{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T01:28:16Z","timestamp":1759541296759},"reference-count":37,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicology Letters"],"published-print":{"date-parts":[[2012,9]]},"DOI":"10.1016\/j.toxlet.2012.07.003","type":"journal-article","created":{"date-parts":[[2012,7,16]],"date-time":"2012-07-16T05:15:37Z","timestamp":1342415737000},"page":"203-210","source":"Crossref","is-referenced-by-count":6,"title":["Luminal transport of thiol S-conjugates of methylmercury in isolated perfused rabbit renal proximal tubules"],"prefix":"10.1016","volume":"213","author":[{"given":"Yanhua","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rudolfs K.","family":"Zalups","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Delon W.","family":"Barfuss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxlet.2012.07.003_bib0005","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1146\/annurev.pa.23.040183.001205","article-title":"DMSA and DMPS\u2014water soluble antidotes for heavy metal poisoning","volume":"23","author":"Aposhian","year":"1983","journal-title":"Annual Review of Pharmacology and Toxicology"},{"issue":"4","key":"10.1016\/j.toxlet.2012.07.003_bib0010","doi-asserted-by":"crossref","first-page":"505","DOI":"10.3109\/15563659209017938","article-title":"Human studies with the chelating agents, DMPS and DMSA","volume":"30","author":"Aposhian","year":"1992","journal-title":"Journal of Toxicology. Clinical Toxicology"},{"issue":"1","key":"10.1016\/j.toxlet.2012.07.003_bib0015","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1289\/ehp.10383","article-title":"N-Acetylcysteine as a potential antidote and biomonitoring agent of methylmercury exposure","volume":"116","author":"Aremu","year":"2008","journal-title":"Environmental Health Perspectives"},{"issue":"1","key":"10.1016\/j.toxlet.2012.07.003_bib0020","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0006-8993(88)90581-1","article-title":"Uptake of methylmercury in the rat brain: effects of amino acids","volume":"462","author":"Aschner","year":"1988","journal-title":"Brain Research"},{"issue":"Suppl. 5","key":"10.1016\/j.toxlet.2012.07.003_bib0025","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1289\/ehp.02110s5689","article-title":"Transport of toxic metals by molecular mimicry","volume":"110","author":"Ballatori","year":"2002","journal-title":"Environmental Health Perspectives"},{"issue":"2 Suppl.","key":"10.1016\/j.toxlet.2012.07.003_bib0030","first-page":"S28","article-title":"Some health physics aspects of working with 203Hg in university research","volume":"80","author":"Belanger","year":"2001","journal-title":"Health Physics"},{"issue":"5","key":"10.1016\/j.toxlet.2012.07.003_bib0035","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/0272-0590(85)90166-6","article-title":"Renal glutathione and mercury uptake by kidney","volume":"5","author":"Berndt","year":"1985","journal-title":"Fundamental and Applied Toxicology"},{"issue":"3","key":"10.1016\/j.toxlet.2012.07.003_bib0040","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1097\/01.ASN.0000113553.62380.F5","article-title":"Mercuric conjugates of cysteine are transported by the amino acid transporter system b(0,+): implications of molecular mimicry","volume":"15","author":"Bridges","year":"2004","journal-title":"Journal of the American Society of Nephrology"},{"issue":"2","key":"10.1016\/j.toxlet.2012.07.003_bib0045","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1124\/jpet.106.109371","article-title":"System b0,+ and the transport of thiol-s-conjugates of methylmercury","volume":"319","author":"Bridges","year":"2006","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"issue":"1","key":"10.1016\/j.toxlet.2012.07.003_bib0050","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1152\/physrev.00018.2006","article-title":"Amino acid transport across mammalian intestinal and renal epithelia","volume":"88","author":"Broer","year":"2008","journal-title":"Physiological Reviews"},{"key":"10.1016\/j.toxlet.2012.07.003_bib0055","first-page":"433","article-title":"The chemistry of mercury in biological systems","volume":"vol. 3","author":"Carty","year":"1979"},{"issue":"Suppl. 1","key":"10.1016\/j.toxlet.2012.07.003_bib0060","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1289\/ehp.02110s111","article-title":"The three modern faces of mercury","volume":"110","author":"Clarkson","year":"2002","journal-title":"Environmental Health Perspectives"},{"issue":"2\u20133","key":"10.1016\/j.toxlet.2012.07.003_bib0065","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/0378-4274(90)90017-G","article-title":"Role of gamma-glutamyltranspeptidase and beta-lyase in the nephrotoxicity of hexachloro-1,3-butadiene and methyl mercury in mice","volume":"50","author":"de Ceaurriz","year":"1990","journal-title":"Toxicology Letters"},{"issue":"13","key":"10.1016\/j.toxlet.2012.07.003_bib0070","doi-asserted-by":"crossref","first-page":"9746","DOI":"10.1016\/S0021-9258(17)36946-6","article-title":"Transport of the glutathione-methylmercury complex across liver canalicular membranes on reduced glutathione carriers","volume":"269","author":"Dutczak","year":"1994","journal-title":"Journal of Biological Chemistry"},{"issue":"4","key":"10.1016\/j.toxlet.2012.07.003_bib0075","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s00726-002-0316-6","article-title":"Regulation of renal amino acid (AA) transport by hormones, drugs and xenobiotics \u2013 a review","volume":"24","author":"Fleck","year":"2003","journal-title":"Amino Acids"},{"issue":"21","key":"10.1016\/j.toxlet.2012.07.003_bib0080","doi-asserted-by":"crossref","first-page":"6944","DOI":"10.1021\/ja00802a013","article-title":"Nuclear magnetic resonance studies of the solution chemistry of metal complexes. IX. The binding of cadmium, zinc, lead, and mercury by glutathione","volume":"95","author":"Fuhr","year":"1973","journal-title":"Journal of the American Chemical Society"},{"issue":"36","key":"10.1016\/j.toxlet.2012.07.003_bib0085","doi-asserted-by":"crossref","first-page":"27060","DOI":"10.1016\/S0021-9258(19)74218-5","article-title":"rBAT, related to L-cysteine transport, is localized to the microvilli of proximal straight tubules, and its expression is regulated in kidney by development","volume":"268","author":"Furriols","year":"1993","journal-title":"Journal of Biological Chemistry"},{"issue":"1","key":"10.1016\/j.toxlet.2012.07.003_bib0090","first-page":"27","article-title":"Effect of inhibition of gamma-glutamyltranspeptidase on biliary and urinary excretion of glutathione-derived thiols and methylmercury","volume":"242","author":"Gregus","year":"1987","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"issue":"1","key":"10.1016\/j.toxlet.2012.07.003_bib0095","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1080\/00039896.1980.10667458","article-title":"The relationship between blood levels and dose of methylmercury in man","volume":"35","author":"Kershaw","year":"1980","journal-title":"Archives of Environment Health"},{"issue":"4","key":"10.1016\/j.toxlet.2012.07.003_bib0100","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1124\/mol.62.4.921","article-title":"Identification of a mechanism by which the methylmercury antidotes N-acetylcysteine and dimercaptopropanesulfonate enhance urinary metal excretion: transport by the renal organic anion transporter-1","volume":"62","author":"Koh","year":"2002","journal-title":"Molecular Pharmacology"},{"issue":"1","key":"10.1016\/j.toxlet.2012.07.003_bib0105","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1124\/jpet.107.122812","article-title":"Accelerated urinary excretion of methylmercury following administration of its antidote N-acetylcysteine requires Mrp2\/Abcc2, the apical multidrug resistance-associated protein","volume":"322","author":"Madejczyk","year":"2007","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"issue":"3","key":"10.1016\/j.toxlet.2012.07.003_bib0110","first-page":"1277","article-title":"Methylmercury-thiol uptake into cultured brain capillary endothelial cells on amino acid system L","volume":"272","author":"Mokrzan","year":"1995","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"issue":"18","key":"10.1016\/j.toxlet.2012.07.003_bib0115","doi-asserted-by":"crossref","first-page":"10569","DOI":"10.1074\/jbc.271.18.10569","article-title":"The rBAT gene is responsible for l-cystine uptake via the b0(+)-like amino acid transport system in a \u201crenal proximal tubular\u201d cell line (OK cells)","volume":"271","author":"Mora","year":"1996","journal-title":"Journal of Biological Chemistry"},{"issue":"2","key":"10.1016\/j.toxlet.2012.07.003_bib0120","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0006-2952(88)90731-9","article-title":"Possible role of hepatic glutathione in transport of methylmercury into mouse kidney","volume":"37","author":"Naganuma","year":"1988","journal-title":"Biochemical Pharmacology"},{"issue":"Pt 2","key":"10.1016\/j.toxlet.2012.07.003_bib0125","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1111\/j.1469-7793.2001.0297f.x","article-title":"Na+- and Cl\u2212-coupled active transport of carnitine by the amino acid transporter ATB(0,+) from mouse colon expressed in HRPE cells and Xenopus oocytes","volume":"532","author":"Nakanishi","year":"2001","journal-title":"The Journal of Physiology"},{"issue":"2","key":"10.1016\/j.toxlet.2012.07.003_bib0130","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/0041-008X(88)90382-1","article-title":"Histological localization of methylmercury in mouse brain and kidney by emulsion autoradiography of 203Hg","volume":"92","author":"Rodier","year":"1988","journal-title":"Toxicology and Applied Pharmacology"},{"key":"10.1016\/j.toxlet.2012.07.003_bib0135","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1002\/(SICI)1099-0739(199709)11:9<751::AID-AOC631>3.0.CO;2-Z","article-title":"Fast and high yield synthesis of radioactive CH3203Hg (II)","volume":"11","author":"Rouleau","year":"1997","journal-title":"Applied Organometallic Chemistry"},{"issue":"Pt 1","key":"10.1016\/j.toxlet.2012.07.003_bib0140","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1042\/bj20020841","article-title":"Transport of a neurotoxicant by molecular mimicry: the methylmercury\u2013l-cysteine complex is a substrate for human L-type large neutral amino acid transporter (LAT) 1 and LAT2","volume":"367","author":"Simmons-Willis","year":"2002","journal-title":"Biochemical Journal"},{"issue":"34","key":"10.1016\/j.toxlet.2012.07.003_bib0145","doi-asserted-by":"crossref","first-page":"23740","DOI":"10.1074\/jbc.274.34.23740","article-title":"Cloning and functional expression of a human Na(+) and Cl(\u2212)-dependent neutral and cationic amino acid transporter B(0+)","volume":"274","author":"Sloan","year":"1999","journal-title":"Journal of Biological Chemistry"},{"issue":"1","key":"10.1016\/j.toxlet.2012.07.003_bib0150","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.toxlet.2009.12.007","article-title":"Potential mechanisms involved in the absorptive transport of cadmium in isolated perfused rabbit renal proximal tubules","volume":"193","author":"Wang","year":"2010","journal-title":"Toxicology Letters"},{"issue":"4","key":"10.1016\/j.toxlet.2012.07.003_bib0155","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1111\/j.1471-4159.2008.05683.x","article-title":"The methylmercury\u2013l-cysteine conjugate is a substrate for the l-type large neutral amino acid transporter","volume":"107","author":"Yin","year":"2008","journal-title":"Journal of Neurochemistry"},{"issue":"1","key":"10.1016\/j.toxlet.2012.07.003_bib0160","first-page":"113","article-title":"Molecular interactions with mercury in the kidney","volume":"52","author":"Zalups","year":"2000","journal-title":"Pharmacological Reviews"},{"issue":"4","key":"10.1016\/j.toxlet.2012.07.003_bib0165","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1111\/j.1523-1755.2005.00585.x","article-title":"Handling of cysteine S-conjugates of methylmercury in MDCK cells expressing human OAT1","volume":"68","author":"Zalups","year":"2005","journal-title":"Kidney International"},{"issue":"2","key":"10.1016\/j.toxlet.2012.07.003_bib0170","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1124\/jpet.105.090530","article-title":"Handling of the homocysteine S-conjugate of methylmercury by renal epithelial cells: role of organic anion transporter 1 and amino acid transporters","volume":"315","author":"Zalups","year":"2005","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"issue":"3","key":"10.1016\/j.toxlet.2012.07.003_bib0175","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1124\/jpet.105.086645","article-title":"Transport of N-acetylcysteine s-conjugates of methylmercury in Madin\u2013Darby canine kidney cells stably transfected with human isoform of organic anion transporter 1","volume":"314","author":"Zalups","year":"2005","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"issue":"2","key":"10.1016\/j.toxlet.2012.07.003_bib0180","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1006\/taap.1993.1143","article-title":"Transport and toxicity of methylmercury along the proximal tubule of the rabbit","volume":"121","author":"Zalups","year":"1993","journal-title":"Toxicology and Applied Pharmacology"},{"issue":"1","key":"10.1016\/j.toxlet.2012.07.003_bib0185","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.taap.2008.11.003","article-title":"MRP2 involvement in renal proximal tubular elimination of methylmercury mediated by DMPS or DMSA","volume":"235","author":"Zalups","year":"2009","journal-title":"Toxicology and Applied Pharmacology"}],"container-title":["Toxicology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427412012003?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427412012003?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T21:56:59Z","timestamp":1714168619000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378427412012003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9]]},"references-count":37,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["S0378427412012003"],"URL":"https:\/\/doi.org\/10.1016\/j.toxlet.2012.07.003","relation":{},"ISSN":["0378-4274"],"issn-type":[{"value":"0378-4274","type":"print"}],"subject":[],"published":{"date-parts":[[2012,9]]}}}