{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T05:02:38Z","timestamp":1777870958610,"version":"3.51.4"},"reference-count":38,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81371730"],"award-info":[{"award-number":["81371730"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["11040606M213"],"award-info":[{"award-number":["11040606M213"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013286","name":"Specialized Research Fund for the Doctoral Program of Higher Education of China","doi-asserted-by":"publisher","award":["20133420110001"],"award-info":[{"award-number":["20133420110001"]}],"id":[{"id":"10.13039\/501100013286","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/I025379\/1"],"award-info":[{"award-number":["BB\/I025379\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/G015554\/1"],"award-info":[{"award-number":["BB\/G015554\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002338","name":"Ministry of Education of the People's Republic of China","doi-asserted-by":"publisher","award":["210100"],"award-info":[{"award-number":["210100"]}],"id":[{"id":"10.13039\/501100002338","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology Letters"],"published-print":{"date-parts":[[2014,8]]},"DOI":"10.1016\/j.toxlet.2014.06.841","type":"journal-article","created":{"date-parts":[[2014,6,26]],"date-time":"2014-06-26T12:01:53Z","timestamp":1403784113000},"page":"229-239","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["Complement C3a binding to its receptor as a negative modulator of Th2 response in liver injury in trichloroethylene-sensitized mice"],"prefix":"10.1016","volume":"229","author":[{"given":"Feng","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wan-sheng","family":"Zha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia-xiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu-long","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang-ping","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tong","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang-hao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi-xing","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"6603","key":"10.1016\/j.toxlet.2014.06.841_bib0005","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/383787a0","article-title":"Functional diversity of helper T lymphocytes","volume":"383","author":"Abbas","year":"1996","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.toxlet.2014.06.841_bib0010","doi-asserted-by":"crossref","first-page":"6341","DOI":"10.4049\/jimmunol.166.10.6341","article-title":"Identification of a selective nonpeptide antagonist of the anaphylatoxin C3a receptor that demonstrates antiinflammatory activity in animal models","volume":"166","author":"Ames","year":"2001","journal-title":"J. Immunol."},{"key":"10.1016\/j.toxlet.2014.06.841_bib0015","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s00281-003-0133-3","article-title":"Complement in transplant rejection: diagnostic and mechanistic considerations","volume":"25","author":"Baldwin","year":"2003","journal-title":"Springer Semin. Immunopathol."},{"issue":"3","key":"10.1016\/j.toxlet.2014.06.841_bib0020","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.4049\/jimmunol.175.3.1947","article-title":"Signaling through up-regulated C3a receptor is key to the development of experimental lupus nephritis","volume":"175","author":"Bao","year":"2005","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.toxlet.2014.06.841_bib0025","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.taap.2007.11.031","article-title":"Chronic exposure to trichloroethene causes early onset of SLE-like disease in female MRL+\/+ mice","volume":"228","author":"Cai","year":"2008","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"12","key":"10.1016\/j.toxlet.2014.06.841_bib0030","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1164\/rccm.200701-049OC","article-title":"Complement C3a regulates Muc5ac expression by airway Clara cells independently of Th2 responses","volume":"175","author":"Dillard","year":"2007","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"10","key":"10.1016\/j.toxlet.2014.06.841_bib0035","doi-asserted-by":"crossref","first-page":"5233","DOI":"10.4049\/jimmunol.169.10.5926","article-title":"Absence of the complement anaphylatoxin C3a receptor suppresses Th2 effector functions in a murine model of pulmonary allergy","volume":"169","author":"Drouin","year":"2002","journal-title":"J. Immunol."},{"issue":"5","key":"10.1016\/j.toxlet.2014.06.841_bib0040","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1038\/sj.jcbfm.9600608","article-title":"C3a receptor modulation of granulocyte infiltration after murine focal cerebral ischemia is reperfusion dependent","volume":"28","author":"Ducruet","year":"2008","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"1","key":"10.1016\/j.toxlet.2014.06.841_bib0045","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1093\/toxsci\/kfs093","article-title":"Epigenetic alterations may regulate temporary reversal of CD4+ T cell activation caused by trichloroethylene exposure","volume":"127","author":"Gilbert","year":"2012","journal-title":"Toxicol. Sci."},{"issue":"4","key":"10.1016\/j.toxlet.2014.06.841_bib0050","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1021\/tx800409r","article-title":"Delineating liver events in trichloroethylene-induced autoimmune hepatitis","volume":"22","author":"Gilbert","year":"2009","journal-title":"Chem. Res. Toxicol."},{"issue":"3","key":"10.1016\/j.toxlet.2014.06.841_bib0055","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1001\/archderm.137.3.274","article-title":"A case of trichloroethylene hypersen-sitivity syndrome","volume":"137","author":"Goon","year":"2001","journal-title":"Arch. Dermatol."},{"issue":"2","key":"10.1016\/j.toxlet.2014.06.841_bib0060","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1093\/toxsci\/57.2.345","article-title":"CD4+ T-cell activation and induction of autoimmune hepatitis following trichloroethylene treatment in MRL+\/+ mice","volume":"57","author":"Griffin","year":"2000","journal-title":"Toxicol. Sci."},{"issue":"8","key":"10.1016\/j.toxlet.2014.06.841_bib0065","doi-asserted-by":"crossref","first-page":"2863","DOI":"10.1182\/blood.V89.8.2863","article-title":"C3a and C5a stimulate chemotaxis of human mast cells","volume":"89","author":"Hartmann","year":"1997","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.toxlet.2014.06.841_bib0070","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.biortech.2009.07.079","article-title":"Biological removal of the xenobiotic trichloroethylene (TCE) through cometabolism in nitrifying systems","volume":"101","author":"Kocamemi","year":"2010","journal-title":"Bioresour. Technol."},{"issue":"1-3","key":"10.1016\/j.toxlet.2014.06.841_bib0075","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s12026-012-8327-1","article-title":"Complement regulation of T cell immunity","volume":"54","author":"Kwan","year":"2012","journal-title":"Immunol. Res."},{"issue":"4","key":"10.1016\/j.toxlet.2014.06.841_bib0080","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1046\/j.1471-4159.1997.68041581.x","article-title":"Sublytic terminal complement attack on myotubes decreases the expression of mRNAs encoding muscle-specific proteins","volume":"68","author":"Lang","year":"1997","journal-title":"J. Neurochem."},{"issue":"4","key":"10.1016\/j.toxlet.2014.06.841_bib0085","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1002\/eji.1830260405","article-title":"Expression of high- and low-affinity receptors for C3a on the human mast cell line, HMC-1","volume":"26","author":"Legler","year":"1996","journal-title":"Eur. J. Immunol."},{"issue":"9","key":"10.1016\/j.toxlet.2014.06.841_bib0090","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.2337\/db09-0323","article-title":"The C3a anaphylatoxin receptor is a key mediator of insulin resistance and functions by modulating adipose tissue macrophage infiltration and activation","volume":"58","author":"Mamane","year":"2009","journal-title":"Diabetes"},{"issue":"3","key":"10.1016\/j.toxlet.2014.06.841_bib0095","doi-asserted-by":"crossref","first-page":"715","DOI":"10.2353\/ajpath.2007.070166","article-title":"The role of complement in inflammatory diseases from behind the scenes into the spotlight","volume":"171","author":"Markiewski","year":"2007","journal-title":"Am. J. Pathol."},{"issue":"1","key":"10.1016\/j.toxlet.2014.06.841_bib0100","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1539\/joh.45.8","article-title":"Generalized skin reactions in relation to trichloroethylene exposure: a review from the viewpoint of drug-metabolizing enzymes","volume":"45","author":"Nakajima","year":"2003","journal-title":"J. Occup. Health"},{"issue":"1","key":"10.1016\/j.toxlet.2014.06.841_bib0105","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1111\/j.1600-0625.2011.01403.x","article-title":"Participation of complement 3a receptor (C3aR) in the sensitization phase of Th2 mediated allergic contact dermatitis","volume":"21","author":"Niebuhr","year":"2012","journal-title":"Exp. Dermatol."},{"issue":"4","key":"10.1016\/j.toxlet.2014.06.841_bib0110","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.4049\/jimmunol.157.4.1693","article-title":"C3a and C5a are chemotaxins for human mast-cells and act through distinct receptors via a pertussis toxin-sensitive signal transduction pathway","volume":"157","author":"Nilsson","year":"1996","journal-title":"J. Immunol."},{"key":"10.1016\/j.toxlet.2014.06.841_bib0115","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/1471-2377-12-95","article-title":"TH1\/TH2 cytokine profile in relapsing-remitting multiple sclerosis patients treated with Glatiramer acetate or Nataliumab","volume":"12","author":"Oreja-Guevara","year":"2012","journal-title":"BMC Neurol."},{"issue":"3","key":"10.1016\/j.toxlet.2014.06.841_bib0120","doi-asserted-by":"crossref","first-page":"385","DOI":"10.2486\/indhealth.42.385","article-title":"Generalized eruption accompanied by hepatitis in two Thai metal cleaners exposed to trichloroethylene","volume":"42","author":"Pantucharoensri","year":"2004","journal-title":"Ind. Health"},{"issue":"2","key":"10.1016\/j.toxlet.2014.06.841_bib0125","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1289\/ehp.1002106","article-title":"A case\u2013control study of occupational exposure to trichloroethylene and non-Hodgkin lymphoma","volume":"119","author":"Purdue","year":"2011","journal-title":"Environ. Health Perspect."},{"issue":"6","key":"10.1016\/j.toxlet.2014.06.841_bib0130","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1182\/blood-2003-06-2099","article-title":"Mobilization studies in mice deficient in either C3 or C3a receptor (C3aR) reveal a novel role for complement in retention of hematopoietic stem\/progenitor cells in bone marrow","volume":"103","author":"Ratajczak","year":"2004","journal-title":"Blood"},{"issue":"9","key":"10.1016\/j.toxlet.2014.06.841_bib0135","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/ni.1923","article-title":"Complement: a key system for immune surveillance and homeostasis","volume":"11","author":"Ricklin","year":"2010","journal-title":"Nat. Immunol."},{"issue":"2\u20133","key":"10.1016\/j.toxlet.2014.06.841_bib0140","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.tox.2008.03.016","article-title":"Trichloroethylene induced cutaneous irritation in BALB\/c hairless mice: histopathological changes and oxidative damage","volume":"248","author":"Shen","year":"2008","journal-title":"Toxicology"},{"issue":"10","key":"10.1016\/j.toxlet.2014.06.841_bib0145","doi-asserted-by":"crossref","first-page":"4581","DOI":"10.4049\/jimmunol.150.10.4581","article-title":"Enhanced degradation of messenger RNA encoding myelin proteins by terminal complement complexes in oligodendrocytes","volume":"150","author":"Shirazi","year":"1993","journal-title":"J. Immunol."},{"issue":"6","key":"10.1016\/j.toxlet.2014.06.841_bib0150","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1084\/jem.20030374","article-title":"The proinflammatory mediators C3a and C5a are essential for liver regeneration","volume":"198","author":"Strey","year":"2003","journal-title":"J. Exp. Med."},{"issue":"2","key":"10.1016\/j.toxlet.2014.06.841_bib0155","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1539\/joh.L7114","article-title":"Characterization of liver injury associated with hypersensitive skin reactions induced by trichloroethylene in the guinea pig maximization test","volume":"50","author":"Tang","year":"2008","journal-title":"J. Occup. Health"},{"issue":"1","key":"10.1016\/j.toxlet.2014.06.841_bib0160","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s12026-011-8239-5","article-title":"Membrane attack by complement: assembly and biology of terminal complement complexes","volume":"51","author":"Tegla","year":"2011","journal-title":"Immunol. Res."},{"issue":"2","key":"10.1016\/j.toxlet.2014.06.841_bib0165","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1161\/01.RES.0000255032.33661.88","article-title":"Antibody and complement in transplant vasculopathy","volume":"100","author":"Wehner","year":"2007","journal-title":"Circ. Res."},{"issue":"9","key":"10.1016\/j.toxlet.2014.06.841_bib0170","first-page":"641","article-title":"Changes in humoral immunity in sensitized guinea pigs exposed to trichloroethylene","volume":"30","author":"Xu","year":"2012","journal-title":"Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi"},{"issue":"2\u20133","key":"10.1016\/j.toxlet.2014.06.841_bib0175","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.tox.2012.06.008","article-title":"Possible role of complement activation in renal impairment in trichloroethylene-sensitized guinea pigs","volume":"302","author":"Yu","year":"2012","journal-title":"Toxicology"},{"issue":"8","key":"10.1016\/j.toxlet.2014.06.841_bib0180","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1111\/j.1600-6143.2011.03579.x","article-title":"Liver ischemia and reperfusion injury: new insights into mechanisms of innate-adaptive immune-mediated tissue inflammation","volume":"11","author":"Zhai","year":"2011","journal-title":"Am. J. Transplant."},{"issue":"6","key":"10.1016\/j.toxlet.2014.06.841_bib0185","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1177\/1091581813511337","article-title":"Complement activation and liver impairment in trichloroethylene-sensitized BALB\/c mice","volume":"32","author":"Zhang","year":"2013","journal-title":"Int. J. Toxicol."},{"issue":"4","key":"10.1016\/j.toxlet.2014.06.841_bib0190","first-page":"284","article-title":"Studying the changes of the related serum complement immune indexes in patients with occupational medicamentosa-like dermatitis induced by trichloroethylene and workers occupationally exposed to trichloroethylene","volume":"30","author":"Zhao","year":"2012","journal-title":"Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi"}],"container-title":["Toxicology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427414010911?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427414010911?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T16:53:36Z","timestamp":1777568016000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378427414010911"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["S0378427414010911"],"URL":"https:\/\/doi.org\/10.1016\/j.toxlet.2014.06.841","relation":{},"ISSN":["0378-4274"],"issn-type":[{"value":"0378-4274","type":"print"}],"subject":[],"published":{"date-parts":[[2014,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Complement C3a binding to its receptor as a negative modulator of Th2 response in liver injury in trichloroethylene-sensitized mice","name":"articletitle","label":"Article Title"},{"value":"Toxicology Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxlet.2014.06.841","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Published by Elsevier Ireland Ltd.","name":"copyright","label":"Copyright"}]}}