{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T14:48:45Z","timestamp":1785163725486,"version":"3.55.0"},"reference-count":51,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T00:00:00Z","timestamp":1272672000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicology Letters"],"published-print":{"date-parts":[[2010,5]]},"DOI":"10.1016\/j.toxlet.2010.02.003","type":"journal-article","created":{"date-parts":[[2010,2,12]],"date-time":"2010-02-12T09:36:50Z","timestamp":1265967410000},"page":"70-78","source":"Crossref","is-referenced-by-count":41,"title":["Methylmercury chloride induces alveolar type II epithelial cell damage through an oxidative stress-related mitochondrial cell death pathway"],"prefix":"10.1016","volume":"194","author":[{"given":"Tien Hui","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun Hung","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming Jye","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsung Jung","family":"Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuk Man","family":"Leung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Zong","family":"Hung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng Chien","family":"Yen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsung Ying","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya Wen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxlet.2010.02.003_bib1","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1172\/JCI3236","article-title":"Generation of lyso-phospholipids from surfactant in acute lung injury is mediated by type-II phospholipase A2 and inhibited by a direct surfactant protein A\u2013phospholipase A2 protein interaction","volume":"102","author":"Arbibe","year":"1998","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.toxlet.2010.02.003_bib2","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.tox.2008.05.003","article-title":"Cytotoxicity of folpet fungicide on human bronchial epithelial cells","volume":"249","author":"Canal-Raffin","year":"2008","journal-title":"Toxicology"},{"key":"10.1016\/j.toxlet.2010.02.003_bib3","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/j.mehy.2004.03.033","article-title":"Periodic dip of lipidperoxidation in humans: a redox signal to synchronize peripheral circadian clocks?","volume":"63","author":"Cardona","year":"2004","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.toxlet.2010.02.003_bib4","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1021\/tx0600705","article-title":"Methylmercury induces pancreatic beta-cell apoptosis and dysfunction","volume":"19","author":"Chen","year":"2006","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.toxlet.2010.02.003_bib5","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.2337\/db06-0029","article-title":"The role of phosphoinositide 3-kinase\/Akt signaling in low-dose mercury-induced mouse pancreatic beta-cell dysfunction in vitro and in vivo","volume":"55","author":"Chen","year":"2006","journal-title":"Diabetes"},{"key":"10.1016\/j.toxlet.2010.02.003_bib6","first-page":"332","article-title":"Cell number and cell characteristics of the normal human lung","volume":"126","author":"Crapo","year":"1982","journal-title":"Am. Rev. Respir. Dis."},{"key":"10.1016\/j.toxlet.2010.02.003_bib7","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0009-3084(97)00072-8","article-title":"Methylmercury-induced alterations in lung and pulmonary surfactant properties of adult mice","volume":"89","author":"Das","year":"1997","journal-title":"Chem. Phys. Lipids"},{"key":"10.1016\/j.toxlet.2010.02.003_bib8","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1289\/ehp.9918","article-title":"Relationship of blood mercury levels to health parameters in the loggerhead sea turtle (Caretta caretta)","volume":"115","author":"Day","year":"2007","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.toxlet.2010.02.003_bib9","first-page":"111","article-title":"Human health effects of methylmercury exposure","volume":"198","author":"Diez","year":"2009","journal-title":"Rev. Environ. Contam. Toxicol."},{"key":"10.1016\/j.toxlet.2010.02.003_bib10","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1124\/mol.108.048751","article-title":"Imidazoquinolinone, imidazopyridine, and isoquinolindione derivatives as novel and potent inhibitors of the poly(ADP-ribose) polymerase (PARP): a comparison with standard PARP inhibitors","volume":"74","author":"Eltze","year":"2008","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.toxlet.2010.02.003_bib11","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1080\/15563650600671795","article-title":"Neither DMPS nor DMSA is effective in quantitative elimination of elemental mercury after intentional IV injection","volume":"44","author":"Eyer","year":"2006","journal-title":"Clin. Toxicol. (Phila)"},{"key":"10.1016\/j.toxlet.2010.02.003_bib12","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.freeradbiomed.2009.05.013","article-title":"Methylmercury neurotoxicity is associated with inhibition of the antioxidant enzyme glutathione peroxidase","volume":"47","author":"Franco","year":"2009","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.toxlet.2010.02.003_bib13","first-page":"578","article-title":"Influence of 60% oxygen inhalation on type II alveolar epithelial cells and protective role of calcitonin gene-related peptide from their damage induced in premature rat","volume":"20","author":"Fu","year":"2008","journal-title":"Zhongguo Wei Zhong Bing Ji Jiu Yi Xue"},{"key":"10.1016\/j.toxlet.2010.02.003_bib14","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.neuro.2008.10.002","article-title":"Methylmercury exposure downregulates the expression of Racl and leads to neuritic degeneration and ultimately apoptosis in cerebrocortical neurons","volume":"30","author":"Fujimura","year":"2009","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.toxlet.2010.02.003_bib15","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1183\/09031936.99.13614779","article-title":"Pulmonary surfactant in health and human lung diseases: state of the art","volume":"13","author":"Griese","year":"1999","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.toxlet.2010.02.003_bib16","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1164\/rccm.200405-575OC","article-title":"Pulmonary surfactant, lung function, and endobronchial inflammation in cystic fibrosis","volume":"170","author":"Griese","year":"2004","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.toxlet.2010.02.003_bib17","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0197-0186(01)00013-4","article-title":"Lipid peroxidation-mediated oxidative stress and dopamine neuronal apoptosis in the substantia nigra during development","volume":"39","author":"Groc","year":"2001","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.toxlet.2010.02.003_bib18","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1007\/s00204-009-0437-8","article-title":"Low level and sub-chronic exposure to methylmercury induces hypertension in rats: nitric oxide depletion and oxidative damage as possible mechanisms","volume":"83","author":"Grotto","year":"2009","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.toxlet.2010.02.003_bib19","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1080\/15287390701212695","article-title":"Comparative cytotoxicity of cadmium and mercury in a human bronchial epithelial cell line (BEAS-2B) and its role in oxidative stress and induction of heat shock protein 70","volume":"70","author":"Han","year":"2007","journal-title":"J. Toxicol. Environ. Health A"},{"key":"10.1016\/j.toxlet.2010.02.003_bib20","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.taap.2006.12.017","article-title":"Role of surfactant protein-A (SP-A) in lung injury in response to acute ozone exposure of SP-A deficient mice","volume":"220","author":"Haque","year":"2007","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.toxlet.2010.02.003_bib21","first-page":"4396","article-title":"Induction of apoptosis by caffeine is mediated by the p53, Bax, and caspase 3 pathways","volume":"63","author":"He","year":"2003","journal-title":"Cancer Res."},{"key":"10.1016\/j.toxlet.2010.02.003_bib22","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.taap.2009.02.007","article-title":"Dispersion medium modulates oxidative stress response of human lung epithelial cells upon exposure to carbon nanomaterial samples","volume":"236","author":"Herzog","year":"2009","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.toxlet.2010.02.003_bib23","doi-asserted-by":"crossref","first-page":"S24","DOI":"10.1111\/j.1440-1843.2006.00803.x","article-title":"Surfactant catabolism","volume":"11 Suppl.","author":"Ikegami","year":"2006","journal-title":"Respirology"},{"key":"10.1016\/j.toxlet.2010.02.003_bib24","doi-asserted-by":"crossref","first-page":"L363","DOI":"10.1152\/ajplung.00078.2003","article-title":"Induction of 1-cys peroxiredoxin expression by oxidative stress in lung epithelial cells","volume":"285","author":"Kim","year":"2003","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.toxlet.2010.02.003_bib25","doi-asserted-by":"crossref","first-page":"3537","DOI":"10.1074\/jbc.M807001200","article-title":"Oxidative stress alters syndecan-1 distribution in lungs with pulmonary fibrosis","volume":"284","author":"Kliment","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxlet.2010.02.003_bib26","first-page":"199","article-title":"Mercuric chloride induces apoptosis in MDCK cells","volume":"39","author":"Lee","year":"2006","journal-title":"J. Prev. Med. Pub. Health"},{"key":"10.1016\/j.toxlet.2010.02.003_bib27","unstructured":"Lepparanta, O., Pulkkinen, V., Koli, K., Vahatalo, R., Salmenkivi, K., Kinnula, V.L., Heikinheimo, M., Myllarniemi, M., in press. Transcription factor GATA-6 is expressed in quiescent myofibroblasts in idiopathic pulmonary fibrosis. Am. J. Respir. Cell. Mol. Biol."},{"key":"10.1016\/j.toxlet.2010.02.003_bib28","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1080\/01902140290092001","article-title":"Reactive species mediated injury of human lung epithelial cells after hypoxia\u2013reoxygenation","volume":"28","author":"Li","year":"2002","journal-title":"Exp. Lung Res."},{"key":"10.1016\/j.toxlet.2010.02.003_bib29","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1097\/00029330-200708020-00010","article-title":"Effect of intramuscular injection of hepatocyte growth factor plasmid DNA with electroporation on bleomycin-induced lung fibrosis in rats","volume":"120","author":"Long","year":"2007","journal-title":"Chin. Med. J. (Engl.)"},{"key":"10.1016\/j.toxlet.2010.02.003_bib30","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1183\/09031936.01.17201800","article-title":"Upregulation of Fas-signalling molecules in lung epithelial cells from patients with idiopathic pulmonary fibrosis","volume":"17","author":"Maeyama","year":"2001","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.toxlet.2010.02.003_bib31","doi-asserted-by":"crossref","first-page":"5671","DOI":"10.4049\/jimmunol.155.12.5671","article-title":"Mouse surfactant protein-D. cDNA cloning, characterization, and gene localization to chromosome 14","volume":"155","author":"Motwani","year":"1995","journal-title":"J. Immunol."},{"key":"10.1016\/j.toxlet.2010.02.003_bib32","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0006-2952(01)00652-9","article-title":"The effect of aliphatic, naphthenic, and aromatic hydrocarbons on production of reactive oxygen species and reactive nitrogen species in rat brain synaptosome fraction: the involvement of calcium, nitric oxide synthase, mitochondria, and phospholipase A","volume":"62","author":"Myhre","year":"2001","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.toxlet.2010.02.003_bib33","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1093\/clinchem\/43.7.1209","article-title":"Plasma malondialdehyde as biomarker for oxidative stress: reference interval and effects of life-style factors","volume":"43","author":"Nielsen","year":"1997","journal-title":"Clin. Chem."},{"key":"10.1016\/j.toxlet.2010.02.003_bib34","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1016\/j.bcp.2004.06.021","article-title":"Cadmium induces apoptotic cell death in WI 38 cells via caspase-dependent Bid cleavage and calpain-mediated mitochondrial Bax cleavage by Bcl-2-independent pathway","volume":"68","author":"Oh","year":"2004","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.toxlet.2010.02.003_bib35","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1165\/rcmb.2004-0361OC","article-title":"Poly(ADP-ribose)polymerase activation mediates lung epithelial cell death in vitro but is not essential in hyperoxia-induced lung injury","volume":"33","author":"Pagano","year":"2005","journal-title":"Am. J. Respir. Cell. Mol. Biol."},{"key":"10.1016\/j.toxlet.2010.02.003_bib36","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s00204-006-0167-0","article-title":"Uranium induces oxidative stress in lung epithelial cells","volume":"81","author":"Periyakaruppan","year":"2007","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.toxlet.2010.02.003_bib37","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.tox.2009.06.019","article-title":"Wood dusts induce the production of reactive oxygen species and caspase-3 activity in human bronchial epithelial cells","volume":"262","author":"Pylkkanen","year":"2009","journal-title":"Toxicology"},{"key":"10.1016\/j.toxlet.2010.02.003_bib38","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0109-5641(00)00029-4","article-title":"Cytotoxicity of dental composite components and mercury compounds in lung cells","volume":"17","author":"Reichl","year":"2001","journal-title":"Dent. Mater."},{"key":"10.1016\/j.toxlet.2010.02.003_bib39","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1006\/taap.1999.8652","article-title":"Induction of apoptosis in human T-cells by methyl mercury: temporal relationship between mitochondrial dysfunction and loss of reductive reserve","volume":"157","author":"Shenker","year":"1999","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.toxlet.2010.02.003_bib40","first-page":"61","article-title":"A study on apoptosis and apoptotic mechanisms of HL-7702 cell line induced by methylmercury","volume":"43","author":"Sun","year":"2009","journal-title":"Zhonghua Yu Fang Yi Xue Za Zhi"},{"key":"10.1016\/j.toxlet.2010.02.003_bib41","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1165\/rcmb.2005-0172OC","article-title":"Hypoxia-induced mitogenic factor modulates surfactant protein B and C expression in mouse lung","volume":"34","author":"Tong","year":"2006","journal-title":"Am. J. Respir. Cell. Mol. Biol."},{"key":"10.1016\/j.toxlet.2010.02.003_bib42","doi-asserted-by":"crossref","first-page":"467","DOI":"10.2341\/07-123","article-title":"Amalgam safety and dentists\u2019 attitude: a survey among a subpopulation of Nigerian dentists","volume":"33","author":"Udoye","year":"2008","journal-title":"Oper. Dent."},{"key":"10.1016\/j.toxlet.2010.02.003_bib43","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1089\/15230860260196209","article-title":"Redox control of cell death","volume":"4","author":"Ueda","year":"2002","journal-title":"Antioxid. Redox. Signal."},{"key":"10.1016\/j.toxlet.2010.02.003_bib44","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1096\/fj.08-114546","article-title":"Proapoptotic Noxa is required for particulate matter-induced cell death and lung inflammation","volume":"23","author":"Urich","year":"2009","journal-title":"FASEB J."},{"key":"10.1016\/j.toxlet.2010.02.003_bib45","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1080\/15563650701725102","article-title":"Intravenous injection of metallic mercury: case report and course of mercury during chelation therapy with DMPS","volume":"46","author":"Vallant","year":"2008","journal-title":"Clin. Toxicol. (Phila)"},{"key":"10.1016\/j.toxlet.2010.02.003_bib46","doi-asserted-by":"crossref","first-page":"L109","DOI":"10.1152\/ajplung.90461.2008","article-title":"Lipid-soluble components in cigarette smoke induce mitochondrial production of reactive oxygen species in lung epithelial cells","volume":"297","author":"van der Toorn","year":"2009","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.toxlet.2010.02.003_bib47","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/j.tiv.2006.12.004","article-title":"Development of a mechanistically based genetically engineered PC12 cell system to detect p53-mediated cytotoxicity","volume":"21","author":"van Vliet","year":"2007","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.toxlet.2010.02.003_bib48","unstructured":"Vulimiri, S.V., Misra, M., Hamm, J.T., Mitchell, M., Berger, A., in press. Effects of mainstream cigarette smoke on the global metabolome of human lung epithelial cells. Chem. Res. Toxicol."},{"key":"10.1016\/j.toxlet.2010.02.003_bib49","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0048-9697(98)00228-9","article-title":"Bioaccumulation of mercury in pelagic freshwater food webs","volume":"219","author":"Watras","year":"1998","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.toxlet.2010.02.003_bib50","doi-asserted-by":"crossref","first-page":"36841","DOI":"10.1074\/jbc.M304156200","article-title":"PPARgamma and ligands inhibit SP-B gene expression in the lung","volume":"278","author":"Yang","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxlet.2010.02.003_bib51","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1007\/s10495-008-0228-3","article-title":"Changes in FADD levels, distribution, and phosphorylation in TNFalpha-induced apoptosis in hepatocytes is caspase-3, caspase-8 and BID dependent","volume":"13","author":"Zhang","year":"2008","journal-title":"Apoptosis"}],"container-title":["Toxicology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427410000664?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427410000664?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T06:33:32Z","timestamp":1685428412000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378427410000664"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5]]},"references-count":51,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,5]]}},"alternative-id":["S0378427410000664"],"URL":"https:\/\/doi.org\/10.1016\/j.toxlet.2010.02.003","relation":{},"ISSN":["0378-4274"],"issn-type":[{"value":"0378-4274","type":"print"}],"subject":[],"published":{"date-parts":[[2010,5]]}}}