{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T21:48:06Z","timestamp":1789768086812,"version":"4.0.1"},"reference-count":50,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicology Letters"],"published-print":{"date-parts":[[2012,11]]},"DOI":"10.1016\/j.toxlet.2012.09.026","type":"journal-article","created":{"date-parts":[[2012,10,8]],"date-time":"2012-10-08T07:01:41Z","timestamp":1349679701000},"page":"70-75","source":"Crossref","is-referenced-by-count":93,"title":["Acute toxicant exposure and cardiac autonomic dysfunction from smoking a single narghile waterpipe with tobacco and with a \u201chealthy\u201d tobacco-free alternative"],"prefix":"10.1016","volume":"215","author":[{"given":"Caroline O.","family":"Cobb","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamar","family":"Sahmarani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Eissenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Shihadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxlet.2012.09.026_bib0005","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.biopsycho.2006.08.005","article-title":"The many metrics of cardiac chronotropy: a pragmatic primer and a brief comparison of metrics","volume":"74","author":"Allen","year":"2007","journal-title":"Biological Psychology"},{"key":"10.1016\/j.toxlet.2012.09.026_bib0010","first-page":"1085","article-title":"Cigarettes and waterpipe smoking among medical students in Syria: a cross-sectional study","volume":"12","author":"Almerie","year":"2008","journal-title":"International Journal of Tuberculosis and Lung Disease"},{"key":"10.1016\/j.toxlet.2012.09.026_bib0015","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1111\/j.1440-1843.2006.00873.x","article-title":"Comparative analysis of the effects of hubble-bubble (Sheesha) and cigarette smoking on respiratory and metabolic parameters in hubble-bubble and cigarette smokers","volume":"11","author":"Al Mutairi","year":"2006","journal-title":"Respirology"},{"key":"10.1016\/j.toxlet.2012.09.026_bib0020","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1093\/ntr\/ntq055","article-title":"Waterpipe tobacco smoking among university students in Jordan","volume":"12","author":"Azab","year":"2010","journal-title":"Nicotine and Tobacco Research"},{"key":"10.1016\/j.toxlet.2012.09.026_bib0025","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1002\/hup.470100207","article-title":"Effects of smoking abstinence and nicotine abstinence on heart rate, activity and cigarette craving under field conditions","volume":"10","author":"Baldinger","year":"1995","journal-title":"Human Psychopharmacology"},{"key":"10.1016\/j.toxlet.2012.09.026_bib0030","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.drugalcdep.2010.11.026","article-title":"Acute effects of waterpipe tobacco smoking: a double-blind, placebo\u2013control study","volume":"116","author":"Blank","year":"2011","journal-title":"Drug and Alcohol Dependence"},{"key":"10.1016\/j.toxlet.2012.09.026_bib0035","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1080\/14622200600789585","article-title":"Clinical laboratory evaluation of potential reduced exposure products for smokers","volume":"8","author":"Breland","year":"2006","journal-title":"Nicotine and Tobacco Research"},{"key":"10.1016\/j.toxlet.2012.09.026_bib0040","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1161\/CIR.0b013e3181dbece1","article-title":"Particulate matter air pollution and cardiovascular disease: an update to the scientific statement from the American Heart Association","volume":"121","author":"Brook","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.toxlet.2012.09.026_bib0045","doi-asserted-by":"crossref","first-page":"2655","DOI":"10.1161\/01.CIR.0000128587.30041.C8","article-title":"Air pollution and cardiovascular disease. A statement for healthcare professionals from the expert panel on population and prevention science of the American Heart Association","volume":"109","author":"Brook","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.toxlet.2012.09.026_bib0050","doi-asserted-by":"crossref","first-page":"H632","DOI":"10.1152\/ajpheart.91535.2007","article-title":"Short-term secondhand smoke exposure decreases heart rate variability and increases arrhythmia susceptibility in mice","volume":"295","author":"Chen","year":"2008","journal-title":"American Journal of Physiology: Heart and Circulatory Physiology"},{"key":"10.1016\/j.toxlet.2012.09.026_bib0055","unstructured":"Cobb, C.O., 2012. Evaluating the acute effects of caffeinated waterpipe tobacco in waterpipe users. Doctoral dissertation. Virginia Commonwealth University."},{"key":"10.1016\/j.toxlet.2012.09.026_bib0060","doi-asserted-by":"crossref","first-page":"297","DOI":"10.7196\/SAMJ.3965","article-title":"High prevalence of hookah smoking among secondary school students in a disadvantaged community in Johannesburg","volume":"100","author":"Combrink","year":"2010","journal-title":"South African Medical Journal"},{"key":"10.1016\/j.toxlet.2012.09.026_bib0065","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.atmosenv.2009.10.004","article-title":"Comparison of carcinogen, carbon monoxide, and ultrafine particle emissions from narghile waterpipe and cigarette smoking: sidestream smoke measurements and assessment of second-hand smoke emission factors","volume":"44","author":"Daher","year":"2010","journal-title":"Atmospheric Environment"},{"key":"10.1016\/j.toxlet.2012.09.026_bib0070","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1161\/01.CIR.102.11.1239","article-title":"Low heart rate variability in a 2-minute rhythm strip predicts risk of coronary heart disease and mortality from several causes: the ARIC study","volume":"102","author":"Dekker","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.toxlet.2012.09.026_bib0075","doi-asserted-by":"crossref","unstructured":"Dinas, P.C., Koutedakis, Y., Flouris, A.D., 2011. Effects of active and passive tobacco cigarette smoking on heart rate variability. International Journal of Cardiology, in press.","DOI":"10.1016\/j.ijcard.2011.10.140"},{"issue":"23","key":"10.1016\/j.toxlet.2012.09.026_bib0080","doi-asserted-by":"crossref","first-page":"e215","DOI":"10.1161\/01.CIR.101.23.e215","article-title":"PhysioBank, PhysioToolkit, and PhysioNet: components of a new research resource for complex physiologic signals","volume":"101","author":"Goldberger","year":"2000","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.toxlet.2012.09.026_bib0085","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1080\/07448481.2011.589419","article-title":"Smoking among college students in the United States: a review of the literature","volume":"60","author":"Grekin","year":"2012","journal-title":"Journal of American College Health"},{"key":"10.1016\/j.toxlet.2012.09.026_bib0090","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/0002-9149(90)90030-5","article-title":"Short- and long-term effects of cigarette smoking on heart rate variability","volume":"65","author":"Hayano","year":"1990","journal-title":"American Journal of Cardiology"},{"key":"10.1016\/j.toxlet.2012.09.026_bib0095","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1098\/rsta.2008.0294","article-title":"Clinical impact of evaluation of cardiovascular control by novel methods of heart rate dynamics","volume":"367","author":"Huikuri","year":"2009","journal-title":"Philosophical Transaction of the Royal Society A"},{"key":"10.1016\/j.toxlet.2012.09.026_bib0100","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.1158\/1055-9965.EPI-11-0545","article-title":"Nicotine, carbon monoxide, and carcinogen exposure after a single use of a waterpipe","volume":"20","author":"Jacob","year":"2011","journal-title":"Cancer Epidemiology, Biomarkers and Prevention"},{"key":"10.1016\/j.toxlet.2012.09.026_bib0105","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.3109\/10826081003682909","article-title":"Waterpipe use predicts progression to regular cigarette smoking among Danish youth","volume":"45","author":"Jensen","year":"2010","journal-title":"Substance Use and Misuse"},{"key":"10.1016\/j.toxlet.2012.09.026_bib0110","series-title":"Monitoring the Future National Results on Adolescent Drug Use: Overview of Key Findings.","author":"Johnston","year":"2011"},{"key":"10.1016\/j.toxlet.2012.09.026_bib0115","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1177\/0003319706294555","article-title":"Acute effect of cigarette smoking on heart rate variability","volume":"58","author":"Karakaya","year":"2007","journal-title":"Angiology"},{"key":"10.1016\/j.toxlet.2012.09.026_bib0120","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.3109\/08958378.2010.524265","article-title":"Direct measurement of toxicants inhaled by water pipe users in the natural environment using a real-time in situ sampling technique","volume":"22","author":"Katurji","year":"2010","journal-title":"Inhalation Toxicology"},{"key":"10.1016\/j.toxlet.2012.09.026_bib0125","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1002\/em.20601","article-title":"Assessment of genotoxicity of waterpipe and cigarette smoking in lymphocytes using the sister-chromatid exchange assay: a comparative study","volume":"52","author":"Khabour","year":"2011","journal-title":"Environmental and Molecular Mutagenesis"},{"key":"10.1016\/j.toxlet.2012.09.026_bib0130","doi-asserted-by":"crossref","first-page":"360","DOI":"10.5271\/sjweh.919","article-title":"Acute effects of cigarette smoking on the heart rate variability of taxi drivers during work","volume":"31","author":"Kobayashi","year":"2005","journal-title":"Scandinavian Journal of Work, Environment and Health"},{"key":"10.1016\/j.toxlet.2012.09.026_bib0135","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.cppeds.2010.10.001","article-title":"Waterpipe (hookah) tobacco smoking among youth","volume":"41","author":"Martinasek","year":"2011","journal-title":"Current Problems in Pediatric and Adolescent Health Care"},{"key":"10.1016\/j.toxlet.2012.09.026_bib0140","doi-asserted-by":"crossref","first-page":"4807","DOI":"10.1016\/j.scitotenv.2009.05.028","article-title":"Exposure to environmental carbon monoxide may have a greater negative effect on cardiac autonomic function in people with metabolic syndrome","volume":"407","author":"Min","year":"2009","journal-title":"Science of the Total Environment"},{"key":"10.1016\/j.toxlet.2012.09.026_bib0145","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1136\/tc.2007.021097","article-title":"Ultrafine particle emissions from waterpipes","volume":"16","author":"Monn","year":"2007","journal-title":"Tobacco Control"},{"key":"10.1016\/j.toxlet.2012.09.026_bib0150","doi-asserted-by":"crossref","first-page":"2991","DOI":"10.1016\/j.fct.2008.05.031","article-title":"Charcoal emissions as a source of CO and carcinogenic PAH in mainstream narghile waterpipe smoke","volume":"46","author":"Monzer","year":"2008","journal-title":"Food and Chemical Toxicology"},{"issue":"4","key":"10.1016\/j.toxlet.2012.09.026_bib0155","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1093\/oxfordjournals.aje.a009656","article-title":"Narghile (hubble-bubble) smoking, low birth weight, and other pregnancy outcomes","volume":"148","author":"Nuwayhid","year":"1998","journal-title":"American Journal of Epidemiology"},{"key":"10.1016\/j.toxlet.2012.09.026_bib0160","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1186\/1471-2458-8-392","article-title":"Cigarette and waterpipe smoking among adolescents in Estonia","volume":"8","author":"P\u00e4rna","year":"2008","journal-title":"BMC Public Health"},{"key":"10.1016\/j.toxlet.2012.09.026_bib0165","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1016\/S0140-6736(02)11289-X","article-title":"Cardiopulmonary mortality and air pollution","volume":"360","author":"Peters","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.toxlet.2012.09.026_bib0170","doi-asserted-by":"crossref","unstructured":"Primack, B.A., Shensa, A., Kim, K.H., Carroll, M., Hoban, M., Leino, E.V., Eissenberg, T., Dachille, K., Fine, M.J., 2012. Waterpipe smoking among U.S. university students. Nicotine and Tobacco Research, in press.","DOI":"10.1093\/ntr\/nts076"},{"key":"10.1016\/j.toxlet.2012.09.026_bib0175","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1378\/chest.10-0991","article-title":"Effects of water-pipe smoking on lung function: a systematic review and meta-analysis","volume":"139","author":"Raad","year":"2011","journal-title":"Chest"},{"key":"10.1016\/j.toxlet.2012.09.026_bib0180","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s10286-010-0098-y","article-title":"Low frequency power of heart rate variability reflects baroreflex function, not cardiac sympathetic innervation","volume":"21","author":"Rahman","year":"2011","journal-title":"Clinical Autonomic Research"},{"key":"10.1016\/j.toxlet.2012.09.026_bib0185","first-page":"H2039","article-title":"Physiological time-series analysis using approximate entropy and sample entropy","volume":"278","author":"Richman","year":"2000","journal-title":"American Journal of Physiology: Heart and Circulatory Physiology"},{"key":"10.1016\/j.toxlet.2012.09.026_bib0190","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/sj.jea.7500453","article-title":"Personal PM2.5 and CO exposures and heart rate variability in subjects with known ischemic heart disease in Mexico City","volume":"6","author":"Riojas-Rodr\u00edguez","year":"2006","journal-title":"Journal of Exposure Science and Environmental Epidemiology"},{"key":"10.1016\/j.toxlet.2012.09.026_bib0195","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.envres.2004.12.007","article-title":"PM(2.5) induces acute electrocardiographic alterations in healthy rats","volume":"99","author":"Rodriguez Ferreira Rivero","year":"2005","journal-title":"Environmental Research"},{"key":"10.1016\/j.toxlet.2012.09.026_bib0200","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1471-2458-9-10","article-title":"Canadian and English students\u2019 beliefs about waterpipe smoking: a qualitative study","volume":"9","author":"Roskin","year":"2009","journal-title":"BMC Public Health"},{"key":"10.1016\/j.toxlet.2012.09.026_bib0205","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1136\/hrt.2004.051672","article-title":"Effect of inhaled sulphur dioxide and carbon particles on heart rate variability and markers of inflammation and coagulation in human subjects","volume":"92","author":"Routledge","year":"2006","journal-title":"Heart"},{"key":"10.1016\/j.toxlet.2012.09.026_bib0210","first-page":"243","article-title":"Tobacco use and cessation counseling among health professional: Lebanon global health professions student survey 2005","volume":"57","author":"Saade","year":"2009","journal-title":"Lebanese Medical Journal"},{"key":"10.1016\/j.toxlet.2012.09.026_bib0215","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.aca.2011.10.012","article-title":"Waterpipe smoke: a considerable source of human exposure against furanic compounds","volume":"709","author":"Schubert","year":"2012","journal-title":"Analytica Chimica Acta"},{"key":"10.1016\/j.toxlet.2012.09.026_bib0220","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.toxlet.2011.06.017","article-title":"Mainstream smoke of the waterpipe: does this environmental matrix reveal as significant source of toxic compounds?","volume":"205","author":"Schubert","year":"2011","journal-title":"Toxicology Letters"},{"key":"10.1016\/j.toxlet.2012.09.026_bib0225","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0278-6915(02)00220-X","article-title":"Investigation of the mainstream smoke aerosol of the argileh water pipe","volume":"41","author":"Shihadeh","year":"2003","journal-title":"Food and Chemical Toxicology"},{"key":"10.1016\/j.toxlet.2012.09.026_bib0230","doi-asserted-by":"crossref","first-page":"186","DOI":"10.3758\/BF03206414","article-title":"Portable low-resistance puff topography instrument for pulsating, high-flow smoking devices","volume":"37","author":"Shihadeh","year":"2005","journal-title":"Behavior Research Methods"},{"key":"10.1016\/j.toxlet.2012.09.026_bib0235","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1016\/j.fct.2012.02.041","article-title":"Does switching to a tobacco-free waterpipe product reduce toxicant intake? A crossover study comparing CO, NO, PAH, volatile aldehydes, \u201ctar\u201d and nicotine yields","volume":"50","author":"Shihadeh","year":"2012","journal-title":"Food and Chemical Toxicology"},{"key":"10.1016\/j.toxlet.2012.09.026_bib0240","doi-asserted-by":"crossref","first-page":"2850","DOI":"10.1161\/01.CIR.94.11.2850","article-title":"Impact of reduced heart rate variability on risk for cardiac events: the Framingham Heart Study","volume":"94","author":"Tsuji","year":"1996","journal-title":"Circulation"},{"key":"10.1016\/j.toxlet.2012.09.026_bib0245","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s00392-010-0236-5","article-title":"Heart rate variability and biomarkers of systemic inflammation in patients with stable coronary heart disease: findings from the Heart and Soul Study","volume":"100","author":"von K\u00e4nel","year":"2011","journal-title":"Clinical Research in Cardiology"},{"issue":"1","key":"10.1016\/j.toxlet.2012.09.026_bib0250","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.lfs.2003.06.020","article-title":"Narghile (water pipe) smoking influences platelet function and (iso-)eicosanoids","volume":"74","author":"Wolfram","year":"2003","journal-title":"Life Sciences"}],"container-title":["Toxicology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427412013318?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427412013318?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,11,20]],"date-time":"2018-11-20T08:27:25Z","timestamp":1542702445000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378427412013318"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["S0378427412013318"],"URL":"https:\/\/doi.org\/10.1016\/j.toxlet.2012.09.026","relation":{},"ISSN":["0378-4274"],"issn-type":[{"value":"0378-4274","type":"print"}],"subject":[],"published":{"date-parts":[[2012,11]]}}}