{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:05:45Z","timestamp":1791306345286,"version":"4.3.1"},"reference-count":71,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,2,24]],"date-time":"2014-02-24T00:00:00Z","timestamp":1393200000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology Letters"],"published-print":{"date-parts":[[2014,5]]},"DOI":"10.1016\/j.toxlet.2014.02.014","type":"journal-article","created":{"date-parts":[[2014,2,25]],"date-time":"2014-02-25T12:02:00Z","timestamp":1393329720000},"page":"264-276","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":72,"title":["Uptake of different crystal structures of TiO2 nanoparticles by Caco-2 intestinal cells"],"prefix":"10.1016","volume":"226","author":[{"given":"Constantinos","family":"Gitrowski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aliaa R.","family":"Al-Jubory","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard D.","family":"Handy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxlet.2014.02.014_bib0005","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1093\/occmed\/kql051","article-title":"Hull Manufacture and use of nanomaterials: current status in the UK and global trends","volume":"56","author":"Aitken","year":"2006","journal-title":"Occupat. Med.-Oxford"},{"key":"10.1016\/j.toxlet.2014.02.014_bib0010","doi-asserted-by":"crossref","first-page":"5592","DOI":"10.1016\/S0021-9258(18)45614-1","article-title":"Genistein, a specific inhibitor of Tyrosine-specific protein kinases","volume":"262","author":"Akiyama","year":"1987","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxlet.2014.02.014_bib0015","first-page":"1","article-title":"Uptake of TiO2 nanoparticles across the isolated perfused intestine of rainbow trout: nystatin, vanadate, and novel gas-sensitive components","author":"Al-Jubory","year":"2012","journal-title":"Nanotoxicology"},{"key":"10.1016\/j.toxlet.2014.02.014_bib0020","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0304-4165(00)00015-5","article-title":"Regulation of copper uptake and transport in intestinal monolayers by acute and chronic copper exposure","volume":"1474","author":"Arrendondo","year":"2000","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.toxlet.2014.02.014_bib0025","first-page":"95","article-title":"Inhibition of iron and copper uptake by iron, copper and zinc","volume":"39","author":"Arrendondo","year":"2006","journal-title":"Biol. Res."},{"key":"10.1016\/j.toxlet.2014.02.014_bib0030","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1093\/jn\/130.5.1329","article-title":"Caco-2 cells can be used ti assess human iron bioavailability from semipurified meal","volume":"130","author":"Au","year":"2000","journal-title":"J. Nutr."},{"key":"10.1016\/j.toxlet.2014.02.014_bib0035","doi-asserted-by":"crossref","first-page":"12050","DOI":"10.1073\/pnas.211341698","article-title":"Lipid rafts required for GLUT4 internalization in adipose cells","volume":"98","author":"Baro","year":"2001","journal-title":"PNAS"},{"key":"10.1016\/j.toxlet.2014.02.014_bib0040","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1093\/toxsci\/kfh019","article-title":"Pulmonary responses of mice, rats, and hamsters to subchronic inhalation of ultrafine titanium dioxide particles","volume":"77","author":"Bermudez","year":"2004","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.toxlet.2014.02.014_bib0045","first-page":"140","article-title":"Blood titanium levels before and after oral administration titanium dioxide","volume":"55","author":"Bockmann","year":"2000","journal-title":"Pharmazie"},{"key":"10.1016\/j.toxlet.2014.02.014_bib0050","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.yrtph.2008.10.008","article-title":"Review of health safety aspects of nanotechnologies in food production","volume":"53","author":"Bouwmeester","year":"2009","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.toxlet.2014.02.014_bib0055","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1136\/gut.2006.094060","article-title":"Modulation of iron transport proteins in human colorectal carcinogenesis","volume":"55","author":"Brookes","year":"2006","journal-title":"Gut"},{"key":"10.1016\/j.toxlet.2014.02.014_bib0060","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1242\/jeb.01379","article-title":"Sodium-sensitive and -insensitive copper accumulation by isolated intestinal cells of rainbow trout Oncorhynchus mykiss","volume":"208","author":"Burke","year":"2005","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.toxlet.2014.02.014_bib0065","first-page":"107","article-title":"Copper and iron uptake in teleost fish","volume":"vol. 2","author":"Bury","year":"2010"},{"key":"10.1016\/j.toxlet.2014.02.014_bib0070","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1038\/272552a0","article-title":"Vanadate inhibits the red cell (Na+, K+) ATPase from the cytoplasmic side","volume":"272","author":"Cantley","year":"1978","journal-title":"Nature"},{"key":"10.1016\/j.toxlet.2014.02.014_bib0075","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1080\/02652030701744538","article-title":"Applications and implications of nanotechnologies for the food sector","volume":"Part A 25","author":"Chaudry","year":"2008","journal-title":"Food Addit. Contam."},{"key":"10.1016\/j.toxlet.2014.02.014_bib0080","doi-asserted-by":"crossref","first-page":"2891","DOI":"10.1021\/cr0500535","article-title":"Titanium dioxide nanomaterials: synthesis, properties, modifications, and applications","volume":"107","author":"Chen","year":"2007","journal-title":"Chem. Rev."},{"key":"10.1016\/j.toxlet.2014.02.014_bib0085","doi-asserted-by":"crossref","first-page":"6392","DOI":"10.1182\/blood-2010-12-322867","article-title":"Cholesterol sequestration by nystatin enhances the uptake and activity of endostatin in endothelium via regulating distinct endocytic pathways","volume":"117","author":"Chen","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.toxlet.2014.02.014_bib0090","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.toxlet.2005.10.003","article-title":"Acute toxicological effects of copper nanoparticles in vivo","volume":"163","author":"Chen","year":"2006","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.toxlet.2014.02.014_bib0095","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1093\/ajcn\/67.5.1091S","article-title":"Mechanisms for protection against copper toxicity","volume":"67","author":"Dameron","year":"1998","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.toxlet.2014.02.014_bib0100","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1080\/15298668591394419","article-title":"Biological effects and toxicity assessment of titanium dioxides: anatase and rutile","volume":"46","author":"Ferin","year":"1985","journal-title":"Am. Ind. Hyg. Assoc. J."},{"key":"10.1016\/j.toxlet.2014.02.014_bib0105","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/0076-6879(90)92082-O","article-title":"Established intestinal cell lines as model systems for electrolyte transport studies","volume":"192","author":"Dharmsathaphorn","year":"1990","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.toxlet.2014.02.014_bib0110","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1165\/ajrcmb\/6.5.535","article-title":"Pulmonary retention of ultrafine and fine particles in rats","volume":"6","author":"Ferin","year":"1992","journal-title":"Am. J. Respir. Cell. Mol. Biol."},{"key":"10.1016\/j.toxlet.2014.02.014_bib0115","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1093\/occmed\/kql052","article-title":"Nanomedicines and nanotoxicology: some physiological principles","volume":"56","author":"Garnett","year":"2006","journal-title":"Occup. Med. (Lond.)"},{"key":"10.1016\/j.toxlet.2014.02.014_bib0120","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1002\/ieam.5630030316","article-title":"Ecotoxicity of nanomaterials to fish: Challenges for ecotoxicity testing","volume":"3","author":"Handy","year":"2007","journal-title":"Integr. Environ. Assess. Manage"},{"key":"10.1016\/j.toxlet.2014.02.014_bib0125","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S1095-6433(03)00018-7","article-title":"Chronic effects of copper exposure versus endocrine toxicity: two sides of the same toxicological process","volume":"135","author":"Handy","year":"2003","journal-title":"Comp. Biochem. Physiol., Part A: Mol. Integr. Physiol."},{"key":"10.1016\/j.toxlet.2014.02.014_bib0130","doi-asserted-by":"crossref","first-page":"2365","DOI":"10.1242\/jeb.203.15.2365","article-title":"Mechanisms of gastrointestinal copper absorption in the African walking catfish: copper dose-effects and a novel anion-dependent pathway in the intestine","volume":"203","author":"Handy","year":"2000","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.toxlet.2014.02.014_bib0135","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/S0005-2736(02)00590-4","article-title":"Sodium-dependent copper uptake across epithelia: a review of rationale with experimental evidence from gill and intestine","volume":"1566","author":"Handy","year":"2002","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.toxlet.2014.02.014_bib0140","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1006\/jmcc.1996.0154","article-title":"Na-dependent regulation of intracellular free magnesium concentration in isolated rat ventricular myocytes","volume":"28","author":"Handy","year":"1996","journal-title":"J. Mol. Cell Cardiol."},{"key":"10.1016\/j.toxlet.2014.02.014_bib0145","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.nantod.2011.02.003","article-title":"Endocytosis and intracellular transport of nanoparticles: Present knowledge and need for future studies","volume":"6","author":"Iverson","year":"2011","journal-title":"Nano Today"},{"key":"10.1016\/j.toxlet.2014.02.014_bib0150","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/0378-5173(94)90461-8","article-title":"Titanium dioxide (rutile) particle uptake from the rat GI tract and translocation to systemic organs after oral administration","volume":"105","author":"Jani","year":"1994","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.toxlet.2014.02.014_bib0155","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0005-2736(97)00242-3","article-title":"Characterization of Mg2+ transport in brush border membrane vesicles of rabbit ileum studied with mag-fura-2","volume":"1370","author":"Juttner","year":"1997","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.toxlet.2014.02.014_bib0160","doi-asserted-by":"crossref","first-page":"25461","DOI":"10.1074\/jbc.R109.031286","article-title":"Copper transport in mammalian cells: Special care for metal with special needs","volume":"284","author":"Kaplan","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxlet.2014.02.014_bib0165","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.tcb.2009.09.002","article-title":"Imaging endocytic clathrin structures in living cells","volume":"19","author":"Kirchhausen","year":"2009","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.toxlet.2014.02.014_bib0170","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.tox.2009.08.002","article-title":"Comparative pulmonary toxicity study of nano-TiO(2) particles of different sizes and agglomerations in rats: different short- and long-term post-instillation results","volume":"264","author":"Kobayashi","year":"2009","journal-title":"Toxicology"},{"key":"10.1016\/j.toxlet.2014.02.014_bib0175","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s10565-009-9132-z","article-title":"Toxicity and cellular responses of intestinal cells exposed to titanium dioxide","volume":"26","author":"Koeneman","year":"2010","journal-title":"Cell Biol. Toxicol."},{"key":"10.1016\/j.toxlet.2014.02.014_bib0180","first-page":"427","article-title":"Nystatin as a probe for investigating the electrical properties of a tight epithelium","volume":"70","author":"Lewis","year":"1977","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.toxlet.2014.02.014_bib0185","first-page":"1211","article-title":"Experimental study on toxicity of nanosized titanium dioxide","volume":"33","author":"Liu","year":"2006","journal-title":"Modern Prevent. Med."},{"key":"10.1016\/j.toxlet.2014.02.014_bib0190","doi-asserted-by":"crossref","first-page":"143","DOI":"10.4067\/S0716-97602006000100016","article-title":"Vesicular transport of Fe and interaction with other metal ions in polarized Caco-2 Cell monolayers","volume":"39","author":"Linder","year":"2006","journal-title":"Biol. Res."},{"key":"10.1016\/j.toxlet.2014.02.014_bib0195","first-page":"2339","article-title":"Determination of titanium dioxide in foods using inductively coupled plasma optical emission spectrometry","volume":"125","author":"Lomer","year":"2000","journal-title":"Roy. Soc. Ch."},{"key":"10.1016\/j.toxlet.2014.02.014_bib0200","first-page":"301","article-title":"Vesicular transport and apotransferrin in intestinal iron absorbtion, as shown in the Caco-2 cell model","volume":"290","author":"Moriya","year":"2005","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.toxlet.2014.02.014_bib0205","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1083\/jcb.200302028","article-title":"Caveolae\/raft-dependent endocytosis","volume":"161","author":"Nabi","year":"2003","journal-title":"J. Cell. Biol."},{"key":"10.1016\/j.toxlet.2014.02.014_bib0210","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1088\/0953-8984\/18\/33\/S34","article-title":"Biological cellular response to carbon nanoparticle toxicity","volume":"18","author":"Panessa-Warren","year":"2006","journal-title":"J. Phys.-Condens. Matter."},{"key":"10.1016\/j.toxlet.2014.02.014_bib0215","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1242\/jcs.105.2.445","article-title":"An in vitro model for the analysis of intestinal brush border assembly I. Ultrastructural analysis of cell contact induced brush border assembly in Caco-2BBe cells","volume":"105","author":"Peterson","year":"1993","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.toxlet.2014.02.014_bib0220","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1242\/jcs.105.2.461","article-title":"An in vitro model for the analysis of intestinal brush border assembly II. Changes in expression and localization of brush border proteins during cell contact induced brush border assembly in Caco-2BBe cells","volume":"105","author":"Peterson","year":"1993","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.toxlet.2014.02.014_bib0225","series-title":"An Introduction to Practical Biochemistry","author":"Plummer","year":"1971"},{"key":"10.1016\/j.toxlet.2014.02.014_bib0230","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1007\/s10646-009-0357-7","article-title":"Dietary exposure to titanium dioxide nanoparticles in rainbow trout, (Oncorhynchus mykiss): no effect on growth, but subtle biochemical disturbances in the brain","volume":"18","author":"Ramsden","year":"2009","journal-title":"Ecotoxicology"},{"key":"10.1016\/j.toxlet.2014.02.014_bib0235","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1124\/pr.54.3.431","article-title":"Caveolae from cell biology to animal physiology","volume":"54","author":"Razani","year":"2002","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.toxlet.2014.02.014_bib0240","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0003-9861(92)90086-C","article-title":"Regulation of cell magnesium","volume":"298","author":"Romani","year":"1992","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.toxlet.2014.02.014_bib0245","first-page":"1","article-title":"The crystalline forms of titanium dioxide nanoparticles affect their interactions with individual cells","volume":"8","author":"Ryabchikova","year":"2010","journal-title":"J. Med. CBR Def."},{"key":"10.1016\/j.toxlet.2014.02.014_bib0250","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1093\/toxsci\/kfj197","article-title":"Correlating nanoscale titania structure with toxicity: A cytotoxicity and inflammatory response study with human dermal fibroblasts and human lung epithelial cells","volume":"92","author":"Sayes","year":"2006","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.toxlet.2014.02.014_bib0255","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1007\/s10953-009-9445-9","article-title":"Aqueous long- term solubility of titania nanoparticles and titanium (IV) hydrolysis in a sodium chloride system studied by adsorbative stripping voltammetry","volume":"38","author":"Schmidt","year":"2009","journal-title":"J. Sol. Chem."},{"key":"10.1016\/j.toxlet.2014.02.014_bib0260","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1107\/S0567739476001551","article-title":"Revised effective ionic radii and systematic studies of interatomic distances in halides and chalcogenides","volume":"A32","author":"Shannon","year":"1976","journal-title":"Acta Cryst."},{"key":"10.1016\/j.toxlet.2014.02.014_bib0265","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/j.envint.2011.03.009","article-title":"Physiological effects of nanoparticles on fish: A comparison of nanometals versus metal ions","volume":"37","author":"Shaw","year":"2011","journal-title":"Environ. Int."},{"key":"10.1016\/j.toxlet.2014.02.014_bib0270","doi-asserted-by":"crossref","first-page":"3625","DOI":"10.1529\/biophysj.105.075408","article-title":"Competitive binding of cholesterol and ergosterol to the polyene antibiotic Nystatin. A fluorescence study","volume":"90","author":"Silva","year":"2006","journal-title":"Biophys. J."},{"key":"10.1016\/j.toxlet.2014.02.014_bib0275","doi-asserted-by":"crossref","first-page":"125","DOI":"10.3109\/17435390.2010.502979","article-title":"Titanium dioxide nanoparticles induced intracellular calcium homeostasis modification in primary keratinocytes. Towards an in vitro explanation of titanium dioxide nanoparticles toxicity","volume":"5","author":"Simon","year":"2011","journal-title":"Nanotoxicology"},{"key":"10.1016\/j.toxlet.2014.02.014_bib0280","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.taap.2007.05.001","article-title":"Endocytosis, oxidative stress and IL-8 expression in human lung epithelial cells upon treatment with fine and ultrafine TiO2: Role of the specific surface area and of surface methylation of the particles","volume":"222","author":"Singh","year":"2007","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.toxlet.2014.02.014_bib0285","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1016\/S0016-5085(11)64340-0","article-title":"TNF-(induced vectorial secretion of IL-8 corresponds to development of transepithelial electrical resistance in Caco-2 cells (2011)","volume":"140","author":"Sonnier","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.toxlet.2014.02.014_bib0290","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1080\/02652030802007553","article-title":"Detection and characterization of engineered nanoparticles in food and the environment","volume":"Part A 25","author":"Tiede","year":"2008","journal-title":"Food Addit. Contam."},{"key":"10.1016\/j.toxlet.2014.02.014_bib0295","doi-asserted-by":"crossref","first-page":"8784","DOI":"10.1158\/0008-5472.CAN-09-2496","article-title":"Titanium dioxide nanoparticles induce DNA damage and genetic instability in vivo in mice","volume":"69","author":"Trouiller","year":"2009","journal-title":"Cancer Res."},{"key":"10.1016\/j.toxlet.2014.02.014_bib0300","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1007\/s11095-007-9287-3","article-title":"Cellular uptake of cationic polymer- DNA complexes via caveolae plays a pivotal role in gene transfection in COS-7 cells","volume":"24","author":"Van der Ma","year":"2007","journal-title":"Pharm. Res."},{"key":"10.1016\/j.toxlet.2014.02.014_bib0305","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.toxlet.2005.08.007","article-title":"Acute toxicity of nano - and micro-scaled zinc powder in adult healthy mice","volume":"161","author":"Wang","year":"2006","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.toxlet.2014.02.014_bib0310","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1083\/jcb.123.5.1107","article-title":"Mis-assembly of clathrin lattices on endosomes reveals a regulatory switch for coated pit formation","volume":"123","author":"Wang","year":"1993","journal-title":"J. Cell. Biol."},{"key":"10.1016\/j.toxlet.2014.02.014_bib0315","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.toxlet.2006.12.001","article-title":"Acute toxicity and biodistribution of different sized titanium dioxide particles in mice after oral administration","volume":"168","author":"Wang","year":"2007","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.toxlet.2014.02.014_bib0320","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.tox.2008.09.014","article-title":"Time-dependent translocation and potential impairment on central nervous system by intranasally instilled TiO2 nanoparticles","volume":"254","author":"Wang","year":"2008","journal-title":"Toxicology"},{"key":"10.1016\/j.toxlet.2014.02.014_bib0325","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0092-8674(03)00603-2","article-title":"Phosphatidylinositol 4 phosphate regulates targeting of clathrin adaptor AP-1 complexes to the golgi","volume":"114","author":"Wang","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.toxlet.2014.02.014_bib0330","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.tox.2006.11.002","article-title":"Pulmonary toxicity study in rats with three forms of ultrafine-TiO2 particles: Differential responses related to surface properties","volume":"230","author":"Warheit","year":"2007","journal-title":"Toxicology"},{"key":"10.1016\/j.toxlet.2014.02.014_bib0335","doi-asserted-by":"crossref","first-page":"2242","DOI":"10.1021\/es204168d","article-title":"Titanium dioxide nanoparticles in food and personal care products","volume":"46","author":"Weir","year":"2012","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.toxlet.2014.02.014_bib0340","doi-asserted-by":"crossref","first-page":"3643","DOI":"10.1242\/jcs.107.12.3643","article-title":"Tyrosine phosphorylation is involved in reorganization of the actin cytoskeleton in response to serum or LPA stimulation","volume":"107","author":"Wodnicka","year":"1994","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.toxlet.2014.02.014_bib0345","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1002\/jps.10050","article-title":"New and better protocols for short term Caco-2 cell culture system","volume":"91","author":"Yamashita","year":"2002","journal-title":"J. Pharm. Cell Sci."},{"key":"10.1016\/j.toxlet.2014.02.014_bib0350","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/S0955-2863(01)00205-4","article-title":"Effects of copper and ceruloplasmin on iron transport in the Caco-2 cell intestinal model","volume":"13","author":"Zerounian","year":"2002","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.toxlet.2014.02.014_bib0355","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1093\/toxsci\/kfp087","article-title":"Mechanisms of quantum dot nanoparticle cellular uptake","volume":"110","author":"Zhang","year":"2009","journal-title":"Toxicol. Sci."}],"container-title":["Toxicology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427414000927?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427414000927?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,3,27]],"date-time":"2022-03-27T17:13:35Z","timestamp":1648401215000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378427414000927"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5]]},"references-count":71,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["S0378427414000927"],"URL":"https:\/\/doi.org\/10.1016\/j.toxlet.2014.02.014","relation":{},"ISSN":["0378-4274"],"issn-type":[{"value":"0378-4274","type":"print"}],"subject":[],"published":{"date-parts":[[2014,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Uptake of different crystal structures of TiO2 nanoparticles by Caco-2 intestinal cells","name":"articletitle","label":"Article Title"},{"value":"Toxicology Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxlet.2014.02.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 The Authors. Published by Elsevier Ireland Ltd.","name":"copyright","label":"Copyright"}]}}