{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T12:04:50Z","timestamp":1792757090862,"version":"4.5.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology Letters"],"published-print":{"date-parts":[[2014,8]]},"DOI":"10.1016\/j.toxlet.2014.05.011","type":"journal-article","created":{"date-parts":[[2014,5,21]],"date-time":"2014-05-21T06:03:53Z","timestamp":1400652233000},"page":"140-146","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["Prenatal alcohol exposure causes the over-expression of DHAND and EHAND by increasing histone H3K14 acetylation in C57 BL\/6 mice"],"prefix":"10.1016","volume":"228","author":[{"given":"Weihua","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqun","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiewei","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingjuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenguo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Xv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxlet.2014.05.011_bib0005","first-page":"35","article-title":"Where, when and what type of alcohol do pregnant women drink?","volume":"47","author":"Adusi-Poku","year":"2013","journal-title":"Ghana Med. J."},{"key":"10.1016\/j.toxlet.2014.05.011_bib0010","first-page":"407","article-title":"Using biochemical findings to study the effect of silymarin on the liver of pregnant rat that consumed ethanol","volume":"49","author":"Ahmadi-Ashtiani","year":"2011","journal-title":"Acta Med. Iranica"},{"key":"10.1016\/j.toxlet.2014.05.011_bib0015","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1161\/01.RES.0000197782.21444.8f","article-title":"Control of cardiac growth by histone acetylation\/deacetylation","volume":"98","author":"Backs","year":"2006","journal-title":"Circ. Res."},{"key":"10.1016\/j.toxlet.2014.05.011_bib0020","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.canlet.2009.02.013","article-title":"Isoform-specific histone deacetylase inhibitors: the next step?","volume":"280","author":"Balasubramanian","year":"2009","journal-title":"Cancer Lett."},{"key":"10.1016\/j.toxlet.2014.05.011_bib0025","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.ctrv.2013.05.009","article-title":"The promise and failures of epigenetic therapies for cancer treatment","volume":"40","author":"Bojang","year":"2014","journal-title":"Cancer Treat. Rev."},{"key":"10.1016\/j.toxlet.2014.05.011_bib0030","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/nsmb.2489","article-title":"Epigenetic programming and reprogramming during development","volume":"20","author":"Cantone","year":"2013","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.toxlet.2014.05.011_bib0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.toxlet.2005.07.010","article-title":"Dosage effects of resveratrol on ethanol-induced cell death in the human K562 cell line","volume":"161","author":"Chan","year":"2006","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.toxlet.2014.05.011_bib0040","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.cbi.2013.05.002","article-title":"Molecular flexibility and the electrostatic moments of curcumin and its derivatives in the active site of p300: a theoretical charge density study","volume":"204","author":"Devipriya","year":"2013","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.toxlet.2014.05.011_bib0045","doi-asserted-by":"crossref","first-page":"8353","DOI":"10.1074\/jbc.M113.540732","article-title":"Histone H3 lysine 14 (H3K14) acetylation facilitates DNA repair in a positioned nucleosome by stabilizing the binding of the chromatin remodeler RSC (remodels structure of chromatin)","volume":"289","author":"Duan","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxlet.2014.05.011_bib0050","doi-asserted-by":"crossref","first-page":"1943S","DOI":"10.3945\/ajcn.110.000927","article-title":"Developmental programming and epigenetics","volume":"94","author":"Gabory","year":"2011","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.toxlet.2014.05.011_bib0055","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.2353\/ajpath.2010.090528","article-title":"Renal failure increases cardiac histone h3 acetylation, dimethylation, and phosphorylation and the induction of cardiomyopathy-related genes in type 2 diabetes","volume":"176","author":"Gaikwad","year":"2010","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.toxlet.2014.05.011_bib0060","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.ydbio.2013.07.025","article-title":"The basic helix\u2013loop\u2013helix transcription factor Hand1 regulates mouse development as a homodimer","volume":"382","author":"Hu","year":"2013","journal-title":"Dev. Biol."},{"key":"10.1016\/j.toxlet.2014.05.011_bib0065","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.ab.2006.03.036","article-title":"An improved cloning strategy for chromatin-immunoprecipitation-derived DNA fragments","volume":"356","author":"Huang","year":"2006","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.toxlet.2014.05.011_bib0070","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.pnpbp.2013.07.009","article-title":"Antidepressant-like effects of curcumin in chronic mild stress of rats: involvement of its anti-inflammatory action","volume":"47","author":"Jiang","year":"2013","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.toxlet.2014.05.011_bib0075","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1186\/1471-2164-13-424","article-title":"H3K9 and H3K14 acetylation co-occur at many gene regulatory elements, while H3K14ac marks a subset of inactive inducible promoters in mouse embryonic stem cells","volume":"13","author":"Karmodiya","year":"2012","journal-title":"BMC Genomics"},{"key":"10.1016\/j.toxlet.2014.05.011_bib0080","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.vascn.2012.08.001","article-title":"Epigenetic histone acetylation and deacetylation mechanisms in experimental models of neurodegenerative disorders","volume":"66","author":"Konsoula","year":"2012","journal-title":"J. Pharmacol. Toxicol. Methods"},{"key":"10.1016\/j.toxlet.2014.05.011_bib0085","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1124\/mol.111.071126","article-title":"Resveratrol restores Nrf2 level and prevents ethanol-induced toxic effects in the cerebellum of a rodent model of fetal alcohol spectrum disorders","volume":"80","author":"Kumar","year":"2011","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.toxlet.2014.05.011_bib0090","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.ejpn.2013.03.008","article-title":"Diagnosis of fetal alcohol syndrome (FAS): German Guideline Version 2013","volume":"17","author":"Landgraf","year":"2013","journal-title":"Eur. J. Paediatr. Neurol.: EJPN"},{"key":"10.1016\/j.toxlet.2014.05.011_bib0095","first-page":"703","article-title":"The diagnosis of fetal alcohol syndrome","volume":"110","author":"Landgraf","year":"2013","journal-title":"Dtsch. Arztebl. Int."},{"key":"10.1016\/j.toxlet.2014.05.011_bib0100","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/1471-2199-9-53","article-title":"Selection of reference genes for quantitative real-time PCR in a rat asphyxial cardiac arrest model","volume":"9","author":"Langnaese","year":"2008","journal-title":"BMC Mol. Biol."},{"key":"10.1016\/j.toxlet.2014.05.011_bib0105","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.taap.2012.10.010","article-title":"Protective effects and mechanisms of curcumin on podophyllotoxin toxicity in vitro and in vivo","volume":"265","author":"Li","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.toxlet.2014.05.011_bib0110","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.tox.2012.08.010","article-title":"Neonatal exposure to benzo[a]pyrene decreases the levels of serum testosterone and histone H3K14 acetylation of the StAR promoter in the testes of SD rats","volume":"302","author":"Liang","year":"2012","journal-title":"Toxicology"},{"key":"10.1016\/j.toxlet.2014.05.011_bib0115","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.bbagrm.2010.05.008","article-title":"Histone deacetylase inhibitors: a chemical genetics approach to understanding cellular functions","volume":"1799","author":"Marks","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.toxlet.2014.05.011_bib0120","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.mcp.2005.09.008","article-title":"Effects of histone deacetylase inhibitor (HDACi); Trichostatin-A (TSA) on the expression of housekeeping genes","volume":"20","author":"Mogal","year":"2006","journal-title":"Mol. Cell. Probes"},{"key":"10.1016\/j.toxlet.2014.05.011_bib0125","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/modpathol.2012.214","article-title":"Molecular pathological epidemiology of epigenetics: emerging integrative science to analyze environment, host, and disease","volume":"26","author":"Ogino","year":"2013","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.toxlet.2014.05.011_bib0130","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.yexmp.2011.02.006","article-title":"Protective effect of quercetin, EGCG, catechin and betaine against oxidative stress induced by ethanol in vitro","volume":"90","author":"Oliva","year":"2011","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.toxlet.2014.05.011_bib0135","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.1126\/science.1132292","article-title":"Gene regulatory networks in the evolution and development of the heart","volume":"313","author":"Olson","year":"2006","journal-title":"Science (New York, NY)"},{"key":"10.1016\/j.toxlet.2014.05.011_bib0140","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.3390\/ijerph10041547","article-title":"Prevalence of fetal alcohol syndrome and maternal characteristics in a sample of schoolchildren from a rural province of Croatia","volume":"10","author":"Petkovic","year":"2013","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.toxlet.2014.05.011_bib0145","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/j.bbagrm.2010.09.005","article-title":"Small molecule modulators of histone acetylation and methylation: a disease perspective","volume":"1799","author":"Selvi","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.toxlet.2014.05.011_bib0150","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.lfs.2010.10.009","article-title":"Inhibition of p300-HAT results in a reduced histone acetylation and down-regulation of gene expression in cardiac myocytes","volume":"87","author":"Sun","year":"2010","journal-title":"Life Sci."},{"key":"10.1016\/j.toxlet.2014.05.011_bib0155","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1006\/dbio.1998.8849","article-title":"The bHLH factors, dHAND and eHAND, specify pulmonary and systemic cardiac ventricles independent of left\u2013right sidedness","volume":"196","author":"Thomas","year":"1998","journal-title":"Dev. Biol."},{"key":"10.1016\/j.toxlet.2014.05.011_bib0160","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.ydbio.2013.05.027","article-title":"The bHLH transcription factor hand is required for proper wing heart formation in Drosophila","volume":"381","author":"Togel","year":"2013","journal-title":"Dev. Biol."},{"key":"10.1016\/j.toxlet.2014.05.011_bib0165","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.bbrc.2006.02.122","article-title":"Essential role of Hand2 in interventricular septum formation and trabeculation during cardiac development","volume":"343","author":"Togi","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.toxlet.2014.05.011_bib0170","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.ab.2011.08.014","article-title":"Detecting multiple proteins by Western blotting using same-species primary antibodies, precomplexed serum, and hydrogen peroxide","volume":"419","author":"Upadhaya","year":"2011","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.toxlet.2014.05.011_bib0175","article-title":"Distal enhancers: new insights into heart development and disease","author":"Wamstad","year":"2013","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.toxlet.2014.05.011_bib0180","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.bbrc.2012.06.158","article-title":"Inhibition of histone acetylation by curcumin reduces alcohol-induced expression of heart development-related transcription factors in cardiac progenitor cells","volume":"424","author":"Wang","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.toxlet.2014.05.011_bib0185","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.ijcard.2009.01.073","article-title":"The protective role of curcumin in cardiovascular diseases","volume":"133","author":"Wongcharoen","year":"2009","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.toxlet.2014.05.011_bib0190","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1006\/dbio.2001.0417","article-title":"The combinatorial activities of Nkx2.5 and dHAND are essential for cardiac ventricle formation","volume":"239","author":"Yamagishi","year":"2001","journal-title":"Dev. Biol."},{"key":"10.1016\/j.toxlet.2014.05.011_bib0195","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.pedneo.2012.11.010","article-title":"Prevalence, mortality, and the disease burden of pediatric congenital heart disease in Taiwan","volume":"54","author":"Yeh","year":"2013","journal-title":"Pediatr. Neonatol."}],"container-title":["Toxicology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427414002161?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427414002161?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,3]],"date-time":"2018-10-03T21:58:53Z","timestamp":1538603933000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378427414002161"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8]]},"references-count":39,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["S0378427414002161"],"URL":"https:\/\/doi.org\/10.1016\/j.toxlet.2014.05.011","relation":{},"ISSN":["0378-4274"],"issn-type":[{"value":"0378-4274","type":"print"}],"subject":[],"published":{"date-parts":[[2014,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prenatal alcohol exposure causes the over-expression of DHAND and EHAND by increasing histone H3K14 acetylation in C57 BL\/6 mice","name":"articletitle","label":"Article Title"},{"value":"Toxicology Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxlet.2014.05.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ireland Ltd. Published by Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}