{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:22:47Z","timestamp":1759969367598,"version":"build-2065373602"},"reference-count":18,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2010,2,1]],"date-time":"2010-02-01T00:00:00Z","timestamp":1264982400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,2,1]],"date-time":"2010-02-01T00:00:00Z","timestamp":1264982400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology Letters"],"published-print":{"date-parts":[[2010,2]]},"DOI":"10.1016\/j.toxlet.2009.10.009","type":"journal-article","created":{"date-parts":[[2009,10,18]],"date-time":"2009-10-18T04:08:20Z","timestamp":1255838900000},"page":"97-100","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Di-(2-ethylhexyl) phthalate enhances skin sensitization to isocyanate haptens in mice"],"prefix":"10.1016","volume":"192","author":[{"given":"Tomoko","family":"Matsuda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohta","family":"Kurohane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuyuki","family":"Imai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxlet.2009.10.009_bib1","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1289\/ehp.7187","article-title":"The association between asthma and allergic symptoms in children and phthalates in house dust: a nested case-control study","volume":"112","author":"Bornehag","year":"2004","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.toxlet.2009.10.009_bib2","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1034\/j.1600-0536.2002.460115.x","article-title":"Allergic contact dermatitis from dibutyl phthalate and benzalkonium chloride in Timodine cream","volume":"46","author":"Chowdhury","year":"2002","journal-title":"Contact Derm."},{"key":"10.1016\/j.toxlet.2009.10.009_bib3","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.tox.2007.11.017","article-title":"Di-(2-ethylhexyl) phthalate is without adjuvant effect in mice on ovalbumin","volume":"244","author":"Dearman","year":"2008","journal-title":"Toxicology"},{"key":"10.1016\/j.toxlet.2009.10.009_bib4","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1046\/j.1365-2567.2000.01126.x","article-title":"Role of CD4+ T helper 2-type cells in cutaneous inflammatory responses induced by fluorescein isothiocyanate","volume":"101","author":"Dearman","year":"2000","journal-title":"Immunology"},{"key":"10.1016\/j.toxlet.2009.10.009_bib5","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1111\/j.1365-2222.2006.02574.x","article-title":"Effects of phthalate esters on the sensitization phase of contact hypersensitivity induced by fluorescein isothiocyanate","volume":"36","author":"Imai","year":"2006","journal-title":"Clin. Exp. Allergy"},{"key":"10.1016\/j.toxlet.2009.10.009_bib6","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1289\/ehp.10498","article-title":"The association between phthalates in dust and allergic diseases among Bulgarian children","volume":"116","author":"Kolarik","year":"2008","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.toxlet.2009.10.009_bib7","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.tox.2007.03.010","article-title":"Airway inflammation and adjuvant effect after repeated airborne exposures to di-(2-ethylhexyl) phthalate and ovalbumin in BALB\/c mice","volume":"235","author":"Larsen","year":"2007","journal-title":"Toxicology"},{"key":"10.1016\/j.toxlet.2009.10.009_bib8","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0378-4274(01)00419-2","article-title":"Di-(2-ethylhexyl) phthalate possesses an adjuvant effect in a subcutaneous injection model with BALB\/c mice","volume":"125","author":"Larsen","year":"2001","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.toxlet.2009.10.009_bib9","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1159\/000078768","article-title":"Enhancement of interleukin-4 production in activated CD4+ T cells by diphthalate plasticizers via increased NF-AT binding activity","volume":"134","author":"Lee","year":"2004","journal-title":"Int. Arch. Allergy Immunol."},{"key":"10.1016\/j.toxlet.2009.10.009_bib10","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1159\/000099081","article-title":"Influence of local treatments with capsaicin or allyl isothiocyanate in the sensitization phase of a fluorescein-isothiocyanate-induced contact sensitivity model","volume":"143","author":"Maruyama","year":"2007","journal-title":"Int. Arch. Allergy Immunol."},{"key":"10.1016\/j.toxlet.2009.10.009_bib11","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1111\/j.1348-0421.2007.tb03914.x","article-title":"Effects of phthalate esters on dendritic cell subsets and interleukin-4 production in fluorescein isothiocyanate-induced contact hypersensitivity","volume":"51","author":"Maruyama","year":"2007","journal-title":"Microbiol. Immunol."},{"key":"10.1016\/j.toxlet.2009.10.009_bib12","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1111\/j.1600-0668.2006.00468.x","article-title":"Do indoor chemicals promote development of airway allergy?","volume":"17","author":"Nielsen","year":"2007","journal-title":"Indoor Air"},{"key":"10.1016\/j.toxlet.2009.10.009_bib13","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.jneuroim.2008.12.001","article-title":"TRPA1 and TRPV1 activation is a novel adjuvant effect mechanism in contact hypersensitivity","volume":"207","author":"Shiba","year":"2009","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.toxlet.2009.10.009_bib14","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1289\/ehp.8985","article-title":"Di-(2-ethylhexyl) phthalate enhances atopic dermatitis-like skin lesions in mice","volume":"114","author":"Takano","year":"2006","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.toxlet.2009.10.009_bib15","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1093\/intimm\/dxh073","article-title":"Essential role of MHC II-independent CD4+ T cells, IL-4 and STAT6 in contact hypersensitivity induced by fluorescein isothiocyanate in the mouse","volume":"16","author":"Takeshita","year":"2004","journal-title":"Int. Immunol."},{"key":"10.1016\/j.toxlet.2009.10.009_bib16","doi-asserted-by":"crossref","first-page":"117","DOI":"10.4049\/jimmunol.157.1.117","article-title":"Suppression of murine allergic contact dermatitis by CTLA4Ig. Tolerance induction of Th2 responses requires additional blockade of CD40-ligand","volume":"157","author":"Tang","year":"1996","journal-title":"J. Immunol."},{"key":"10.1016\/j.toxlet.2009.10.009_bib17","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1093\/toxsci\/kfh155","article-title":"Respiratory response to toluene diisocyanate depends on prior frequency and concentration of dermal sensitization in mice","volume":"80","author":"Vanoirbeek","year":"2004","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.toxlet.2009.10.009_bib18","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1289\/ehp.11191","article-title":"Effects of maternal exposure to di-(2-ethylhexyl) phthalate during fetal and\/or neonatal periods on atopic dermatitis in male offspring","volume":"116","author":"Yanagisawa","year":"2008","journal-title":"Environ. Health Perspect."}],"container-title":["Toxicology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427409014507?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427409014507?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T05:11:38Z","timestamp":1759900298000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378427409014507"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,2]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,2]]}},"alternative-id":["S0378427409014507"],"URL":"https:\/\/doi.org\/10.1016\/j.toxlet.2009.10.009","relation":{},"ISSN":["0378-4274"],"issn-type":[{"type":"print","value":"0378-4274"}],"subject":[],"published":{"date-parts":[[2010,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Di-(2-ethylhexyl) phthalate enhances skin sensitization to isocyanate haptens in mice","name":"articletitle","label":"Article Title"},{"value":"Toxicology Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxlet.2009.10.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}