{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T16:51:39Z","timestamp":1791046299807,"version":"4.1.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2009,3,1]],"date-time":"2009-03-01T00:00:00Z","timestamp":1235865600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicology Letters"],"published-print":{"date-parts":[[2009,3]]},"DOI":"10.1016\/j.toxlet.2008.12.008","type":"journal-article","created":{"date-parts":[[2008,12,25]],"date-time":"2008-12-25T05:29:47Z","timestamp":1230182987000},"page":"153-159","source":"Crossref","is-referenced-by-count":22,"title":["Investigation of the immunogenicity of p-phenylenediamine and Bandrowski's base in the mouse"],"prefix":"10.1016","volume":"185","author":[{"given":"John","family":"Farrell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Jenkinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sidonie N.","family":"Lavergne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James L.","family":"Maggs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Kevin Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dean J.","family":"Naisbitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxlet.2008.12.008_bib1","article-title":"Skin sensitization to p-phenylenediamine: the diverging roles of oxidation and n-acetylation for dendritic cell activation and the immune response","author":"Aeby","year":"2008","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.toxlet.2008.12.008_bib2","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1111\/j.1600-0536.2006.00906.x","article-title":"The impact of exposure variables on the induction of skin sensitization","volume":"55","author":"Basketter","year":"2006","journal-title":"Contact Dermat."},{"key":"10.1016\/j.toxlet.2008.12.008_bib3","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.toxlet.2008.12.008_bib4","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/sj.bjp.0703845","article-title":"Influence of reduced glutathione on the proliferative response of sulfamethoxazole-specific and sulfamethoxazole-metabolite-specific human CD4+ T-cells","volume":"132","author":"Burkhart","year":"2001","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.toxlet.2008.12.008_bib5","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1046\/j.1365-2222.2002.01513.x","article-title":"Non-covalent presentation of sulfamethoxazole to human CD4+ T cells is independent of distinct human leucocyte antigen-bound peptides","volume":"32","author":"Burkhart","year":"2002","journal-title":"Clin. Exp. Allergy"},{"key":"10.1016\/j.toxlet.2008.12.008_bib6","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/j.immuni.2008.04.020","article-title":"Human leukocyte antigen class I-restricted activation of CD8+ T cells provides the immunogenetic basis of a systemic drug hypersensitivity","volume":"28","author":"Chessman","year":"2008","journal-title":"Immunity"},{"key":"10.1016\/j.toxlet.2008.12.008_bib7","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/428486a","article-title":"Medical genetics: a marker for Stevens\u2013Johnson syndrome","volume":"428","author":"Chung","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.toxlet.2008.12.008_bib8","first-page":"125","article-title":"Investigation of the requirement for antigen processing and presentation in T-cell hypersensitivity to phenytoin","author":"Cooper","year":"2005","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.toxlet.2008.12.008_bib9","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1124\/jpet.106.113803","article-title":"Activation of human dendritic cells by p-phenylenediamine","volume":"320","author":"Coulter","year":"2007","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.toxlet.2008.12.008_bib10","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1038\/sj.jid.5701071","article-title":"Activation of T-cells from allergic patients and volunteers by p-phenylenediamine and Bandrowski's base","volume":"128","author":"Coulter","year":"2008","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.toxlet.2008.12.008_bib11","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1021\/tx0601408","article-title":"Synthesis and reactivity toward nucleophilic amino acids of 2,5-[13C]-dimethyl-p-benzoquinonediimine","volume":"19","author":"Eilstein","year":"2006","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.toxlet.2008.12.008_bib12","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1021\/tx700040s","article-title":"Mechanistic studies on the lysine-induced N-formylation of 2,5-dimethyl-p-benzoquinonediimine","volume":"20","author":"Eilstein","year":"2007","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.toxlet.2008.12.008_bib13","doi-asserted-by":"crossref","first-page":"5482","DOI":"10.1016\/j.bmc.2008.04.014","article-title":"Sensitization to p-amino aromatic compounds: study of the covalent binding of 2,5-dimethyl-p-benzoquinonediimine to a model peptide by electrospray ionization tandem mass spectrometry","volume":"16","author":"Eilstein","year":"2008","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.toxlet.2008.12.008_bib14","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1124\/jpet.103.050112","article-title":"Characterization of sulfamethoxazole and sulfamethoxazole metabolite-specific T-cell responses in animals and humans","volume":"306","author":"Farrell","year":"2003","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.toxlet.2008.12.008_bib15","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1111\/j.1365-2133.2005.06742.x","article-title":"Analysis of para-phenylenediamine allergic patients in relation to strength of patch test reaction","volume":"153","author":"Ho","year":"2005","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.toxlet.2008.12.008_bib16","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.1365-2125.1988.tb03358.x","article-title":"A comparative study of the formation of chemically reactive drug metabolites by human liver microsomes","volume":"26","author":"Kitteringham","year":"1988","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.toxlet.2008.12.008_bib17","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1159\/000236573","article-title":"Dissociation of allergenic and immunogenic functions in contact sensitivity to para-phenylenediamine","volume":"102","author":"Krasteva","year":"1993","journal-title":"Int. Arch. Allergy Immunol."},{"key":"10.1016\/j.toxlet.2008.12.008_bib18","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1111\/j.1365-2222.1996.tb00577.x","article-title":"In vitro primary sensitization of hapten-specific T cells by cultured human epidermal Langerhans cells\u2014a screening predictive assay for contact sensitizers","volume":"26","author":"Krasteva","year":"1996","journal-title":"Clin. Exp. Allergy"},{"key":"10.1016\/j.toxlet.2008.12.008_bib19","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/S0140-6736(02)07873-X","article-title":"Association between presence of HLA-B*5701, HLA-DR7, and HLA-DQ3 and hypersensitivity to HIV-1 reverse-transcriptase inhibitor abacavir","volume":"359","author":"Mallal","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.toxlet.2008.12.008_bib20","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1136\/bmj.39042.643206.BE","article-title":"Allergy to hair dye","volume":"334","author":"McFadden","year":"2007","journal-title":"BMJ"},{"key":"10.1016\/j.toxlet.2008.12.008_bib21","doi-asserted-by":"crossref","first-page":"3308","DOI":"10.1002\/eji.1830251216","article-title":"Characterization of processing requirements and metal cross-reactivities in T cell clones from patients with allergic contact dermatitis to nickel","volume":"25","author":"Moulon","year":"1995","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.toxlet.2008.12.008_bib22","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1038\/sj.bjp.0702453","article-title":"Cellular disposition of sulphamethoxazole and its metabolites: implications for hypersensitivity","volume":"126","author":"Naisbitt","year":"1999","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.toxlet.2008.12.008_bib23","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1067\/mai.2003.1507","article-title":"Characterization of drug-specific T cells in lamotrigine hypersensitivity","volume":"111","author":"Naisbitt","year":"2003","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.toxlet.2008.12.008_bib24","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1517\/14740338.6.2.109","article-title":"Immunological principles of T-cell-mediated adverse drug reactions in skin","volume":"6","author":"Naisbitt","year":"2007","journal-title":"Expert Opin. Drug Saf."},{"key":"10.1016\/j.toxlet.2008.12.008_bib25","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1016\/j.jaci.2004.07.047","article-title":"Toxic epidermal necrolysis: effector cells are drug-specific cytotoxic T cells","volume":"114","author":"Nassif","year":"2004","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.toxlet.2008.12.008_bib26","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1159\/000247895","article-title":"Study on cross-reactivity to the para group","volume":"181","author":"Picardo","year":"1990","journal-title":"Dermatologica"},{"key":"10.1016\/j.toxlet.2008.12.008_bib27","doi-asserted-by":"crossref","first-page":"683","DOI":"10.7326\/0003-4819-139-8-200310210-00012","article-title":"Delayed drug hypersensitivity reactions","volume":"139","author":"Pichler","year":"2003","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.toxlet.2008.12.008_bib28","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1038\/sj.jid.5700581","article-title":"Investigation of mechanisms underlying the T-cell response to the hapten 2,4-dinitrochlorobenzene","volume":"127","author":"Pickard","year":"2007","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.toxlet.2008.12.008_bib29","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1046\/j.1523-1747.1998.00150.x","article-title":"Evaluation of the capacity of dendritic cells derived from cord blood CD34+ precursors to present haptens to unsensitized autologous T cells in vitro","volume":"110","author":"Rougier","year":"1998","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.toxlet.2008.12.008_bib30","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0300-483X(99)00222-X","article-title":"In vitro evaluation of the sensitization potential of weak contact allergens using langerhans-like dendritic cells and autologous T cells","volume":"145","author":"Rougier","year":"2000","journal-title":"Toxicology"},{"key":"10.1016\/j.toxlet.2008.12.008_bib31","doi-asserted-by":"crossref","first-page":"6647","DOI":"10.4049\/jimmunol.164.12.6647","article-title":"Recognition of sulfamethoxazole and its reactive metabolites by drug-specific CD4+ T cells from allergic individuals","volume":"164","author":"Schnyder","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.toxlet.2008.12.008_bib32","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1067\/mai.2002.123872","article-title":"Delayed-type hypersensitivity reaction to paraphenylenediamine is mediated by 2 different pathways of antigen recognition by specific alphabeta human T-cell clones","volume":"109","author":"Sieben","year":"2002","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.toxlet.2008.12.008_bib33","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1002\/(SICI)1099-1263(199907\/08)19:4<255::AID-JAT573>3.0.CO;2-S","article-title":"Local lymph node assay responses to paraphenylenediamine: intra- and inter-laboratory evaluations","volume":"19","author":"Warbrick","year":"1999","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.toxlet.2008.12.008_bib34","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1111\/j.1365-2222.2006.02561.x","article-title":"p-Phenylenediamine allergy: the role of Bandrowski's base","volume":"36","author":"White","year":"2006","journal-title":"Clin. Exp. Allergy"},{"key":"10.1016\/j.toxlet.2008.12.008_bib35","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.jaci.2006.03.005","article-title":"Activation of T cells by carbamazepine and carbamazepine metabolites","volume":"118","author":"Wu","year":"2006","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.toxlet.2008.12.008_bib36","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1172\/JCI3544","article-title":"HLA-restricted, processing- and metabolism-independent pathway of drug recognition by human alpha beta T lymphocytes","volume":"102","author":"Zanni","year":"1998","journal-title":"J. Clin. Invest."}],"container-title":["Toxicology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427408013866?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427408013866?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,23]],"date-time":"2018-12-23T05:55:35Z","timestamp":1545544535000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378427408013866"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,3]]},"references-count":36,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,3]]}},"alternative-id":["S0378427408013866"],"URL":"https:\/\/doi.org\/10.1016\/j.toxlet.2008.12.008","relation":{},"ISSN":["0378-4274"],"issn-type":[{"value":"0378-4274","type":"print"}],"subject":[],"published":{"date-parts":[[2009,3]]}}}