{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T22:59:31Z","timestamp":1776725971018,"version":"3.51.2"},"reference-count":30,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2009,3,1]],"date-time":"2009-03-01T00:00:00Z","timestamp":1235865600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicology Letters"],"published-print":{"date-parts":[[2009,3]]},"DOI":"10.1016\/j.toxlet.2008.12.013","type":"journal-article","created":{"date-parts":[[2008,12,31]],"date-time":"2008-12-31T04:40:27Z","timestamp":1230698427000},"page":"160-167","source":"Crossref","is-referenced-by-count":11,"title":["Modifying effects of prepubertal exposure to potassium perchlorate and tetrabromobisphenol A on susceptibility to N-bis(2-hydroxypropyl)nitrosamine- and 7,12-dimethylbenz(a)anthracene-induced carcinogenesis in rats"],"prefix":"10.1016","volume":"185","author":[{"given":"Toshio","family":"Imai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeaki","family":"Takami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young-Man","family":"Cho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masao","family":"Hirose","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiyoshi","family":"Nishikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxlet.2008.12.013_bib1","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1002\/mnfr.200700077","article-title":"Exposure assessment of fetus and newborn to brominated flame retardants in France: preliminary data","volume":"52","author":"Antignac","year":"2008","journal-title":"Mol Nutr Food Res"},{"key":"10.1016\/j.toxlet.2008.12.013_bib2","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.reprotox.2004.07.002","article-title":"In utero and lactational exposure of Long\u2013Evans rats to ammonium perchlorate (AP) disrupts ovarian follicle maturation","volume":"19","author":"Baldridge","year":"2004","journal-title":"Reprod Toxicol"},{"key":"10.1016\/j.toxlet.2008.12.013_bib3","author":"Barton","year":"2005"},{"key":"10.1016\/j.toxlet.2008.12.013_bib4","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1289\/ehp.9466","article-title":"Urinary perchlorate and thyroid hormone levels in adolescent and adult men and women living in the United States","volume":"114","author":"Blount","year":"2006","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.toxlet.2008.12.013_bib5","article-title":"Thyroid gland (follicular cells)","volume":"vol. 723\u2013734","author":"Capen","year":"2001"},{"key":"10.1016\/j.toxlet.2008.12.013_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2008.07.084","article-title":"Exposure assessment of French women and their newborns to tetrabromobisphenol-A: occurrence measurements in maternal adipose tissue, serum, breast milk and cord serum","author":"Cariou","year":"2008","journal-title":"Chemosphere"},{"key":"10.1016\/j.toxlet.2008.12.013_bib7","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1006\/faat.1993.1121","article-title":"Comparative carcinogenicity of polybrominated biphenyls with or without perinatal exposure in rats and mice","volume":"21","author":"Chhabra","year":"1993","journal-title":"Fundam Appl Toxicol"},{"key":"10.1016\/j.toxlet.2008.12.013_bib8","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/0272-0590(92)90139-9","article-title":"Comparative carcinogenicity of ethylene thiourea with or without perinatal exposure in rats and mice","volume":"18","author":"Chhabra","year":"1992","journal-title":"Fundam Appl Toxicol"},{"key":"10.1016\/j.toxlet.2008.12.013_bib9","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1111\/j.1349-7006.2006.00303.x","article-title":"Lack of enhancement of susceptibility to mammary and thyroid carcinogenesis in rats exposed to DMBA and DHPN following prepubertal iodine deficiency","volume":"97","author":"Cho","year":"2006","journal-title":"Cancer Sci"},{"key":"10.1016\/j.toxlet.2008.12.013_bib10","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.canlet.2004.10.017","article-title":"Lack of prepubertal administration of ethinyl estradiol on susceptibility to multiple organ carcinogenesis in rats exposed to 7,12-dimethylbenz[a]anthracene and N-bis(2-hydroxypropyl)nitrosamine during adolescence","volume":"223","author":"Cho","year":"2005","journal-title":"Cancer Lett"},{"key":"10.1016\/j.toxlet.2008.12.013_bib11","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1093\/toxsci\/kfg147","article-title":"Predicting neonatal perchlorate dose and inhibition of iodide uptake in the rat during lactation using physiologically-based pharmacokinetic modeling","volume":"74","author":"Clewell","year":"2003","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.toxlet.2008.12.013_bib12","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1080\/15287390490483818","article-title":"Lack of effects of postnatal exposure to a mixture of aryl hydrocarbon-receptor agonists on the development of methylnitrosourea-induced mammary tumors in Sprague\u2013Dawley rats","volume":"67","author":"Desaulniers","year":"2004","journal-title":"J Toxicol Environ Health A"},{"key":"10.1016\/j.toxlet.2008.12.013_bib13","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1530\/eje.0.1340649","article-title":"Effect of hypothyroidism on ovarian follicular development, granulosa cell proliferation and peripheral hormone levels in the prepubertal rat","volume":"134","author":"Dijkstra","year":"1996","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.toxlet.2008.12.013_bib14","first-page":"2332","article-title":"Rat mammary gland atypia produced by iodine blockade with perchlorate","volume":"35","author":"Eskin","year":"1975","journal-title":"Cancer Res"},{"key":"10.1016\/j.toxlet.2008.12.013_bib15","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0027-5107(01)00223-8","article-title":"Role of human cytochrome P450 (CYP) in the metabolic activation of N-alkylnitrosamines: application of genetically engineered Salmonella typhimurium YG7108 expressing each form of CYP together with human NADPH-cytochrome P450 reductase","volume":"483","author":"Fujita","year":"2001","journal-title":"Mutat Res"},{"key":"10.1016\/j.toxlet.2008.12.013_bib16","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.toxlet.2004.01.001","article-title":"Unexpected nephrotoxicity induced by tetrabromobisphenol A in newborn rats","volume":"150","author":"Fukuda","year":"2004","journal-title":"Toxicol Lett"},{"key":"10.1016\/j.toxlet.2008.12.013_bib17","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.tox.2005.10.019","article-title":"Subacute effects of the brominated flame retardants hexabromocyclododecane and tetrabromobisphenol A on hepatic cytochrome P450 levels in rats","volume":"218","author":"Germer","year":"2006","journal-title":"Toxicology"},{"key":"10.1016\/j.toxlet.2008.12.013_bib18","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.canlet.2004.03.028","article-title":"p-Nonylphenol pretreatment during the late neonatal period has no effect on 3,2\u2032-dimethyl-4-aminobiphenyl-induced prostate carcinogenesis in male F344 rats","volume":"212","author":"Inaguma","year":"2004","journal-title":"Cancer Lett"},{"key":"10.1016\/j.toxlet.2008.12.013_bib19","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1021\/es048118t","article-title":"Perchlorate and iodide in dairy and breast milk","volume":"39","author":"Kirk","year":"2005","journal-title":"Environ Sci Technol"},{"key":"10.1016\/j.toxlet.2008.12.013_bib20","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/S0006-291X(02)00262-0","article-title":"Thyroid hormonal activity of the flame retardants tetrabromobisphenol A and tetrachlorobisphenol A","volume":"293","author":"Kitamura","year":"2002","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.toxlet.2008.12.013_bib21","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1093\/toxsci\/kfm006","article-title":"The effects of dose, route, and repeated dosing on the disposition and kinetics of tetrabromobisphenol A in male F-344 rats","volume":"96","author":"Kuester","year":"2007","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.toxlet.2008.12.013_bib22","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1210\/jc.86.3.1072","article-title":"Estrogen promotes growth of human thyroid tumor cells by different molecular mechanisms","volume":"86","author":"Manole","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.toxlet.2008.12.013_bib23","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1080\/01926230701584205","article-title":"Effects of neonatally administered diethylstilbestrol on induction of mammary carcinomas induced by 7, 12-dimethylbenz(a)anthracene in female rats","volume":"35","author":"Ninomiya","year":"2007","journal-title":"Toxicol Pathol"},{"key":"10.1016\/j.toxlet.2008.12.013_bib24","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0300-483X(99)00108-0","article-title":"Hepatotoxicity of tetrabromobisphenol-A: effects of repeated dosage in rats","volume":"142","author":"Szymanska","year":"2000","journal-title":"Toxicology"},{"key":"10.1016\/j.toxlet.2008.12.013_bib25","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1016\/j.fct.2006.03.006","article-title":"Effects of tetrabromobisphenol A, brominated flame retardant, in ICR mice after prenatal and postnatal exposure","volume":"44","author":"Tada","year":"2006","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.toxlet.2008.12.013_bib26","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/j.1349-7006.2005.00132.x","article-title":"Comparison of enhancing effects of different goitrogen treatments in combination with beta-estradiol-3-benzoate for establishing a rat two-stage thyroid carcinogenesis model to detect modifying effects of estrogenic compounds","volume":"97","author":"Takizawa","year":"2006","journal-title":"Cancer Sci"},{"key":"10.1016\/j.toxlet.2008.12.013_bib27","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1089\/thy.2005.15.963","article-title":"Long-term environmental exposure to perchlorate through drinking water and thyroid function during pregnancy and the neonatal period","volume":"15","author":"Tellez Tellez","year":"2005","journal-title":"Thyroid"},{"key":"10.1016\/j.toxlet.2008.12.013_bib28","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/j.1349-7006.2005.00008.x","article-title":"Possible enhancing effects of atrazine on growth of 7, 12-dimethylbenz(a) anthracene-induced mammary tumors in ovariectomized Sprague\u2013Dawley rats","volume":"96","author":"Ueda","year":"2005","journal-title":"Cancer Sci"},{"key":"10.1016\/j.toxlet.2008.12.013_bib29","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1126\/science.6800033","article-title":"A 7-hydroxymethyl sulfate ester as an active metabolite of 7, 12-dimethylbenz[alpha]anthracene","volume":"215","author":"Watabe","year":"1982","journal-title":"Science"},{"key":"10.1016\/j.toxlet.2008.12.013_bib30","first-page":"3661","article-title":"Carcinogenicity and mutagenicity of the 3,4-dihydrodiols and other metabolites of 7,12-dimethylbenz(a)anthracene and its hydroxymethyl derivatives","volume":"40","author":"Wislocki","year":"1980","journal-title":"Cancer Res"}],"container-title":["Toxicology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037842740801388X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037842740801388X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,16]],"date-time":"2019-05-16T18:08:45Z","timestamp":1558030125000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S037842740801388X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,3]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,3]]}},"alternative-id":["S037842740801388X"],"URL":"https:\/\/doi.org\/10.1016\/j.toxlet.2008.12.013","relation":{},"ISSN":["0378-4274"],"issn-type":[{"value":"0378-4274","type":"print"}],"subject":[],"published":{"date-parts":[[2009,3]]}}}