewski","year":"2005","journal-title":"Clin. Exp. Allergy"},{"key":"10.1016\/j.toxlet.2008.11.017_bib30","doi-asserted-by":"crossref","first-page":"2330","DOI":"10.1164\/ajrccm.162.6.2002086","article-title":"Identification of human lung and skin proteins conjugated with hexamethylene diisocyanate in vitro and in vivo","volume":"162","author":"Wisnewski","year":"2000","journal-title":"Am. J. Respir. Crit. Care Med."}],"container-title":["Toxicology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427408013544?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427408013544?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,22]],"date-time":"2023-05-22T10:45:00Z","timestamp":1684752300000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378427408013544"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,2]]}},"alternative-id":["S0378427408013544"],"URL":"https:\/\/doi.org\/10.1016\/j.toxlet.2008.11.017","relation":{},"ISSN":["0378-4274"],"issn-type":[{"value":"0378-4274","type":"print"}],"subject":[],"published":{"date-parts":[[2009,2]]}}}