{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T04:34:46Z","timestamp":1777610086991,"version":"3.51.4"},"reference-count":71,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology Letters"],"published-print":{"date-parts":[[2014,4]]},"DOI":"10.1016\/j.toxlet.2014.01.023","type":"journal-article","created":{"date-parts":[[2014,1,26]],"date-time":"2014-01-26T00:01:19Z","timestamp":1390694479000},"page":"98-105","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":62,"title":["Prenatal ethanol exposure enhances the susceptibility to metabolic syndrome in offspring rats by HPA axis-associated neuroendocrine metabolic programming"],"prefix":"10.1016","volume":"226","author":[{"given":"L.P.","family":"Xia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Kou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.J.","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.J.","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxlet.2014.01.023_bib0005","doi-asserted-by":"crossref","first-page":"269853","DOI":"10.1155\/2011\/269853","article-title":"Intrauterine growth retardation and nonalcoholic fatty liver disease in children","volume":"2011","author":"Alisi","year":"2011","journal-title":"Int. J. Endocrinol."},{"key":"10.1016\/j.toxlet.2014.01.023_bib0010","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.atherosclerosis.2008.09.008","article-title":"Baseline blood pressure, low- and high-density lipoproteins, and triglycerides and the risk of vascular events in the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) trial","volume":"204","author":"Amarenco","year":"2009","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.toxlet.2014.01.023_bib0015","doi-asserted-by":"crossref","first-page":"2692","DOI":"10.1210\/jc.2009-0370","article-title":"Clinical review: the pathogenetic role of cortisol in the metabolic syndrome: a hypothesis","volume":"94","author":"Anagnostis","year":"2009","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.toxlet.2014.01.023_bib0020","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1253\/circj.CJ-10-0448","article-title":"Is low-density lipoprotein\/high-density lipoprotein (LDL\/HDL)-cholesterol ratio a more important predictor of vulnerable plaque in coronary artery disease than LDL- or HDL-cholesterol?","volume":"74","author":"Awano","year":"2010","journal-title":"Circ. J."},{"key":"10.1016\/j.toxlet.2014.01.023_bib1025","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.jacc.2013.05.064","article-title":"Prevalence and trends of metabolic syndrome in the adult U.S. population 1999\u20132010","volume":"62","author":"Beltr\u00e1n-S\u00e1nchez","year":"2013","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.toxlet.2014.01.023_bib0025","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/S0899-9007(97)00191-3","article-title":"Body fat distribution, insulin resistance, and metabolic diseases","volume":"13","author":"Bj\u00f6rntorp","year":"1997","journal-title":"Nutrition"},{"key":"10.1016\/j.toxlet.2014.01.023_bib0030","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1046\/j.1467-789x.2001.00027.x","article-title":"Do stress reactions cause abdominal obesity and comorbidities?","volume":"2","author":"Bj\u00f6rntorp","year":"2001","journal-title":"Obes. Rev."},{"key":"10.1016\/j.toxlet.2014.01.023_bib0035","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1096\/fj.04-2846fje","article-title":"Hepatic leptin signaling in obesity","volume":"19","author":"Brabant","year":"2005","journal-title":"FASEB J."},{"key":"10.1016\/j.toxlet.2014.01.023_bib0040","doi-asserted-by":"crossref","first-page":"65","DOI":"10.2119\/2005-00029.Saltiel","article-title":"Insulin signaling and the regulation of glucose transport","volume":"10","author":"Chang","year":"2004","journal-title":"Mol. Med."},{"key":"10.1016\/j.toxlet.2014.01.023_bib0045","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1210\/en.2002-220623","article-title":"Glucose intolerance and resistin expression in rat offspring exposed to ethanol in utero: modulation by postnatal high-fat diet","volume":"144","author":"Chen","year":"2003","journal-title":"Endocrinology"},{"key":"10.1016\/j.toxlet.2014.01.023_bib0050","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1152\/japplphysiol.00751.2003","article-title":"Whole body insulin resistance in rat offspring of mothers consuming alcohol during pregnancy or lactation: comparing prenatal and postnatal exposure","volume":"96","author":"Chen","year":"2004","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.toxlet.2014.01.023_bib0055","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.etp.2007.05.007","article-title":"Nicotine-induced prenatal overexposure to maternal glucocorticoid and intrauterine growth retardation in rat","volume":"59","author":"Chen","year":"2007","journal-title":"Exp. Toxicol. Pathol."},{"key":"10.1016\/j.toxlet.2014.01.023_bib0060","series-title":"Extreme Fear, Shyness and Social Phobia: Origins, Biological Mechanisms and Clinical Outcomes","first-page":"193","article-title":"The inhibited child syndrome. Thoughts on its potential pathogenesis and sequelae","author":"Chrousos","year":"1999"},{"key":"10.1016\/j.toxlet.2014.01.023_bib0065","doi-asserted-by":"crossref","first-page":"R796","DOI":"10.1152\/ajpregu.00633.2005","article-title":"Intrauterine ethanol exposure results in hypothalamic oxidative stress and neuroendocrine alterations in adult rat offspring","volume":"291","author":"Dembele","year":"2006","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.toxlet.2014.01.023_bib0070","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1016\/S0140-6736(05)66378-7","article-title":"The metabolic syndrome","volume":"365","author":"Eckel","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.toxlet.2014.01.023_bib0075","doi-asserted-by":"crossref","first-page":"212","DOI":"10.3164\/jcbn.09-83","article-title":"A mouse model of metabolic syndrome: insulin resistance, fatty liver and nonalcoholic fatty pancreas disease (NAFPD) in C57BL\/6 mice fed a high fat diet","volume":"46","author":"Fraulob","year":"2010","journal-title":"J. Clin. Biochem. Nutr."},{"key":"10.1016\/j.toxlet.2014.01.023_bib0080","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1055\/s-0028-1119406","article-title":"The combination of a high-fat diet and chronic stress aggravates insulin resistance in Wistar male rats","volume":"117","author":"Fu","year":"2009","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"10.1016\/j.toxlet.2014.01.023_bib0085","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.tem.2004.03.002","article-title":"The developmental origins of the metabolic syndrome","volume":"15","author":"Gluckman","year":"2004","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.toxlet.2014.01.023_bib0090","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1093\/toxsci\/kfi209","article-title":"A systems-based computational model for dose\u2013response comparisons of two mode of action hypotheses for ethanol-induced neurodevelopmental toxicity","volume":"86","author":"Gohlke","year":"2005","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.toxlet.2014.01.023_bib0095","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1016\/S0140-6736(05)66375-1","article-title":"Prevalence of the metabolic syndrome and overweight among adults in China","volume":"365","author":"Gu","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.toxlet.2014.01.023_bib0100","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1590\/S0004-27302011000800012","article-title":"Metabolic syndrome in children born small-for-gestational age","volume":"55","author":"Hernandez","year":"2011","journal-title":"Arq. Bras. Endocrinol. Metabol."},{"key":"10.1016\/j.toxlet.2014.01.023_bib0105","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.2337\/diabetes.50.5.1126","article-title":"Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys","volume":"50","author":"Hotta","year":"2001","journal-title":"Diabetes"},{"key":"10.1016\/j.toxlet.2014.01.023_bib0110","first-page":"1401","article-title":"Insulin resistance early in adulthood in subjects born with intrauterine growth retardation","volume":"85","author":"Jaquet","year":"2000","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.toxlet.2014.01.023_bib0115","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/j.1749-6632.2010.05683.x","article-title":"Fetal origins of adult diabetes","volume":"1205","author":"Kanaka-Gantenbein","year":"2010","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.toxlet.2014.01.023_bib0120","doi-asserted-by":"crossref","first-page":"36","DOI":"10.3400\/avd.oa.11.00068","article-title":"Lowered postoperative ldl-C\/hdl-C ratio reduces later cardiovascular events after abdominal aortic aneurysm surgery","volume":"5","author":"Kanaoka","year":"2012","journal-title":"Ann. Vasc. Dis."},{"key":"10.1016\/j.toxlet.2014.01.023_bib0130","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1253\/circj.CJ-09-0849","article-title":"Low-density lipoprotein-cholesterol\/high-density lipoprotein-cholesterol ratio predicts lipid-rich coronary plaque in patients with coronary artery disease \u2013 integrated-backscatter intravascular ultrasound study","volume":"74","author":"Kimura","year":"2010","journal-title":"Circ. J."},{"key":"10.1016\/j.toxlet.2014.01.023_bib0135","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.neuroscience.2011.03.028","article-title":"Long-term exposure to high fat diet is bad for your brain: exacerbation of focal ischemic brain injury","volume":"182","author":"Langdon","year":"2011","journal-title":"Neuroscience"},{"key":"10.1016\/j.toxlet.2014.01.023_bib0140","doi-asserted-by":"crossref","first-page":"587","DOI":"10.33549\/physiolres.932313","article-title":"Natural postmenopause is associated with an increase in combined cardiovascular risk factors","volume":"61","author":"Lejskov\u00e1","year":"2012","journal-title":"Physiol. Res."},{"key":"10.1016\/j.toxlet.2014.01.023_bib0145","first-page":"123","article-title":"Small for gestational age and the metabolic syndrome: which mechanism is suggested by epidemiological and clinical studies?","volume":"65","author":"Levy-Marchal","year":"2006","journal-title":"Horm. Res."},{"key":"10.1016\/j.toxlet.2014.01.023_bib0150","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.etp.2010.04.015","article-title":"Ethanol-induced inhibition of fetal hypothalamic\u2013pituitary\u2013adrenal axis due to prenatal overexposure to maternal glucocorticoid in mice","volume":"63","author":"Liang","year":"2011","journal-title":"Exp. Toxicol. Pathol."},{"key":"10.1016\/j.toxlet.2014.01.023_bib0160","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.toxlet.2012.09.001","article-title":"Prenatal nicotine exposure induced a hypothalamic\u2013pituitary\u2013adrenal axis-associated neuroendocrine metabolic programmed alteration in IUGR offspring rats","volume":"214","author":"Liu","year":"2012","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.toxlet.2014.01.023_bib0165","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.taap.2012.05.002","article-title":"Fetal rat metabonome alteration by prenatal caffeine ingestion probably due to the increased circulatory glucocorticoid level and altered peripheral glucose and lipid metabolic pathways","volume":"262","author":"Liu","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.toxlet.2014.01.023_bib0170","doi-asserted-by":"crossref","first-page":"222","DOI":"10.3109\/14767058.2012.715006","article-title":"Short-term and long-term sequelae in intrauterine growth retardation (IUGR)","volume":"26","author":"Longo","year":"2013","journal-title":"J. Matern. Fetal. Neonatal. Med."},{"key":"10.1016\/j.toxlet.2014.01.023_bib0175","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1046\/j.1365-2265.2004.01977.x","article-title":"Adiponectin, hepatocellular dysfunction and insulin sensitivity","volume":"60","author":"L\u00f3pez-Bermejo","year":"2004","journal-title":"Clin. Endocrinol. (Oxf.)"},{"key":"10.1016\/j.toxlet.2014.01.023_bib0180","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/S1047-2797(97)00081-1","article-title":"Low-to-moderate gestational alcohol use and intrauterine growth retardation, low birth weight, and preterm delivery","volume":"7","author":"Lundsberg","year":"1997","journal-title":"Ann. Epidemiol."},{"key":"10.1016\/j.toxlet.2014.01.023_bib0185","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/pr.2012.173","article-title":"Plasma lipid levels and body weight altered by intrauterine growth restriction and postnatal fructose diet in adult rats","volume":"73","author":"Malo","year":"2013","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.toxlet.2014.01.023_bib0190","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.arcmed.2010.06.002","article-title":"Fetal malnutrition affects hypothalamic leptin receptor expression after birth in male mice","volume":"41","author":"Manuel-Apolinar","year":"2010","journal-title":"Arch. Med. Res."},{"key":"10.1016\/j.toxlet.2014.01.023_bib0195","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s00125-010-1963-x","article-title":"The stress of starvation: glucocorticoid restraint of beta cell development","volume":"54","author":"Matthews","year":"2011","journal-title":"Diabetologia"},{"key":"10.1016\/j.toxlet.2014.01.023_bib0200","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.2105\/AJPH.2003.037093","article-title":"Maternal risk factors for fetal alcohol syndrome in the Western cape province of South Africa: a population-based study","volume":"95","author":"May","year":"2005","journal-title":"Am. J. Public Health"},{"key":"10.1016\/j.toxlet.2014.01.023_bib0205","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.molmed.2007.05.003","article-title":"Epigenetic mechanisms of perinatal programming of hypothalamic\u2013pituitary\u2013adrenal function and health","volume":"13","author":"Meaney","year":"2007","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.toxlet.2014.01.023_bib0210","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1007\/s00467-009-1407-3","article-title":"Fetal growth restriction, catch-up growth and the early origins of insulin resistance and visceral obesity","volume":"25","author":"Morrison","year":"2010","journal-title":"Pediatr. Nephrol."},{"key":"10.1016\/j.toxlet.2014.01.023_bib0215","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/BF03403909","article-title":"Prevalence and predictors of health risk behaviours during early pregnancy: Saskatoon Pregnancy and Health Study","volume":"88","author":"Muhajarine","year":"1997","journal-title":"Can. J. Public Health"},{"key":"10.1016\/j.toxlet.2014.01.023_bib0220","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/1471-2393-11-27","article-title":"Prevalence, predictors and perinatal outcomes of peri-conceptional alcohol exposure \u2013 retrospective cohort study in an urban obstetric population in Ireland","volume":"11","author":"Mullally","year":"2011","journal-title":"BMC Pregnancy Childbirth"},{"key":"10.1016\/j.toxlet.2014.01.023_bib0225","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1471-2393-13-8","article-title":"Behavioural change in relation to alcohol exposure in early pregnancy and impact on perinatal outcomes \u2013 a prospective cohort study","volume":"13","author":"Murphy","year":"2013","journal-title":"BMC Pregnancy Childbirth"},{"key":"10.1016\/j.toxlet.2014.01.023_bib0230","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/S0140-6736(06)69472-5","article-title":"Primary prevention of cardiovascular disease with pravastatin in Japan (MEGA Study): a prospective randomised controlled trial","volume":"368","author":"Nakamura","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.toxlet.2014.01.023_bib0235","first-page":"351982","article-title":"Rodent models for metabolic syndrome research","volume":"2011","author":"Panchal","year":"2011","journal-title":"J. Biomed. Biotechnol."},{"key":"10.1016\/j.toxlet.2014.01.023_bib0240","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0741-8329(92)90048-F","article-title":"Alcohol reduces the number of pheochromocytoma (PC12) cells in culture","volume":"9","author":"Pantazis","year":"1992","journal-title":"Alcohol"},{"key":"10.1016\/j.toxlet.2014.01.023_bib0245","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1055\/s-2007-981461","article-title":"Post-traumatic stress disorder in children and adolescents: from Sigmund Freud's Trauma\u201d to psychopathology and the (Dys)metabolic syndrome","volume":"39","author":"Pervanidou","year":"2007","journal-title":"Horm. Metab. Res."},{"key":"10.1016\/j.toxlet.2014.01.023_bib0250","doi-asserted-by":"crossref","first-page":"558","DOI":"10.2298\/MPNS0512558R","article-title":"The growth hormone axis and insulin-like growth factors","volume":"58","author":"Radosavljevic","year":"2005","journal-title":"Med. Pregl."},{"key":"10.1016\/j.toxlet.2014.01.023_bib0255","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1530\/EJE-08-0914","article-title":"Small for gestational age status is associated with metabolic syndrome in overweight children","volume":"160","author":"Reinehr","year":"2009","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.toxlet.2014.01.023_bib0260","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jsbmb.2010.01.009","article-title":"Corticosteroid-mediated programming and the pathogenesis of obesity and diabetes","volume":"122","author":"Reynolds","year":"2010","journal-title":"J. Steroid. Biochem. Mol. Biol."},{"key":"10.1016\/j.toxlet.2014.01.023_bib0265","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.psyneuen.2004.05.007","article-title":"Role of stress in the pathogenesis of the metabolic syndrome","volume":"30","author":"Rosmond","year":"2005","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.toxlet.2014.01.023_bib0270","doi-asserted-by":"crossref","first-page":"507","DOI":"10.2337\/db10-1239","article-title":"Hypoxia-induced intrauterine growth restriction increases the susceptibility of rats to high-fat diet-induced metabolic syndrome","volume":"60","author":"Rueda-Clausen","year":"2011","journal-title":"Diabetes"},{"key":"10.1016\/j.toxlet.2014.01.023_bib0275","first-page":"25","article-title":"A survey of recent results concerning glycyrrhizic acid in stress and adaptation","volume":"12","author":"Ruszymah","year":"1999","journal-title":"Med. J. Islamic Acad. Sci."},{"key":"10.1016\/j.toxlet.2014.01.023_bib0280","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.taap.2013.11.009","article-title":"Intrauterine programming of high susceptibility to fatty liver disease in female offspring rats with prenatal ethanol exposure","volume":"274","author":"Shen","year":"2014","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.toxlet.2014.01.023_bib0285","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1210\/me.2010-0395","article-title":"Maternal protein restriction elevates cholesterol in adult rat offspring due to repressive changes in histone modifications at the cholesterol 7alpha-hydroxylase promoter","volume":"25","author":"Sohi","year":"2011","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.toxlet.2014.01.023_bib0290","series-title":"Handbook of Life Stress, Cognition and Health","first-page":"631","article-title":"Allostasis: a new paradigm to explain arousal pathology","author":"Sterling","year":"1988"},{"key":"10.1016\/j.toxlet.2014.01.023_bib0295","series-title":"Encyclopedia of Behavioral Neuroscience","first-page":"316","article-title":"Stress and emotionality","author":"Stinnett","year":"2010"},{"key":"10.1016\/j.toxlet.2014.01.023_bib0300","doi-asserted-by":"crossref","first-page":"G1023","DOI":"10.1152\/ajpgi.00052.2010","article-title":"Epigenetics of programmed obesity: alteration in IUGR rat hepatic IGF1 mRNA expression and histone structure in rapid vs. delayed postnatal catch-up growth","volume":"299","author":"Tosh","year":"2010","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.toxlet.2014.01.023_bib0305","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1249\/MSS.0b013e3181eeb12d","article-title":"Exercise reverses metabolic syndrome in high-fat diet-induced obese rats","volume":"43","author":"Touati","year":"2011","journal-title":"Med. Sci. Sports Exerc."},{"key":"10.1016\/j.toxlet.2014.01.023_bib0310","doi-asserted-by":"crossref","first-page":"S16","DOI":"10.1016\/j.psyneuen.2007.03.014","article-title":"HPA axis programming by maternal undernutrition in the male rat offspring","volume":"32","author":"Vieau","year":"2007","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.toxlet.2014.01.023_bib0315","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1111\/j.1464-5491.2006.01998.x","article-title":"Cortisol \u2013 cause and cure for metabolic syndrome?","volume":"23","author":"Walker","year":"2006","journal-title":"Diabet. Med."},{"key":"10.1016\/j.toxlet.2014.01.023_bib0320","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1007\/s00125-010-1956-9","article-title":"Tissue-specific dysregulation of hexose-6-phosphate dehydrogenase and glucose-6-phosphate transporter production in db\/db mice as a model of type 2 diabetes","volume":"54","author":"Wang","year":"2011","journal-title":"Diabetologia"},{"key":"10.1016\/j.toxlet.2014.01.023_bib0325","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1111\/j.1365-2826.2008.01669.x","article-title":"Prenatal alcohol exposure: foetal programming, the hypothalamic\u2013pituitary\u2013adrenal axis and sex differences in outcome","volume":"20","author":"Weinberg","year":"2008","journal-title":"J. Neuroendocrinol."},{"issue":"2","key":"10.1016\/j.toxlet.2014.01.023_bib0330","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/j.1365-2826.2001.00601.x","article-title":"Prenatal stress, glucocorticoids and the programming of the brain","volume":"13","author":"Welberg","year":"2001","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.toxlet.2014.01.023_bib0340","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1159\/000087097","article-title":"Chronic mild stress (CMS) revisited: consistency and behavioral neurobiological concordance in the effects of CMS","volume":"52","author":"Willner","year":"2005","journal-title":"Neuropsychobiology"},{"key":"10.1016\/j.toxlet.2014.01.023_bib0345","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1111\/j.1749-6632.2010.05658.x","article-title":"Fetal origins of the metabolic syndrome","volume":"1205","author":"Xita","year":"2010","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.toxlet.2014.01.023_bib0350","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.toxlet.2012.01.006","article-title":"Nicotine-induced over-exposure to maternal glucocorticoid and activated glucocorticoid metabolism causes hypothalamic\u2013pituitary\u2013adrenal axis-associated neuroendocrine metabolic alterations in fetal rats","volume":"209","author":"Xu","year":"2012","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.toxlet.2014.01.023_bib0355","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.taap.2012.08.016","article-title":"A hypothalamic\u2013pituitary\u2013adrenal axis-associated neuroendocrine metabolic programmed alteration in offspring rats of IUGR induced by prenatal caffeine ingestion","volume":"264","author":"Xu","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.toxlet.2014.01.023_bib0360","doi-asserted-by":"crossref","first-page":"e44497","DOI":"10.1371\/journal.pone.0044497","article-title":"Caffeine-induced activated glucocorticoid metabolism in the hippocampus causes hypothalamic\u2013pituitary\u2013adrenal axis inhibition in fetal rats","volume":"7","author":"Xu","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.toxlet.2014.01.023_bib0365","doi-asserted-by":"crossref","first-page":"R1926","DOI":"10.1152\/ajpregu.00822.2006","article-title":"Abnormal glucose homeostasis in adult female rat offspring after intrauterine ethanol exposure","volume":"292","author":"Yao","year":"2007","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."}],"container-title":["Toxicology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427414000344?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427414000344?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T05:13:40Z","timestamp":1759900420000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378427414000344"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4]]},"references-count":71,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["S0378427414000344"],"URL":"https:\/\/doi.org\/10.1016\/j.toxlet.2014.01.023","relation":{},"ISSN":["0378-4274"],"issn-type":[{"value":"0378-4274","type":"print"}],"subject":[],"published":{"date-parts":[[2014,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prenatal ethanol exposure enhances the susceptibility to metabolic syndrome in offspring rats by HPA axis-associated neuroendocrine metabolic programming","name":"articletitle","label":"Article Title"},{"value":"Toxicology Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxlet.2014.01.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}