{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T13:30:10Z","timestamp":1790429410152,"version":"4.1.0"},"reference-count":55,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicology Letters"],"published-print":{"date-parts":[[2011,6]]},"DOI":"10.1016\/j.toxlet.2011.03.009","type":"journal-article","created":{"date-parts":[[2011,3,16]],"date-time":"2011-03-16T21:10:58Z","timestamp":1300309858000},"page":"127-134","source":"Crossref","is-referenced-by-count":48,"title":["Lung fibrosis induced by crystalline silica particles is uncoupled from lung inflammation in NMRI mice"],"prefix":"10.1016","volume":"203","author":[{"given":"Virginie","family":"Rabolli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Lo Re","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francine","family":"Uwambayinema","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yousof","family":"Yakoub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Lison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Huaux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxlet.2011.03.009_bib0005","first-page":"319","article-title":"Instillation of chemotactic factor to silica-injected lungs lowers interstitial particle content and reduces pulmonary fibrosis","volume":"141","author":"Adamson","year":"1992","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.toxlet.2011.03.009_bib0010","doi-asserted-by":"crossref","first-page":"223","DOI":"10.3109\/01902149409064384","article-title":"Enhanced clearance of silica from mouse lung after instillation of a leukocyte chemotactic factor","volume":"20","author":"Adamson","year":"1994","journal-title":"Exp. Lung Res."},{"key":"10.1016\/j.toxlet.2011.03.009_bib0015","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.ejphar.2007.02.065","article-title":"Anti-fibrotic effect of meloxicam in a murine lung fibrosis model","volume":"564","author":"Arafa","year":"2007","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.toxlet.2011.03.009_bib0020","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1165\/rcmb.2003-0299OC","article-title":"Characterization of the effect of interleukin-10 on silica-induced lung fibrosis in mice","volume":"31","author":"Barbarin","year":"2004","journal-title":"Am. J. Respir. Cell. Mol. Biol."},{"issue":"1","key":"10.1016\/j.toxlet.2011.03.009_bib0025","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/1465-9921-6-112","article-title":"The role of pro- and anti-inflammatory responses in silica-induced lung fibrosis","volume":"6","author":"Barbarin","year":"2005","journal-title":"Respir. Res."},{"key":"10.1016\/j.toxlet.2011.03.009_bib0030","doi-asserted-by":"crossref","first-page":"L841","DOI":"10.1152\/ajplung.00329.2004","article-title":"Pulmonary overexpression of IL-10 augments lung fibrosis and Th2 responses induced by silica particles","volume":"288","author":"Barbarin","year":"2005","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.toxlet.2011.03.009_bib0035","doi-asserted-by":"crossref","first-page":"L186","DOI":"10.1152\/ajplung.00474.2004","article-title":"Scavenger receptor class A type I\/II (CD204) null mice fail to develop fibrosis following silica exposure","volume":"289","author":"Beamer","year":"2005","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.toxlet.2011.03.009_bib0040","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1164\/rccm.200405-612OC","article-title":"Progressive transforming growth factor beta1-induced lung fibrosis is blocked by an orally active ALK5 kinase inhibitor","volume":"171","author":"Bonniaud","year":"2005","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.toxlet.2011.03.009_bib0045","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0378-4274(96)03725-3","article-title":"Particles, inflammation and respiratory tract carcinogenesis","volume":"88","author":"Borm","year":"1996","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.toxlet.2011.03.009_bib0050","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/j.1365-2567.2008.02824.x","article-title":"Dexamethasone transforms lipopolysaccharide-stimulated human blood myeloid dendritic cells into myeloid dendritic cells that prime interleukin-10 production in T cells","volume":"125","author":"Bosma","year":"2008","journal-title":"Immunology"},{"key":"10.1016\/j.toxlet.2011.03.009_bib0055","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/BF01982875","article-title":"Anti-inflammatory activity of orpanoxin administered orally and topically to rodents","volume":"16","author":"Brooks","year":"1985","journal-title":"Agents Actions"},{"key":"10.1016\/j.toxlet.2011.03.009_bib0060","first-page":"547","article-title":"Kinetics of inflammatory and fibrotic pulmonary changes in a murine model of silicosis","volume":"105","author":"Callis","year":"1985","journal-title":"J. Lab. Clin. Med."},{"key":"10.1016\/j.toxlet.2011.03.009_bib0065","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.ejphar.2006.03.011","article-title":"Short courses of low dose dexamethasone delay bleomycin-induced lung fibrosis in rats","volume":"536","author":"Chen","year":"2006","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.toxlet.2011.03.009_bib0075","doi-asserted-by":"crossref","first-page":"e5689","DOI":"10.1371\/journal.pone.0005689","article-title":"Systemic inhibition of NF-kappaB activation protects from silicosis","volume":"4","author":"Di Giuseppe","year":"2009","journal-title":"PLoS. One"},{"key":"10.1016\/j.toxlet.2011.03.009_bib0080","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1136\/thorax.58.9.765","article-title":"Short course dexamethasone treatment following injury inhibits bleomycin induced fibrosis in rats","volume":"58","author":"Dik","year":"2003","journal-title":"Thorax"},{"key":"10.1016\/j.toxlet.2011.03.009_bib0085","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1006\/taap.1996.8057","article-title":"Modulation of silica-induced pulmonary toxicity by dexamethasone-containing liposomes","volume":"142","author":"DiMatteo","year":"1997","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.toxlet.2011.03.009_bib0090","doi-asserted-by":"crossref","first-page":"473","DOI":"10.3109\/01902149409031733","article-title":"Macrophage inflammatory proteins\u2014biology and role in pulmonary inflammation","volume":"20","author":"Driscoll","year":"1994","journal-title":"Exp. Lung Res."},{"key":"10.1016\/j.toxlet.2011.03.009_bib0095","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1016\/j.molimm.2005.01.006","article-title":"Immunosuppressive agents mediate reduced allostimulatory properties of myeloid-derived dendritic cells despite induction of divergent molecular phenotypes","volume":"42","author":"Duperrier","year":"2005","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.toxlet.2011.03.009_bib0100","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1164\/rccm.200808-1274OC","article-title":"Uric acid is a danger signal activating NALP3 inflammasome in lung injury inflammation and fibrosis","volume":"179","author":"Gasse","year":"2009","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.toxlet.2011.03.009_bib0105","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.2174\/092986709787846497","article-title":"Recent advances in molecular targets and treatment of idiopathic pulmonary fibrosis: focus on TGFbeta signaling and the myofibroblast","volume":"16","author":"Gharaee-Kermani","year":"2009","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.toxlet.2011.03.009_bib0110","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1378\/chest.101.2.366","article-title":"Acute silicosis responding to corticosteroid therapy","volume":"101","author":"Goodman","year":"1992","journal-title":"Chest"},{"key":"10.1016\/j.toxlet.2011.03.009_bib0115","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.disamonth.2007.09.020","article-title":"Silicosis: a review","volume":"53","author":"Greenberg","year":"2007","journal-title":"Dis. Mon."},{"key":"10.1016\/j.toxlet.2011.03.009_bib0120","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2353\/ajpath.2009.081170","article-title":"Emerging concepts in the pathogenesis of lung fibrosis","volume":"175","author":"Hardie","year":"2009","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.toxlet.2011.03.009_bib0125","doi-asserted-by":"crossref","first-page":"655","DOI":"10.2310\/JIM.0b013e3181a4f32a","article-title":"Association of transforming growth factor beta1 gene polymorphisms and asbestos-induced fibrosis and tumors","volume":"57","author":"Helmig","year":"2009","journal-title":"J. Investig. Med."},{"key":"10.1016\/j.toxlet.2011.03.009_bib0130","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/S0091-6749(99)70337-4","article-title":"Differential regulation of cytokine expression after allergen exposure of sensitized rats by cyclosporin A and corticosteroids: relationship to bronchial hyperresponsiveness","volume":"104","author":"Huang","year":"1999","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.toxlet.2011.03.009_bib0135","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1097\/ACI.0b013e32802bf8a5","article-title":"New developments in the understanding of immunology in silicosis","volume":"7","author":"Huaux","year":"2007","journal-title":"Curr. Opin. Allergy Clin. Immunol."},{"key":"10.1016\/j.toxlet.2011.03.009_bib0140","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1165\/ajrcmb.18.1.2911","article-title":"Role of interleukin-10 in the lung response to silica in mice","volume":"18","author":"Huaux","year":"1998","journal-title":"Am. J. Respir. Cell. Mol. Biol."},{"key":"10.1016\/j.toxlet.2011.03.009_bib0145","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1165\/ajrcmb.21.1.3570","article-title":"Soluble tumor necrosis factor (TNF) receptors p55 and p75 and interleukin-10 downregulate TNF-alpha activity during the lung response to silica particles in NMRI mice","volume":"21","author":"Huaux","year":"1999","journal-title":"Am. J. Respir. Cell. Mol. Biol."},{"key":"10.1016\/j.toxlet.2011.03.009_bib0150","doi-asserted-by":"crossref","first-page":"2653","DOI":"10.4049\/jimmunol.169.5.2653","article-title":"A profibrotic function of IL-12p40 in experimental pulmonary fibrosis","volume":"169","author":"Huaux","year":"2002","journal-title":"J. Immunol."},{"key":"10.1016\/j.toxlet.2011.03.009_bib0155","unstructured":"IARC, 1997. Silica, some silicates, coal dusts and para-amid fibrils. 68. Lyon. France."},{"key":"10.1016\/j.toxlet.2011.03.009_bib0160","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1164\/ajrccm.154.4.8887610","article-title":"Transforming growth factor-beta (TGF-beta) in silicosis","volume":"154","author":"Jagirdar","year":"1996","journal-title":"Am. J. Respir. Crit Care Med."},{"key":"10.1016\/j.toxlet.2011.03.009_bib0165","doi-asserted-by":"crossref","first-page":"96","DOI":"10.2353\/ajpath.2006.051160","article-title":"Overexpression of the transcription factor GATA-3 enhances the development of pulmonary fibrosis","volume":"169","author":"Kimura","year":"2006","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.toxlet.2011.03.009_bib0170","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1172\/JCI12568","article-title":"Transient expression of IL-1beta induces acute lung injury and chronic repair leading to pulmonary fibrosis","volume":"107","author":"Kolb","year":"2001","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.toxlet.2011.03.009_bib0175","doi-asserted-by":"crossref","first-page":"35466","DOI":"10.1074\/jbc.M206395200","article-title":"Transgenic overexpression of interleukin (IL)-10 in the lung causes mucus metaplasia, tissue inflammation, and airway remodeling via IL-13-dependent and -independent pathways","volume":"277","author":"Lee","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxlet.2011.03.009_bib0180","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.immuni.2008.03.003","article-title":"Contextual regulation of inflammation: a duet by transforming growth factor-beta and interleukin-10","volume":"28","author":"Li","year":"2008","journal-title":"Immunity"},{"key":"10.1016\/j.toxlet.2011.03.009_bib0185","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.cell.2008.07.025","article-title":"TGF-beta: a master of all T cell trades","volume":"134","author":"Li","year":"2008","journal-title":"Cell."},{"key":"10.1016\/j.toxlet.2011.03.009_bib0195","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1164\/rccm.200410-1349OC","article-title":"Tumor necrosis factor-alpha overexpression in lung disease: a single cause behind a complex phenotype","volume":"171","author":"Lundblad","year":"2005","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.toxlet.2011.03.009_bib0200","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1093\/toxsci\/kfh110","article-title":"Progression of lung inflammation and damage in rats after cessation of silica inhalation","volume":"79","author":"Porter","year":"2004","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.toxlet.2011.03.009_bib0205","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1080\/08958370252870998","article-title":"Time course of pulmonary response of rats to inhalation of crystalline silica: NF-kappa B activation, inflammation, cytokine production, and damage","volume":"14","author":"Porter","year":"2002","journal-title":"Inhal. Toxicol."},{"key":"10.1016\/j.toxlet.2011.03.009_bib0220","first-page":"1","article-title":"Cryptogenic fibrosing alveolitis. Relationships of pulmonary physiology and bronchoalveolar lavage to response to treatment and prognosis","volume":"124","author":"Rudd","year":"1981","journal-title":"Am. Rev. Respir. Dis."},{"key":"10.1016\/j.toxlet.2011.03.009_bib0225","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/rr175","article-title":"Idiopathic pulmonary fibrosis: an epithelial\/fibroblastic cross-talk disorder","volume":"3","author":"Selman","year":"2002","journal-title":"Respir. Res."},{"key":"10.1016\/j.toxlet.2011.03.009_bib0230","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1164\/ajrccm\/143.4_Pt_1.814","article-title":"Effect of prednisolone treatment in chronic silicosis","volume":"143","author":"Sharma","year":"1991","journal-title":"Am. Rev. Respir. Dis."},{"key":"10.1016\/j.toxlet.2011.03.009_bib0235","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.3748\/wjg.v12.i15.2357","article-title":"Relationship between transforming growth factor beta1 and anti-fibrotic effect of interleukin-10","volume":"12","author":"Shi","year":"2006","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.toxlet.2011.03.009_bib0240","doi-asserted-by":"crossref","first-page":"L341","DOI":"10.1152\/ajplung.00122.2010","article-title":"New concepts of IL-10 induced lung fibrosis: fibrocyte recruitment and M2 activation in a CCL2\/CCR2 axis","volume":"3","author":"Sun","year":"2011","journal-title":"Am. J. Physiol Lung Cell Mol. Physiol."},{"key":"10.1016\/j.toxlet.2011.03.009_bib0245","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1164\/rccm.200606-862OC","article-title":"All-trans-retinoic acid prevents radiation- or bleomycin-induced pulmonary fibrosis","volume":"174","author":"Tabata","year":"2006","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.toxlet.2011.03.009_bib0250","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1093\/toxsci\/kfp011","article-title":"Critical role of MARCO in crystalline silica-induced pulmonary inflammation","volume":"108","author":"Thakur","year":"2009","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.toxlet.2011.03.009_bib0255","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1080\/15476910802085863","article-title":"Role of scavenger receptor a family in lung inflammation from exposure to environmental particles","volume":"5","author":"Thakur","year":"2008","journal-title":"J. Immunotoxicol."},{"key":"10.1016\/j.toxlet.2011.03.009_bib0260","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.toxlet.2008.11.020","article-title":"Comparing fate and effects of three particles of different surface properties: nano-TiO(2), pigmentary TiO(2) and quartz","volume":"186","author":"van Ravenzwaay","year":"2009","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.toxlet.2011.03.009_bib0265","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/S0140-6736(96)07336-9","article-title":"Asbestosis and silicosis","volume":"349","author":"Wagner","year":"1997","journal-title":"Lancet"},{"key":"10.1016\/j.toxlet.2011.03.009_bib0270","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/1465-9921-10-36","article-title":"Silencing CD36 gene expression results in the inhibition of latent-TGF-beta1 activation and suppression of silica-induced lung fibrosis in the rat","volume":"10","author":"Wang","year":"2009","journal-title":"Respir. Res."},{"key":"10.1016\/j.toxlet.2011.03.009_bib0275","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1080\/08958370390229898","article-title":"Assessing the role of neutrophil apoptosis in the resolution of particle-induced pulmonary inflammation","volume":"15","author":"Wiethoff","year":"2003","journal-title":"Inhal. Toxicol."},{"key":"10.1016\/j.toxlet.2011.03.009_bib0280","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1080\/08958370802596298","article-title":"Treatment with dexamethasone or liposome-encapsuled vitamin E provides beneficial effects after chemical-induced lung injury","volume":"21","author":"Wigenstam","year":"2009","journal-title":"Inhal. Toxicol."},{"key":"10.1016\/j.toxlet.2011.03.009_bib0285","first-page":"215","article-title":"Phosphodiesterase-5 inhibition by sildenafil citrate in a rat model of bleomycin-induced lung fibrosis","volume":"3","author":"Yildirim","year":"2009","journal-title":"Pulm. Pharmacol. Ther."},{"key":"10.1016\/j.toxlet.2011.03.009_bib0290","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1080\/15287390490447296","article-title":"Role of inducible nitric oxide synthase-derived nitric oxide in silica-induced pulmonary inflammation and fibrosis","volume":"67","author":"Zeidler","year":"2004","journal-title":"J. Toxicol. Environ. Health. A"},{"key":"10.1016\/j.toxlet.2011.03.009_bib0295","doi-asserted-by":"crossref","first-page":"S67","DOI":"10.1164\/ajrccm.164.supplement_2.2106070","article-title":"Airway inflammation and remodeling in asthma. Lessons from interleukin 11 and interleukin 13 transgenic mice","volume":"164","author":"Zhu","year":"2001","journal-title":"Am. J. Respir. Crit Care Med."}],"container-title":["Toxicology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427411001081?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427411001081?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,3]],"date-time":"2018-12-03T23:50:57Z","timestamp":1543881057000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378427411001081"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6]]},"references-count":55,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,6]]}},"alternative-id":["S0378427411001081"],"URL":"https:\/\/doi.org\/10.1016\/j.toxlet.2011.03.009","relation":{},"ISSN":["0378-4274"],"issn-type":[{"value":"0378-4274","type":"print"}],"subject":[],"published":{"date-parts":[[2011,6]]}}}