{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T01:26:20Z","timestamp":1759541180656},"reference-count":28,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicology Letters"],"published-print":{"date-parts":[[2013,4]]},"DOI":"10.1016\/j.toxlet.2013.01.016","type":"journal-article","created":{"date-parts":[[2013,1,31]],"date-time":"2013-01-31T22:31:29Z","timestamp":1359671489000},"page":"137-143","source":"Crossref","is-referenced-by-count":9,"title":["Nonylphenol, an environmental estrogen, affects voltage-gated K+ currents and L-type Ca2+ currents in a non-monotonic manner in GH3 pituitary cells"],"prefix":"10.1016","volume":"218","author":[{"given":"Qinghua","family":"Gao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tong","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shizheng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiyuan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liying","family":"Hao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxlet.2013.01.016_bib0005","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1093\/humupd\/dml018","article-title":"The sensitivity of the child to sex steroids: possible impact of exogenous estrogens","volume":"12","author":"Aksglaede","year":"2006","journal-title":"Human Reproduction Update"},{"key":"10.1016\/j.toxlet.2013.01.016_bib0010","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1289\/ehp.8002","article-title":"Low doses of bisphenol A and diethylstilbestrol impair Ca2+ signals in pancreatic alpha-cells through a nonclassical membrane estrogen receptor within intact islets of Langerhans","volume":"113","author":"Alonso-Magdalena","year":"2005","journal-title":"Environmental Health Perspectives"},{"key":"10.1016\/j.toxlet.2013.01.016_bib0015","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1477-7827-1-13","article-title":"Expression and localization of estrogen receptor-alpha protein in normal and abnormal term placentae and stimulation of trophoblast differentiation by estradiol","volume":"1","author":"Bukovsky","year":"2003","journal-title":"Reproductive Biology and Endocrinology"},{"key":"10.1016\/j.toxlet.2013.01.016_bib0020","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1289\/ehp.7175","article-title":"Xenoestrogen-induced ERK-1 and ERK-2 activation via multiple membrane-initiated signaling pathways","volume":"112","author":"Bulayeva","year":"2004","journal-title":"Environmental Health Perspectives"},{"key":"10.1016\/j.toxlet.2013.01.016_bib0025","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1289\/ehp.7534","article-title":"Urinary concentrations of bisphenol A and 4-nonylphenol in a human reference population","volume":"113","author":"Calafat","year":"2005","journal-title":"Environmental Health Perspectives"},{"key":"10.1016\/j.toxlet.2013.01.016_bib0030","doi-asserted-by":"crossref","first-page":"7508","DOI":"10.1074\/jbc.274.11.7508","article-title":"L-type Ca2+ channels and K+ channels specifically modulate the frequency and amplitude of spontaneous Ca2+ oscillations and have distinct roles in prolactin release in GH3 cells","volume":"274","author":"Charles","year":"1999","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.toxlet.2013.01.016_bib0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000126631","article-title":"Voltage-dependent potassium currents in ovine somatotrophs and their function in growth hormone secretion","volume":"59","author":"Chen","year":"1994","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.toxlet.2013.01.016_bib0040","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0303-7207(02)00303-9","article-title":"A Galphas protein-coupled membrane receptor, distinct from the classical oestrogen receptor, transduces rapid effects of oestradiol on [Ca2+]i in female rat distal colon","volume":"199","author":"Doolan","year":"2003","journal-title":"Molecular and Cellular Endocrinology"},{"key":"10.1016\/j.toxlet.2013.01.016_bib0045","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1113\/jphysiol.1978.sp012565","article-title":"Action potentials in gland cells of rat pituitary pars intermedia: inhibition by dopamine, an inhibitor of MSH secretion","volume":"285","author":"Douglas","year":"1978","journal-title":"Journal of Physiology"},{"key":"10.1016\/j.toxlet.2013.01.016_bib0050","doi-asserted-by":"crossref","first-page":"e20213","DOI":"10.1371\/journal.pone.0020213","article-title":"Mechanism of estradiol-induced block of voltage-gated K+ currents in rat medial preoptic neurons","volume":"6","author":"Druzin","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.toxlet.2013.01.016_bib0055","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1054\/ceca.2001.0260","article-title":"Correlation between electrical activity and intracellular Ca2+ oscillations in GH3 rat anterior pituitary cells","volume":"31","author":"Giraldez","year":"2002","journal-title":"Cell Calcium"},{"issue":"Suppl. 2","key":"10.1016\/j.toxlet.2013.01.016_bib0060","first-page":"40","article-title":"Female infertility\u2014effect of perinatal xenoestrogen exposure on reproductive functions in animals and humans","volume":"39","author":"Gotz","year":"2001","journal-title":"Folia Histochemica et Cytobiologica"},{"key":"10.1016\/j.toxlet.2013.01.016_bib0065","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1021\/es010199v","article-title":"Endocrine disrupting nonylphenols are ubiquitous in food","volume":"36","author":"Guenther","year":"2002","journal-title":"Environmental Science and Technology"},{"key":"10.1016\/j.toxlet.2013.01.016_bib0070","doi-asserted-by":"crossref","first-page":"9682","DOI":"10.1016\/S0021-9258(19)81571-5","article-title":"Spontaneous oscillations of intracellular calcium and growth hormone secretion","volume":"263","author":"Holl","year":"1988","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.toxlet.2013.01.016_bib0075","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1750-2187-4-2","article-title":"Membrane estrogen receptor-alpha-mediated nongenomic actions of phytoestrogens in GH3\/B6\/F10 pituitary tumor cells","volume":"4","author":"Jeng","year":"2009","journal-title":"Journal of Molecular Signaling"},{"key":"10.1016\/j.toxlet.2013.01.016_bib0080","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0048-9697(99)80017-5","article-title":"Amphibians as a model to study endocrine disruptors. II. Estrogenic activity of environmental chemicals in vitro and in vivo","volume":"225","author":"Kloas","year":"1999","journal-title":"Science of the Total Environment"},{"key":"10.1016\/j.toxlet.2013.01.016_bib0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2006.07.104","article-title":"Acute estradiol application increases inward and decreases outward whole-cell currents of neurons in rat hypothalamic ventromedial nucleus","volume":"1116","author":"Kow","year":"2006","journal-title":"Brain Research"},{"key":"10.1016\/j.toxlet.2013.01.016_bib0090","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/j.envint.2007.04.008","article-title":"Daily intake of 4-nonylphenol in Taiwanese","volume":"33","author":"Lu","year":"2007","journal-title":"Environment International"},{"key":"10.1016\/j.toxlet.2013.01.016_bib0095","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1095\/biolreprod.104.036301","article-title":"Long-term effects of fetal exposure to low doses of the xenoestrogen bisphenol-A in the female mouse genital tract","volume":"72","author":"Markey","year":"2005","journal-title":"Biology of Reproduction"},{"key":"10.1016\/j.toxlet.2013.01.016_bib0100","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1113\/jphysiol.1988.sp017349","article-title":"Whole-cell recordings of ionic currents in bovine somatotrophs and their involvement in growth hormone secretion","volume":"405","author":"Mason","year":"1988","journal-title":"Journal of Physiology"},{"key":"10.1016\/j.toxlet.2013.01.016_bib0105","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S0160-4120(02)00031-4","article-title":"Breast cancer incidence and exposure to pesticides among women originating from Jaipur","volume":"28","author":"Mathur","year":"2002","journal-title":"Environment International"},{"key":"10.1016\/j.toxlet.2013.01.016_bib0110","doi-asserted-by":"crossref","first-page":"2789","DOI":"10.1210\/endo-127-6-2789","article-title":"Is the mammosomatotrope a transitional cell for the functional interconversion of growth hormone- and prolactin-secreting cells? Suggestive evidence from virgin, gestating, and lactating rats","volume":"127","author":"Porter","year":"1990","journal-title":"Endocrinology"},{"key":"10.1016\/j.toxlet.2013.01.016_bib0115","doi-asserted-by":"crossref","first-page":"s110","DOI":"10.2741\/1010","article-title":"Xenoestrogen exposure and mechanisms of endocrine disruption","volume":"8","author":"Singleton","year":"2003","journal-title":"Frontiers in Bioscience"},{"key":"10.1016\/j.toxlet.2013.01.016_bib0120","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1039\/b211323f","article-title":"Dietary exposure to xenoestrogens in New Zealand","volume":"5","author":"Thomson","year":"2003","journal-title":"Journal of Environmental Monitoring"},{"key":"10.1016\/j.toxlet.2013.01.016_bib0125","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1210\/er.2011-1050","article-title":"Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses","volume":"33","author":"Vandenberg","year":"2012","journal-title":"Endocrine Reviews"},{"key":"10.1016\/j.toxlet.2013.01.016_bib0130","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1038\/sj.embor.7400336","article-title":"Steadying the boat: integrating mechanisms of membrane and nuclear-steroid-receptor signalling","volume":"6","author":"Watson","year":"2005","journal-title":"EMBO Reports"},{"key":"10.1016\/j.toxlet.2013.01.016_bib0135","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/toxsci\/kfp288","article-title":"Nongenomic signaling pathways of estrogen toxicity","volume":"115","author":"Watson","year":"2010","journal-title":"Toxicological Sciences"},{"key":"10.1016\/j.toxlet.2013.01.016_bib0140","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1289\/ehp.7505","article-title":"Xenoestrogens at picomolar to nanomolar concentrations trigger membrane estrogen receptor-alpha-mediated Ca2+ fluxes and prolactin release in GH3\/B6 pituitary tumor cells","volume":"113","author":"Wozniak","year":"2005","journal-title":"Environmental Health Perspectives"}],"container-title":["Toxicology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427413000386?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427413000386?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,2,7]],"date-time":"2022-02-07T03:23:32Z","timestamp":1644204212000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378427413000386"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["S0378427413000386"],"URL":"https:\/\/doi.org\/10.1016\/j.toxlet.2013.01.016","relation":{},"ISSN":["0378-4274"],"issn-type":[{"value":"0378-4274","type":"print"}],"subject":[],"published":{"date-parts":[[2013,4]]}}}