{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T15:26:00Z","timestamp":1773674760084,"version":"3.50.1"},"reference-count":45,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"National Important Science Research Program of China","award":["2006CB933205"],"award-info":[{"award-number":["2006CB933205"]}]},{"name":"National Important Science Research Program of China","award":["2011CB933503"],"award-info":[{"award-number":["2011CB933503"]}]},{"name":"US-China international S & T cooperation project","award":["2009DFA31990"],"award-info":[{"award-number":["2009DFA31990"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["60871014"],"award-info":[{"award-number":["60871014"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicology Letters"],"published-print":{"date-parts":[[2011,8]]},"DOI":"10.1016\/j.toxlet.2011.05.1031","type":"journal-article","created":{"date-parts":[[2011,6,3]],"date-time":"2011-06-03T17:05:54Z","timestamp":1307120754000},"page":"130-139","source":"Crossref","is-referenced-by-count":38,"title":["Effects of DMSA-coated Fe3O4 magnetic nanoparticles on global gene expression of mouse macrophage RAW264.7 cells"],"prefix":"10.1016","volume":"205","author":[{"given":"Yingxun","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongping","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Gu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinke","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxlet.2011.05.1031_bib0005","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.jpeds.2004.01.057","article-title":"Innate immunity and toll-like receptors: clinical implications of basic science research","volume":"144","author":"Abreu","year":"2004","journal-title":"J. Pediatr."},{"key":"10.1016\/j.toxlet.2011.05.1031_bib0010","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nri1391","article-title":"Toll-like receptor signalling","volume":"4","author":"Akira","year":"2004","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.toxlet.2011.05.1031_bib0015","doi-asserted-by":"crossref","first-page":"4367","DOI":"10.1021\/es060691k","article-title":"In vitro interactions between DMSA-coated maghemite nanoparticles and human fibroblasts: a physicochemical and cyto-genotoxical study","volume":"40","author":"Auffan","year":"2006","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.toxlet.2011.05.1031_bib0020","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.ijpharm.2003.09.042","article-title":"The influence of transferrin stabilised magnetic nanoparticles on human dermal fibroblasts in culture","volume":"269","author":"Berry","year":"2004","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.toxlet.2011.05.1031_bib0025","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1093\/bioinformatics\/19.2.185","article-title":"A comparison of normalization methods for high density oligonucleotide array data based on variance and bias","volume":"19","author":"Bolstad","year":"2003","journal-title":"Bioinformatics"},{"key":"10.1016\/j.toxlet.2011.05.1031_bib0030","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/S1748-0132(08)70015-X","article-title":"The toxicological impact of nanoparticles","volume":"3","author":"Brayner","year":"2008","journal-title":"Nano Today"},{"key":"10.1016\/j.toxlet.2011.05.1031_bib0035","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/4462","article-title":"Exploring the new world of the genome with DNA microarrays","volume":"21","author":"Brown","year":"1999","journal-title":"Nat. Genet."},{"key":"10.1016\/j.toxlet.2011.05.1031_bib0040","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.colsurfa.2007.09.017","article-title":"Preparation and characterization of water-soluble monodisperse magnetic iron oxide nanoparticles via surface double-exchange with DMSA","volume":"316","author":"Chen","year":"2008","journal-title":"Colloids Surf. A"},{"key":"10.1016\/j.toxlet.2011.05.1031_bib0045","doi-asserted-by":"crossref","first-page":"2448","DOI":"10.1021\/nl051748o","article-title":"Molecular characterization of the cytotoxic mechanism of multiwall carbon nanotubes and nano-onions on human skin fibroblast","volume":"5","author":"Ding","year":"2005","journal-title":"Nano Lett."},{"key":"10.1016\/j.toxlet.2011.05.1031_bib0050","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/S0891-5849(02)00772-4","article-title":"Molecular bases of cellular iron toxicity","volume":"32","author":"Eaton","year":"2002","journal-title":"Free Radical Biol. Med."},{"key":"10.1016\/j.toxlet.2011.05.1031_bib0055","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1038\/43213","article-title":"A new protein containing an SH2 domain that inhibits JAK kinases","volume":"387","author":"Endo","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.toxlet.2011.05.1031_bib0060","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1002\/mus.10462","article-title":"Cytokines, chemokines, and cell adhesion molecules in inflammatory myopathies","volume":"28","author":"Figarella-Branger","year":"2003","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.toxlet.2011.05.1031_bib0065","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.toxlet.2009.08.011","article-title":"Effects of ultrafine TiO2 particles on gene expression profile in human keratinocytes without illumination: involvement of extracellular matrix and cell adhesion","volume":"191","author":"Fujita","year":"2009","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.toxlet.2011.05.1031_bib0070","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/S0304-8853(98)00560-5","article-title":"In vitro and in vivo toxicity of magnetic microspheres","volume":"194","author":"Hafeli","year":"1999","journal-title":"J. Magn. Magn. Mater."},{"key":"10.1016\/j.toxlet.2011.05.1031_bib0075","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s10646-008-0206-0","article-title":"The ecotoxicology of nanoparticles and nanomaterials: current status, knowledge gaps, challenges, and future needs","volume":"17","author":"Handy","year":"2008","journal-title":"Ecotoxicology"},{"issue":"Suppl. 1","key":"10.1016\/j.toxlet.2011.05.1031_bib0080","doi-asserted-by":"crossref","first-page":"S167","DOI":"10.1016\/S1076-6332(98)80095-0","article-title":"MR imaging of lymph nodes in patients with primary abdominal and pelvic malignancies using ultrasmall superparamagnetic iron oxide (Combidex)","volume":"5","author":"Harisinghani","year":"1998","journal-title":"Acad. Radiol."},{"key":"10.1016\/j.toxlet.2011.05.1031_bib0085","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0898-6568(01)00148-6","article-title":"Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38","volume":"13","author":"Harper","year":"2001","journal-title":"Cell Signal."},{"key":"10.1016\/j.toxlet.2011.05.1031_bib0090","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/smll.200700217","article-title":"Assessing the effect of surface chemistry on gold nanorod uptake, toxicity, and gene expression in mammalian cells","volume":"4","author":"Hauck","year":"2008","journal-title":"Small"},{"key":"10.1016\/j.toxlet.2011.05.1031_bib0095","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0898-6568(01)00141-3","article-title":"Inhibition of protein synthesis by the T cell receptor-inducible human TDAG51 gene product","volume":"13","author":"Hinz","year":"2001","journal-title":"Cell Signal."},{"key":"10.1016\/j.toxlet.2011.05.1031_bib0100","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1126\/science.1072682","article-title":"Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases","volume":"298","author":"Johnson","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.toxlet.2011.05.1031_bib0105","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1093\/bioinformatics\/btg436","article-title":"Tailored gene array databases: applications in mechanistic toxicology","volume":"20","author":"Karpinets","year":"2004","journal-title":"Bioinformatics"},{"key":"10.1016\/j.toxlet.2011.05.1031_bib0110","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1089\/10665270050514954","article-title":"Analysis of variance for gene expression microarray data","volume":"7","author":"Kerr","year":"2000","journal-title":"J. Comput. Biol."},{"key":"10.1016\/j.toxlet.2011.05.1031_bib0115","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-1119(02)00398-0","article-title":"Signaling through the JAK\/STAT pathway, recent advances and future challenges","volume":"285","author":"Kisseleva","year":"2002","journal-title":"Gene"},{"key":"10.1016\/j.toxlet.2011.05.1031_bib0120","first-page":"339","article-title":"Innate defence functions of macrophages can be biased by nano-sized ceramic and metallic particles","volume":"15","author":"Lucarelli","year":"2004","journal-title":"Eur. Cytokine Netw."},{"key":"10.1016\/j.toxlet.2011.05.1031_bib0125","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/eji.1830260207","article-title":"CC chemokines induce the generation of killer cells from CD56+ cells","volume":"26","author":"Maghazachi","year":"1996","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.toxlet.2011.05.1031_bib0130","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1038\/43219","article-title":"Structure and function of a new STAT-induced STAT inhibitor","volume":"387","author":"Naka","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.toxlet.2011.05.1031_bib0135","first-page":"5920","article-title":"Identification of the human PHLDA1\/TDAG51 gene: down-regulation in metastatic melanoma contributes to apoptosis resistance and growth deregulation","volume":"62","author":"Neef","year":"2002","journal-title":"Cancer Res."},{"key":"10.1016\/j.toxlet.2011.05.1031_bib0140","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1242\/jcs.00963","article-title":"The JAK\/STAT signaling pathway","volume":"117","author":"Rawlings","year":"2004","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.toxlet.2011.05.1031_bib0145","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1477-3155-2-3","article-title":"Applications of nanoparticles in biology and medicine","volume":"2","author":"Salata","year":"2004","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.toxlet.2011.05.1031_bib0150","doi-asserted-by":"crossref","first-page":"7387","DOI":"10.1073\/pnas.0802878105","article-title":"Perturbational profiling of nanomaterial biologic activity","volume":"105","author":"Shaw","year":"2008","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.toxlet.2011.05.1031_bib0155","doi-asserted-by":"crossref","first-page":"2866","DOI":"10.1166\/jnn.2009.048","article-title":"In vitro cellular uptake and effects of Fe3O4 magnetic nanoparticles on HeLa cells","volume":"9","author":"Shen","year":"2009","journal-title":"J. Nanosci. Nanotechnol."},{"key":"10.1016\/j.toxlet.2011.05.1031_bib0160","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1034\/j.1600-065X.2000.17610.x","article-title":"Transcriptional regulation of RANTES expression in T lymphocytes","volume":"177","author":"Song","year":"2000","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.toxlet.2011.05.1031_bib0165","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/43206","article-title":"A family of cytokine-inducible inhibitors of signalling","volume":"387","author":"Starr","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.toxlet.2011.05.1031_bib0170","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1016\/j.addr.2008.03.018","article-title":"Magnetic nanoparticles in MR imaging and drug delivery","volume":"60","author":"Sun","year":"2008","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.toxlet.2011.05.1031_bib0175","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0163-7258(02)00188-2","article-title":"Docking interactions in the mitogen-activated protein kinase cascades","volume":"93","author":"Tanoue","year":"2002","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.toxlet.2011.05.1031_bib0180","doi-asserted-by":"crossref","first-page":"25898","DOI":"10.1074\/jbc.M400661200","article-title":"TDAG51 mediates the effects of insulin-like growth factor I (IGF-I) on cell survival","volume":"279","author":"Toyoshima","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxlet.2011.05.1031_bib0185","doi-asserted-by":"crossref","first-page":"3240","DOI":"10.1038\/sj.onc.1210415","article-title":"MAP kinases and the control of nuclear events","volume":"26","author":"Turjanski","year":"2007","journal-title":"Oncogene"},{"key":"10.1016\/j.toxlet.2011.05.1031_bib0190","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.tips.2003.10.004","article-title":"Leukocyte and endothelial cell adhesion molecules as targets for therapeutic interventions in inflammatory disease","volume":"24","author":"Ulbrich","year":"2003","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.toxlet.2011.05.1031_bib0195","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.biomaterials.2009.09.053","article-title":"The effect of DMSA-functionalized magnetic nanoparticles on transendothelial migration of monocytes in the murine lung via a beta(2) integrin-dependent pathway","volume":"31","author":"Valois","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.toxlet.2011.05.1031_bib0200","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1093\/toxsci\/kfn250","article-title":"Macrophage responses to silica nanoparticles are highly conserved across particle sizes","volume":"107","author":"Waters","year":"2009","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.toxlet.2011.05.1031_bib0205","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.copbio.2007.11.005","article-title":"Bioinformatics applications for pathway analysis of microarray data","volume":"19","author":"Werner","year":"2008","journal-title":"Curr. Opin. Biotechnol."},{"key":"10.1016\/j.toxlet.2011.05.1031_bib0210","doi-asserted-by":"crossref","first-page":"2941","DOI":"10.1016\/j.biomaterials.2008.04.023","article-title":"On the mechanisms of biocompatibility","volume":"29","author":"Williams","year":"2008","journal-title":"Biomaterials"},{"key":"10.1016\/j.toxlet.2011.05.1031_bib0215","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0092-8674(00)00005-2","article-title":"Biomedical discovery with DNA arrays","volume":"102","author":"Young","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.toxlet.2011.05.1031_bib0220","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1007\/s11671-008-9204-7","article-title":"The effect of iron oxide magnetic nanoparticles on smooth muscle cells","volume":"4","author":"Zhang","year":"2009","journal-title":"Nanoscale Res. Lett."},{"key":"10.1016\/j.toxlet.2011.05.1031_bib0225","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1021\/nl0603350","article-title":"Cellular effect of high doses of silica-coated quantum dot profiled with high throughput gene expression analysis and high content cellomics measurements","volume":"6","author":"Zhang","year":"2006","journal-title":"Nano Lett."}],"container-title":["Toxicology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427411012409?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427411012409?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,2]],"date-time":"2018-12-02T10:57:04Z","timestamp":1543748224000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378427411012409"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8]]},"references-count":45,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,8]]}},"alternative-id":["S0378427411012409"],"URL":"https:\/\/doi.org\/10.1016\/j.toxlet.2011.05.1031","relation":{},"ISSN":["0378-4274"],"issn-type":[{"value":"0378-4274","type":"print"}],"subject":[],"published":{"date-parts":[[2011,8]]}}}