{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T01:30:33Z","timestamp":1789349433354,"version":"build-2803163510"},"reference-count":47,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicology Letters"],"published-print":{"date-parts":[[2013,2]]},"DOI":"10.1016\/j.toxlet.2012.12.014","type":"journal-article","created":{"date-parts":[[2012,12,26]],"date-time":"2012-12-26T21:45:15Z","timestamp":1356558315000},"page":"102-110","source":"Crossref","is-referenced-by-count":60,"title":["Protective effect of genistein isolated from Hydrocotyle sibthorpioides on hepatic injury and fibrosis induced by chronic alcohol in rats"],"prefix":"10.1016","volume":"217","author":[{"given":"Quanfang","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renbin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shijun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lang","family":"Zhuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxlet.2012.12.014_bib0005","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/s12272-010-0313-3","article-title":"Selective inhibition of activated stellate cells and protection from carbon tetrachloride-induced liver injury in rats by a new PPAR\u03b3 agonist KR62776","volume":"33","author":"Bae","year":"2010","journal-title":"Archives of Pharmacal Research"},{"key":"10.1016\/j.toxlet.2012.12.014_bib0010","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1007\/s00244-010-9529-y","article-title":"Mixture toxicity assessment of nickel and chlorpyrifos in the sea bass Dicentrarchus labrax","volume":"60","author":"Banni","year":"2011","journal-title":"Archives of Environmental Contamination and Toxicology"},{"key":"10.1016\/j.toxlet.2012.12.014_bib0020","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.bpg.2011.02.010","article-title":"Fibrosis in alcoholic and nonalcoholic steatohepatitis","volume":"25","author":"Bataller","year":"2011","journal-title":"Best Practice & Research Clinical Gastroenterology"},{"key":"10.1016\/j.toxlet.2012.12.014_bib0025","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/j.tiv.2007.01.023","article-title":"Preliminary studies on induction of apoptosis by genistein on HepG2 cell line","volume":"21","author":"Chodon","year":"2007","journal-title":"Toxicology In Vitro"},{"key":"10.1016\/j.toxlet.2012.12.014_bib0030","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1111\/j.1440-1746.2008.05720.x","article-title":"Stephania tetrandra prevents and regresses liver fibrosis induced by carbon tetrachloride in rats","volume":"24","author":"Chor","year":"2009","journal-title":"Journal of Gastroenterology and Hepatology"},{"key":"10.1016\/j.toxlet.2012.12.014_bib0035","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.mam.2007.09.011","article-title":"Isoprostanes and hepatic fibrosis","volume":"29","author":"Comporti","year":"2008","journal-title":"Molecular Aspects of Medicine"},{"key":"10.1016\/j.toxlet.2012.12.014_bib0040","first-page":"63","article-title":"Oxidative stress in ethanol intoxicated rats","volume":"28","author":"Dinu","year":"1991","journal-title":"Revue Roumaine de Physiologie"},{"key":"10.1016\/j.toxlet.2012.12.014_bib0045","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/s00726-007-0543-y","article-title":"The effect of taurine on polymorphonuclear leukocyte functions in endotoxemia","volume":"33","author":"Erdamar","year":"2007","journal-title":"Amino Acids"},{"key":"10.1016\/j.toxlet.2012.12.014_bib0050","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.lfs.2010.10.021","article-title":"Genistein attenuates d-galactose-induced oxidative damage through decreased reactive oxygen species and NF-\u03ba B binding activity in neuronal PC12 cells","volume":"88","author":"Hsieh","year":"2010","journal-title":"Life Sciences"},{"key":"10.1016\/j.toxlet.2012.12.014_bib0055","first-page":"713","article-title":"Hepatoprotective effects of total saponins isolated from Taraphochlamys affinis against carbon tetrachloride induced liver injury in rats","volume":"4","author":"Huang","year":"2011","journal-title":"Food and Chemical Toxicology"},{"key":"10.1016\/j.toxlet.2012.12.014_bib0060","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s11095-007-9311-7","article-title":"Matrix metalloproteinase gene delivery for liver fibrosis","volume":"25","author":"Iimuro","year":"2008","journal-title":"Pharmaceutical Research"},{"key":"10.1016\/j.toxlet.2012.12.014_bib0065","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/0891-5849(90)90131-2","article-title":"Malondialdehyde and thiobarbituric acid-reactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injury","volume":"9","author":"Janero","year":"1990","journal-title":"Free Radical Biology and Medicine"},{"key":"10.1016\/j.toxlet.2012.12.014_bib0070","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/j.intimp.2011.01.036","article-title":"Anti-inflammatory effect of genistein on non-alcoholic steatohepatitis rats induced by high fat diet and its potential mechanisms","volume":"11","author":"Ji","year":"2011","journal-title":"International Immunopharmacology"},{"key":"10.1016\/j.toxlet.2012.12.014_bib0075","doi-asserted-by":"crossref","first-page":"304","DOI":"10.4236\/abb.2012.34043","article-title":"Response of hydrogenase enzymes (ALDH and ADH) in Trapa natans under physiological stress","volume":"3","author":"Kaur","year":"2012","journal-title":"Advances in Bioscience and Biotechnology"},{"key":"10.1016\/j.toxlet.2012.12.014_bib0080","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1111\/j.1440-1746.2011.06658.x","article-title":"Therapeutic effects of cytokine modulator Y-40138 in the rat alcoholic liver disease model","volume":"26","author":"Kawaratani","year":"2011","journal-title":"Journal of Gastroenterology and Hepatology"},{"key":"10.1016\/j.toxlet.2012.12.014_bib0085","doi-asserted-by":"crossref","first-page":"509","DOI":"10.2174\/1566524033479609","article-title":"CYP2E1: biochemistry, toxicology, regulation and function in ethanol-induced liver injury","volume":"3","author":"Kessova","year":"2003","journal-title":"Current Molecular Medicine"},{"key":"10.1016\/j.toxlet.2012.12.014_bib0090","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.tox.2010.09.017","article-title":"Perillyl alcohol protects against ethanol induced acute liver injury in Wistar rats by inhibiting oxidative stress, NF\u03ba-B activation and proinflammatory cytokine production","volume":"279","author":"Khan","year":"2011","journal-title":"Toxicology"},{"key":"10.1016\/j.toxlet.2012.12.014_bib0095","first-page":"296","article-title":"Allopurinol prevents early alcohol-induced liver injury in rats","volume":"293","author":"Kono","year":"2000","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"10.1016\/j.toxlet.2012.12.014_bib0100","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1172\/JCI9020","article-title":"NADPH oxidase-derived free radicals are key oxidants in alcohol-induced liver disease","volume":"106","author":"Kono","year":"2000","journal-title":"Journal of Clinical Investigation"},{"key":"10.1016\/j.toxlet.2012.12.014_bib0105","doi-asserted-by":"crossref","first-page":"G652","DOI":"10.1152\/ajpgi.2000.278.4.G652","article-title":"Gender differences in early alcohol-induced liver injury: role of CD14, NF-\u03baB, and TNF-\u03b1","volume":"278","author":"Kono","year":"2000","journal-title":"American Journal of Physiology-Gastrointestinal and Liver Physiology"},{"key":"10.1016\/j.toxlet.2012.12.014_bib0110","first-page":"363","article-title":"Protective role of genistein in acute liver damage induced by carbon tetrachloride","volume":"1","author":"Kuzu","year":"2007","journal-title":"Mediators of Inflammation"},{"key":"10.1016\/j.toxlet.2012.12.014_bib0115","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.tox.2008.03.009","article-title":"Protective effect of caffeic acid phenethyl ester against carbon tetrachloride-induced hepatotoxicity in mice","volume":"248","author":"Lee","year":"2008","journal-title":"Toxicology"},{"key":"10.1016\/j.toxlet.2012.12.014_bib0120","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.bpg.2011.02.005","article-title":"Mechanisms of hepatic fibrogenesis","volume":"25","author":"Lee","year":"2011","journal-title":"Best Practice & Research Clinical Gastroenterology"},{"key":"10.1016\/j.toxlet.2012.12.014_bib0125","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1016\/S0024-3205(02)02448-7","article-title":"The collagenolytic effects of the traditional Chinese medicine preparation, Han-Dan-Gan-Le, contribute to reversal of chemical-induced liver fibrosis in rats","volume":"72","author":"Li","year":"2003","journal-title":"Life Sciences"},{"key":"10.1016\/j.toxlet.2012.12.014_bib0130","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.jep.2011.06.030","article-title":"Icaritin induces cell death in activated hepatic stellate cells through mitochondrial activated apoptosis and ameliorates the development of liver fibrosis in rats","volume":"137","author":"Li","year":"2011","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.toxlet.2012.12.014_bib0135","doi-asserted-by":"crossref","first-page":"3413","DOI":"10.1016\/j.fct.2012.07.053","article-title":"Methyl helicterate protects against CCl 4-induced liver injury in rats by inhibiting oxidative stress, NF-\u03baB activation, Fas\/FasL pathway and cytochrome P4502E1 level","volume":"50","author":"Lin","year":"2012","journal-title":"Food and Chemical Toxicology"},{"key":"10.1016\/j.toxlet.2012.12.014_bib0140","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.mam.2007.10.001","article-title":"Alcohol induced hepatic fibrosis: role of acetaldehyde","volume":"29","author":"Mello","year":"2008","journal-title":"Molecular Aspects of Medicine"},{"key":"10.1016\/j.toxlet.2012.12.014_bib0145","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1042\/0264-6021:3630769","article-title":"Inhibition effects of furfural on alcohol dehydrogenase, aldehyde dehydrogenase and pyruvate dehydrogenase","volume":"363","author":"Modig","year":"2002","journal-title":"Biochemical Journal"},{"key":"10.1016\/j.toxlet.2012.12.014_bib0235","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1002\/hep.20618","article-title":"Metalloproteinase inhibitor TIMP-1 affects hepatocyte cell cycle via HGF activation in murine liver regeneration","volume":"41","author":"Mohammed","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.toxlet.2012.12.014_bib0150","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1111\/j.1753-0407.2009.00045.x","article-title":"Genistein improves liver function and attenuates non-alcoholic fatty liver disease in a rat model of insulin resistance","volume":"1","author":"Mohamed Salih","year":"2009","journal-title":"Journal of Diabetes"},{"key":"10.1016\/j.toxlet.2012.12.014_bib0155","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1007\/s12072-009-9158-6","article-title":"Role of free radicals in liver diseases","volume":"3","author":"Muriel","year":"2009","journal-title":"Hepatology International"},{"key":"10.1016\/j.toxlet.2012.12.014_bib0160","doi-asserted-by":"crossref","first-page":"951","DOI":"10.2741\/1589","article-title":"Tissue-distribution of aldehyde dehydrogenase 2 and effects of the ALDH2 gene-disruption on the expression of enzymes involved in alcohol metabolism","volume":"10","author":"Oyama","year":"2005","journal-title":"Frontiers in Bioscience"},{"key":"10.1016\/j.toxlet.2012.12.014_bib0165","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1038\/labinvest.2008.91","article-title":"Activation of hepatic stellate cells is associated with cytokine expression in thioacetamide-induced hepatic fibrosis in mice","volume":"88","author":"Palacios","year":"2008","journal-title":"Laboratory Investigation"},{"key":"10.1016\/j.toxlet.2012.12.014_bib0170","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.ejphar.2011.06.011","article-title":"Genistein modulates NF-\u03baB-associated renal inflammation, fibrosis and podocyte abnormalities in fructose-fed rats","volume":"667","author":"Palanisamy","year":"2011","journal-title":"European Journal of Pharmacology"},{"key":"10.1016\/j.toxlet.2012.12.014_bib0175","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1002\/hep.22306","article-title":"Toll-like receptors and adaptor molecules in liver disease: update","volume":"48","author":"Seki","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.toxlet.2012.12.014_bib0180","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/S0024-3205(03)00358-8","article-title":"Role of naringin supplement in regulation of lipid and ethanol metabolism in rats","volume":"73","author":"Seo","year":"2003","journal-title":"Life sciences"},{"key":"10.1016\/j.toxlet.2012.12.014_bib0185","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1097\/00042737-200402000-00001","article-title":"How can transforming growth factor beta be targeted usefully to combat liver fibrosis?","volume":"16","author":"Shek","year":"2004","journal-title":"European Journal of Gastroenterology & Hepatology"},{"key":"10.1016\/j.toxlet.2012.12.014_bib0190","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.ejphar.2009.09.026","article-title":"Chlorogenic acid against carbon tetrachloride-induced liver fibrosis in rats","volume":"623","author":"Shi","year":"2009","journal-title":"European Journal of Pharmacology"},{"key":"10.1016\/j.toxlet.2012.12.014_bib0195","doi-asserted-by":"crossref","first-page":"3707","DOI":"10.1016\/j.fct.2008.09.051","article-title":"Hsian-tsao (Mesona procumbens Heml.) prevents against rat liver fibrosis induced by CCl4 via inhibition of hepatic stellate cells activation","volume":"46","author":"Shyu","year":"2008","journal-title":"Food and Chemical Toxicology"},{"key":"10.1016\/j.toxlet.2012.12.014_bib0200","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.3748\/wjg.v16.i11.1321","article-title":"Alcoholic liver disease and the gut-liver axis","volume":"16","author":"Szabo","year":"2010","journal-title":"World Journal of Gastroenterology: WJG"},{"key":"10.1016\/j.toxlet.2012.12.014_bib0205","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/j.ejphar.2010.10.060","article-title":"The soy isoflavone genistein reverses oxidative and inflammatory state, neuropathic pain, neurotrophic and vasculature deficits in diabetes mouse model","volume":"650","author":"Valsecchi","year":"2011","journal-title":"European Journal of Pharmacology"},{"key":"10.1016\/j.toxlet.2012.12.014_bib0210","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.jhep.2006.09.014","article-title":"IFN-\u03b3 abrogates profibrogenic TGF-\u03b2 signaling in liver by targeting expression of inhibitory and receptor Smads","volume":"46","author":"Weng","year":"2007","journal-title":"Journal of Hepatology"},{"key":"10.1016\/j.toxlet.2012.12.014_bib0215","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1042\/BST0340761","article-title":"Reversible ubiquitination regulates the Smad\/TGF-beta signalling pathway","volume":"34","author":"Wicks","year":"2006","journal-title":"Biochemical Society Transactions"},{"key":"10.1016\/j.toxlet.2012.12.014_bib0220","first-page":"81","article-title":"Proinflammatory role of protease-activated receptor-2 in intestinal ischemia\/reperfusion injury in rats","volume":"4","author":"Yoshida","year":"2011","journal-title":"Molecular Medicine Reports"},{"key":"10.1016\/j.toxlet.2012.12.014_bib0225","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.arcmed.2010.10.010","article-title":"Expression of discoidin domain receptors (DDR2) in alcoholic liver fibrosis in rats","volume":"41","author":"Zhang","year":"2010","journal-title":"Archives of Medical Research"},{"key":"10.1016\/j.toxlet.2012.12.014_bib0230","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1111\/j.1478-3231.2004.0946.x","article-title":"Expression of matrix metalloproteinase-2 and-14 persists during early resolution of experimental liver fibrosis and might contribute to fibrolysis","volume":"24","author":"Zhou","year":"2004","journal-title":"Liver International"},{"key":"10.1016\/j.toxlet.2012.12.014_bib0240","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.jep.2008.09.023","article-title":"Potential therapeutic effects of a traditional Chinese formulation, BJ-JN, on liver fibrosis induced by carbon tetrachloride in rats","volume":"120","author":"Zou","year":"2008","journal-title":"Journal of Ethnopharmacology"}],"container-title":["Toxicology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427412014439?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427412014439?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,7,7]],"date-time":"2019-07-07T16:01:52Z","timestamp":1562515312000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378427412014439"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2]]},"references-count":47,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["S0378427412014439"],"URL":"https:\/\/doi.org\/10.1016\/j.toxlet.2012.12.014","relation":{},"ISSN":["0378-4274"],"issn-type":[{"value":"0378-4274","type":"print"}],"subject":[],"published":{"date-parts":[[2013,2]]}}}