{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:59:17Z","timestamp":1792159157605,"version":"4.4.0"},"reference-count":47,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:00:00Z","timestamp":1404172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:00:00Z","timestamp":1404172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology Letters"],"published-print":{"date-parts":[[2014,7]]},"DOI":"10.1016\/j.toxlet.2014.04.013","type":"journal-article","created":{"date-parts":[[2014,4,24]],"date-time":"2014-04-24T11:00:36Z","timestamp":1398337236000},"page":"85-92","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":86,"title":["Mitochondrial dysfunction in early life resulted from perinatal bisphenol A exposure contributes to hepatic steatosis in rat offspring"],"prefix":"10.1016","volume":"228","author":[{"given":"Ying","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingshuang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaocui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danqi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huailong","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gengqi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunqing","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxlet.2014.04.013_bib0005","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0891-5849(01)00769-9","article-title":"Contribution of mitochondria to oxidative stress associated with alcoholic liver disease","volume":"32","author":"Bailey","year":"2002","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.toxlet.2014.04.013_bib0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mito.2005.10.004","article-title":"Mitochondrial dysfunction in NASH: causes, consequences and possible means to prevent it","volume":"6","author":"Begriche","year":"2006","journal-title":"Mitochondrion"},{"key":"10.1016\/j.toxlet.2014.04.013_bib0015","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.jhep.2010.11.006","article-title":"Drug-induced toxicity on mitochondria and lipid metabolism: mechanistic diversity and deleterious consequences for the liver","volume":"54","author":"Begriche","year":"2011","journal-title":"J. Hepatol."},{"issue":"Pt 1","key":"10.1016\/j.toxlet.2014.04.013_bib0020","first-page":"1","article-title":"Control of respiration and ATP synthesis in mammalian mitochondria and cells","volume":"284","author":"Brown","year":"1992","journal-title":"Biochem. J."},{"key":"10.1016\/j.toxlet.2014.04.013_bib0025","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1002\/hep.20466","article-title":"Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity","volume":"40","author":"Browning","year":"2004","journal-title":"Hepatology"},{"key":"10.1016\/j.toxlet.2014.04.013_bib0030","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1002\/hep.23205","article-title":"Maternal high-fat feeding primes steatohepatitis in adult mice offspring, involving mitochondrial dysfunction and altered lipogenesis gene expression","volume":"50","author":"Bruce","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.toxlet.2014.04.013_bib0035","doi-asserted-by":"crossref","first-page":"648","DOI":"10.3945\/jn.109.111179","article-title":"The developmental origins, mechanisms, and implications of metabolic syndrome","volume":"140","author":"Bruce","year":"2010","journal-title":"J. Nutr."},{"issue":"Suppl. 1","key":"10.1016\/j.toxlet.2014.04.013_bib0040","first-page":"S67L 74","article-title":"Insulin resistance and obesity in childhood","volume":"159","author":"Chiarelli","year":"2008","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.toxlet.2014.04.013_bib0045","doi-asserted-by":"crossref","first-page":"2670","DOI":"10.1093\/hmg\/ddp208","article-title":"Elucidation of separate, but collaborative functions of the rRNA methyltransferase-related human mitochondrial transcription factors B1 and B2 in mitochondrial biogenesis reveals new insight into maternally inherited deafness","volume":"18","author":"Cotney","year":"2009","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.toxlet.2014.04.013_bib0050","doi-asserted-by":"crossref","first-page":"2398","DOI":"10.1126\/science.1077780","article-title":"Rates of behavior and aging specified by mitochondrial function during development","volume":"298","author":"Dillin","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.toxlet.2014.04.013_bib0055","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1093\/ilar.43.4.244","article-title":"Guidelines for the design and statistical analysis of experiments using laboratory animals","volume":"43","author":"Festing","year":"2002","journal-title":"ILAR J.\/National Research Council, Institute of Laboratory Animal Resources"},{"key":"10.1016\/j.toxlet.2014.04.013_bib0060","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0005-2728(91)90009-D","article-title":"On the thyroid hormone-induced increase in respiratory capacity of isolated rat hepatocytes","volume":"1098","author":"Gregory","year":"1991","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.toxlet.2014.04.013_bib0065","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.mce.2009.02.018","article-title":"Endocrine disrupters as obesogens","volume":"304","author":"Grun","year":"2009","journal-title":"Mol. Cell Endocrinol."},{"key":"10.1016\/j.toxlet.2014.04.013_bib0070","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1136\/gut.2004.053850","article-title":"Apoptosis: a mechanism of acute and chronic liver injury","volume":"54","author":"Guicciardi","year":"2005","journal-title":"Gut"},{"key":"10.1016\/j.toxlet.2014.04.013_bib0075","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/978-1-60327-517-0_8","article-title":"Determination of high mitochondrial membrane potential in spermatozoa loaded with the mitochondrial probe 5,5\u2032,6,6\u2032-tetrachloro-1,1\u2032,3,3\u2032-tetraethylbenzimidazolyl-carbocyanine iodide (JC-1) by using fluorescence-activated flow cytometry","volume":"477","author":"Guthrie","year":"2008","journal-title":"Methods Mol. Biol. (Clifton, NJ)"},{"key":"10.1016\/j.toxlet.2014.04.013_bib0080","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1038\/nature04634","article-title":"Reactive oxygen species have a causal role in multiple forms of insulin resistance","volume":"440","author":"Houstis","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.toxlet.2014.04.013_bib0085","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.tiv.2012.03.017","article-title":"Low concentrations of bisphenol A induce lipid accumulation mediated by the production of reactive oxygen species in the mitochondria of HepG2 cells","volume":"26","author":"Huc","year":"2012","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.toxlet.2014.04.013_bib0090","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1016\/j.bbalip.2011.09.010","article-title":"Fatty acid transport proteins, implications in physiology and disease","volume":"1821","author":"Kazantzis","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.toxlet.2014.04.013_bib0095","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1002\/hep.20701","article-title":"Design and validation of a histological scoring system for nonalcoholic fatty liver disease","volume":"41","author":"Kleiner","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.toxlet.2014.04.013_bib0100","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1126\/science.275.5303.1132","article-title":"The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis","volume":"275","author":"Kluck","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.toxlet.2014.04.013_bib0105","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1001\/jama.300.11.1303","article-title":"Association of urinary bisphenol A concentration with medical disorders and laboratory abnormalities in adults","volume":"300","author":"Lang","year":"2008","journal-title":"JAMA"},{"key":"10.1016\/j.toxlet.2014.04.013_bib0110","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/j.jtcvs.2010.08.030","article-title":"Transient mitochondrial permeability transition pore opening after neonatal cardioplegic arrest","volume":"141","author":"Leung","year":"2011","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"10.1016\/j.toxlet.2014.04.013_bib0115","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1002\/hep.22183","article-title":"The lysosomal-mitochondrial axis in free fatty acid-induced hepatic lipotoxicity","volume":"47","author":"Li","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.toxlet.2014.04.013_bib0120","first-page":"49","article-title":"An innovative methodology for the automated morphometric and quantitative estimation of liver steatosis","volume":"24","author":"Liquori","year":"2009","journal-title":"Histol. Histopathol."},{"key":"10.1016\/j.toxlet.2014.04.013_bib0125","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxlet.2014.04.013_bib0130","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1002\/hep.24685","article-title":"Low doses of bisphenol A induce gene expression related to lipid synthesis and trigger triglyceride accumulation in adult mouse liver","volume":"55","author":"Marmugi","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.toxlet.2014.04.013_bib0135","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.cmet.2012.04.004","article-title":"Increased hepatic synthesis and dysregulation of cholesterol metabolism is associated with the severity of nonalcoholic fatty liver disease","volume":"15","author":"Min","year":"2012","journal-title":"Cell Metab."},{"key":"10.1016\/j.toxlet.2014.04.013_bib0140","doi-asserted-by":"crossref","first-page":"245","DOI":"10.5551\/jat.E486","article-title":"Perinatal and postnatal exposure to bisphenol a increases adipose tissue mass and serum cholesterol level in mice","volume":"14","author":"Miyawaki","year":"2007","journal-title":"J. Atheroscler. Thromb."},{"key":"10.1016\/j.toxlet.2014.04.013_bib0145","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.reprotox.2009.06.012","article-title":"Neonatal exposure to bisphenol A alters estrogen-dependent mechanisms governing sexual behavior in the adult female rat","volume":"28","author":"Monje","year":"2009","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.toxlet.2014.04.013_bib0150","first-page":"16","article-title":"Nonalcoholic fatty liver disease: biochemical and therapeutic considerations","volume":"81","author":"Patrick-Melin","year":"2009","journal-title":"Ukr. Biokhim. Zh."},{"key":"10.1016\/j.toxlet.2014.04.013_bib0155","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1002\/hep.1840380426","article-title":"Defective hepatic mitochondrial respiratory chain in patients with nonalcoholic steatohepatitis","volume":"38","author":"Perez-Carreras","year":"2003","journal-title":"Hepatology"},{"key":"10.1016\/j.toxlet.2014.04.013_bib0160","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.mito.2012.02.003","article-title":"Preliminary evidences on mitochondrial injury and impaired oxidative metabolism in breast cancer","volume":"12","author":"Putignani","year":"2012","journal-title":"Mitochondrion"},{"key":"10.1016\/j.toxlet.2014.04.013_bib0165","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.jhep.2009.11.030","article-title":"Mitochondrial dysfunction precedes insulin resistance and hepatic steatosis and contributes to the natural history of non-alcoholic fatty liver disease in an obese rodent model","volume":"52","author":"Rector","year":"2010","journal-title":"J. Hepatol."},{"key":"10.1016\/j.toxlet.2014.04.013_bib0170","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.reprotox.2007.06.004","article-title":"In vivo effects of bisphenol A in laboratory rodent studies","volume":"24","author":"Richter","year":"2007","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.toxlet.2014.04.013_bib0175","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1016\/S0140-6736(03)14942-2","article-title":"Hormones and insulin resistance during pregnancy","volume":"362","author":"Ryan","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.toxlet.2014.04.013_bib0180","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0014-5793(97)00669-8","article-title":"JC-1, but not DiOC6(3) or rhodamine 123, is a reliable fluorescent probe to assess delta psi changes in intact cells: implications for studies on mitochondrial functionality during apoptosis","volume":"411","author":"Salvioli","year":"1997","journal-title":"FEBS Lett."},{"issue":"Suppl. 3","key":"10.1016\/j.toxlet.2014.04.013_bib0185","first-page":"451","article-title":"Identifying critical windows of exposure for children's health","volume":"108","author":"Selevan","year":"2000","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.toxlet.2014.04.013_bib0190","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/j.freeradbiomed.2013.08.174","article-title":"Free radical biology for medicine: learning from nonalcoholic fatty liver disease","volume":"65C","author":"Serviddio","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.toxlet.2014.04.013_bib0195","doi-asserted-by":"crossref","first-page":"481641","DOI":"10.1155\/2012\/481641","article-title":"Urinary bisphenol A and hypertension in a multiethnic sample of US adults","volume":"2012","author":"Shankar","year":"2012","journal-title":"J. Environ. Public Health"},{"key":"10.1016\/j.toxlet.2014.04.013_bib0200","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1289\/ehp.11342","article-title":"Perinatal exposure to bisphenol a alters early adipogenesis in the rat","volume":"117","author":"Somm","year":"2009","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.toxlet.2014.04.013_bib0205","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/0076-6879(79)55040-X","article-title":"Isolation of an oligomycin-sensitive ATPase complex from rat liver mitochondria","volume":"55","author":"Soper","year":"1979","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.toxlet.2014.04.013_bib0210","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.reprotox.2007.07.010","article-title":"Human exposure to bisphenol A (BPA)","volume":"24","author":"Vandenberg","year":"2007","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.toxlet.2014.04.013_bib0215","doi-asserted-by":"crossref","first-page":"3771","DOI":"10.1210\/endo.138.9.5407","article-title":"Neuronal mitochondrial morphology and transmembrane potential are severely altered by hypothyroidism during rat brain development","volume":"138","author":"Vega-Nunez","year":"1997","journal-title":"Endocrinology"},{"key":"10.1016\/j.toxlet.2014.04.013_bib0220","doi-asserted-by":"crossref","first-page":"3049","DOI":"10.1210\/en.2011-0045","article-title":"Perinatal exposure to bisphenol A at reference dose predisposes offspring to metabolic syndrome in adult rats on a high-fat diet","volume":"152","author":"Wei","year":"2011","journal-title":"Endocrinology"},{"key":"10.1016\/j.toxlet.2014.04.013_bib0225","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1007\/s12012-010-9085-8","article-title":"Perinatal tobacco smoke exposure increases vascular oxidative stress and mitochondrial damage in non-human primates","volume":"10","author":"Westbrook","year":"2010","journal-title":"Cardiovasc. Toxicol."},{"key":"10.1016\/j.toxlet.2014.04.013_bib0230","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/S0890-6238(02)00051-5","article-title":"Maternal serum and amniotic fluid bisphenol A concentrations in the early second trimester","volume":"16","author":"Yamada","year":"2002","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.toxlet.2014.04.013_bib0235","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1002\/hep.26167","article-title":"Resistin reduces mitochondria and induces hepatic steatosis in mice by the protein kinase C\/protein kinase G\/p65\/PPAR gamma coactivator 1 alpha pathway","volume":"57","author":"Zhou","year":"2013","journal-title":"Hepatology"}],"container-title":["Toxicology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427414001726?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427414001726?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T05:13:37Z","timestamp":1759900417000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378427414001726"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7]]},"references-count":47,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["S0378427414001726"],"URL":"https:\/\/doi.org\/10.1016\/j.toxlet.2014.04.013","relation":{},"ISSN":["0378-4274"],"issn-type":[{"value":"0378-4274","type":"print"}],"subject":[],"published":{"date-parts":[[2014,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mitochondrial dysfunction in early life resulted from perinatal bisphenol A exposure contributes to hepatic steatosis in rat offspring","name":"articletitle","label":"Article Title"},{"value":"Toxicology Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxlet.2014.04.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}